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Conserved domains on  [gi|1034638695|ref|XP_016863319|]
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ATPase family gene 2 protein homolog A isoform X14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 350-572 1.18e-96

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 298.07  E-value: 1.18e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE-KRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAA 508
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFE---SRGDVLIIAATNRPDLLDPA 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:COG1222   232 LLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAG 294
CDC48_N super family cl21693
Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 7.02e-05

Cell division protein 48 (CDC48), N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases pfam00004 is a substrate 185-residue recognition domain.


The actual alignment was detected with superfamily member smart01073:

Pssm-ID: 451359 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 7.02e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695   65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 350-572 1.18e-96

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 298.07  E-value: 1.18e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE-KRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAA 508
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFE---SRGDVLIIAATNRPDLLDPA 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:COG1222   232 LLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAG 294
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 323-583 4.81e-94

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 304.14  E-value: 4.81e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 323 FYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 403 IARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 483 GIGsevSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGA 562
Cdd:TIGR01243 308 GLK---GRGRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383

                         250       260
                  ....*....|....*....|.
gi 1034638695 563 DLKVLCNEAGPQrrrggALRR 583
Cdd:TIGR01243 384 DLAALAKEAAMA-----ALRR 399
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 355-521 3.21e-91

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 278.02  E-value: 3.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19503     2 IGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGR 514
Cdd:cd19503    82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMS---SRGKVVVIAATNRPDAIDPALRRPGR 158


                  ....*..
gi 1034638695 515 FDKEIEI 521
Cdd:cd19503   159 FDREVEI 165
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 349-572 2.62e-70

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 231.64  E-value: 2.62e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:PRK03992  127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 429 GETeAKL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPH 503
Cdd:PRK03992  207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGFD---PRGNVKIIAATNRID 281

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034638695 504 ALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:PRK03992  282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAG 349
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 390-523 2.68e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.39  E-value: 2.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 470 EKRVVASLLTLMDGIgsEVSEGQVLVLGATNRPHALDAALRrpGRFDKEIEIGV 523
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 387-525 4.29e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.49  E-value: 4.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695  387 PRGVLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEAKLRQIFAEATLRHPSI 449
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034638695  450 IFIDELDALCPKREGAQNEVEKRVVAslltlmdgIGSEVSEGQVLVLGATNRPHALDAALRRPgRFDKEIEIGVPN 525
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 7.02e-05

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 7.02e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695   65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
 
Name Accession Description Interval E-value
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 350-572 1.18e-96

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 298.07  E-value: 1.18e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:COG1222    75 VTFDDIGGLDEQIEEIREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSELVSKYIG 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVE-KRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAA 508
Cdd:COG1222   155 EGARNVREVFELAREKAPSIIFIDEIDAIAARRTDDGTSGEvQRTVNQLLAELDGFE---SRGDVLIIAATNRPDLLDPA 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:COG1222   232 LLRPGRFDRVIEVPLPDEEAREEILKIHLRDMP-LADDVDLDKLAKLTEGFSGADLKAIVTEAG 294
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 323-583 4.81e-94

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 304.14  E-value: 4.81e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 323 FYFISSTTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTM 402
Cdd:TIGR01243 148 FVYVTEATEVEIREKPVREEIERKVPKVTYEDIGGLKEAKEKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTL 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 403 IARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMD 482
Cdd:TIGR01243 228 LAKAVANEAGAYFISINGPEIMSKYYGESEERLREIFKEAEENAPSIIFIDEIDAIAPKREEVTGEVEKRVVAQLLTLMD 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 483 GIGsevSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGA 562
Cdd:TIGR01243 308 GLK---GRGRVIVIGATNRPDALDPALRRPGRFDREIVIRVPDKRARKEILKVHTRNMP-LAEDVDLDKLAEVTHGFVGA 383

                         250       260
                  ....*....|....*....|.
gi 1034638695 563 DLKVLCNEAGPQrrrggALRR 583
Cdd:TIGR01243 384 DLAALAKEAAMA-----ALRR 399
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 355-521 3.21e-91

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 278.02  E-value: 3.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19503     2 IGGLDEQIASLKELIELPLKYPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEAGANFLSISGPSIVSKYLGESEKN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGR 514
Cdd:cd19503    82 LREIFEEARSHAPSIIFIDEIDALAPKREEDQREVERRVVAQLLTLMDGMS---SRGKVVVIAATNRPDAIDPALRRPGR 158


                  ....*..
gi 1034638695 515 FDKEIEI 521
Cdd:cd19503   159 FDREVEI 165
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 355-522 2.56e-87

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 268.15  E-value: 2.56e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19519     2 IGGCRKQLAQIREMVELPLRHPELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGR 514
Cdd:cd19519    82 LRKAFEEAEKNAPAIIFIDEIDAIAPKREKTHGEVERRIVSQLLTLMDGLK---QRAHVIVMAATNRPNSIDPALRRFGR 158


                  ....*...
gi 1034638695 515 FDKEIEIG 522
Cdd:cd19519   159 FDREIDIG 166
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 329-571 8.30e-78

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 251.75  E-value: 8.30e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 329 TTRVNFTEIDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVA 408
Cdd:COG0464   133 APLVTYEDIGGLEEELLELREAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALA 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 409 NEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIgsev 488
Cdd:COG0464   213 GELGLPLIEVDLSDLVSKYVGETEKNLREVFDKARGLAPCVLFIDEADALAGKRGEVGDGVGRRVVNTLLTEMEEL---- 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 489 sEGQVLVLGATNRPHALDAALRRpgRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLC 568
Cdd:COG0464   289 -RSDVVVIAATNRPDLLDPALLR--RFDEIIFFPLPDAEERLEIFRIHLRKRP-LDEDVDLEELAEATEGLSGADIRNVV 364


                  ...
gi 1034638695 569 NEA 571
Cdd:COG0464   365 RRA 367
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 349-572 2.62e-70

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 231.64  E-value: 2.62e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:PRK03992  127 NVTYEDIGGLEEQIREVREAVELPLKKPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSELVQKFI 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 429 GETeAKL-RQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPH 503
Cdd:PRK03992  207 GEG-ARLvRELFELAREKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAEMDGFD---PRGNVKIIAATNRID 281

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034638695 504 ALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:PRK03992  282 ILDPAILRPGRFDRIIEVPLPDEEGRLEILKIHTRKM-NLADDVDLEELAELTEGASGADLKAICTEAG 349
26Sp45 TIGR01242
26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an ...
 343-572 7.32e-65

26S proteasome subunit P45 family; Many proteins may score above the trusted cutoff because an internal


Pssm-ID: 130309 [Multi-domain]  Cd Length: 364  Bit Score: 216.59  E-value: 7.32e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 343 EQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPE 422
Cdd:TIGR01242 112 EVEERPNVSYEDIGGLEEQIREIREAVELPLKHPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSE 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 423 IISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGA 498
Cdd:TIGR01242 192 LVRKYIGEGARLVREIFELAKEKAPSIIFIDEIDAIAAKRtdsgTSGDREVQ-RTLMQLLAELDGFD---PRGNVKVIAA 267

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 499 TNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILqKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:TIGR01242 268 TNRPDILDPALLRPGRFDRIIEVPLPDFEGRLEIL-KIHTRKMKLAEDVDLEAIAKMTEGASGADLKAICTEAG 340
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 355-519 8.11e-65

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 209.57  E-value: 8.11e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19518     2 IGGMDSTLKELCELLIHPILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELKVPFLKISATEIVSGVSGESEEK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQ-VLVLGATNRPHALDAALRRPG 513
Cdd:cd19518    82 IRELFDQAISNAPCIVFIDEIDAITPKRESAQREMERRIVSQLLTCMDELNNEKTAGGpVLVIGATNRPDSLDPALRRAG 161


