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Conserved domains on  [gi|1034648348|ref|XP_016865716|]
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BTB/POZ domain-containing protein 9 isoform X5 [Homo sapiens]

Protein Classification

BTB/POZ domain-containing protein 9( domain architecture ID 13033442)

BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein 9 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Gene Symbol:  BTBD9
Gene Ontology:  GO:0005515
PubMed:  27521773|17120193|15544948

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 4.43e-77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 233.67  E-value: 4.43e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLK 93
Cdd:cd18287     1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287    80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 137-235 3.62e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


:

Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 182.04  E-value: 3.62e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNS-- 214
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPds 80

                          90       100
                  ....*....|....*....|.
gi 1034648348 215 KENHAEIMQAVRLPLMSLTEL 235
Cdd:cd14822    81 KEDAKEILEAVRLPLMSLTEL 101
 
Name Accession Description Interval E-value
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 4.43e-77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 233.67  E-value: 4.43e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLK 93
Cdd:cd18287     1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287    80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 137-235 3.62e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 182.04  E-value: 3.62e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNS-- 214
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPds 80

                          90       100
                  ....*....|....*....|.
gi 1034648348 215 KENHAEIMQAVRLPLMSLTEL 235
Cdd:cd14822    81 KEDAKEILEAVRLPLMSLTEL 101
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-137 3.14e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 101.18  E-value: 3.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESqPEAEIPLQDTTAEAFTMLLKYIYTGRAtltdEKEEVLLD 112
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES-SVSEITLDDVSPEDFEALLEFMYTGKL----ISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 1034648348 113 FLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 142-240 9.89e-25

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 96.85  E-value: 9.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 142 VCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSF-AAPEKDIFLALLNWCKHNS---KEN 217
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLnVPSEEEVFEAVIRWVKHDVerrKKH 80

                          90       100
                  ....*....|....*....|...
gi 1034648348 218 HAEIMQAVRLPLMSLTELLNVVR 240
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 37-137 4.17e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 92.37  E-value: 4.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348   37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKeevLLDFLSL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD-KSEIYLDDVSPEDFRALLNFLYTGKLDLPEEN---VEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 1034648348  117 AHKYGFPELEDSTSEYLCTIL 137
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 149-238 1.29e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 77.38  E-value: 1.29e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  149 ASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENH---AEIMQA 224
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHDPEKRRehlPELLEH 87

                           90
                   ....*....|....
gi 1034648348  225 VRLPLMSLTELLNV 238
Cdd:smart00875  88 VRLPLLSPDYLLEV 101
PHA03098 PHA03098
kelch-like protein; Provisional
 38-250 3.24e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 61.71  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  38 VTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESqpeaEIPLQDTTaEAFTMLLKYIYTGRATLTDEKEEvllDFLSLA 117
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLNIDY-DSFNEVIKYIYTGKINITSNNVK---DILSIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 118 HKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIvLRDS--F 195
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI-LSDDklN 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 196 AAPEKDIFLALLNWCKHNSKENHAEImqavrlplmslTELLNVVRPSgLLSPDAI 250
Cdd:PHA03098  165 VSSEDVVLEIIIKWLTSKKNNKYKDI-----------CLILKVLRIT-FLSEEGI 207
 
Name Accession Description Interval E-value
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-133 4.43e-77

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 233.67  E-value: 4.43e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLK 93
Cdd:cd18287     1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287    80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 137-235 3.62e-57

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 182.04  E-value: 3.62e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNS-- 214
Cdd:cd14822     1 LNIRNVCLIYDVASLYSLDDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCAPEVDIFNAVRRWCEHNPds 80

                          90       100
                  ....*....|....*....|.
gi 1034648348 215 KENHAEIMQAVRLPLMSLTEL 235
Cdd:cd14822    81 KEDAKEILEAVRLPLMSLTEL 101
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 1.24e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 104.17  E-value: 1.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTdekEEVLLDFLSL 116
Cdd:cd18186     3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESS-SSEIELDDVSPEAFEALLDYIYTGELELS---EENVEELLAA 78


                  ....
gi 1034648348 117 AHKY 120
Cdd:cd18186    79 ADKL 82
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 33-137 3.14e-26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 101.18  E-value: 3.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESqPEAEIPLQDTTAEAFTMLLKYIYTGRAtltdEKEEVLLD 112
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES-SVSEITLDDVSPEDFEALLEFMYTGKL----ISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 1034648348 113 FLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-133 9.55e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 100.01  E-value: 9.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFP--AHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGR 99
Cdd:cd18294     1 FAADMKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034648348 100 ATLTDekeEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18294    81 VTLSN---HTVIEVLAAAVEYGLDELRKLCERFI 111
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 142-240 9.89e-25

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 96.85  E-value: 9.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 142 VCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSF-AAPEKDIFLALLNWCKHNS---KEN 217
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLnVPSEEEVFEAVIRWVKHDVerrKKH 80

                          90       100
                  ....*....|....*....|...
gi 1034648348 218 HAEIMQAVRLPLMSLTELLNVVR 240
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 37-137 4.17e-23

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 92.37  E-value: 4.17e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348   37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKeevLLDFLSL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD-KSEIYLDDVSPEDFRALLNFLYTGKLDLPEEN---VEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 1034648348  117 AHKYGFPELEDSTSEYLCTIL 137
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-126 8.30e-23

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 91.64  E-value: 8.30e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTdekEEVLLD 112
Cdd:cd18314     4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESN-LKEVTLEDVEPEIFETVLKYMYTGQVTLS---EENVLD 79

                          90
                  ....*....|....
gi 1034648348 113 FLSLAHKYGFPELE 126
Cdd:cd18314    80 LLMLASKYQVPDLE 93
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-134 7.86e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 86.94  E-value: 7.86e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRE-SQPEAEIPlqDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18297    10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEaQTPVIEIP--DIRYDIFQLMMQYLYTGGVESLDVAQDDAL 87

                          90       100
                  ....*....|....*....|...
gi 1034648348 112 DFLSLAHKYGFPELEDSTsEYLC 134
Cdd:cd18297    88 ELLRAASFFQLDGLKRHC-EILL 109
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 33-125 1.99e-18

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 79.98  E-value: 1.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVllD 112
Cdd:cd18300     7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESS-AKEVELPGVSKETFLALLEYLYTDQAPILEDGDCV--G 83

                          90
                  ....*....|...
gi 1034648348 113 FLSLAHKYGFPEL 125
Cdd:cd18300    84 LIVLANRLCLPRL 96
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 29-133 2.56e-18

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 80.00  E-value: 2.56e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  29 LLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDekEE 108
Cdd:cd18286    11 LFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSS-EITLTGVSHAAVSFVLLFIYGGVLDLPD--DV 87

                          90       100
                  ....*....|....*....|....*
gi 1034648348 109 VLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18286    88 NLGELLSLADMYGLDGLKDVVAYTL 112
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 149-238 1.29e-17

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 77.38  E-value: 1.29e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  149 ASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENH---AEIMQA 224
Cdd:smart00875   8 ADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSsEEEVFEAVLRWVKHDPEKRRehlPELLEH 87

                           90
                   ....*....|....
gi 1034648348  225 VRLPLMSLTELLNV 238
Cdd:smart00875  88 VRLPLLSPDYLLEV 101
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-97 1.96e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 77.75  E-value: 1.96e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18280     1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREEN-EGEIVIEDVEPPVFKALLHFIYK 75
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-142 4.56e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 76.73  E-value: 4.56e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  19 VHILSeHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTG 98
Cdd:cd18250     6 LHLLR-GLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRAD-RVVLHGVSAEILGLLLDFSYTG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034648348  99 RATLTDEKEEVLLDFLSLahkYGFPELEDSTSEYLCTILNIQNV 142
Cdd:cd18250    84 RVTVTQDNVEALLRAADL---FQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-141 1.07e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 75.64  E-value: 1.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  20 HILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGR 99
Cdd:cd18279     3 CRLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESK-KNRVEINDVDPEVFKEMMRFIYTGK 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1034648348 100 ATLTDEKEEvllDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18279    82 APNLDKMAD---DLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-142 4.19e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 74.11  E-value: 4.19e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRAT 101
Cdd:cd18345     5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERK-QNRVEITDVDHEVMREMLRFIYTGKAP 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034648348 102 LTDEKEEvllDFLSLAHKYGFPELEDSTSEYLCTILNIQNV 142
Cdd:cd18345    84 NLDKMAD---DLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 5.62e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 73.68  E-value: 5.62e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLD 112
Cdd:cd18237    19 KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESK-SSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLD 97

