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Conserved domains on  [gi|1370484904|ref|XP_016862509|]
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protein SEC13 homolog isoform X7 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-302 3.03e-34

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 122
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 202
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 203 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 280
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....
gi 1370484904 281 --DVVWHVSWSITANILAVSGGDN 302
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDG 352
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-302 3.03e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 122
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 202
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 203 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 280
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....
gi 1370484904 281 --DVVWHVSWSITANILAVSGGDN 302
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDG 352
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-303 1.04e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 107
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 108 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 182
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 183 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370484904 262 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNK 303
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGT 242
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 67-104 1.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370484904   67 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 104
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 29-108 1.46e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  29 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 101
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 1370484904 102 IIWREEN 108
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
220-261 3.25e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370484904 220 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
43-302 3.03e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.88  E-value: 3.03e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 122
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPHdyGLILACGSSDGAISLltYTGEGQWEVKKInNAHTIGCNAVSWapavvpgslidHPSGQkpnyikRFAS 202
Cdd:COG2319   206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAF-----------SPDGR------LLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 203 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN- 280
Cdd:COG2319   264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                         250       260
                  ....*....|....*....|....
gi 1370484904 281 --DVVWHVSWSITANILAVSGGDN 302
Cdd:COG2319   329 htGAVRSVAFSPDGKTLASGSDDG 352
WD40 COG2319
WD40 repeat [General function prediction only];
43-302 6.23e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 6.23e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 122
Cdd:COG2319   174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPhDyGLILACGSSDGAISLLTYTGegqWEVKKINNAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFAS 202
Cdd:COG2319   248 SVRSVAFSP-D-GRLLASGSADGTVRLWDLAT---GELLRTLTGHSGGVNSVAF-----------SPDG------KLLAS 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 203 GGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddassNTWSPKLLHKFN-- 280
Cdd:COG2319   306 GSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW-------DLATGELLRTLTgh 371

                         250       260
                  ....*....|....*....|...
gi 1370484904 281 -DVVWHVSWSITANILAVSGGDN 302
Cdd:COG2319   372 tGAVTSVAFSPDGRTLASGSADG 394
WD40 COG2319
WD40 repeat [General function prediction only];
43-261 3.09e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.48  E-value: 3.09e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWReeNGTWEKSHEHAGHDS 122
Cdd:COG2319   216 GKLLASGSADGTVRLWDLATGK--LLRTLTGHSGSVRSVAFSP--DGRLLASGSADGTVRLWD--LATGELLRTLTGHSG 289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPHdyGLILACGSSDGAISLltytgegqWEVK-----KINNAHTIGCNAVSWapavvpgslidHPSGqkpnyi 197
Cdd:COG2319   290 GVNSVAFSPD--GKLLASGSDDGTVRL--------WDLAtgkllRTLTGHTGAVRSVAF-----------SPDG------ 342

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370484904 198 KRFASGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:COG2319   343 KTLASGSDDGTVRLW---DLATGELLRTLTGHTGAVTSVAFSPD----GRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
28-302 7.29e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 122.71  E-value: 7.29e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 107
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 108 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWApavvpgsli 186
Cdd:COG2319   151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFS--------- 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 187 dhPSGQkpnyikRFASGGCDNLIKLWkEEEDGqwKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 266
Cdd:COG2319   214 --PDGK------LLASGSADGTVRLW-DLATG--KLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1370484904 267 SSNTWsPKLLHKFNDVVWHVSWSITANILAVSGGDN 302
Cdd:COG2319   276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDG 310
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-303 1.04e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.05  E-value: 1.04e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 107
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 108 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 182
Cdd:cd00200    82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 183 gslidhpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:cd00200   147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1370484904 262 tcdDASSNTWSpKLLHKFNDVVWHVSWSITANILAVSGGDNK 303
Cdd:cd00200   205 ---DLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGT 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-302 1.42e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 111.27  E-value: 1.42e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  25 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 104
Cdd:cd00200    45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 105 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWapa 179
Cdd:cd00200   121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAF--- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 180 vvpgslidHPSGqkpnyiKRFASGGCDNLIKLWkEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 259
Cdd:cd00200   186 --------SPDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370484904 260 IWtcddassNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDN 302
Cdd:cd00200   245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADG 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-261 2.48e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 2.48e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQIliADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWreE 107
Cdd:cd00200    90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKLW--D 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 108 NGTWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLLTYTGegqWEVKKINNAHTIGCNAVSWAPavvpgslid 187
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPD--GEKLLSSSSDGTIKLWDLST---GKCLGTLRGHENGVNSVAFSP--------- 229

