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Conserved domains on  [gi|1034638449|ref|XP_016863236|]
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PACRG-like protein isoform X4 [Homo sapiens]

Protein Classification

parkin coregulated gene family protein( domain architecture ID 10563193)

parkin coregulated gene (PACRG) family protein similar to human PACRG that suppresses cell death induced by the accumulation of unfolded Pael receptor (Pael-R), which is a substrate of parkin

PubMed:  18387367|12547187

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
126-266 1.71e-54

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


:

Pssm-ID: 431190  Cd Length: 183  Bit Score: 174.02  E-value: 1.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 126 SAFAAIYSKGGIPCRLVHGSVKHRLQWECPPESLSFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVKGaPEKAIPLLP 205
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAEG-GEKILPVLP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 206 RLIPVLKAALVHSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLT-------------------------------- 250
Cdd:pfam10274  80 QLILPLKAALNTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPvlnlfknkrvnlgdridyrkrknigdliqetl 159
                         170       180
                  ....*....|....*....|....
gi 1034638449 251 --------SGSLSIIKSKIPTYCS 266
Cdd:pfam10274 160 ellernggPDALINIKYMIPTYES 183
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
126-266 1.71e-54

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 174.02  E-value: 1.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 126 SAFAAIYSKGGIPCRLVHGSVKHRLQWECPPESLSFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVKGaPEKAIPLLP 205
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAEG-GEKILPVLP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 206 RLIPVLKAALVHSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLT-------------------------------- 250
Cdd:pfam10274  80 QLILPLKAALNTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPvlnlfknkrvnlgdridyrkrknigdliqetl 159
                         170       180
                  ....*....|....*....|....
gi 1034638449 251 --------SGSLSIIKSKIPTYCS 266
Cdd:pfam10274 160 ellernggPDALINIKYMIPTYES 183
 
Name Accession Description Interval E-value
ParcG pfam10274
Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA ...
126-266 1.71e-54

Parkin co-regulated protein; This family of proteins is transcribed anti-sense along the DNA to the Parkin gene product and the two appear to be transcribed under the same promoter. The protein has predicted alpha-helical and beta-sheet domains which suggest its function is in the ubiquitin/proteasome system. Mutations in parkin are the genetic cause of early-onset and autosomal recessive juvenile parkinsonism.


Pssm-ID: 431190  Cd Length: 183  Bit Score: 174.02  E-value: 1.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 126 SAFAAIYSKGGIPCRLVHGSVKHRLQWECPPESLSFDPLLITLAEGLRETKHPYTFVSKEGFRELLLVKGaPEKAIPLLP 205
Cdd:pfam10274   1 TSFRYVYDRGDIPCRINHGSVKNKIQWKVDPEQLDYHPYLPTFFDGLRETKHPYRFVARNGIRDLLEAEG-GEKILPVLP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638449 206 RLIPVLKAALVHSDDEVFERGLNALVQL---SVVVGPSLNDHLKHLLT-------------------------------- 250
Cdd:pfam10274  80 QLILPLKAALNTRDPEVFCVALKVLQLLvksSDLIGEALVPYYRQLLPvlnlfknkrvnlgdridyrkrknigdliqetl 159
                         170       180
                  ....*....|....*....|....
gi 1034638449 251 --------SGSLSIIKSKIPTYCS 266
Cdd:pfam10274 160 ellernggPDALINIKYMIPTYES 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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