                          90       100
                  ....*....|....*....|....*....
gi 1034648348 113 flsLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18237    98 ---AANQYQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-110 9.74e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 72.81  E-value: 9.74e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLT-DEKEEVL 110
Cdd:cd18255    20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESS-QDEIELKGVSAKGLKHILDFAYTSELTLDlDCIQDVL 93
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 1.05e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 72.73  E-value: 1.05e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRAT 101
Cdd:cd18343     8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESK-KNRVEINDVDPEVFKEMMRFIYTGKAP 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348 102 LTDEKEEVLldfLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18343    87 NLDKMADNL---LAAADKYALERLKVMCEEALCNNLSVEN 123
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-143 1.94e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 71.94  E-value: 1.94e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  31 IGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPE-AEIP---LQDTTAEAFTMLLKYIYTGRATLTDek 106
Cdd:cd18296    13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENnGSIPvvtLHDVSPEVFAIVLYYIYTDDTDLPP-- 90

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034648348 107 eEVLLDFLSLAHKYGFPELEDstseyLCTILNIQNVC 143
Cdd:cd18296    91 -ENAYDVLYVADMYLLPGLKR-----LCGTVLAQSLD 121
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-111 1.95e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 71.63  E-value: 1.95e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18234     3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREAT-EEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLL 76
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-142 2.63e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 71.70  E-value: 2.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18242    23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKG-KSEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPAACL 101

                          90       100
                  ....*....|....*....|....*.
gi 1034648348 117 AHKYGfpeLEDSTSEYLCTILNIQNV 142
Cdd:cd18242   102 LQLKG---VKQACCEFLESQLDPSNC 124
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 38-120 6.68e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 69.23  E-value: 6.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  38 VTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPeAEIPLQDTTAEAFTMLLKYIYTGRATLtdeKEEVLLDFLSLA 117
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQ-AEINLRDISPEDFRALLEFLYGGKRDL---DASNLLELLEAA 76


                  ...
gi 1034648348 118 HKY 120
Cdd:cd01165    77 NFL 79
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-137 9.84e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 69.73  E-value: 9.84e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVV----EKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYTGRATLTdekEEVLLD 112
Cdd:cd18282     9 DVHFIVgppgGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIP--DVEPAAFLNLLRYLYCDEIDLE---PDTVLA 83

                          90       100
                  ....*....|....*....|....*
gi 1034648348 113 FLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:cd18282    84 TLYAAKKYLVPHLARACVQFLETSL 108
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-141 1.46e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 69.74  E-value: 1.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  18 HVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18256     3 HASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKD-VVQIHGVEPDIFHILLDFIYT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034648348  98 GRATLTDEKEEVLL---DFLSLahkygfPELEDSTSEYLCTILNIQN 141
Cdd:cd18256    82 GVVEVTVSNVQELLvaaDMLQL------TEVVEICCEFLKGQLHPSN 122
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 1.51e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 69.63  E-value: 1.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18238    17 DVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESK-QDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASL 95

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 ahkYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18238    96 ---LQVEEVAKACCEFMKDHLHPSN 117
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-137 3.55e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 68.61  E-value: 3.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18235    23 DVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANR-VTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLPAANL 101

                          90       100
                  ....*....|....*....|.
gi 1034648348 117 AHkygFPELEDSTSEYLCTIL 137
Cdd:cd18235   102 LQ---LTDVRDACCDFLQSQL 119
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 7.66e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 67.85  E-value: 7.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYt 97
Cdd:cd18281     9 VKERFAFLFNNETLSDVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELP--DVEPAAFLALLRFLY- 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034648348  98 gratlTDEKE---EVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18281    86 -----SDEVQigpETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB1_POZ_LZTR1 cd18308
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-133 8.54e-14

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349617 [Multi-domain]  Cd Length: 156  Bit Score: 68.56  E-value: 8.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVV--EKKRFPAHRVILAARCQYFR------------------------ALLYGGMRESQPE 75
Cdd:cd18308    10 LHDDFGRLLESRQFCDVEFIVgeEEERIPAHIAFVAARSKWLRnkilqarerqkqkaeqevedegseADSSSASKNDSPM 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348  76 AEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEE------VLL--DFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18308    90 LEVRLPEADPEAFELILSFIYTDKIDPTRKGQDpgsnevVLLmmDVYRLALQFQMSRLEQLCVQYL 155
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-132 1.06e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 66.93  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  24 EHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLY--GGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRAT 101
Cdd:cd18292     6 QDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSndWWSESKQSEIELVEDPECAAVFEKFLRYLYTGQIS 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034648348 102 LTdekEEVLLDFLSLAHKYGFPELEDSTSEY 132
Cdd:cd18292    86 VN---LETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 3.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 65.95  E-value: 3.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDflsL 116
Cdd:cd18265    25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAV-VEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLE---A 100

                          90
                  ....*....|....*..
gi 1034648348 117 AHKYGFPELEDSTSEYL 133
Cdd:cd18265   101 SDLLQVSKLREACVRFL 117
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-123 5.86e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 64.28  E-value: 5.86e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRE-SQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLS 115
Cdd:cd18283     4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYgAEIPVDLPTAGIDVPMFSALLRYLYTGEFGSEDSRSQNLDVLIQ 83


                  ....*...
gi 1034648348 116 LAHKYGFP 123
Cdd:cd18283    84 LSEEFGTP 91
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-110 6.31e-13

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 64.96  E-value: 6.31e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMReSQPEAEIPLQDTTAEAFTMLLKYIYTGR-A 100
Cdd:cd18295     6 YDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWK-DKREINLKHPLVNPDAFRALLQYLYTGRlE 84

                          90
                  ....*....|
gi 1034648348 101 TLTDEKEEVL 110
Cdd:cd18295    85 IHVDDVEDCK 94
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 31-122 6.79e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 65.10  E-value: 6.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  31 IGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDT--TAEAFTMLLKYIYTGRATLTDEKee 108
Cdd:cd18309    16 VGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDN-TVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPED-- 92

                          90
                  ....*....|....
gi 1034648348 109 vLLDFLSLAHKYGF 122
Cdd:cd18309    93 -SLYLFSAPYFYGF 105
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-133 6.92e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 65.78  E-value: 6.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  25 HIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTT-AEAFTMLLKYIYTGRATLT 103
Cdd:cd18267    30 HLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQ-DSEVNFHDSIhPEVLELLLDYAYSSRVIIN 108

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034648348 104 DEKEEVLLDFLSLAHkygFPELEDSTSEYL 133
Cdd:cd18267   109 EENAESLLEAGDMLE---FQDIRDACAEFL 135
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 31-111 1.16e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 64.04  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  31 IGEEY------GDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTD 104
Cdd:cd18352     3 LGEQYvnnatlSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEAR-DIEIPNIRWEVFELMMRFIYTGSVDITN 81


                  ....*..
gi 1034648348 105 EKEEVLL 111
Cdd:cd18352    82 DIAKDLL 88
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-104 1.19e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 64.32  E-value: 1.19e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348  37 DVTFVVE----KKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTD 104
Cdd:cd18248    23 DVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGME-VVPIEGVHPCVMSRLIEFAYTASISVGE 93
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 1.54e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 64.31  E-value: 1.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEK----------KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTML 91
Cdd:cd18346     9 LKERFAFLFNNELLSDVRFVVGKgrprgpgpgaQRIPAHRFVLAAGSAVFDAMFNGGMATTSAEIELP--DVEPAAFLAL 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034648348  92 LKYIYTGRATLtdeKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18346    87 LRFLYSDEVQI---GPETVMTTLYTAKKYAVPALEAHCVEFLTKHLRADN 133
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 1.62e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 63.88  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggmreSQPEAEIPLQDTTAEAFTMLLKYIYTGRAT 101
Cdd:cd18303     5 LLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNEN------LASTNELDLSDISYEVVLALLRWLYTDELD 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348 102 LTDEkEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18303    79 LTLD-DEFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-104 1.82e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 64.46  E-value: 1.82e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348  36 GDVTFVVEK--------KRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTD 104
Cdd:cd18273    27 TDVTIEVNGpgsgpgsgRLFPCNRNVLAAASPYFKSMFTGGLYESK-QETVTIHDVDSESMALIIDYCYTGRVTLSE 102
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-111 1.83e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 63.50  E-value: 1.83e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQP-EAEIPlqDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18240    19 DVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKkVYKIP--GVSPEMMELIIEYAYTRTVPITAENVEELL 92
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-141 3.54e-12