                  ....*.
gi 1034638695 514 RFDKEI 519
Cdd:cd19518   162 RFDREI 167
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 350-571 2.09e-62

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 219.39  E-value: 2.09e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:TIGR01243 450 VRWSDIGGLEEVKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIAVRGPEILSKWVG 529

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNE-VEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAA 508
Cdd:TIGR01243 530 ESEKAIREIFRKARQAAPAIIFFDEIDAIAPARGARFDTsVTDRIVNQLLTEMDGI---QELSNVVVIAATNRPDILDPA 606

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034638695 509 LRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEA 571
Cdd:TIGR01243 607 LLRPGRFDRLILVPPPDEEARKEIFKIHTRSMP-LAEDVDLEELAEMTEGYTGADIEAVCREA 668
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 363-519 3.08e-61

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 199.82  E-value: 3.08e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 363 KAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19511     3 RELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFISVKGPELFSKYVGESERAVREIFQKA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034638695 443 TLRHPSIIFIDELDALCPKReGAQNE--VEKRVVASLLTLMDGIGSEVsegQVLVLGATNRPHALDAALRRPGRFDKEI 519
Cdd:cd19511    83 RQAAPCIIFFDEIDSLAPRR-GQSDSsgVTDRVVSQLLTELDGIESLK---GVVVIAATNRPDMIDPALLRPGRLDKLI 157
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 351-521 2.74e-60

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 197.95  E-value: 2.74e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 351 TYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGE 430
Cdd:cd19502     1 TYEDIGGLDEQIREIREVVELPLKHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSELVQKYIGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 431 TEAKLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQNEVEkRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALD 506
Cdd:cd19502    81 GARLVRELFEMAREKAPSIIFIDEIDAIGAKRFdsgtGGDREVQ-RTMLELLNQLDGFD---PRGNIKVIMATNRPDILD 156

                         170
                  ....*....|....*
gi 1034638695 507 AALRRPGRFDKEIEI 521
Cdd:cd19502   157 PALLRPGRFDRKIEF 171
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
353-571 7.19e-60

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 199.34  E-value: 7.19e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 353 DMIGGlSSQLKAIREIIElPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETE 432
Cdd:COG1223     3 DVVGQ-EEAKKKLKLIIK-ELRRRENLRKFGLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDSLIGSYLGETA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 433 AKLRQIFAEATlRHPSIIFIDELDALCpKREGAQNEV-E-KRVVASLLTLMDGIGSEvsegqVLVLGATNRPHALDAALR 510
Cdd:COG1223    81 RNLRKLFDFAR-RAPCVIFFDEFDAIA-KDRGDQNDVgEvKRVVNALLQELDGLPSG-----SVVIAATNHPELLDSALW 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034638695 511 RpgRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEA 571
Cdd:COG1223   154 R--RFDEVIEFPLPDKEERKEILELNLKKFP-LPFELDLKKLAKKLEGLSGADIEKVLKTA 211
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 361-521 1.95e-58

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 192.50  E-value: 1.95e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 361 QLKAIREIIELPLKQPELFKsYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFA 440
Cdd:cd19481     1 LKASLREAVEAPRRGSRLRR-YGLGLPKGILLYGPPGTGKTLLAKALAGELGLPLIVVKLSSLLSKYVGESEKNLRKIFE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 441 EATLRHPSIIFIDELDALCPKREG-AQNEVEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAALRRPGRFDKEI 519
Cdd:cd19481    80 RARRLAPCILFIDEIDAIGRKRDSsGESGELRRVLNQLLTELDGV---NSRSKVLVIAATNRPDLLDPALLRPGRFDEVI 156


                  ..
gi 1034638695 520 EI 521
Cdd:cd19481   157 EF 158
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 365-521 1.06e-56

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 188.09  E-value: 1.06e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATL 444
Cdd:cd19529     5 LKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFISVKGPELLSKWVGESEKAIREIFRKARQ 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 445 RHPSIIFIDELDALCPKR-EGAQNEVEKRVVASLLTLMDGIgseVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19529    85 VAPCVIFFDEIDSIAPRRgTTGDSGVTERVVNQLLTELDGL---EEMNGVVVIAATNRPDIIDPALLRAGRFDRLIYI 159
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 350-577 1.66e-54

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 189.97  E-value: 1.66e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:PTZ00454  142 VTYSDIGGLDIQKQEIREAVELPLTCPELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVGSEFVQKYLG 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEkRVVASLLTLMDGIGSEVSegqVLVLGATNRPHAL 505
Cdd:PTZ00454  222 EGPRMVRDVFRLARENAPSIIFIDEVDSIATKRfdaqTGADREVQ-RILLELLNQMDGFDQTTN---VKVIMATNRADTL 297

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034638695 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLCNEAGPQRRR 577
Cdd:PTZ00454  298 DPALLRPGRLDRKIEFPLPDRRQKRLIFQTITSKM-NLSEEVDLEDFVSRPEKISAADIAAICQEAGMQAVR 368
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 355-518 1.82e-54

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 182.32  E-value: 1.82e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVI-----NGPEIISKFYG 429
Cdd:cd19517     2 IGGLSHYINQLKEMVFFPLLYPEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKGGQKVsffmrKGADCLSKWVG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAAL 509
Cdd:cd19517    82 EAERQLRLLFEEAYRMQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGLD---NRGQVVVIGATNRPDALDPAL 158


                  ....*....
gi 1034638695 510 RRPGRFDKE 518
Cdd:cd19517   159 RRPGRFDRE 167
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 355-521 1.12e-53

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 180.24  E-value: 1.12e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKsyGIPA-PRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19509     1 IAGLDDAKEALKEAVILPSLRPDLFP--GLRGpPRGILLYGPPGTGKTLLARAVASESGSTFFSISASSLVSKWVGESEK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 434 KLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALDAALRRpg 513
Cdd:cd19509    79 IVRALFALARELQPSIIFIDEIDSLLSERGSGEHEASRRVKTEFLVQMDGVLNK-PEDRVLVLGATNRPWELDEAFLR-- 155


                  ....*...
gi 1034638695 514 RFDKEIEI 521
Cdd:cd19509   156 RFEKRIYI 163
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 390-523 2.68e-51

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 172.39  E-value: 2.68e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEV 469
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKYVGESEKRLRELFEAAKKLAPCVIFIDEIDALAGSRGSGGDSE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 470 EKRVVASLLTLMDGIgsEVSEGQVLVLGATNRPHALDAALRrpGRFDKEIEIGV 523
Cdd:pfam00004  81 SRRVVNQLLTELDGF--TSSNSKVIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 332-572 5.04e-51

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 181.89  E-value: 5.04e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 332 VNFTEIDKNSKEqdnqfkvTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV 411
Cdd:PTZ00361  169 VSVMKVDKAPLE-------SYADIGGLEQQIQEIKEAVELPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANET 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 412 GAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEK---RVVASLLTLMDGIGsev 488
Cdd:PTZ00361  242 SATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAIGTKRYDATSGGEKeiqRTMLELLNQLDGFD--- 318

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 489 SEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVpHLLTEAELLQLANSAHGYVGADLKVLC 568
Cdd:PTZ00361  319 SRGDVKVIMATNRIESLDPALIRPGRIDRKIEFPNPDEKTKRRIFEIHTSKM-TLAEDVDLEEFIMAKDELSGADIKAIC 397


                  ....
gi 1034638695 569 NEAG 572
Cdd:PTZ00361  398 TEAG 401
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 362-517 6.29e-51

