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Conserved domains on  [gi|1034648326|ref|XP_016865710|]
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melanocortin-2 receptor accessory protein 2 isoform X3 [Homo sapiens]

Protein Classification

MRAP domain-containing protein( domain architecture ID 10633540)

MRAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRAP super family cl21048
Melanocortin-2 receptor accessory protein family; This family is thought to be involved in ...
 13-76 2.52e-33

Melanocortin-2 receptor accessory protein family; This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.


The actual alignment was detected with superfamily member pfam15183:

Pssm-ID: 464550  Cd Length: 89  Bit Score: 112.64  E-value: 2.52e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648326  13 QQSASNSDYT-WEYEYY----EIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQD 76
Cdd:pfam15183   1 MANATNASYPyYSYEYYldylDLIPVDEKKLKAHKYSIVIGFWVSLAVFVVLLFFVLLYMSWSGSPQQR 69
 
Name Accession Description Interval E-value
MRAP pfam15183
Melanocortin-2 receptor accessory protein family; This family is thought to be involved in ...
 13-76 2.52e-33

Melanocortin-2 receptor accessory protein family; This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.


Pssm-ID: 464550  Cd Length: 89  Bit Score: 112.64  E-value: 2.52e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648326  13 QQSASNSDYT-WEYEYY----EIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQD 76
Cdd:pfam15183   1 MANATNASYPyYSYEYYldylDLIPVDEKKLKAHKYSIVIGFWVSLAVFVVLLFFVLLYMSWSGSPQQR 69
 
Name Accession Description Interval E-value
MRAP pfam15183
Melanocortin-2 receptor accessory protein family; This family is thought to be involved in ...
 13-76 2.52e-33

Melanocortin-2 receptor accessory protein family; This family is thought to be involved in cell trafficking. It is required for MC2R expression in certain cell types, suggesting that it is involved in the processing, trafficking or function of MC2R. MRAP may be involved in the intracellular trafficking pathways in adipocyte cells. This family of proteins is found in eukaryotes. Proteins in this family are typically between 47 and 205 amino acids in length.


Pssm-ID: 464550  Cd Length: 89  Bit Score: 112.64  E-value: 2.52e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648326  13 QQSASNSDYT-WEYEYY----EIGPVSFEGLKAHKYSIVIGFWVGLAVFVIFMFFVLTLLTKTGAPHQD 76
Cdd:pfam15183   1 MANATNASYPyYSYEYYldylDLIPVDEKKLKAHKYSIVIGFWVSLAVFVVLLFFVLLYMSWSGSPQQR 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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