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 62.23  E-value: 3.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  24 EHIGALLIGEEYGDVTFVV-EKKRFPAHRVILAARCQYFRALLyGGMRESQPEAEIplqdtTAEAFTMLLKYIYTGRAtl 102
Cdd:cd18299     1 EDLRNLLHSPSCADVVFILqGGVRIFAHRIVLAAASSVFADLF-LMMTVVTLDSDI-----TPEAFRRVLEFLYTGVL-- 72

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034648348 103 tDEKEEVLLDFLSLAHKYGFPELEDStseylctILNIQN 141
Cdd:cd18299    73 -DENEDDLKELKDAAELLELFDLVMM-------CTNVLN 103
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-141 3.76e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 63.05  E-value: 3.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  17 DHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIY 96
Cdd:cd18344     5 DPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNP-IEIHDLDPQVFKEMMGFIY 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034648348  97 TGRATlTDEKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18344    84 TGKAP-HLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 4.65e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 62.30  E-value: 4.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL---DF 113
Cdd:cd18247    21 DVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQD-EITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLvgaSF 99

                          90       100
                  ....*....|....*....|
gi 1034648348 114 LSLahkygfPELEDSTSEYL 133
Cdd:cd18247   100 LQL------QSVKDACCEFL 113
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-116 4.96e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 62.43  E-value: 4.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPeAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18339    23 DVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKA-KKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASL 101
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 5.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 62.56  E-value: 5.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18236    26 DVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKY-EEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVLEAASL 104

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 ahkYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18236   105 ---FQFLRMVDACASFLTEALHPEN 126
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 7.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 62.04  E-value: 7.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRAT 101
Cdd:cd18342     9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESK-KNRVEINDVEPEVFKEMMCFIYTGKAP 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034648348 102 LTDEKEEvllDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18342    88 NLDKMAD---DLLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-110 7.34e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 62.14  E-value: 7.34e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLT-DEKEEVL 110
Cdd:cd18251    25 DVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQ-QTEVLIHGVSYNAMCKILDFIYTSELELSlDNVQETL 98
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-104 8.73e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 61.74  E-value: 8.73e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTD 104
Cdd:cd18276    19 AELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECS-QREVVLHDITAESVSIILNYMYSSDLHLTN 89
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 37-116 9.94e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 60.26  E-value: 9.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLygGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18315     3 DVTLACEGGSLKAHKLVLAAASPYFAALL--KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-141 1.17e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 61.54  E-value: 1.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  45 KRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLahkYGFPE 124
Cdd:cd18274    33 KTFSCHRNVLAAISPYFRSMFTSGLTEST-QKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASI---FQIPS 108

                          90
                  ....*....|....*..
gi 1034648348 125 LEDSTSEYLCTILNIQN 141
Cdd:cd18274   109 LQDQCAQFMISRLDPQN 125
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-137 2.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 60.38  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVV----EKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYTGRATLtdeKEE 108
Cdd:cd18349     6 ELMADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIP--DVEPAAFLILLKYMYSDEIDL---EAD 80

                          90       100
                  ....*....|....*....|....*....
gi 1034648348 109 VLLDFLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:cd18349    81 TVLATLYAAKKYIVPALAKACVNFLETSL 109
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-116 3.67e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 59.85  E-value: 3.67e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18253    20 DVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESR-EMLVEINGILAEAMDCFLQYVYTGKVKITTENVQYLFETSSL 98
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-133 4.55e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 60.03  E-value: 4.55e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTT-AEAFTMLLKYIYTGRATLTDEKEEVLLDF 113
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESL-DSTVNFHDSLhPEVLELLLDFAYSSRIIINEENAESLLEA 100

                          90       100
                  ....*....|....*....|
gi 1034648348 114 LSLAHkygFPELEDSTSEYL 133
Cdd:cd18254   101 GDMLQ---FHDVRDAAAEFL 117
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-98 6.74e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 58.45  E-value: 6.74e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALL----IGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggmRESQPEAE-------IPLQDTTAEAFTM 90
Cdd:cd18301     1 FQEDFKKLLdeadEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLF----LSSLLTSEdavgcdvVHIEKVPPEIFEQ 76


                  ....*...
gi 1034648348  91 LLKYIYTG 98
Cdd:cd18301    77 LLQFIYTD 84
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-98 8.35e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 59.06  E-value: 8.35e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTG 98
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKEST-QSVVQLPTIPAKDLRLLISFAYSG 75
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 1.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 59.07  E-value: 1.20e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18259    34 DVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESI-SARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSNR 112

                          90
                  ....*....|....*..
gi 1034648348 117 AHkygFPELEDSTSEYL 133
Cdd:cd18259   113 LQ---FPTVRKVCSRYL 126
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-141 1.22e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 58.55  E-value: 1.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEK----KRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYT 97
Cdd:cd18347     9 VQERFAFLFNNEVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELP--DVEPAAFLALLKFLYS 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034648348  98 GRATLtdeKEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18347    87 DEVQI---GPETVMTTLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-146 1.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 58.69  E-value: 1.40e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  29 LLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEE 108
Cdd:cd18340    21 LLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESK-KREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQ 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034648348 109 vllDFLSLAHKYGFPELEDSTSEYLCTILNIQNVCMTF 146
Cdd:cd18340   100 ---DIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-138 1.94e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 57.77  E-value: 1.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18338    23 DVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAK-RVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGL 101

                          90       100
                  ....*....|....*....|..
gi 1034648348 117 AHkygFPELEDSTSEYLCTILN 138
Cdd:cd18338   102 LQ---LQDVKKTCCEFLESQLH 120
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-138 2.19e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 58.05  E-value: 2.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLtdeKEEVLLDFLSL 116
Cdd:cd18261    30 DITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEAD-EVNLHGVTSLGLKQALDFAYTGQILL---EPGVIQDVLAA 105

                          90       100
                  ....*....|....*....|..
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILN 138
Cdd:cd18261   106 GSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 2.27e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 57.35  E-value: 2.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA-EIPLQDTTAEAFTMLLKYIYTGRATLTdekEEVLLDFLS 115
Cdd:cd18245    16 DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTyKIELEGISVEVMEEILDYIYTGQIKLS---EDNIQDIVQ 92

                          90
                  ....*....|....*...
gi 1034648348 116 LAHKYGFPELEDSTSEYL 133
Cdd:cd18245    93 AADLLLMTDLKDLCCEFL 110
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 2.64e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 58.09  E-value: 2.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSl 116
Cdd:cd18270    28 DIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESK-QTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYETAC- 105

                          90       100
                  ....*....|....*....|....*...
gi 1034648348 117 ahkygFPELED---STSEYLCTILNIQN 141
Cdd:cd18270   106 -----FLQVEDvlqRCREYLIKKINAEN 128
PHA03098 PHA03098
kelch-like protein; Provisional
 38-250 3.24e-10

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 61.71  E-value: 3.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  38 VTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESqpeaEIPLQDTTaEAFTMLLKYIYTGRATLTDEKEEvllDFLSLA 117
Cdd:PHA03098   14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLNIDY-DSFNEVIKYIYTGKINITSNNVK---DILSIA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 118 HKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIvLRDS--F 195
Cdd:PHA03098   86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI-LSDDklN 164

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 196 AAPEKDIFLALLNWCKHNSKENHAEImqavrlplmslTELLNVVRPSgLLSPDAI 250
Cdd:PHA03098  165 VSSEDVVLEIIIKWLTSKKNNKYKDI-----------CLILKVLRIT-FLSEEGI 207
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 6.35e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 56.72  E-value: 6.35e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKeevLLDFLSL 116
Cdd:cd18268    25 DVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESS-QAKVDLKGIDSDVLDQIVDYVYTGEILITRDN---VLPLMEA 100