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 172.67  E-value: 6.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 362 LKAIREIIEL----PLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQ 437
Cdd:cd19530     1 LDHVREELTMsilrPIKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGANFISVKGPELLNKYVGESERAVRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 438 IFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALDAALRRPGRFDK 517
Cdd:cd19530    81 VFQRARASAPCVIFFDEVDALVPKRGDGGSWASERVVNQLLTEMDGLE---ERSNVFVIAATNRPDIIDPAMLRPGRLDK 157
FtsH_fam TIGR01241
ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct ...
 345-571 5.94e-50

ATP-dependent metalloprotease FtsH; HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. It has ATP-dependent zinc metalloprotease activity. It was formerly designated cell division protein FtsH. [Cellular processes, Cell division, Protein fate, Degradation of proteins, peptides, and glycopeptides]


Pssm-ID: 273520 [Multi-domain]  Cd Length: 495  Bit Score: 180.17  E-value: 5.94e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 345 DNQFKVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:TIGR01241  47 EEKPKVTFKDVAGIDEAKEELMEIVDF-LKNPSKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFV 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKRE----GAQNEVEkRVVASLLTLMDGIGSevSEGqVLVLGATN 500
Cdd:TIGR01241 126 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQRGaglgGGNDERE-QTLNQLLVEMDGFGT--NTG-VIVIAATN 201

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034638695 501 RPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEA 571
Cdd:TIGR01241 202 RPDVLDPALLRPGRFDRQVVVDLPDIKGREEILKVHAKNKK-LAPDVDLKAVARRTPGFSGADLANLLNEA 271
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 365-521 1.47e-47

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 163.84  E-value: 1.47e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATL 444
Cdd:cd19528     5 LQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVRDIFDKARA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 445 RHPSIIFIDELDALCPKREGA---QNEVEKRVVASLLTLMDGIGSEVSegqVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19528    85 AAPCVLFFDELDSIAKARGGNigdAGGAADRVINQILTEMDGMNTKKN---VFIIGATNRPDIIDPAILRPGRLDQLIYI 161
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 350-521 6.31e-46

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 159.71  E-value: 6.31e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19501     1 VTFKDVAGCEEAKEELKEVVEF-LKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDFVEMFVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR---EGAQNEVEKRVVASLLTLMDGIGSEVsegQVLVLGATNRPHALD 506
Cdd:cd19501    80 VGASRVRDLFEQAKKNAPCIVFIDEIDAVGRKRgagLGGGHDEREQTLNQLLVEMDGFESNT---GVIVIAATNRPDVLD 156

                         170
                  ....*....|....*
gi 1034638695 507 AALRRPGRFDKEIEI 521
Cdd:cd19501   157 PALLRPGRFDRQVYV 171
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 363-520 3.04e-45

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 157.21  E-value: 3.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 363 KAIREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19526     3 KALEETIEWPSKYPKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFISVKGPELLNKYIGASEQNVRDLFSRA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 443 TLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIgsEVSEGqVLVLGATNRPHALDAALRRPGRFDKEIE 520
Cdd:cd19526    83 QSAKPCILFFDEFDSIAPKRGHDSTGVTDRVVNQLLTQLDGV--EGLDG-VYVLAATSRPDLIDPALLRPGRLDKLVY 157
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
349-571 6.02e-45

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 167.91  E-value: 6.02e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 349 KVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGayvsV----INGPEII 424
Cdd:COG0465   138 KVTFDDVAGVDEAKEELQEIVDF-LKDPEKFTRLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAG----VpffsISGSDFV 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKReGA--------------QnevekrvvasLLTLMDGIgsEVSE 490
Cdd:COG0465   213 EMFVGVGASRVRDLFEQAKKNAPCIIFIDEIDAVGRQR-GAglggghdereqtlnQ----------LLVEMDGF--EGNE 279

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 491 GqVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNE 570
Cdd:COG0465   280 G-VIVIAATNRPDVLDPALLRPGRFDRQVVVDLPDVKGREAILKVHARKKP-LAPDVDLEVIARRTPGFSGADLANLVNE 357


                  .
gi 1034638695 571 A 571
Cdd:COG0465   358 A 358
ftsH CHL00176
cell division protein; Validated
 350-571 1.17e-44

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 167.92  E-value: 1.17e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:CHL00176  180 ITFRDIAGIEEAKEEFEEVVSF-LKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEVPFFSISGSEFVEMFVG 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKR----EGAQNEVEKrVVASLLTLMDGIgsEVSEGqVLVLGATNRPHAL 505
Cdd:CHL00176  259 VGAARVRDLFKKAKENSPCIVFIDEIDAVGRQRgagiGGGNDEREQ-TLNQLLTEMDGF--KGNKG-VIVIAATNRVDIL 334

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034638695 506 DAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEA 571
Cdd:CHL00176  335 DAALLRPGRFDRQITVSLPDREGRLDILKVHARNKK-LSPDVSLELIARRTPGFSGADLANLLNEA 399
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 349-521 1.25e-44

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 156.18  E-value: 1.25e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 349 KVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPApRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFY 428
Cdd:cd19521     3 NVKWEDVAGLEGAKEALKEAVILPVKFPHLFTGNRKPW-SGILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDLVSKWM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 429 GETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGqVLVLGATNRPHALDAA 508
Cdd:cd19521    82 GESEKLVKQLFAMARENKPSIIFIDEVDSLCGTRGEGESEASRRIKTELLVQMNGVGND-SQG-VLVLGATNIPWQLDSA 159

                         170
                  ....*....|...
gi 1034638695 509 LRRpgRFDKEIEI 521
Cdd:cd19521   160 IRR--RFEKRIYI 170
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 363-517 1.90e-43

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 152.67  E-value: 1.90e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 363 KAIREIIELPLKQPELFKSyGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEA 442
Cdd:cd19527     3 KEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIATECSLNFLSVKGPELINMYIGESEANVREVFQKA 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034638695 443 TLRHPSIIFIDELDALCPKR--EGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLGATNRPHALDAALRRPGRFDK 517
Cdd:cd19527    82 RDAKPCVIFFDELDSLAPSRgnSGDSGGVMDRVVSQLLAELDGMSS--SGQDVFVIGATNRPDLLDPALLRPGRFDK 156
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
345-578 4.14e-43

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 163.67  E-value: 4.14e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 345 DNQFKVTYDMIGGLSSQLKAIREIIELpLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEII 424
Cdd:PRK10733  144 EDQIKTTFADVAGCDEAKEEVAELVEY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFV 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 425 SKFYGETEAKLRQIFAEATLRHPSIIFIDELDALCPKRE---GAQNEVEKRVVASLLTLMDGIgsEVSEGqVLVLGATNR 501
Cdd:PRK10733  223 EMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGaglGGGHDEREQTLNQMLVEMDGF--EGNEG-IIVIAATNR 299

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034638695 502 PHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPhLLTEAELLQLANSAHGYVGADLKVLCNEAGPQRRRG 578
Cdd:PRK10733  300 PDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVP-LAPDIDAAIIARGTPGFSGADLANLVNEAALFAARG 375
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 350-521 9.10e-43

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 151.68  E-value: 9.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 350 VTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYG 429
Cdd:cd19525    19 INWADIAGLEFAKKTIKEIVVWPMLRPDIFTGLRGP-PKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALDAAL 509
Cdd:cd19525    98 EGEKMVRALFSVARCKQPAVIFIDEIDSLLSQRGEGEHESSRRIKTEFLVQLDGATTS-SEDRILVVGATNRPQEIDEAA 176

                         170
                  ....*....|..
gi 1034638695 510 RRpgRFDKEIEI 521
Cdd:cd19525   177 RR--RLVKRLYI 186
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 355-515 1.09e-40