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1370484904 188 hpsgqkPNYIkrFASGGCDNLIKLWKEEEdgqWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:cd00200   230 ------DGYL--LASGSEDGTIRVWDLRT---GECVQTLSGHTNSVTSLAWSPD----GKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
43-303 4.26e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 4.26e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  43 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 122
Cdd:COG2319    48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 123 SVNSVCWAPHdyGLILACGSSDGAISLL-TYTGEGQWEVKkinnAHTIGCNAVSWapavvpgslidHPSGqkpnyiKRFA 201
Cdd:COG2319   122 AVRSVAFSPD--GKTLASGSADGTVRLWdLATGKLLRTLT----GHSGAVTSVAF-----------SPDG------KLLA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 202 SGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDASSNTWsPKLLHKFND 281
Cdd:COG2319   179 SGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD-G---KLLASGSADGTVRLW---DLATGKL-LRTLTGHSG 247

                         250       260
                  ....*....|....*....|..
gi 1370484904 282 VVWHVSWSITANILAVSGGDNK 303
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-302 1.57e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.09  E-value: 1.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  67 LIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDSSVNSV-CWAPHDYgliLACGSSDG 145
Cdd:cd00200     1 LRRTLKGHTGGVTCVAF-SPD-GKLLATGSGDGTIKVWDLETGELLRTLK--GHTGPVRDVaASADGTY---LASGSSDK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 146 AISLLTYTGEgqwEVKKINNAHTIGCNAVSWAPAvvpGSLIdhpsgqkpnyikrfASGGCDNLIKLWKEEEDgqwKEEQK 225
Cdd:cd00200    74 TIRLWDLETG---ECVRTLTGHTSYVSSVAFSPD---GRIL--------------SSSSRDKTIKVWDVETG---KCLTT 130

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370484904 226 LEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddaSSNTWSP-KLLHKFNDVVWHVSWSITANILAVSGGDN 302
Cdd:cd00200   131 LRGHTDWVNSVAFSPD----GTFVASSSQDGTIKLW-----DLRTGKCvATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 28-213 4.08e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIWreE 107
Cdd:cd00200   132 RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK--CVATLTGHTGEVNSVAF-SPD-GEKLLSSSSDGTIKLW--D 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904 108 NGTWEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLltytgegqWEVKKIN-----NAHTIGCNAVSWapavvp 182
Cdd:cd00200   206 LSTGKCLGTLRGHENGVNSVAFSPDGY--LLASGSEDGTIRV--------WDLRTGEcvqtlSGHTNSVTSLAW------ 269

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1370484904 183 gslidHPSGQkpnyikRFASGGCDNLIKLWK 213
Cdd:cd00200   270 -----SPDGK------RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
28-105 4.31e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.01  E-value: 4.31e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370484904  28 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 105
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 67-104 1.78e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 1.78e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1370484904   67 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 104
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 219-261 7.84e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 7.84e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1370484904  219 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 29-108 1.46e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370484904  29 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 101
Cdd:PTZ00420   72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                  ....*..
gi 1370484904 102 IIWREEN 108
Cdd:PTZ00420  151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
220-261 3.25e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.25e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370484904 220 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 261
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
67-104 3.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.35e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1370484904  67 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 104
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 110-149 1.72e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 1.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1370484904  110 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 149
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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