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18268   101 ASMLQYPKLFEACSLYLQDQLTPEN 125
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-105 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 55.51  E-value: 1.19e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDE 105
Cdd:cd18199    20 DCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQ 88
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-105 1.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 55.32  E-value: 1.33e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDE 105
Cdd:cd18330    18 FCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSE 88
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 1.62e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 55.67  E-value: 1.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIYTGRATLtdeKEEVLLD 112
Cdd:cd18272    30 GLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRV-IELKDVSESVFQLLVDYIYHGTVKL---RVEELQE 105

                          90       100
                  ....*....|....*....|....*....
gi 1034648348 113 FLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18272   106 TYEVADMYQLTALFEECSRFLARTVQVRN 134
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-144 2.44e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 55.02  E-value: 2.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  36 GDVTFVVE----KKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYTGRATLTdekEEVLL 111
Cdd:cd18348    22 ADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIP--DVEPAAFLAMLKYIYCDEIDLA---ADTVL 96

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034648348 112 DFLSLAHKYGFPELEDSTSEYLCTILNIQNVCM 144
Cdd:cd18348    97 ATLYAAKKYIVPHLARACVNFLETSLSAKNACV 129
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-123 2.61e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 55.10  E-value: 2.61e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEvllDFLSL 116
Cdd:cd18269    29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESK-KKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQ---DIFAL 104


                  ....*..
gi 1034648348 117 AHKYGFP 123
Cdd:cd18269   105 ASRFQIP 111
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-118 2.99e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 54.65  E-value: 2.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGgmrESQPEAEIPLQDTTAeAFTMLLKYIYTGRATLTDEKEEVLL--- 111
Cdd:cd18289    29 YCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSG---NSKSAFELPATVPPA-CFQQILSFCYTGKLTMAASEQLVVMyta 104


                  ....*..
gi 1034648348 112 DFLSLAH 118
Cdd:cd18289   105 GFLQIQH 111
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-102 3.47e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 54.43  E-value: 3.47e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  37 DVTFVVEK--KRFPAHRVILAARCQYFRALLYGGMREsQPEAEIPLQDTTAEAFTMLLKYIYTGRATL 102
Cdd:cd18239    25 DVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKE-QELMCIKLHGVSKIGLKNIIDFIYTAKLSL 91
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 3.72e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 54.47  E-value: 3.72e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYG-GMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18350    22 KEMSDVTFLVEGKLFYAHKVLLVTASNRFKSLLTNkSEQESQGSKTIEISDIKYHIFQMLMQYLYYGGTESMEIPIADVL 101

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034648348 112 DFLSLAHKYGFPELEdSTSEYLCT-ILNIQN 141
Cdd:cd18350   102 ELLSAASLFQLDALQ-RHCEILCSqTINLEN 131
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 27-99 4.66e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 54.62  E-value: 4.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  27 GALLIGE-EYGDVTFVVEKKR-FPAHRVILAARCQYFRALLYGGMRES---QPEAE----IPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18310     9 NLLDSPDlFYSDAEIIVEGGRpVPVHRCILAARSPFFRDIFASAKAEGantKPKLElrelIPGGIVGYDAFMLVLSYLYS 88


                  ..
gi 1034648348  98 GR 99
Cdd:cd18310    89 GR 90
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 5.14e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 54.07  E-value: 5.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMREsQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVlldFLSL 116
Cdd:cd18271    26 DFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKE-RDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEM---FFQM 101

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18271   102 SSFLQVSLLSKACSDFLIKSIDLTN 126
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 134-231 6.02e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 53.08  E-value: 6.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 134 CTILNIQNVCMTFDVASLYSlpkltcMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKH 212
Cdd:cd18457     4 NNCLGIRQFAETMMCSSLVD------AANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKsEEQVFEAALAWVKY 77

                          90       100
                  ....*....|....*....|..
gi 1034648348 213 ---NSKENHAEIMQAVRLPLMS 231
Cdd:cd18457    78 dreNREEYLPELLSKVRLPLLR 99
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-121 7.04e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 53.03  E-value: 7.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLD 112
Cdd:cd18298    10 PRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKN-VIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLD 88


                  ....*....
gi 1034648348 113 flsLAHKYG 121
Cdd:cd18298    89 ---LANSYC 94
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-117 7.36e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 53.71  E-value: 7.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRES----QPEAE--IPLQDTTAEAFTMLLKYIYTGRATLTDEKeevL 110
Cdd:cd18228    21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRlvlvSPAGKcvLDLHHVTVTGFAPLLEYAYTSTLSINTEN---I 97


                  ....*..
gi 1034648348 111 LDFLSLA 117
Cdd:cd18228    98 IDVLAAA 104
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-133 8.33e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 53.61  E-value: 8.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  18 HVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVTIRDIDERAMELLIDFAYT 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034648348  98 GRATLTDEKEEVLLDFLSLAHkygFPELEDSTSEYL 133
Cdd:cd18249    85 SQITVEEGNVQTLLPAACLLQ---LAEIQEVCCEFL 117
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-129 1.11e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 52.87  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFR-ALLYGGMRESQPEAEIPlqDTTAEAFTMLLKYIYTgrATLTDEKEEVLLDFLS 115
Cdd:cd18223    20 DVTIVVEDTKFKAHKNVLAASSLYFKnAFSSQEIWISSHVLELP--DLKAEVFAEILNFIYS--SKVVVKRQETVTDLVA 95

                          90
                  ....*....|....
gi 1034648348 116 LAHKYGFPELEDST 129
Cdd:cd18223    96 AGKKLGITFLENLT 109
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 1.14e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 52.09  E-value: 1.14e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGgmrESQPEAEIPL-QDTTAEAFTMLLKYIYTGRATLTDEKeevLLDFLS 115
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVG---QTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKEN---VLEVCR 76

                          90
                  ....*....|....*...
gi 1034648348 116 LAHKYGFPELEDSTSEYL 133
Cdd:cd18955    77 CAEFLGVHNIEKACFDFL 94
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-111 1.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 52.54  E-value: 1.49e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18257    16 HELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENS-EVEFQCIDETALQAIVEYAYTGTVFISQATVESLL 93
BACK_BTBD6 cd18525
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); ...
 137-215 2.10e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also called lens BTB domain protein, is a BTB-domain-containing Kelch-like protein that is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350600  Cd Length: 95  Bit Score: 51.24  E-value: 2.10e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSK 215
Cdd:cd18525     1 LEAKNACVLLSQSRLFEEPELTQRCWEVIDAQAELALKSEGFCEIDQQTLEIILTRETLNTKEVVVFEAVLNWAEAECK 79
BACK_BTBD3_like cd18488
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and ...
 137-225 2.23e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This subfamily includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionarily-conserved role during neuronal development.


Pssm-ID: 350563  Cd Length: 95  Bit Score: 51.21  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNW----CKH 212
Cdd:cd18488     1 LSARNACVLLSQSRLFEEPELMQRCWEVIDAQAELALKSEGFTEIDYKTLESILRRETLNAKESVVFEAALRWaeaeCQR 80

                          90
                  ....*....|...
gi 1034648348 213 NSKENHAEIMQAV 225
Cdd:cd18488    81 RGLEPTPENKRKV 93
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-111 2.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 51.97  E-value: 2.37e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18336    21 DVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQE-EIKMEGVDPDALKALVHYAYTGVLELKEDTIESLL 94
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-105 2.40e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 50.89  E-value: 2.40e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034648348  42 VEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDE 105
Cdd:cd18320     8 VEEQLFTVDKALLVENSEYFRALFRSGMRECT-QDEIRLQGLSARGFRIMLRVLAGERPILNGE 70
BTB_POZ_ARMC5 cd18191
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-109 2.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in armadillo repeat-containing protein 5 (ARMC5); ARMC5 plays a role in steroidogenesis, and modulates the expression and cortisol production of steroidogenic enzymes. It negatively regulates adrenal cells survival. It contains armadillo (ARM) repeats and a BTB domain, which is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349500 [Multi-domain]  Cd Length: 100  Bit Score: 51.35  E-value: 2.42e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  36 GDVTFVVEK-KRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGR---ATLTDEKEEV 109
Cdd:cd18191     2 HDLRFLLDGgTQLPASRAALTGASEVFRAMLEGGFAEAQ-QDLVPLRQVPSGAFLPVLHYLHGCRgcdANEDDEKSDQ 78
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-111 2.89e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 51.30  E-value: 2.89e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648348  34 EYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMresqpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDE-KEEVLL 111
Cdd:cd18232    17 QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT-----SGSVVLPESFAEVFGLLLDFFYTGELALTREnRDRVLL 90
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-103 3.50e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 51.36  E-value: 3.50e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLT 103
Cdd:cd18329    19 ELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFVYSGKLSLT 89
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 3.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 51.47  E-value: 3.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGG-MRESQPEAEIPLqdTTAEAFTMLLKYIYTgrATLTDEKEEVlLDFLS 115
Cdd:cd18326    27 DVVILVEGREFPTHRSVLAACSQYFKKLFTSGaVVDQQNVYEIDF--VSAEALTALLDFAYT--ATLTVSTSNV-GDILS 101