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 145.26  E-value: 1.09e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGI-PAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19520     2 IGGLDEVITELKELVILPLQRPELFDNSRLlQPPKGVLLYGPPGCGKTMLAKATAKEAGARFINLQVSSLTDKWYGESQK 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 434 KLRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEgQVLVLGATNRPHALDAALRR-- 511
Cdd:cd19520    82 LVAAVFSLASKLQPSIIFIDEIDSFLRQRSSTDHEATAMMKAEFMSLWDGLSTDGNC-RVIVMGATNRPQDLDEAILRrm 160


                  ....
gi 1034638695 512 PGRF 515
Cdd:cd19520   161 PKRF 164
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 355-521 1.53e-40

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 145.13  E-value: 1.53e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKsyGIPAP-RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEA 433
Cdd:cd19522     2 IADLEEAKKLLEEAVVLPMWMPEFFK--GIRRPwKGVLMVGPPGTGKTLLAKAVATECGTTFFNVSSSTLTSKYRGESEK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 434 KLRQIFAEATLRHPSIIFIDELDALCPKR-EGAQNEVEKRVVASLLTLMDGI-GSEVSEGQ---VLVLGATNRPHALDAA 508
Cdd:cd19522    80 LVRLLFEMARFYAPTTIFIDEIDSICSRRgTSEEHEASRRVKSELLVQMDGVgGASENDDPskmVMVLAATNFPWDIDEA 159

                         170
                  ....*....|...
gi 1034638695 509 LRRpgRFDKEIEI 521
Cdd:cd19522   160 LRR--RLEKRIYI 170
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 355-511 1.11e-36

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 134.21  E-value: 1.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19524     2 IAGQDLAKQALQEMVILPSLRPELFTGLRAP-ARGLLLFGPPGNGKTMLAKAVAAESNATFFNISAASLTSKYVGEGEKL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEvSEGQVLVLGATNRPHALD-AALRR 511
Cdd:cd19524    81 VRALFAVARELQPSIIFIDEVDSLLSERSEGEHEASRRLKTEFLIEFDGVQSN-GDDRVLVMGATNRPQELDdAVLRR 157
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 355-521 6.17e-36

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 132.61  E-value: 6.17e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAY-VSVINGPEIISKFYGETE 432
Cdd:cd19504     2 IGGLDKEFSDIfRRAFASRVFPPEIVEQLGCKHVKGILLYGPPGTGKTLMARQIGKMLNARePKIVNGPEILNKYVGESE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 433 AKLRQIFAEATLRHPS--------IIFIDELDALCPKREGAQNE--VEKRVVASLLTLMDGIGsevSEGQVLVLGATNRP 502
Cdd:cd19504    82 ANIRKLFADAEEEQRRlgansglhIIIFDEIDAICKQRGSMAGStgVHDTVVNQLLSKIDGVE---QLNNILVIGMTNRK 158

                         170
                  ....*....|....*....
gi 1034638695 503 HALDAALRRPGRFDKEIEI 521
Cdd:cd19504   159 DLIDEALLRPGRLEVQMEI 177
RecA-like_fidgetin cd19523
ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. ...
 355-521 1.69e-27

ATPase domain of fidgetin; Fidgetin (FIGN) is a ATP-dependent microtubule severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410931 [Multi-domain]  Cd Length: 163  Bit Score: 108.82  E-value: 1.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 355 IGGLSSQLKAIREIIELPLKQPELFKSYGIPaPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAK 434
Cdd:cd19523     2 IAGLGALKAAIKEEVLWPLLRPDAFSGLLRL-PRSILLFGPRGTGKTLLGRCLASQLGATFLRLRGSTLVAKWAGEGEKI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 435 LRQIFAEATLRHPSIIFIDELDALCPKREGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLGATNRPHALDAALRRpgR 514
Cdd:cd19523    81 LQASFLAARCRQPSVLFISDLDALLSSQDDEASPVGRLQVELLAQLDGVLGS--GEDGVLVVCTTSKPEEIDESLRR--Y 156


                  ....*..
gi 1034638695 515 FDKEIEI 521
Cdd:cd19523   157 FSKRLLV 163
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 385-522 6.64e-25

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 100.68  E-value: 6.64e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 385 PAPRGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFYGETEAK---LRQIFAEATLRHPSIIFIDELDAL 458
Cdd:cd00009    17 PPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDLLEGLVVAELFGhflVRLLFELAEKAKPGVLFIDEIDSL 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 459 cpkREGAQNEVekrvvasLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIG 522
Cdd:cd00009    97 ---SRGAQNAL-------LRVLETLNDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIP 150
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 380-516 5.56e-21

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 90.12  E-value: 5.56e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 380 KSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQIFAEATLRHPSIIFIDELD-AL 458
Cdd:cd19507    24 SAYGLPTPKGLLLVGIQGTGKSLTAKAIAGVWQLPLLRLDMGRLFGGLVGESESRLRQMIQTAEAIAPCVLWIDEIEkGF 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 459 CPKREGAQNEVEKRVVASLLTLMdgigSEVSEgQVLVLGATNRPHALDAALRRPGRFD 516
Cdd:cd19507   104 SNADSKGDSGTSSRVLGTFLTWL----QEKKK-PVFVVATANNVQSLPPELLRKGRFD 156
ycf46 CHL00195
Ycf46; Provisional
 380-565 5.56e-18

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 87.00  E-value: 5.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 380 KSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGETEAKLRQI--FAEATlrHPSIIFIDELD- 456
Cdd:CHL00195  252 SNYGLPTPRGLLLVGIQGTGKSLTAKAIANDWQLPLLRLDVGKLFGGIVGESESRMRQMirIAEAL--SPCILWIDEIDk 329

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 457 ALCPKREGAQNEVEKRVVASLLTLMdgigSEvSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQKL 536
Cdd:CHL00195  330 AFSNSESKGDSGTTNRVLATFITWL----SE-KKSPVFVVATANNIDLLPLEILRKGRFDEIFFLDLPSLEEREKIFKIH 404

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034638695 537 LRRV-PHLLTEAELLQLANSAHGYVGADLK 565
Cdd:CHL00195  405 LQKFrPKSWKKYDIKKLSKLSNKFSGAEIE 434
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 365-521 1.50e-17

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 79.70  E-value: 1.50e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 365 IREIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfyGETEAKLRQIFAEATL 444
Cdd:cd19510     1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEV-----VLTDDRLNHLLNTAPK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 445 RhpSIIFIDELDA------LCPKREGAQNEVEKRVVASLLTLMDGIGSevSEGQVLVLgATNRPHALDAALRRPGRFDKE 518
Cdd:cd19510    76 Q--SIILLEDIDAafesreHNKKNPSAYGGLSRVTFSGLLNALDGVAS--SEERIVFM-TTNHIERLDPALIRPGRVDMK 150


                  ...
gi 1034638695 519 IEI 521
Cdd:cd19510   151 IYM 153
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 387-525 4.29e-16

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 75.49  E-value: 4.29e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695  387 PRGVLLYGPPGTGKTMIARAVANEVGAY---VSVINGPEI--------------ISKFYGETEAKLRQIFAEATLRHPSI 449
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELGPPgggVIYIDGEDIleevldqllliivgGKKASGSGELRLRLALALARKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034638695  450 IFIDELDALCPKREGAQNEVEKRVVAslltlmdgIGSEVSEGQVLVLGATNRPHALDAALRRPgRFDKEIEIGVPN 525
Cdd:smart00382  82 LILDEITSLLDAEQEALLLLLEELRL--------LLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_ATAD3-like cd19512
ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase ...
 388-520 2.86e-13

