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Conserved domains on  [gi|1034639789|ref|XP_016863665|]
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ankyrin repeat domain-containing protein 37 isoform X1 [Homo sapiens]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 7.90e-17

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 7.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  10 VDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQ 89
Cdd:COG0666   100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1034639789  90 IDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 7.90e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 7.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  10 VDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQ 89
Cdd:COG0666   100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1034639789  90 IDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-116 4.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  36 HLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASdAQIDLCNkNGQTAEDLAWSCGFPDCAKF 115
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  .
gi 1034639789 116 L 116
Cdd:pfam12796  80 L 80
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 7-99 3.36e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 3.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVAS 86
Cdd:PHA02874  134 KGDLESIKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                          90
                  ....*....|...
gi 1034639789  87 DAQIDLCNKNGQT 99
Cdd:PHA02874  213 GNHIMNKCKNGFT 225
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 7-104 2.70e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.30  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVDGLKHLLETGASVNAP--------PDPCK-----QSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLH---- 69
Cdd:cd22192    99 NQNLNLVRELIARGADVVSPratgtffrPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHilvl 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034639789  70 KAAKVGSLECLSLLVASDAQID------LCNKNGQTAEDLA 104
Cdd:cd22192   179 QPNKTFACQMYDLILSYDKEDDlqpldlVPNNQGLTPFKLA 219
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 7.90e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 75.38  E-value: 7.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  10 VDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQ 89
Cdd:COG0666   100 LEIVKLLLEAGADVNAR-DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                          90       100
                  ....*....|....*....|....*..
gi 1034639789  90 IDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   179 VNARDNDGETPLHLAAENGHLEIVKLL 205
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
7-116 5.62e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 73.06  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVdgLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVAS 86
Cdd:COG0666   132 NLEI--VKLLLEAGADVNAQ-DNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034639789  87 DAQIDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   209 GADVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-116 2.39e-14

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 2.39e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   1 MLLLDCNPEVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECL 80
Cdd:COG0666    57 LLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIV 136

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034639789  81 SLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   137 KLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-116 4.13e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.59  E-value: 4.13e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  36 HLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASdAQIDLCNkNGQTAEDLAWSCGFPDCAKF 115
Cdd:pfam12796   2 HLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKL 79


                  .
gi 1034639789 116 L 116
Cdd:pfam12796  80 L 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
10-116 1.91e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.96  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  10 VDGLKHLLETGASVNAPpDPCKQSPVHLAAGSG---LACFLLwqlQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVAS 86
Cdd:COG0666   166 LEIVKLLLEAGADVNAR-DNDGETPLHLAAENGhleIVKLLL---EAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034639789  87 DAQIDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   242 GADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
67-116 1.67e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 1.67e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034639789  67 PLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
10-92 1.65e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 46.65  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  10 VDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLAcFLLWQLQTGADLNQQDvLGEAPLHKAAKVGSLECLSLLVASDAQ 89
Cdd:pfam12796  10 LELVKLLLENGADANLQ-DKNGRTALHLAAKNGHL-EIVKLLLEHADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ...
gi 1034639789  90 IDL 92
Cdd:pfam12796  87 INV 89
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
13-116 2.44e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.80  E-value: 2.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  13 LKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQIDL 92
Cdd:COG0666    36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA 115

                          90       100
                  ....*....|....*....|....
gi 1034639789  93 CNKNGQTAEDLAWSCGFPDCAKFL 116
Cdd:COG0666   116 RDKDGETPLHLAAYNGNLEIVKLL 139
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 7-99 3.36e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.42  E-value: 3.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVAS 86
Cdd:PHA02874  134 KGDLESIKMLFEYGADVNIE-DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                          90
                  ....*....|...
gi 1034639789  87 DAQIDLCNKNGQT 99
Cdd:PHA02874  213 GNHIMNKCKNGFT 225
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 14-132 8.44e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.50  E-value: 8.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789  14 KHLLETGASVNAPPDPCKQSP-----------------VHLAAgSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGS 76
Cdd:PTZ00322   49 THLEALEATENKDATPDHNLTteevidpvvahmltvelCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGH 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034639789  77 LECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPDCAKFLTT-IKCMQTIKASEHPD 132
Cdd:PTZ00322  128 VQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRhSQCHFELGANAKPD 184
Ank_2 pfam12796
Ankyrin repeats (3 copies);
68-116 1.34e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 41.64  E-value: 1.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034639789  68 LHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAedLAWSC--GFPDCAKFL 116
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTA--LHLAAknGHLEIVKLL 49
Ank_5 pfam13857
Ankyrin repeats (many copies);
55-104 1.67e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.41  E-value: 1.67e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034639789  55 ADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAEDLA 104
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
33-84 3.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.57  E-value: 3.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034639789  33 SPVHLAAGSGlaCFLLWQ--LQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLV 84
Cdd:pfam13637   3 TALHAAAASG--HLELLRllLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 9-118 1.46e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 40.72  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   9 EVDGLKHLLETGASVNAPpDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDA 88
Cdd:PHA02874  103 EKDMIKTILDCGIDVNIK-DAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGA 181

