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Conserved domains on  [gi|1034640435|ref|XP_016863855|]
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transmembrane protein 144 isoform X1 [Homo sapiens]

Protein Classification

L-rhamnose-proton symporter family protein; DMT family transporter( domain architecture ID 10545222)

L-rhamnose-proton symporter family protein such as Escherichia coli RhaT, which is involved in uptake of L-rhamnose across the cytoplasmic membrane with the concomitant transport of protons into the cell; DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 9-344 1.81e-176

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


:

Pssm-ID: 285141  Cd Length: 333  Bit Score: 492.33  E-value: 1.81e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435   9 TFGYISCFVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKT 88
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435  89 IGLGLGILIWGSFNALTGWASSRFGWFGLDAEEVSNPLLNYIGAGLSVVSAFIFLFIKSEIPNNTCSMDTTPLITEHVIN 168
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHVPKENETESDTTPLEMEHKKS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 169 TTQDPCSWVDKLS-TVHHRIVGCSLAVISGVLYGSTFVPIIYIKDHSKrndsIYAGASQYDLDYVFAHFSGIFLTSTVYF 247
Cdd:pfam07857 161 LEQDLSSDDGLVKkSCTRRIVCILLAIVSGFLYGSTFVPIIYIKDNPP----IYPGAPQDGLDYVFSHYTGIFLTSTVYF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 248 LAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLMI 327
Cdd:pfam07857 237 FAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLG 316

                         330
                  ....*....|....*..
gi 1034640435 328 LAFCIILTGALCTAFSK 344
Cdd:pfam07857 317 IASAITLIGAIMVALSK 333
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 9-344 1.81e-176

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 492.33  E-value: 1.81e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435   9 TFGYISCFVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKT 88
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435  89 IGLGLGILIWGSFNALTGWASSRFGWFGLDAEEVSNPLLNYIGAGLSVVSAFIFLFIKSEIPNNTCSMDTTPLITEHVIN 168
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHVPKENETESDTTPLEMEHKKS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 169 TTQDPCSWVDKLS-TVHHRIVGCSLAVISGVLYGSTFVPIIYIKDHSKrndsIYAGASQYDLDYVFAHFSGIFLTSTVYF 247
Cdd:pfam07857 161 LEQDLSSDDGLVKkSCTRRIVCILLAIVSGFLYGSTFVPIIYIKDNPP----IYPGAPQDGLDYVFSHYTGIFLTSTVYF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 248 LAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLMI 327
Cdd:pfam07857 237 FAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLG 316

                         330
                  ....*....|....*..
gi 1034640435 328 LAFCIILTGALCTAFSK 344
Cdd:pfam07857 317 IASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 238-344 2.74e-07

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 51.30  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 238 GIFLTSTVYFLAYciamknSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEI 317
Cdd:cd23110    34 GALIVALVVFLFL------GPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEW 107

                          90       100
                  ....*....|....*....|....*..
gi 1034640435 318 KGLQNYLLMILAFCIILTGALCTAFSK 344
Cdd:cd23110   108 SGTGAKLLGLLALALIIIGVLLTSYTD 134
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
247-344 2.93e-07

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 51.01  E-value: 2.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 247 FLAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLM 326
Cdd:COG4975    41 IFAIIVFLFVQPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEWTTTTAKVLG 120

                          90
                  ....*....|....*...
gi 1034640435 327 ILAFCIILTGALCTAFSK 344
Cdd:COG4975   121 FLALILIIIGAVLTSYQD 138
 
Name Accession Description Interval E-value
TMEM144 pfam07857
Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug ...
 9-344 1.81e-176

Transmembrane family, TMEM144 of transporters; Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.


Pssm-ID: 285141  Cd Length: 333  Bit Score: 492.33  E-value: 1.81e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435   9 TFGYISCFVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKT 88
Cdd:pfam07857   1 IVGYVACLVSSVTFGSMFVPLKRFHSGDGFFVQWIMSLAILLVGLIVYATLGFPKFEPLAMLGGMLWATGNAFAVPIMNG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435  89 IGLGLGILIWGSFNALTGWASSRFGWFGLDAEEVSNPLLNYIGAGLSVVSAFIFLFIKSEIPNNTCSMDTTPLITEHVIN 168
Cdd:pfam07857  81 IGLGVGILIWNTVNCLVGWAVTRFGLFGIPAQVPKSPFLNYIGIVLVVVGGFIFLFIKHVPKENETESDTTPLEMEHKKS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 169 TTQDPCSWVDKLS-TVHHRIVGCSLAVISGVLYGSTFVPIIYIKDHSKrndsIYAGASQYDLDYVFAHFSGIFLTSTVYF 247
Cdd:pfam07857 161 LEQDLSSDDGLVKkSCTRRIVCILLAIVSGFLYGSTFVPIIYIKDNPP----IYPGAPQDGLDYVFSHYTGIFLTSTVYF 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 248 LAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLMI 327
Cdd:pfam07857 237 FAYSIVKKNNPYVPSELVLPSIGSGILWAIAMTSWFVANQKLSQVVSYPIISRAPGLIAAAWSVFYFKEIQGKRNYILLG 316

                         330
                  ....*....|....*..
gi 1034640435 328 LAFCIILTGALCTAFSK 344
Cdd:pfam07857 317 IASAITLIGAIMVALSK 333
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 238-344 2.74e-07