ATPase domains of ATPase AAA-domain protein 3A (ATAD3A), -3B, and -3C, and similar ATPase domains; ATPase AAA-domain protein 3 (ATAD3) is a ubiquitously expressed mitochondrial protein involved in mitochondrial dynamics, DNA-nucleoid structural organization, cholesterol transport and steroidogenesis. The ATAD3 gene family in human comprises three paralog genes: ATAD3A, ATAD3B and ATAD3C. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410920 [Multi-domain]  Cd Length: 150  Bit Score: 67.55  E-value: 2.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEiISKFYGETEAKLRQIFAEA-TLRHPSIIFIDELDALCPKRegAQ 466
Cdd:cd19512    23 RNILFYGPPGTGKTLFAKKLALHSGMDYAIMTGGD-VAPMGREGVTAIHKVFDWAnTSRRGLLLFVDEADAFLRKR--ST 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034638695 467 NEVEKRVVASLLTLMDGIGsEVSEGQVLVLgATNRPHALDAALRrpGRFDKEIE 520
Cdd:cd19512   100 EKISEDLRAALNAFLYRTG-EQSNKFMLVL-ASNQPEQFDWAIN--DRIDEMVE 149
T7SS_EccA TIGR03922
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ...
 361-520 8.42e-11

type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]


Pssm-ID: 188437 [Multi-domain]  Cd Length: 557  Bit Score: 64.48  E-value: 8.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 361 QLKAIREIIELPLKQPElfksYGIPAP---RGVLLYGPPGTGKTMIARAVANEVgAYVSVINGPEI--------ISKFYG 429
Cdd:TIGR03922 287 QVAALKSSTAMALARAE----RGLPVAqtsNHMLFAGPPGTGKTTIARVVAKIY-CGLGVLRKPLVrevsradlIGQYIG 361

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 430 ETEAKLRQIFAEATLRhpsIIFIDELDALCPKREGAQNEVEKRVVASLLTLMdgigsEVSEGQVLVLGATNRpHALDAAL 509
Cdd:TIGR03922 362 ESEAKTNEIIDSALGG---VLFLDEAYTLVETGYGQKDPFGLEAIDTLLARM-----ENDRDRLVVIGAGYR-KDLDKFL 432

                         170
                  ....*....|....*
gi 1034638695 510 R-RPG---RFDKEIE 520
Cdd:TIGR03922 433 EvNEGlrsRFTRVIE 447
RarA COG2256
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ...
 390-558 5.35e-10

Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];


Pssm-ID: 441857 [Multi-domain]  Cd Length: 439  Bit Score: 61.61  E-value: 5.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISkfygeTEAKLRQIFAEATLRH----PSIIFIDEL--------DA 457
Cdd:COG2256    52 MILWGPPGTGKTTLARLIANATDAEFVALSA--VTS-----GVKDIREVIEEARERRaygrRTILFVDEIhrfnkaqqDA 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 458 LCPkregaqnEVEKRVVasllTLmdgIGS-------EV-----SEGQVLVLgatnrpHALDaalrrpgrfDKEIEIGVPN 525
Cdd:COG2256   125 LLP-------HVEDGTI----TL---IGAttenpsfEVnsallSRCRVFVL------KPLS---------EEDLEQLLER 175

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1034638695 526 AqdrLDILQKLLRRVPHLLTEAELLQLANSAHG 558
Cdd:COG2256   176 A---LADDERGLGGYKLELDDEALEALARLADG 205
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 390-558 7.13e-10

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 61.25  E-value: 7.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGpeIISKFygeteAKLRQIFAEATLRHPS----IIFIDEL--------DA 457
Cdd:PRK13342   39 MILWGPPGTGKTTLARIIAGATDAPFEALSA--VTSGV-----KDLREVIEEARQRRSAgrrtILFIDEIhrfnkaqqDA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 458 LCPKregaqneVEKrvvaslltlmdgigsevseGQVLVLGAT--NRPHALDAALR---RPGRF----DKEIEIGVPNAqd 528
Cdd:PRK13342  112 LLPH-------VED-------------------GTITLIGATteNPSFEVNPALLsraQVFELkplsEEDIEQLLKRA-- 163

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034638695 529 rldiLQKLLRRVPHLLTEAeLLQLANSAHG 558
Cdd:PRK13342  164 ----LEDKERGLVELDDEA-LDALARLANG 188
RecA-like_Pch2-like cd19508
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ...
 388-509 2.36e-09

ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion


Pssm-ID: 410916 [Multi-domain]  Cd Length: 199  Bit Score: 57.46  E-value: 2.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 388 RGVLLYGPPGTGKTMIARAVANEVGAYVSV---------INGPEIISKFYGETE---AKLRQIFAEATLRHPSIIF--ID 453
Cdd:cd19508    53 RLVLLHGPPGTGKTSLCKALAQKLSIRLSSryrygqlieINSHSLFSKWFSESGklvTKMFQKIQELIDDKDALVFvlID 132

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 454 ELDALCPKREGAQNEVEK----RVVASLLTLMDGIGSEVSegqVLVLGATNRPHALDAAL 509
Cdd:cd19508   133 EVESLAAARSASSSGTEPsdaiRVVNAVLTQIDRIKRYHN---NVILLTSNLLEKIDVAF 189
RecA-like_IQCA1 cd19506
ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein ...
 385-506 4.65e-09

ATPase domain of IQ and AAA domain-containing protein 1 (IQCA1); IQCA1 (also known as dynein regulatory complex subunit 11, DRC11 and IQCA) is an ATPase subunit of the nexin-dynein regulatory complex (N-DRC). The 9 + 2 axoneme of most motile cilia and flagella consists of nine outer doublet microtubules arranged in a ring surrounding a central pair of two singlet microtubules. The N-DRC complex maintains alignment between outer doublet microtubules and limits microtubule sliding in motile axonemes. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410914 [Multi-domain]  Cd Length: 160  Bit Score: 55.61  E-value: 4.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 385 PAPRGVLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKFYGET--EAKLRQIFAEATLRHPSIIFIDELDAL---- 458
Cdd:cd19506    24 PLVKSLLLAGPSGVGKKMLVHAICTETGANLFNLSPSNIAGKYPGKNglQMMLHLVLKVARQLQPSVIWIGDAEKTfykk 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034638695 459 CPKREGAQNevEKRVVASLLTLMDGIGsevSEGQVLVLGATNRPHALD 506
Cdd:cd19506   104 VPKTEKQLD--PKRLKKDLPKILKSLK---PEDRVLIVGTTSRPFEAD 146
44 PHA02544
clamp loader, small subunit; Provisional
 363-539 2.42e-08

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 55.77  E-value: 2.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 363 KAIREIIeLPLKQPELFKSY----GIPAprgVLLYGP-PGTGKTMIARAVANEVGAYVSVINGpeiiskfygeTEAKLRQ 437
Cdd:PHA02544   18 STIDECI-LPAADKETFKSIvkkgRIPN---MLLHSPsPGTGKTTVAKALCNEVGAEVLFVNG----------SDCRIDF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 438 I------FAEATLR--HPSIIFIDELDALCPKregaqnEVEKrvvaSLLTLMDGIGSEVSegqvlVLGATNRPHALDAAL 509
Cdd:PHA02544   84 VrnrltrFASTVSLtgGGKVIIIDEFDRLGLA------DAQR----HLRSFMEAYSKNCS-----FIITANNKNGIIEPL 148

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034638695 510 RrpGRFDkEIEIGVPNAQDRLDILQKLLRR 539
Cdd:PHA02544  149 R--SRCR-VIDFGVPTKEEQIEMMKQMIVR 175
MoxR COG0714
MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway ...
 390-553 4.41e-08