                          90
                  ....*....|....*...
gi 1034648348 116 LAHKYGFPELEDSTSEYL 133
Cdd:cd18326   102 AARLLEIPAVSHVCADLL 119
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-102 3.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 51.43  E-value: 3.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  25 HIGALL--IGEE-----YGDVTFVVEKKRFPAHRVILAARCQYFRALL------------YGGMRESQPEAEIPLQDTTA 85
Cdd:cd18195     1 HAGALLlqLNEQrlrglFCDVTLIAGDTKFRAHRSVLAASSPYFRELLssplplgaaavaAAPGATQSPERVLELPGVKA 80

                          90
                  ....*....|....*..
gi 1034648348  86 EAFTMLLKYIYTGRATL 102
Cdd:cd18195    81 GVFSDVLNFIYSSRVAL 97
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-137 7.19e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 50.77  E-value: 7.19e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEvlLDFL 114
Cdd:cd18359    20 FSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTT-EVVFPYTSRSSMRAVLEYLYTGQFSSSPDLDD--MKLI 96

                          90       100
                  ....*....|....*....|...
gi 1034648348 115 SLAHKYGFPELEDSTSEYLCTIL 137
Cdd:cd18359    97 ILANRLCLPHLVALTEQYTVTVL 119
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 7.75e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 50.45  E-value: 7.75e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGgmresQPEAEIPL---QDTTAEAFTMLLKYIYTGRATLT-DEKEEV--L 110
Cdd:cd18277    29 DVTILVEGQRFRAHRSVLAACSSYFHSRIVG-----QADAELNItlpEEVTVKGFEPLIQFAYTAKLILSkDNVDEVckC 103

                          90       100
                  ....*....|....*....|...
gi 1034648348 111 LDFLSLAHkygfpeLEDSTSEYL 133
Cdd:cd18277   104 VEFLSVHN------IEESCFQFL 120
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-103 8.15e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 50.72  E-value: 8.15e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMREsQPEAEIPLQDTTAEAFTMLLKYIYTGRATLT 103
Cdd:cd18244    32 DVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRE-RDQDKIHLKGLTATGFSHVLQFMYYGTIELS 97
BACK_BTBD3 cd18524
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); ...
 137-211 9.07e-08

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in mammalian neocortex.


Pssm-ID: 350599  Cd Length: 95  Bit Score: 49.73  E-value: 9.07e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCK 211
Cdd:cd18524     1 LSAKNACVLLSQSCLFEEPDLTQRCWEVIDAQAELALKSEGFCDIDFQTLESILRRETLNAKEIVVFEAALNWAE 75
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-126 9.47e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 50.17  E-value: 9.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggmrESQPEAE-----IPLQDTTAEAFTMLLKYIYTGRATLTDEKEEvll 111
Cdd:cd18293    17 DVLLQAEGESVPAHCCVLSACSPYLTERL-----SSEPPPAgqkvvLELQGLKAHTLLKLVDFLYTSELEVSSEEAQ--- 88

                          90
                  ....*....|....*
gi 1034648348 112 DFLSLAHKYGFPELE 126
Cdd:cd18293    89 DVLAAARRLQISELE 103
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 138-190 9.62e-08

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 48.43  E-value: 9.62e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034648348 138 NIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIV 190
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELL 53
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 1.13e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 49.95  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRE----SQPEaeiplqDTTAEAFTMLLKYIYTGRATLTDEK-EEVL- 110
Cdd:cd18278    33 DVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENdlvvSLPE------EVTARGFGPLLQFAYTAKLLLSRENiQEVIr 106

                          90       100
                  ....*....|....*....|....
gi 1034648348 111 -LDFLSLAHkygfpeLEDSTSEYL 133
Cdd:cd18278   107 cAEFLRMHN------LEDSCFRFL 124
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-122 1.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 49.97  E-value: 1.46e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA--EIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVL 110
Cdd:cd18258    15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGEklELTMSNINADVLELLLEFVYTGSLIIDSANAKTL 94

                          90
                  ....*....|..
gi 1034648348 111 LDflsLAHKYGF 122
Cdd:cd18258    95 LE---AANKFQF 103
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-143 1.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 50.18  E-value: 1.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLD---F 113
Cdd:cd18264    30 DVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESK-ARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTLEaasY 108

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034648348 114 LSLAHKYGFpeledsTSEYLCTILNIQNVC 143
Cdd:cd18264   109 LQVTEAIGL------CSQYLINNLAPENCC 132
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-111 1.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 49.67  E-value: 1.85e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18337    25 DVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQE-EIKMEGVEPNALWALVQYAYTGRLELKEDNIECLL 98
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 139-209 2.85e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 47.31  E-value: 2.85e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648348 139 IQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNW 209
Cdd:cd18494     2 VETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEALSVILRSDKLRIDELDILKAVREW 72
BACK_BTBD1_like cd18487
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and ...
 137-212 2.90e-07

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This subfamily includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350562  Cd Length: 95  Bit Score: 48.12  E-value: 2.90e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKH 212
Cdd:cd18487     1 LSSDNAFMLLTQARLFDEPQLASLCLETIDKNTAEALAAEGFTDIDLDTLCVVLERDTLGIRECKLFQAVLRWAEA 76
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-103 4.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 48.32  E-value: 4.00e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA-EIPLqdTTAEAFTMLLKYIYTgrATLT 103
Cdd:cd18198    27 DVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVyEIDF--VSPEALTALLEFAYT--ATLT 90
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 149-255 4.07e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 48.52  E-value: 4.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 149 ASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFA-APEKDIFLALLNWCKHNSK---ENHAEIMQA 224
Cdd:cd18513    13 ADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTvSSEEKVFEAVISWIKYDKEarlEHMAKLMEH 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034648348 225 VRLPLMSLTELLNVVRPSGLLS-----PDAILDAIK 255
Cdd:cd18513    93 VRLPLLPRDYLVQTVEEEALIKnnntcKDFLIEAMK 128
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 164-231 4.48e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 47.81  E-value: 4.48e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348 164 FMDRNAQEVLSSEGFLSLSKTALLNIVLRDSF-AAPEKDIFLALLNWCKHNSKENH---AEIMQAVRLPLMS 231
Cdd:cd18459    29 FTQHNFQEVMESEEFMLLPVNQLIDIISSDELnVRSEEQVFNAVMAWVKYNIQERRphlPQVLQHVRLPLLS 100
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 38-100 6.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 47.17  E-value: 6.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648348  38 VTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRA 100
Cdd:cd18319     4 VQIRLEDRCYNVSKRKLIEQSDYFRALYRSGMRESGEE-VVQLRGLSAPGLELVLDFINTSKV 65
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-141 7.40e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 47.92  E-value: 7.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  21 ILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRA 100
Cdd:cd18341    13 LLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEK-KKEVVLDNVDPNIMDMILKYLYSAEI 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1034648348 101 TLTDEKEEvllDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18341    92 DLNDGNVQ---DIFALASRFQIPSVFTVCVTYLQKRLSPAN 129
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 7.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 47.89  E-value: 7.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAArCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18194    25 DCTVLVGSAQFPAHRAVLAS-CSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAASY 103


                  ....
gi 1034648348 117 AHKY 120
Cdd:cd18194   104 LHMY 107
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-111 1.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 47.34  E-value: 1.03e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESqpeAEIPlQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18290    27 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAV---VELP-AAVQPQSFQQILSFCYTGRLSMNVGDQFLLM 99
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 171-231 1.59e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 46.46  E-value: 1.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 171 EVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENH---AEIMQAVRLPLMS 231
Cdd:cd18445    35 EVVKGEEFLLLSKEQVCELISSDDLTVPsEEKVFEAVMSWVNHDPENRKehlAELLEHVRLPLLS 99
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-111 1.62e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 46.71  E-value: 1.62e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpeAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18212    25 DITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQ--SIYMLEGMVAETFGALLEFIYTGCLQVGEKSLEQIL 97
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 138-226 2.24e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 45.77  E-value: 2.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 138 NIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAA-PEKDIFLALLNWCKHNS-- 214
Cdd:cd18455     1 SAENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVgNEEYIFEAVLRWVRHDPee 80