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 51.30  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 238 GIFLTSTVYFLAYciamknSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEI 317
Cdd:cd23110    34 GALIVALVVFLFL------GPTISPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVSRTMPISTGLQLVGTSLIGVLLFGEW 107

                          90       100
                  ....*....|....*....|....*..
gi 1034640435 318 KGLQNYLLMILAFCIILTGALCTAFSK 344
Cdd:cd23110   108 SGTGAKLLGLLALALIIIGVLLTSYTD 134
GlcU COG4975
Glucose uptake protein GlcU [Carbohydrate transport and metabolism];
247-344 2.93e-07

Glucose uptake protein GlcU [Carbohydrate transport and metabolism];


Pssm-ID: 444000 [Multi-domain]  Cd Length: 288  Bit Score: 51.01  E-value: 2.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 247 FLAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLM 326
Cdd:COG4975    41 IFAIIVFLFVQPELTGTIFIIGFLSGLFWAVGQINQFKSFKLLGVSKAMPISTGMQLVGTSLFGVILFGEWTTTTAKVLG 120

                          90
                  ....*....|....*...
gi 1034640435 327 ILAFCIILTGALCTAFSK 344
Cdd:COG4975   121 FLALILIIIGAVLTSYQD 138
GRP cd23110
glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two ...
 16-340 1.41e-06

glucose/ribose porter family; The glucose/ribose porter (GRP) family (TC 2.A.7.5) includes two functionally characterized members, a glucose uptake permease from Staphylococcus xylosus, and a probable ribose uptake permease from Lactobacillus sakei. Both proteins probably function by H(+) symport. This family also includes several putative and hypothetical membrane proteins that are probably involved in sugar transport across bacterial membranes. GRP family proteins have a distinctive topology: 10 putative transmembrane (TM) alpha-helical spanning domains per polypeptide chain, which apparently arose by intragenic duplication of an element encoding a primordial five-TM polypeptide. In Lactococcus lactis, GlcU was identified as the sole non-PTS (phosphoenolpyruvate:phosphotransferase systems) permease involved in the transport of glucose, which is driven by the proton-motive force. A gene from Bacillus subtilis, ycxE, that is homologous to glcU, could substitute for glcU in Escherichia coli glucose growth experiments and restored glucose repression in Staphylococcus xylosus glcU mutants. RbsU is encoded on the rbsUDK gene cluster, which encodes proteins involved in ribose uptake and phosphorylation. RbsR has been annotated as the repressor of the rbsUDK operon, based on its homology with RbsR repressors. The GRP family belongs to the Drug/Metabolite Transporter (DMT) superfamily (TC 2.A.7).


Pssm-ID: 438513 [Multi-domain]  Cd Length: 279  Bit Score: 48.99  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435  16 FVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIwLVALVVNLILH---CPKFWPFAMLGGCIWATGNIAVVPIIKTIGLG 92
Cdd:cd23110     4 LIPALGWGIMPLILQKIGGSPRNQILGTTLGAL-IVALVVFLFLGptiSPTLFLLAFLSGAFWSIGQIGQFKAFKRIGVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435  93 LGILIWGSF----NALTG------WASSRFGWFGLdaeevsnpllnyigAGLSVVSAFIFLFIKSEIPNNTCSMDTTPLI 162
Cdd:cd23110    83 RTMPISTGLqlvgTSLIGvllfgeWSGTGAKLLGL--------------LALALIIIGVLLTSYTDKGSAKKSKNQKKGL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 163 TehvinttqdpcswvdklstvhhrivgcsLAVISGVLYGSTFVPIIYikdhskrndsiyagASQYDLDYVFAHFSGIFLT 242
Cdd:cd23110   149 L----------------------------ILLLSTIGYWSYSAIPKL--------------FSVSGLAIFLPQALGMLLG 186

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640435 243 STVYFLAyciaMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPgFIAAMWGIFMFKEIKGLQN 322
Cdd:cd23110   187 ALIYALF----TRKPKALKEKASWRNILTGLLWGIANLAYLLSAQANGVATAFTLSQLNV-VISTLGGILILHEKKTKRE 261

                         330
                  ....*....|....*...
gi 1034640435 323 YLLMILAFCIILTGALCT 340
Cdd:cd23110   262 LRFTLIGLVLIVAGAVLT 279
Sugar_transport pfam06800
Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 ...
 268-344 1.55e-03

Sugar transport protein; This is a family of bacterial sugar transporters approximately 300 residues long. Members include glucose uptake proteins, ribose transport proteins, and several putative and hypothetical membrane proteins probably involved in sugar transport across bacterial membranes. These members are transmembrane proteins which are usually 5+5 duplications. This model recognizes a set of five TMs,


Pssm-ID: 429127 [Multi-domain]  Cd Length: 280  Bit Score: 39.56  E-value: 1.55e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640435 268 GFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGPGFIAAMWGIFMFKEIKGLQNYLLMILAFCIILTGALCTAFSK 344
Cdd:pfam06800  58 GFISGAFWAFGQIGQFKSFKLVGVSKAMPISTGMQLVGTSLFGVFAFGEWSTIIQKILGFLALILIVIGIYLTSWTE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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