MoxR-like ATPase [General function prediction only]; MoxR-like ATPase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 440478 [Multi-domain]  Cd Length: 292  Bit Score: 54.79  E-value: 4.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVIN-----------GPEIISKFYGETEAKLRQIFAeatlrhpSIIFIDELDAL 458
Cdd:COG0714    34 LLLEGVPGVGKTTLAKALARALGLPFIRIQftpdllpsdilGTYIYDQQTGEFEFRPGPLFA-------NVLLADEINRA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 459 CPKregaqnevekrVVASLLTLMDgigsevsEGQVLVLGAT----NRPHAL---------------DAALRrpgRFDKEI 519
Cdd:COG0714   107 PPK-----------TQSALLEAME-------ERQVTIPGGTyklpEPFLVIatqnpieqegtyplpEAQLD---RFLLKL 165

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1034638695 520 EIGVPNAQDRLDILQKLLRR----VPHLLTEAELLQLA 553
Cdd:COG0714   166 YIGYPDAEEEREILRRHTGRhlaeVEPVLSPEELLALQ 203
ruvB TIGR00635
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ...
 390-463 5.89e-07

Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129721 [Multi-domain]  Cd Length: 305  Bit Score: 51.53  E-value: 5.89e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygeteAKLRQIFAEATLRHP-SIIFIDELDALCPKRE 463
Cdd:TIGR00635  33 LLLYGPPGLGKTTLAHIIANEMGVNLKITSGPAL---------EKPGDLAAILTNLEEgDVLFIDEIHRLSPAVE 98
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 389-515 6.23e-07

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 48.83  E-value: 6.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 389 GVLLYGPPGTGKTMIARAVA----NEVGAYVSvingpeiISKFYgeTEAKLRQIFAEATL-------------RHPSIIF 451
Cdd:pfam07728   1 GVLLVGPPGTGKTELAERLAaalsNRPVFYVQ-------LTRDT--TEEDLFGRRNIDPGgaswvdgplvraaREGEIAV 71

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034638695 452 IDELdalcpkregaqNEVEKRVVASLLTLMDGI-------GSEVSEGQ--VLVLGATNRPHA----LDAALRRpgRF 515
Cdd:pfam07728  72 LDEI-----------NRANPDVLNSLLSLLDERrlllpdgGELVKAAPdgFRLIATMNPLDRglneLSPALRS--RF 135
TIP49 pfam06068
TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and ...
 356-442 6.48e-07

TIP49 P-loop domain; This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the pfam00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases.


Pssm-ID: 399217 [Multi-domain]  Cd Length: 347  Bit Score: 51.54  E-value: 6.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 356 GGLSSQLKAiREIIELPLkqpELFKSYGIpAPRGVLLYGPPGTGKTMIARAVANEVGAYV--SVINGPEIISKFYGETEA 433
Cdd:pfam06068  24 GGLVGQEKA-REAAGVIV---EMIKEGKI-AGRAVLIAGPPGTGKTALAIAISKELGEDTpfTSISGSEVYSLEMKKTEA 98


                  ....*....
gi 1034638695 434 kLRQIFAEA 442
Cdd:pfam06068  99 -LTQAFRKA 106
TIP49 COG1224
DNA helicase TIP49, TBP-interacting protein [Transcription];
356-438 9.19e-07

DNA helicase TIP49, TBP-interacting protein [Transcription];


Pssm-ID: 440837 [Multi-domain]  Cd Length: 452  Bit Score: 51.51  E-value: 9.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 356 GGLSSQLKAiRE----IIELpLKQPELfksygipAPRGVLLYGPPGTGKTMIARAVANEVGA---YVSvINGPEIISKFY 428
Cdd:COG1224    38 DGLVGQVEA-REaagiVVKM-IKEGKM-------AGKGILIVGPPGTGKTALAVAIARELGEdtpFVA-ISGSEIYSAEL 107

                          90
                  ....*....|
gi 1034638695 429 GETEAKLRQI 438
Cdd:COG1224   108 KKTEFLMQAL 117
ruvB PRK00080
Holliday junction branch migration DNA helicase RuvB;
390-454 2.44e-06

Holliday junction branch migration DNA helicase RuvB;


Pssm-ID: 234619 [Multi-domain]  Cd Length: 328  Bit Score: 49.74  E-value: 2.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIiskfygETEAKLRQIFaeATLRHPSIIFIDE 454
Cdd:PRK00080   54 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAL------EKPGDLAAIL--TNLEEGDVLFIDE 110
RuvB_N pfam05496
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ...
 390-454 2.57e-06

Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.


Pssm-ID: 398900 [Multi-domain]  Cd Length: 159  Bit Score: 47.49  E-value: 2.57e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEIISKfyGETEAKLrqifaeATLRHPSIIFIDE 454
Cdd:pfam05496  36 VLLYGPPGLGKTTLANIIANEMGVNIRITSGPAIERP--GDLAAIL------TNLEPGDVLFIDE 92
PRK13341 PRK13341
AAA family ATPase;
391-460 3.43e-06

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 50.05  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 391 LLYGPPGTGKTMIARAVANEVGAYVSVINgpeiiSKFYGETEakLRQIFAEATLRHP-----SIIFIDEL--------DA 457
Cdd:PRK13341   56 ILYGPPGVGKTTLARIIANHTRAHFSSLN-----AVLAGVKD--LRAEVDRAKERLErhgkrTILFIDEVhrfnkaqqDA 128


                  ...
gi 1034638695 458 LCP 460
Cdd:PRK13341  129 LLP 131
McrB COG1401
5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB ...
 386-558 2.28e-05

5-methylcytosine-specific restriction endonuclease McrBC, GTP-binding regulatory subunit McrB [Defense mechanisms];


Pssm-ID: 441011 [Multi-domain]  Cd Length: 477  Bit Score: 47.07  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 386 APRGVLLYGPPGTGKTMIARAVANEVGAY-------VSV---------ING--PEIISKFYGETEAKLRQIFAEATL--R 445
Cdd:COG1401   220 TKKNVILAGPPGTGKTYLARRLAEALGGEdngriefVQFhpswsyedfLLGyrPSLDEGKYEPTPGIFLRFCLKAEKnpD 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 446 HPSIIFIDELdalcpkregaqN--EVEKrVVASLLTLMD---------------GIGSEVSEGQ-VLVLGATN---RPHA 504
Cdd:COG1401   300 KPYVLIIDEI-----------NraNVEK-YFGELLSLLEsdkrgeelsielpysGEGEEFSIPPnLYIIGTMNtddRSLA 367

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034638695 505 L-DAALRRpgRFD------KEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHG 558
Cdd:COG1401   368 LsDKALRR--RFTfefldpDLDKLSNEEVVDLLEELNEILEKRDFQIGHRALLLLDGLLSG 426
RecA-like_Ycf2 cd19505
ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; ...
 383-521 3.33e-05

ATPase domain of plant YCF2; Ycf2 is a chloroplast ATPase which has an essential function; however, its function remains unclear. The gene encoding YCF2 is the largest known plastid gene in angiosperms and has been used to predict phylogenetic relationships. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410913 [Multi-domain]  Cd Length: 161  Bit Score: 44.29  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 383 GIPAPRGVLLYGPPGTGKTMIARAVANEvgAYVSVI---------NGPEIISK-------FYGETEAKLRQIFAEATLRH 446
Cdd:cd19505     8 GLSPSKGILLIGSIETGRSYLIKSLAAN--SYVPLIrislnkllyNKPDFGNDdwidgmlILKESLHRLNLQFELAKAMS 85

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 447 PSIIF---IDELDALCPKREGAQNevEKRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEI 521
Cdd:cd19505    86 PCIIWipnIHELNVNRSTQNLEED--PKLLLGLLLNYLSRDFEKSSTRNILVIASTHIPQKVDPALIAPNRLDTCINI 161
PRK04195 PRK04195
replication factor C large subunit; Provisional
 383-412 4.27e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.45  E-value: 4.27e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034638695 383 GIPaPRGVLLYGPPGTGKTMIARAVANEVG 412
Cdd:PRK04195   36 GKP-KKALLLYGPPGVGKTSLAHALANDYG 64
RuvB COG2255
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ...
 390-423 6.31e-05

Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];


Pssm-ID: 441856 [Multi-domain]  Cd Length: 337  Bit Score: 45.46  E-value: 6.31e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAYVSVINGPEI 423
Cdd:COG2255    57 VLLYGPPGLGKTTLAHIIANEMGVNIRITSGPAI 90
RecA-like_HslU cd19498
ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease ...
 387-483 6.86e-05

ATP-dependent protease ATPase subunit HslU; HslU is a component of the ATP-dependent protease HslVU. In HslVU, HslU ATPase serves to unfold and translocate protein substrate, and the HslV protease degrades the unfolded proteins. This RecA-like_HslU subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410906 [Multi-domain]  Cd Length: 183  Bit Score: 43.91  E-value: 6.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 387 PRGVLLYGPPGTGKTMIARAVANEVGA-YVSVingpeIISKFygeTEAKLRQIFAEATLRH--PSIIFIDELDALCPKRE 463
Cdd:cd19498    46 PKNILMIGPTGVGKTEIARRLAKLAGApFIKV-----EATKF---TEVGYVGRDVESIIRDlvEGIVFIDEIDKIAKRGG 117

                          90       100
                  ....*....|....*....|.
gi 1034638695 464 GAQNEVEKR-VVASLLTLMDG 483
Cdd:cd19498   118 SSGPDVSREgVQRDLLPIVEG 138
CDC48_N smart01073
Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel ...
 65-133 7.02e-05

Cell division protein 48 (CDC48) N-terminal domain; This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases is a substrate 185-residue recognition domain.


Pssm-ID: 215012 [Multi-domain]  Cd Length: 82  Bit Score: 41.44  E-value: 7.02e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695   65 NSLIHLGLNTMKSANICIGRPVLLTslNGKQEVYTAWP-MAGFPGGKVGLSEMAQKNVGVRPGDAIQVQP 133
Cdd:smart01073  14 RGIARLSPEDMDELGLFPGDYVLIT--GKRRTVAIVWPaYPEDPGGIIRIDGVQRKNAGVSIGDTVTVRK 81
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 377-496 9.09e-05

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 43.26  E-value: 9.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 377 ELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISkFYGETEAKLRQIFAEATLRHPSIIFID 453
Cdd:pfam13191  14 DALDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALerdGGYFLRGKCDENLP-YSPLLEALTREGLLRQLLDELESSLLE 92

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1034638695 454 ELDALCPKREGAQNEVEKRVVASLLTLMDGIGSEVSEGQ---VLVL 496
Cdd:pfam13191  93 AWRAALLEALAPVPELPGDLAERLLDLLLRLLDLLARGErplVLVL 138
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
360-416 1.34e-04

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 44.45  E-value: 1.34e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034638695 360 SQLKAIREIIElPLKQPELfksygipaPRGVLLYGPPGTGKTMIARAVANEVGAYVS 416
Cdd:COG1474    33 EEIEELASALR-PALRGER--------PSNVLIYGPTGTGKTAVAKYVLEELEEEAE 80
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
387-558 1.82e-04

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 43.81  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 387 PRGVLLYGPPGTGKTMIARAVANEV---------------GAYVSVINGPEIIskfYGETEAKLRQI-----------FA 440
Cdd:COG0470    18 PHALLLHGPPGIGKTTLALALARDLlcenpeggkacgqchSRLMAAGNHPDLL---ELNPEEKSDQIgidqirelgefLS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 441 EATLRHPS-IIFIDELDALcpkREGAQNevekrvvaSLLTLMDgigsEVSEGQVLVLgATNRPHALDAALR---RPgrfd 516
Cdd:COG0470    95 LTPLEGGRkVVIIDEADAM---NEAAAN--------ALLKTLE----EPPKNTPFIL-IANDPSRLLPTIRsrcQV---- 154

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1034638695 517 keIEIGVPNAQDRLDILQKllrrvpHLLTEAELLQLANSAHG 558
Cdd:COG0470   155 --IRFRPPSEEEALAWLRE------EGVDEDALEAILRLAGG 188
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
384-466 2.74e-04

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 42.85  E-value: 2.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 384 IPAPRGVLLYGPPGTGKTMIARAVANE-VGAYVSV--INGPEIISKFygeTEAKLRQIFAE--ATLRHPSIIFIDELDAL 458
Cdd:COG1484    96 IERGENLILLGPPGTGKTHLAIALGHEaCRAGYRVrfTTAPDLVNEL---KEARADGRLERllKRLAKVDLLILDELGYL 172


                  ....*...
gi 1034638695 459 CPKREGAQ 466
Cdd:COG1484   173 PLDAEGAE 180
AAA_lid_3 pfam17862
AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the ...
 548-572 3.10e-04

AAA+ lid domain; This entry represents the alpha helical AAA+ lid domain that is found to the C-terminus of AAA domains.


Pssm-ID: 465537 [Multi-domain]  Cd Length: 45  Bit Score: 38.67  E-value: 3.10e-04
                          10        20
                  ....*....|....*....|....*
gi 1034638695 548 ELLQLANSAHGYVGADLKVLCNEAG 572
Cdd:pfam17862   3 DLEELAERTEGFSGADLEALCREAA 27
PRK08116 PRK08116
hypothetical protein; Validated
 388-426 4.51e-04

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 42.32  E-value: 4.51e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034638695 388 RGVLLYGPPGTGKTMIARAVANEV---GAYVSVINGPEIISK 426
Cdd:PRK08116  115 VGLLLWGSVGTGKTYLAACIANELiekGVPVIFVNFPQLLNR 156
RecA-like_superfamily cd01120
RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 ...
 390-485 6.26e-04

RecA-like_NTPases; RecA-like NTPases. This superfamily includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410865 [Multi-domain]  Cd Length: 119  Bit Score: 39.79  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVAN---EVGAYVSVINGPEIIskfygeteakLRQIFAEATLRHPSIIFIDELDALCPKREGAQ 466
Cdd:cd01120     1 ILITGPPGSGKTTLLLQFAEqalLSDEPVIFISFLDTI----------LEAIEDLIEEKKLDIIIIDSLSSLARASQGDR 70

                          90
                  ....*....|....*....
gi 1034638695 467 NEVEKRVVASLLTLMDGIG 485
Cdd:cd01120    71 SSELLEDLAKLLRAARNTG 89
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
 390-492 9.33e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.26  E-value: 9.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAY---VSVINGPE-----IISKFYGETEAKLRQ----IFAEATLRHP-SIIFIDELD 456
Cdd:pfam07724   6 FLFLGPTGVGKTELAKALAELLFGDeraLIRIDMSEymeehSVSRLIGAPPGYVGYeeggQLTEAVRRKPySIVLIDEIE 85

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034638695 457 ALCPkreGAQNevekrvvaSLLTLMDgiGSEVSEGQ 492
Cdd:pfam07724  86 KAHP---GVQN--------DLLQILE--GGTLTDKQ 108
DEXXQc_Helz-like cd18038
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ...
 361-408 1.93e-03

DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350796 [Multi-domain]  Cd Length: 229  Bit Score: 40.30  E-value: 1.93e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034638695 361 QLKAIREIIELPLKqpelfksygiPAPrgVLLYGPPGTGKTM-IARAVA 408
Cdd:cd18038     6 QKLAVRNIVTGTSR----------PPP--YIIFGPPGTGKTVtLVEAIL 42
RecA-like_ClpB_Hsp104-like cd19499
Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and ...
 387-500 2.05e-03

