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Conserved domains on  [gi|1034654333|ref|XP_016867291|]
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gasdermin-E isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
115-304 9.10e-56

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


:

Pssm-ID: 407590  Cd Length: 174  Bit Score: 179.09  E-value: 9.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 115 DGPLSVLKQAtllLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGlsptvavlGELKPRQQQDLVA 194
Cdd:pfam17708   1 HGDFSVLKKE---VERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGG--------GELGPLDGPDGAI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 195 FLQLVGcslqggcpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS-------DL 267
Cdd:pfam17708  70 LLELVG---------DSGLLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLyqenipfSL 140
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034654333 268 EDPTLTPLKDTERfGIVQRLFASADISLERlkSSVKA 304
Cdd:pfam17708 141 PPPLLAPLQDEEL-AITQRLLESCGLELEL--DSPKA 174
Gasdermin super family cl20270
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
1-82 4.14e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam04598:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 103.98  E-value: 4.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333   1 MQKCVISEHMQVEEKCGGIVGiQTKTVQVSATEDgnvtKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLL-RGKQGG 79
Cdd:pfam04598 163 TQEVVLTEHSQVEGSGKGMLP-GTKTVQGSGQGH----KDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGT 237

                  ...
gi 1034654333  80 FEN 82
Cdd:pfam04598 238 FEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
115-304 9.10e-56

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 179.09  E-value: 9.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 115 DGPLSVLKQAtllLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGlsptvavlGELKPRQQQDLVA 194
Cdd:pfam17708   1 HGDFSVLKKE---VERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGG--------GELGPLDGPDGAI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 195 FLQLVGcslqggcpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS-------DL 267
Cdd:pfam17708  70 LLELVG---------DSGLLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLyqenipfSL 140
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034654333 268 EDPTLTPLKDTERfGIVQRLFASADISLERlkSSVKA 304
Cdd:pfam17708 141 PPPLLAPLQDEEL-AITQRLLESCGLELEL--DSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
1-82 4.14e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 103.98  E-value: 4.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333   1 MQKCVISEHMQVEEKCGGIVGiQTKTVQVSATEDgnvtKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLL-RGKQGG 79
Cdd:pfam04598 163 TQEVVLTEHSQVEGSGKGMLP-GTKTVQGSGQGH----KDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGT 237

                  ...
gi 1034654333  80 FEN 82
Cdd:pfam04598 238 FEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
115-304 9.10e-56

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 179.09  E-value: 9.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 115 DGPLSVLKQAtllLERNFHPFAELPEPQQTALSDIFQAVLFDDELLMVLEPVCDDLVSGlsptvavlGELKPRQQQDLVA 194
Cdd:pfam17708   1 HGDFSVLKKE---VERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDLCGG--------GELGPLDGPDGAI 69
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333 195 FLQLVGcslqggcpgPEDAGSKQLFMTAYFLVSALAEMPDSAAALLGTCCKLQIIPTLCHLLRALSDDGVS-------DL 267
Cdd:pfam17708  70 LLELVG---------DSGLLSQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLyqenipfSL 140
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1034654333 268 EDPTLTPLKDTERfGIVQRLFASADISLERlkSSVKA 304
Cdd:pfam17708 141 PPPLLAPLQDEEL-AITQRLLESCGLELEL--DSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
1-82 4.14e-26

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 103.98  E-value: 4.14e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034654333   1 MQKCVISEHMQVEEKCGGIVGiQTKTVQVSATEDgnvtKDSNVVLEIPAATTIAYGVIELYVKLDGQFEFCLL-RGKQGG 79
Cdd:pfam04598 163 TQEVVLTEHSQVEGSGKGMLP-GTKTVQGSGQGH----KDKKVAVTIPKGTVLAYRVIQLVIKSDGQWEILLLdDDKQGT 237

                  ...
gi 1034654333  80 FEN 82
Cdd:pfam04598 238 FEP 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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