                          90
                  ....*....|...
gi 1034648348 215 -KENHAEIMQAVR 226
Cdd:cd18455    81 rKVHLKDLMSSCW 93
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 149-231 2.25e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 45.71  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 149 ASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSF-AAPEKDIFLALLNWCKHNSKENH---AEIMQA 224
Cdd:cd18467    13 AETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLnVVTEETVFYALESWIKYDVQERQkylAQLLHC 92


                  ....*..
gi 1034648348 225 VRLPLMS 231
Cdd:cd18467    93 VRLPLLS 99
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-131 2.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.39  E-value: 2.84e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVE----KKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLD 112
Cdd:cd18211    27 DVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRMLE 106

                          90
                  ....*....|....*....
gi 1034648348 113 flsLAHKYGFPELEDSTSE 131
Cdd:cd18211   107 ---IAEKLKCLDLSETCFQ 122
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-141 2.91e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 46.39  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEK---KRFPAHRVILAARCQYFRALLYGGMRESQPE--------AEIPLQDTTAEAftmLLKYIYTGRATL- 102
Cdd:cd18241    23 FCDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSGrvemrkwsSEPGPDPDTVEA---VIQYMYTGRIRVs 99

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034648348 103 TDEKEEVlldfLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18241   100 TGNVHEV----LELADRFLLIRLKEFCGEFLKKKLNLSN 134
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 149-255 3.07e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 46.18  E-value: 3.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 149 ASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNS---KENHAEIMQA 224
Cdd:cd18512    13 ADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISsEEKVFEAVIAWVNHDKevrQEHMAHLMEH 92

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034648348 225 VRLPLMSLTELLNVVRPSGLLS-----PDAILDAIK 255
Cdd:cd18512    93 VRLPLLSREYLVQRVEEETLVKnssacKDYLIEAMK 128
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-132 4.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 44.79  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTM--LLKYIYTGRATLTDEKEEvllD 112
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDYLSPETVeqLLDYFYTGKIVISEKNVE---D 77

                          90       100
                  ....*....|....*....|
gi 1034648348 113 FLSLAHKYGFPELEDSTSEY 132
Cdd:cd18307    78 LLKGAKYFNIPRLKDHCVDF 97
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-113 4.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 45.31  E-value: 4.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  34 EYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggmrESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDF 113
Cdd:cd18354    19 DTADLKFLVDGKYIYVHKVLLKIRCEHFRSLL-----NENEEEIIEMSQFSYPVYRAFLEYLYTDSISLSPEDAIGLLDL 93
BACK_GPRS_like cd18507
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched ...
 138-213 4.07e-06

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins; The family includes uncharacterized Drosophila melanogaster serine-enriched protein (GPRS) and similar proteins.


Pssm-ID: 350582  Cd Length: 80  Bit Score: 44.42  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 138 NIQNVCMTFDVASLYSLPK----LTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHN 213
Cdd:cd18507     1 NVDTVCALLASAERYDQYKctktLVQKVLEFVDKHGTDVLNLPEFLLLPEHVVRLILSRDSLGADEMTKFQAALAWSRKY 80
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-97 4.99e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 45.23  E-value: 4.99e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18360    10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFL-VPIYGVSKDTFLSFLEYLYT 71
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-144 5.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 45.33  E-value: 5.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggMRESQPEAEI--PLQDTTAEAFTMLLKYIYTGRatLTDEKEEVlLDFL 114
Cdd:cd18306    20 DVILQVGGHEIPAHRAVLACASPYLFELF---SSDSDGESILtvKLDGLDPDAVEVLVNYAYTSR--LEVPADLV-KSVY 93

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034648348 115 SLAHKYGFPELEDSTSEYLCTILNIQNvCM 144
Cdd:cd18306    94 SAAKKLKMDRVKKACGDFLLEKLTPQN-CI 122
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 137-230 7.12e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 44.59  E-value: 7.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCK----- 211
Cdd:cd18523     1 LRADNAFMLLTQARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIREVRLFNAVVRWAEaecqr 80

                          90       100
                  ....*....|....*....|....*.
gi 1034648348 212 -------HNSKENHAEIMQAVRLPLM 230
Cdd:cd18523    81 qqlqvtpENKRKVLGKALSLIRFPLM 106
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-107 7.70e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 44.61  E-value: 7.70e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFrallYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKE 107
Cdd:cd18221    16 DQFTDITLIVDGHQFKAHKAVLAACSQFF----YKFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEE 86
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-117 7.88e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 44.84  E-value: 7.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  34 EYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTgratltdekEEVLLDF 113
Cdd:cd18202    18 QFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT---------SELTFDF 88


                  ....
gi 1034648348 114 LSLA 117
Cdd:cd18202    89 CSMA 92
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-125 8.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 44.38  E-value: 8.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKR-FPAHRVILAARC----QYFRALLYGGMRESQPEAE-IPLQDTTAEAFTMLLKYIYTGRATLTdekEEVL 110
Cdd:cd18288    20 DVQFQTDSGEvLYAHSFVLYARCplliQMVHSEGFSVEEEGGVTTRrVLLGDVSGEAARCFLQYLYTADTGLP---PGLS 96

                          90
                  ....*....|....*
gi 1034648348 111 LDFLSLAHKYGFPEL 125
Cdd:cd18288    97 PHVSELADRFGVSEL 111
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-99 9.12e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 44.57  E-value: 9.12e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  32 GEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGR 99
Cdd:cd18207    24 GGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFAYTSR 91
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 137-231 9.65e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 44.29  E-value: 9.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCK----- 211
Cdd:cd18522     1 LRADNAFMLLTQARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIRESRLFGAVVRWAEaecqr 80

                          90       100
                  ....*....|....*....|....*..
gi 1034648348 212 -------HNSKENHAEIMQAVRLPLMS 231
Cdd:cd18522    81 qqlpvtsENKQKVLGKALSLIRFPLMT 107
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-126 1.09e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 44.58  E-value: 1.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  29 LLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggmrESQPEAE---IPLQDTTAEAFTMLLKYIYTGRATLTDE 105
Cdd:cd18351    18 FLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALL-----SNKPSAEntcIEISYVKYHIFQLVMQYLYCGGTESLLI 92

                          90       100
                  ....*....|....*....|.
gi 1034648348 106 KEEVLLDFLSLAHKYGFPELE 126
Cdd:cd18351    93 KNNEIMELLSAAKFFQLEALQ 113
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-97 1.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 44.09  E-value: 1.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpeAEIPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18209    16 GQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQ--SVFQLDFCEPDAFENVLNYIYS 78
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 1.35e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 44.26  E-value: 1.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggmresqPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEvllDFLSL 116
Cdd:cd18243    34 DVTLTAQGQQFHCHKAVLASCSQYFRSLF--------SINNLVLQGCSSIGLRLVLEYLYTANVTLSLDTVE---EVLSV 102

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18243   103 SKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 1.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 44.26  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRaLLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18325    25 DCTVLVGEAQFRAHRAVLASCSMYFH-LFYRDQLDKRDIVHLNSDIVTAPAFSLLLEFMYEGKLEFSSLPVEDVLAAASY 103


                  ....
gi 1034648348 117 AHKY 120
Cdd:cd18325   104 LHMY 107
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 37-120 1.60e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 42.89  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQD--TTAEAFTMLLKYIYTGRATLTdeKEEVLLDFL 114
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFREST-SDCIDFEEngISIEAMRAVIDFSVTGRLDLF--SVENVHEVL 77


                  ....*.
gi 1034648348 115 SLAHKY 120
Cdd:cd18190    78 ELASKF 83
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-138 1.70e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 43.79  E-value: 1.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTA-EAFTMLLKYIYTGRATLTDEKeevLLDFLS 115
Cdd:cd18201    23 DVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHLDVVAvQGFSVILDFMYSGNLVLTSQN---AIEVMS 99