Chaperone protein ClpB/Hsp104 subfamily; Bacterial Caseinolytic peptidase B (ClpB) and eukaryotic Heat shock protein 104 (Hsp104) are ATP-dependent molecular chaperones and essential proteins of the heat-shock response. ClpB/Hsp104 ATPases, in concert with the DnaK/Hsp70 chaperone system, disaggregate and reactivate aggregated proteins. This RecA-like_ClpB_Hsp104_like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410907 [Multi-domain]  Cd Length: 178  Bit Score: 39.47  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 387 PRGVLLY-GPPGTGKTMIARAVANEV---GAYVSVINGPEIISKFY------------GETE-AKLrqifAEATLRHP-S 448
Cdd:cd19499    40 PIGSFLFlGPTGVGKTELAKALAELLfgdEDNLIRIDMSEYMEKHSvsrligappgyvGYTEgGQL----TEAVRRKPyS 115

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034638695 449 IIFIDELDALCPKregaqnevekrVVASLL------TLMDGIGSEVSEGQVLVLGATN 500
Cdd:cd19499   116 VVLLDEIEKAHPD-----------VQNLLLqvlddgRLTDSHGRTVDFKNTIIIMTSN 162
YifB COG0606
Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational ...
 390-405 2.11e-03

Predicted Mg-chelatase, contains ChlI-like and ATPase domains, YifB family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440371 [Multi-domain]  Cd Length: 502  Bit Score: 40.79  E-value: 2.11e-03
                          10
                  ....*....|....*.
gi 1034638695 390 VLLYGPPGTGKTMIAR 405
Cdd:COG0606   214 LLMIGPPGSGKTMLAR 229
RAD55 COG0467
RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];
383-424 2.17e-03

RecA-superfamily ATPase, KaiC/GvpD/RAD55 family [Signal transduction mechanisms];


Pssm-ID: 440235 [Multi-domain]  Cd Length: 221  Bit Score: 39.90  E-value: 2.17e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1034638695 383 GIPAPRGVLLYGPPGTGKT------MIARAVANEVGAYVSVINGPEII 424
Cdd:COG0467    16 GLPRGSSTLLSGPPGTGKTtlalqfLAEGLRRGEKGLYVSFEESPEQL 63
Mg_chelatase pfam01078
Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that ...
 390-406 2.39e-03

Magnesium chelatase, subunit ChlI; Magnesium-chelatase is a three-component enzyme that catalyzes the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.


Pssm-ID: 426032 [Multi-domain]  Cd Length: 207  Bit Score: 39.44  E-value: 2.39e-03
                          10
                  ....*....|....*..
gi 1034638695 390 VLLYGPPGTGKTMIARA 406
Cdd:pfam01078  25 LLMIGPPGSGKTMLAKR 41
TIGR02928 TIGR02928
orc1/cdc6 family replication initiation protein; Members of this protein family are found ...
 387-459 3.33e-03

orc1/cdc6 family replication initiation protein; Members of this protein family are found exclusively in the archaea. This set of DNA binding proteins shows homology to the origin recognition complex subunit 1/cell division control protein 6 family in eukaryotes. Several members may be found in genome and interact with each other. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274354 [Multi-domain]  Cd Length: 365  Bit Score: 39.92  E-value: 3.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 387 PRGVLLYGPPGTGKTMIARAVANEV-------GAYVSV--INgPEIISKFY-------------GE--------TEAKLR 436
Cdd:TIGR02928  40 PSNVFIYGKTGTGKTAVTKYVMKELeeaaedrDVRVVTvyVN-CQILDTLYqvlvelanqlrgsGEevpttglsTSEVFR 118

                          90       100
                  ....*....|....*....|....
gi 1034638695 437 QIFAEATLRHPSIIFI-DELDALC 459
Cdd:TIGR02928 119 RLYKELNERGDSLIIVlDEIDYLV 142
Parvo_NS1 pfam01057
Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses ...
 390-414 3.65e-03

Parvovirus non-structural protein NS1; This family also contains the NS2 protein. Parvoviruses encode two non-structural proteins, NS1 and NS2. The mRNA for NS2 contains the coding sequence for the first 87 amino acids of NS1, then by an alternative splicing mechanism mRNA from a different reading frame, encoding the last 78 amino acids, makes up the full length of the NS2 mRNA. NS1, is the major non-structural protein. It is essential for DNA replication. It is an 83-kDa nuclear phosphoprotein. It has DNA helicase and ATPase activity.


Pssm-ID: 426020  Cd Length: 271  Bit Score: 39.60  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGAY 414
Cdd:pfam01057 116 VWFYGPASTGKTNLAQAIAHAVPLY 140
BMS1 cd01882
Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is ...
 367-421 4.50e-03

Bms1, an essential GTPase, promotes assembly of preribosomal RNA processing complexes; Bms1 is an essential, evolutionarily conserved, nucleolar protein. Its depletion interferes with processing of the 35S pre-rRNA at sites A0, A1, and A2, and the formation of 40S subunits. Bms1, the putative endonuclease Rc11, and the essential U3 small nucleolar RNA form a stable subcomplex that is believed to control an early step in the formation of the 40S subumit. The C-terminal domain of Bms1 contains a GTPase-activating protein (GAP) that functions intramolecularly. It is believed that Rc11 activates Bms1 by acting as a guanine-nucleotide exchange factor (GEF) to promote GDP/GTP exchange, and that activated (GTP-bound) Bms1 delivers Rc11 to the preribosomes.


Pssm-ID: 206669 [Multi-domain]  Cd Length: 231  Bit Score: 38.86  E-value: 4.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034638695 367 EIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGK-TMIARAVANEVGAYVSVINGP 421
Cdd:cd01882    19 DLEEKKLHVPVVDRTPEEPPPLVVVVVGPPGVGKsTLIRSLIKRYTKQNLSDIKGP 74
KaiC-like cd01124
Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. ...
 383-485 7.30e-03

Circadian Clock Protein KaiC; KaiC is a circadian clock protein, most studied in cyanobacteria. KaiC, an autokinase, autophosphatase, and ATPase, is part of the core oscillator, composed of three proteins: KaiA, KaiB, and KaiC. The circadian oscillation is regulated via KaiC phosphorylation.


Pssm-ID: 410869 [Multi-domain]  Cd Length: 222  Bit Score: 38.40  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 383 GIPAPRGVLLYGPPGTGKTM-----IARAVAN-EVGAYVSV-------------------------------INGPEIIS 425
Cdd:cd01124    15 GIPKGSVTLLTGGPGTGKTLfglqfLYAGAKNgEPGLFFTFeesperllrnaksfgwdfdemedegkliivdAPPTEAGR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 426 KFYGETEAKLRQIFAEatlRHPSIIFIDELDALcpKREGAQNEVEKRVVASLLTLMDGIG 485
Cdd:cd01124    95 FSLDELLSRILSIIKS---FKAKRVVIDSLSGL--RRAKEDQMRARRIVIALLNELRAAG 149
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 382-418 7.91e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 38.62  E-value: 7.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034638695 382 YGIPAPRG-VLLYGPPGTGKTMIARAVANEVGAYVSVI 418
Cdd:COG3267    37 YALAQGGGfVVLTGEVGTGKTTLLRRLLERLPDDVKVA 74
AAA_22 pfam13401
AAA domain;
390-458 8.20e-03

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 36.94  E-value: 8.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034638695 390 VLLYGPPGTGKTMIARAVANEVGA------YVSVING-------PEIISKF-----YGETEAKLRQIFAEA--TLRHPSI 449
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEvrdsvvFVDLPSGtspkdllRALLRALglplsGRLSKEELLAALQQLllALAVAVV 87


                  ....*....
gi 1034638695 450 IFIDELDAL 458
Cdd:pfam13401  88 LIIDEAQHL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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