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034639789  89 QIDLCNKNGQTAEDLAWSCGFPDCAKFLTT 118
Cdd:PHA02874  182 YANVKDNNGESPLHNAAEYGDYACIKLLID 211
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 16-75 2.51e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034639789  16 LLETGASVNAPpDPCKQSPVHLAAGS-GLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVG 75
Cdd:PHA02876  259 LYDAGFSVNSI-DDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNG 318
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 7-83 4.01e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.48  E-value: 4.01e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034639789   7 NPEVDGLKHLLETGASVNApPDPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAakVGSLECLSLL 83
Cdd:PHA02878  178 NKDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIS--VGYCKDYDIL 251
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-69 4.69e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 39.24  E-value: 4.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034639789   2 LLLDCNPEVDGLKHLLETGASVNAPpDPCKQSPVHLaagsgLACF--------LLwqLQTGADLNQQDVLGEAPLH 69
Cdd:PHA03095   55 LHYSSEKVKDIVRLLLEAGADVNAP-ERCGFTPLHL-----YLYNattldvikLL--IKAGADVNAKDKVGRTPLH 122
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 6-99 1.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.11  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   6 CNPEVDGLKHLLETGASVNAppdpcKQSpvhlaagsgLACFLlwqlQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVA 85
Cdd:PHA03100  152 NKIDLKILKLLIDKGVDINA-----KNR---------VNYLL----SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLD 213

                          90
                  ....*....|....
gi 1034639789  86 SDAQIDLCNKNGQT 99
Cdd:PHA03100  214 LGANPNLVNKYGDT 227
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 9-84 1.62e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.94  E-value: 1.62e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034639789   9 EVDGLKHLLETGASVNAPPDPCKQSPVHLAAGSGLACFLLwqLQTGADLNQQDVLGEAPLHKAAKVGS-LECLSLLV 84
Cdd:PHA02878  247 DYDILKLLLEHGVDVNAKSYILGLTALHSSIKSERKLKLL--LEYGADINSLNSYKLTPLSSAVKQYLcINIGRILI 321
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 9-100 2.02e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 37.28  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   9 EVDGLKHLLETGASVNAPPDPcKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDA 88
Cdd:PHA02875  114 KLDIMKLLIARGADPDIPNTD-KFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGA 192

                          90
                  ....*....|..
gi 1034639789  89 QIDLCNKNGQTA 100
Cdd:PHA02875  193 NIDYFGKNGCVA 204
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 9-99 2.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 37.55  E-value: 2.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   9 EVDGLKHLLETGASVNAPPDPCKQSPVHLAA---GSGLACFLLWQlqtGADLNQQDVLGEAPLHKAAKVGSLECLSLLVA 85
Cdd:PHA02878  146 EAEITKLLLSYGADINMKDRHKGNTALHYATenkDQRLTELLLSY---GANVNIPDKTNNSPLHHAVKHYNKPIVHILLE 222

                          90
                  ....*....|....
gi 1034639789  86 SDAQIDLCNKNGQT 99
Cdd:PHA02878  223 NGASTDARDKCGNT 236
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 7-111 2.36e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 37.34  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVdgLKHLLETGASVNAPPDPCKqSPVHLAAGSG--------LACFLLwqlQTGADLNQQDVLGEAPLHKAA--KVGS 76
Cdd:PHA03100   47 NIDV--VKILLDNGADINSSTKNNS-TPLHYLSNIKynltdvkeIVKLLL---EYGANVNAPDNNGITPLLYAIskKSNS 120

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034639789  77 LECLSLLVASDAQIDLCNKNGQTAEDLAWSCGFPD 111
Cdd:PHA03100  121 YSIVEYLLDNGANVNIKNSDGENLLHLYLESNKID 155
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 7-104 2.70e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 37.30  E-value: 2.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034639789   7 NPEVDGLKHLLETGASVNAP--------PDPCK-----QSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLH---- 69
Cdd:cd22192    99 NQNLNLVRELIARGADVVSPratgtffrPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHilvl 178

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034639789  70 KAAKVGSLECLSLLVASDAQID------LCNKNGQTAEDLA 104
Cdd:cd22192   179 QPNKTFACQMYDLILSYDKEDDlqpldlVPNNQGLTPFKLA 219
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 51-104 2.98e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 36.97  E-value: 2.98e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034639789  51 LQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTAEDLA 104
Cdd:PHA02876  165 LEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECA 218
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 28-100 3.87e-03

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 36.77  E-value: 3.87e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034639789  28 DPCKQSPVHLAAGSGLACFLLWQLQTGADLNQQDVLGEAPLHKAAKVGSLECLSLLVASDAQIDLCNKNGQTA 100
Cdd:PLN03192  522 DPNMASNLLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA 594
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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