                          90       100
                  ....*....|....*....|...
gi 1034648348 116 LAHKYGFPELEDSTSEYLCTILN 138
Cdd:cd18201   100 VASYLQMTEVVQSCRNFIKDALN 122
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-102 1.89e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 44.11  E-value: 1.89e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATL 102
Cdd:cd18266    27 DVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAH-QKEVELVGASYIGLKAVIDFLYSSELPL 91
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 164-239 2.17e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 43.93  E-value: 2.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 164 FMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENH---AEIMQAVRLPLMSLTELLNVV 239
Cdd:cd18452    28 FSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDsEEPVFEAVLNWVKHDKEEREdylPELLQYVRLPLLSPRYITDVV 107
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-146 2.35e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 43.00  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYggmreSQPEAeIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEvllDFLSL 116
Cdd:cd18206    24 DCTFVVDGVDFKAHKAVLAACSEYFRMLFV-----DQKDV-VHLDISNAAGLGQVLEFMYTAKLSLSPENVD---DVLAV 94

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034648348 117 AhkyGFPELEDstseylctilnIQNVCMTF 146
Cdd:cd18206    95 A---TFLQMQD-----------IVTACHAL 110
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-103 2.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 43.33  E-value: 2.59e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEA-EIPLqdTTAEAFTMLLKYIYTGRATLT 103
Cdd:cd18328    27 DVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVyEIDF--VTPEALSAILEFAYTSTLTIT 92
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-141 3.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 43.11  E-value: 3.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLKYIYTGRATLtdeKEEVLLDFLSL 116
Cdd:cd18335    21 DVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQE-EIKMEGIDPNALWDLVQFAYTGCLEL---KEDTIENLLAA 96

                          90       100
                  ....*....|....*....|....*
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18335    97 ACLLQLSQVVEVCCHFLMKLLHPSN 121
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-99 3.20e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 42.99  E-value: 3.20e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggMRESQPE-AEIPLQDTTAEAFTMLLKYIYTGR 99
Cdd:cd18231    18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLF---TQNKQLQrVELSLEALTSQGLQQILNFIYTSK 78
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-105 3.37e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 42.51  E-value: 3.37e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALL--YGGMREsqpeaeipLQDTTAEAFTMLLKYIYTG-----RATLTDE 105
Cdd:cd18219    21 FCDVTVIVEDRKFRAHKNILSASSTYFHQLFsvAGQVVE--------LNFIRADIFAEILNYIYSSkivrvRSDLLEE 90
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-132 3.39e-05

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 43.03  E-value: 3.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEevLLDFL 114
Cdd:cd18358    20 FSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESA-NSEVVLPNISKVSMQAVLDYLYTKQLSPTADLD--PLELI 96

                          90
                  ....*....|....*...
gi 1034648348 115 SLAHKYGFPELEDSTSEY 132
Cdd:cd18358    97 ALANRFCLPHLVALTEQH 114
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 3.65e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 42.88  E-value: 3.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRaLLY-----GGMRESQPEAEIplqdTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18956    25 DCTVLVGDARFPAHRAVLAACSVYFH-LFYrdrpaGGRDTVRLNGDI----VTAPAFGRLLDFMYEGRLDLRSLPVEDVL 99


                  ....*....
gi 1034648348 112 DFLSLAHKY 120
Cdd:cd18956   100 AAASYLHMY 108
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-138 6.47e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 42.71  E-value: 6.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18246    41 DIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESR-QTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAASL 119

                          90       100
                  ....*....|....*....|..
gi 1034648348 117 AHKYGfpeLEDSTSEYLCTILN 138
Cdd:cd18246   120 LQLNG---VRDACCKFLLSQLD 138
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 7.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 42.72  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRaLLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18324    25 DCTVLVGDAQFRAHRAVLASCSMYFH-LFYKDQLDKRDIVHLNSDIVTAPAFALLLEFMYEGKLQFKDLPIEDVLAAASY 103


                  ....
gi 1034648348 117 AHKY 120
Cdd:cd18324   104 LHMY 107
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-98 7.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 41.66  E-value: 7.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggMRESQPEAEIPLQDTTAEAFTMLLKYIYTG 98
Cdd:cd18217    20 DCTIVIGQFQFKAHRNVLAAFSEYFGAQY---KDTEDNIVFLDQSQVSADGFQKLLEFIYTG 78
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-144 9.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 41.72  E-value: 9.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggmRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTdekEEVLLDFLSL 116
Cdd:cd18260    20 DLTIATKTKSFDVHKVVMASCSEYFRNIL----KKDPSLQRVELNDISPLGLATVITYAYTGKLTLS---LYTIGSTISA 92

                          90       100
                  ....*....|....*....|....*...
gi 1034648348 117 AHKYGFPELEDSTSEYLCTILNIQNvCM 144
Cdd:cd18260    93 ASYLQIHALVKMCCDFLMQEMNVEN-CM 119
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 32-115 1.08e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 41.20  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  32 GEEYGDVTFV-VEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQdTTAEAFTMLLKYIYTGRATLTDEKEEVl 110
Cdd:cd18302     2 HSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMP-IPSDILEIILDYLYTDEASAVKESQNV- 79


                  ....*
gi 1034648348 111 lDFLS 115
Cdd:cd18302    80 -EFLC 83
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-97 1.15e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 40.80  E-value: 1.15e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348  22 LSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFrALLYGGMRESQPEAE-IPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18285     2 LSQDLLRLLREELHTDVTFYVGSTLFKAHKAILLARVPEF-FSHIIGKLSSLEDQEpINIENLEASEFKTFLRQVYT 77
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-120 1.21e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 41.09  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAeIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLD 112
Cdd:cd18353    18 PETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEV-IEIDQFSYPVYRAFLEYLYTDSVDLPPEDAIGLLD 96


                  ....*...
gi 1034648348 113 flsLAHKY 120
Cdd:cd18353    97 ---LATSY 101
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-105 1.24e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 41.58  E-value: 1.24e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRAlLYGGMRESQPEAEIPLQD-TTAEAFTMLLKYIYTGRATLTDE 105
Cdd:cd18230    23 DVCIIVEGKIFKAHKNVLLGSSRYFKT-LYCQVQKTSDQATVTHLDiVTAQGFKAIIDFMYSAHLALTSK 91
BTB_POZ_NPY3-like cd18312
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-103 1.39e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana protein naked pins in YUC mutants 3 (NPY3), Root phototropism protein 3 (RPT3), and similar proteins; NPY3 may play an essential role in auxin-mediated organogenesis and in root gravitropic responses in Arabidopsis. RPT3 is a signal transducer of the phototropic response and photo-induced movements. It is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening. Proteins in this subfamily contain an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349621 [Multi-domain]  Cd Length: 105  Bit Score: 40.78  E-value: 1.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLKYIYTGRATLT 103
Cdd:cd18312     7 GEPSDITVRVGNTTFHLHKFPLCSKSGYFKRLASSSSESDPSEIELNDFPGGAEAFELVAKFCYGMPINLT 77
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-111 1.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 41.18  E-value: 1.42e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648348  34 EYGDVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLqdTTAEAFTMLLKYIYTGRATLTDEKEEVLL 111
Cdd:cd18204    17 EFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF--LRSDIFEEVLNYMYTAKISVKKEDVNLMM 92
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 1.50e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 41.11  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggMRESQPEAEIPLQDTTaeAFTMLLKYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18334    23 DVIIVVENALFRAHKNILAASSMYFKSLV---LHDNLINLDTDMVNPT--VFRQILDFIYTGKLLTSDQPGEQNFNALLT 97


                  ....
gi 1034648348 117 AHKY 120
Cdd:cd18334    98 AASY 101
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-103 1.79e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 40.98  E-value: 1.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTT------AEAFTMLLKYIYTgrATLT 103
Cdd:cd18327    27 DLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGQDVCeldfvgPEALGALLEFAYT--ATLT 97
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 171-231 2.62e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 40.01  E-value: 2.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 171 EVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKH---NSKENHAEIMQAVRLPLMS 231
Cdd:cd18444    36 EVIQNQEFLLLPAEEVAKLLASDDLNVPsEETIFHALLLWVKHdlpERKKHLAKLLALIRLPLLT 100
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-120 3.03e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 40.27  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRAL-LYGGMRESQPEAEIPlqdttaEAFTMLLKYIYTGRATLTDEKEEVLLDFLS 115
Cdd:cd18333    23 DVIIVVQNALFRAHKNILAASSVYLKSLvVHDNLINLDHEMVSP------GIFRLILDYIYTGRLSEGDPGSEQNLGAVL 96


