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Conserved domains on  [gi|1034659069|ref|XP_016868509|]
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cytochrome c oxidase subunit 6C isoform X1 [Homo sapiens]

Protein Classification

CcO_VIc domain-containing protein( domain architecture ID 10502953)

CcO_VIc domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COX6C pfam02937
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 6-74 5.60e-31

Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.


:

Pssm-ID: 460756  Cd Length: 69  Bit Score: 103.06  E-value: 5.60e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034659069  6 LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSV 74
Cdd:pfam02937  1 LPKPQMRGLLAKRLKRHLVVALALSLGVGLAFKFFVAEPRKKAYADFYKNYDPMKEFERMREAGLFQSV 69
 
Name Accession Description Interval E-value
COX6C pfam02937
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 6-74 5.60e-31

Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.


Pssm-ID: 460756  Cd Length: 69  Bit Score: 103.06  E-value: 5.60e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034659069  6 LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSV 74
Cdd:pfam02937  1 LPKPQMRGLLAKRLKRHLVVALALSLGVGLAFKFFVAEPRKKAYADFYKNYDPMKEFERMREAGLFQSV 69
CcO_VIc cd22901
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase subunit VIc (COX6c) is a subunit of the ...
 6-71 5.18e-30

Cytochrome c oxidase subunit VIc; Cytochrome c oxidase subunit VIc (COX6c) is a subunit of the cytochrome c oxidase (CcO, also called complex IV or CIV), the terminal oxidase in the mitochondrial electron transport chain which drives oxidative phosphorylation. CcO is a multi-chain transmembrane protein complex located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 14 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 11 subunits are encoded within the nuclear genome. The VIc subunit is a single-pass membrane protein found only in eukaryotes and its specific function remains unclear.


Pssm-ID: 438623  Cd Length: 66  Bit Score: 100.39  E-value: 5.18e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034659069  6 LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIF 71
Cdd:cd22901    1 LAKPQMRGLLAKRLKRHLIVAFGLSLGAAAAFKFGVADPRKKAYADFYKNYDAMKEFERMRKAGIF 66
 
Name Accession Description Interval E-value
COX6C pfam02937
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is ...
 6-74 5.60e-31

Cytochrome c oxidase subunit VIc; Cytochrome c oxidase, a 13 sub-unit complex, EC:1.9.3.1 is the terminal oxidase in the mitochondrial electron transport chain. This family is composed of cytochrome c oxidase subunit VIc.


Pssm-ID: 460756  Cd Length: 69  Bit Score: 103.06  E-value: 5.60e-31
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034659069  6 LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIFQSV 74
Cdd:pfam02937  1 LPKPQMRGLLAKRLKRHLVVALALSLGVGLAFKFFVAEPRKKAYADFYKNYDPMKEFERMREAGLFQSV 69
CcO_VIc cd22901
Cytochrome c oxidase subunit VIc; Cytochrome c oxidase subunit VIc (COX6c) is a subunit of the ...
 6-71 5.18e-30

Cytochrome c oxidase subunit VIc; Cytochrome c oxidase subunit VIc (COX6c) is a subunit of the cytochrome c oxidase (CcO, also called complex IV or CIV), the terminal oxidase in the mitochondrial electron transport chain which drives oxidative phosphorylation. CcO is a multi-chain transmembrane protein complex located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 14 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 11 subunits are encoded within the nuclear genome. The VIc subunit is a single-pass membrane protein found only in eukaryotes and its specific function remains unclear.


Pssm-ID: 438623  Cd Length: 66  Bit Score: 100.39  E-value: 5.18e-30
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034659069  6 LPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMKDFEEMRKAGIF 71
Cdd:cd22901    1 LAKPQMRGLLAKRLKRHLIVAFGLSLGAAAAFKFGVADPRKKAYADFYKNYDAMKEFERMRKAGIF 66
CcO_VIc-like cd00927
Cytochrome c oxidase subunit VIc-like; Cytochrome c oxidase subunit VIc-like proteins are ...
 11-60 2.45e-11

Cytochrome c oxidase subunit VIc-like; Cytochrome c oxidase subunit VIc-like proteins are subunits of the cytochrome c oxidase (CcO, also called complex IV or CIV), the terminal oxidase in the mitochondrial electron transport chain which drives oxidative phosphorylation. CcO is a multi-chain transmembrane protein complex located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps protons across the membrane. The number of subunits varies from three to five in bacteria and up to 14 in mammalian mitochondria. Subunits I, II, and III of mammalian CcO are encoded within the mitochondrial genome and the remaining 11 subunits are encoded within the nuclear genome. The VIc subunit-like proteins are single-pass membrane proteins found only in eukaryotes and their specific function remains unclear.


Pssm-ID: 438621  Cd Length: 50  Bit Score: 52.81  E-value: 2.45e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 1034659069 11 MRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK 60
Cdd:cd00927    1 LPGLIKRRLRKDIGYGLMLGLIPGTFFKFGVAEKKQKEREDFYAAYDKRK 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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