                  ....*
gi 1034648348 116 LAHKY 120
Cdd:cd18333    97 AAASY 101
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 168-228 3.42e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 39.70  E-value: 3.42e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 168 NAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKH---NSKENHAEIMQAVRLP 228
Cdd:cd18468    31 NFPDVARQEEILSISKDDIVEYLSHDSLNTKaEELVFETAIKWLKKdpkNRKQHIAELLAVVRLP 95
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-135 4.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 40.03  E-value: 4.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLY-----GGMRESQPEAEIplqdTTAEAFTMLLKYIYTGRATLtdeKEEVLL 111
Cdd:cd18196    23 DCVIVVGNRHFKAHRSVLAACSTHFRALFTvaegdQTMNMIQLDSEV----VTAEAFAALIDMMYTSTLML---GESNVM 95

                          90       100
                  ....*....|....*....|....
gi 1034648348 112 DFLSLAHKYGFPELEDSTSEYLCT 135
Cdd:cd18196    96 DVLLAASHLHLNSVVKACKHYLTT 119
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 171-228 5.26e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 38.95  E-value: 5.26e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648348 171 EVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKHNSKENHA---EIMQAVRLP 228
Cdd:cd18476    35 DVAASEDLKELCASELLDYLGDDELCGEEEQVFETLMVWIRHDPKARKGyihDLFKKVRLQ 95
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-98 6.17e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 39.43  E-value: 6.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  17 DHVHILSEHIGALLIGEEYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggMRESQPEAEIPLQD-TTAEAFTMLLKYI 95
Cdd:cd18224     8 DHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF---LSTELDVARTYVVDfITPANFEKVLSFI 84


                  ...
gi 1034648348  96 YTG 98
Cdd:cd18224    85 YTS 87
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-125 6.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 39.05  E-value: 6.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRAL-LYGGMRESQPEAeiplqdTTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLS 115
Cdd:cd18216    22 DVIIVVENSLFRAHKNVLAASSGYFKSLvLHDNLIHLDQDM------VSPTVFQQILDFIYTGKLLDSLFEEPNLSEVLA 95

                          90
                  ....*....|
gi 1034648348 116 LAHKYGFPEL 125
Cdd:cd18216    96 AANYLQLPDL 105
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-118 7.95e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 39.04  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAArCQYFRALLYggmRESQPEAEIPLQD---TTAEAFTMLLKYIYTGRATLTDEKEEVLLDF 113
Cdd:cd18323    25 DCTVLVGSTQFLAHRAVLAS-CSPFFHMFY---KEQLDKRDLVCINneiVTAPAFSLLLEFMYEGRLSFNDTPVEDVLAA 100


                  ....*
gi 1034648348 114 LSLAH 118
Cdd:cd18323   101 ASYLH 105
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 164-221 8.11e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 38.04  E-value: 8.11e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648348 164 FMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENHAEI 221
Cdd:cd18458    29 YIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRcESEVYNAVIRWVKYDEENRRQYL 87
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-97 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 38.63  E-value: 1.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLyggmrESQPEAE-IPLQDTTAEAFTMLLKYIYT 97
Cdd:cd18226    24 DLVITVEGKEFSAHKVVVAVGSSYFHACL-----SKNPNTDaVTLDHVSYSVFQHLLEFLYT 80
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 35-141 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 38.65  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  35 YGDVTFV-VEKKRFPAHRVILAARCQYFRALLYGGMREsQPEAEIPLQDTTAEAFTMLLKYIYTGRATLTDEKEEVLLDF 113
Cdd:cd18252    21 FTDITLQcASGQIFHCHKAALAACSSYFKVMFTADMKE-KSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEA 99

                          90       100
                  ....*....|....*....|....*...
gi 1034648348 114 LSLAHkygFPELEDSTSEYLCTILNIQN 141
Cdd:cd18252   100 ADLLQ---FISVKKACEQFLVRHLDIDN 124
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 137-181 1.04e-03

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 37.53  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSL 181
Cdd:cd18497     1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAEL 45
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 168-230 1.22e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 38.08  E-value: 1.22e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348 168 NAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKD-IFLALLNWCKHNSKE---NHAEIMQAVRLPLM 230
Cdd:cd18509    33 NIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEEtIFHALMMWVKYDMQRrcsDLSMLLAYIRLPLL 99
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-146 2.02e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 37.56  E-value: 2.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTaeAFTMLLKYIYTGRATLTDEKEEVLLDflsl 116
Cdd:cd18233    20 DCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVFHLDIKNVG--GIGQILDFMYTSHLDLNQDNVQVMLD---- 93

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034648348 117 ahkygfpeledsTSEYLcTILNIQNVCMTF 146
Cdd:cd18233    94 ------------IAQCL-QVQNVLNMCYTF 110
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-127 2.29e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 37.49  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  47 FPAHRVILAARCQYFRALLyggMRESQPEAEIPLQD--TTAEAFTMLLKYIYTGRATLTDEKEEVLLDFLSLAHKYGFPE 124
Cdd:cd18192    33 FQAHKAVLAACSSYFRMMF---INHQHTTAQLNLSNmkISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109


                  ....
gi 1034648348 125 -LED 127
Cdd:cd18192   110 cLED 113
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 137-230 3.18e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 37.06  E-value: 3.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 137 LNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDS-FAAPEKDIFLALLNWCKHNSK 215
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDlYVTEEEQVFETVMRWVRYKES 80

                          90
                  ....*....|....*...
gi 1034648348 216 ENHA---EIMQAVRLPLM 230
Cdd:cd18446    81 ERLPllpRVLENVRLPLL 98
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 171-231 3.27e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 36.90  E-value: 3.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648348 171 EVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHN---SKENHAEIMQAVRLPLMS 231
Cdd:cd18456    35 EVSKTEEFMLLPLKQVLDLISSDSLNVPsEEEVYRAVLSWVKHDvdgRRQHVPRLMKCVRLPLLS 99
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 161-212 4.11e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 36.52  E-value: 4.11e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034648348 161 CCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFLALLNWCKH 212
Cdd:cd18489    26 ALHFLREEFSQIAQSPVLFELTKEYLIEALQSDFLQASELDILKAVLKWGEH 77
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 168-230 5.01e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 36.32  E-value: 5.01e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348 168 NAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKHNSKENHA---EIMQAVRLPLM 230
Cdd:cd18464    31 NFTTLRKTEDFLSLPKDKLLELVSSEELEVEdERLVYEAVIGWIRYDLPRRHEvlpELLRSVRLALL 97
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-102 5.66e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 36.39  E-value: 5.66e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlQDTTAEAFTMLLKYIYTGRATL 102
Cdd:cd18215    21 DVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLD-PEIEPEGFRILLDFMYTSRLNL 85
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-99 6.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 36.34  E-value: 6.35e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648348  33 EEYGDVTFVVEKKRFPAHRVILAARCQYFRALLyggmrESQPEAEIPLQDTTAEAFTMLLKYIYTGR 99
Cdd:cd18225    21 QQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLL-----DSTDTISIDASVVSPEEFALLLEMVYTGK 82
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 37-133 7.10e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 35.97  E-value: 7.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348  37 DVTFVVEKKRFPAHRVILAARCQYF--RALLYGGMRESQPEAEIPLqdttaeAFTMLLKYIYTGRATLTDEKeevLLDFL 114
Cdd:cd18210    23 DISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISLPGVMDPG------AFESVLASAYTGKLTMLADE---IVNYL 93

                          90
                  ....*....|....*....
gi 1034648348 115 SLAHKYGFPELEDSTSEYL 133
Cdd:cd18210    94 TVGSVLQMWHIVDKCTELL 112
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 134-212 7.91e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 35.06  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648348 134 CTILNIQNVcmtfdvASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAP-EKDIFLALLNWCKH 212
Cdd:cd18463     5 CNCLGIQKF------ADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPkEEEVFEAVMRWVYH 78
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 141-212 8.67e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 35.17  E-value: 8.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648348 141 NVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLSSEGFLSLSKTALLNIVLRDSFAAPEKDIFL-ALLNWCKH 212
Cdd:cd18474     5 NCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLeAALRWVDA 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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