NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034660916|ref|XP_016869131|]
View 

phosphoprotein associated with glycosphingolipid-enriched microdomains 1 isoform X1 [Homo sapiens]

Protein Classification

PAG domain-containing protein( domain architecture ID 12173169)

PAG domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PAG pfam15347
Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding ...
1-432 0e+00

Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.


:

Pssm-ID: 434654  Cd Length: 428  Bit Score: 760.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916   1 MGPAGSLLGSGQMQITLWGSLAAVAIFFVITFLIFLCSSCDREKKPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPAS 80
Cdd:pfam15347   1 MGPVGSLLSSGQVQIILWGSLAAVTTFLLLTFLIFLCSSCDREKKPKQQSGDHENLMNVPSDKEVFSHSVTSLATDAPAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916  81 SEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAVDTMLTARSVDGDQGLGM 159
Cdd:pfam15347  81 SEQNGALTNGDILSEDSTGTCMQPYEEVQTSASDLLDSQDSTGKSlKCHQSRELPRIPPNSALETILPARSVENDQGLGM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 160 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQTEGKAEFAEYASVDRNKKCRQS 239
Cdd:pfam15347 161 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVGAPAGLEKGHNGRSKSAPAPKELQGPVSAGKAESAEYASVDRNKKSRQS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 240 VNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAEEsATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSS 319
Cdd:pfam15347 241 ANAESVLGNSADPEEEAPPPVPVKLLDENENVQEKEMEEAGE-ATEGTSETNKRLSSLSYKSREEDPTLTEEEISAMYSS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 320 VNKPGQLVNksgqsltVPESTYTSIQ-GDPQRSPSSCNDLYATVKDFEKTPNS--TLPPAGRPSEEPEPDYEAIQTLNRE 396
Cdd:pfam15347 320 VNKPGQSVN-------VPESDYTCIQeIAPQRSPSSCNDLYATVRDFEKTPNSttTPPPAERPNGEPEPDYEAIQTLSRE 392
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1034660916 397 EEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL 432
Cdd:pfam15347 393 EERTTLGPNGGHALFPKENDYESIGDLQQGRDITRL 428
 
Name Accession Description Interval E-value
PAG pfam15347
Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding ...
1-432 0e+00

Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.


Pssm-ID: 434654  Cd Length: 428  Bit Score: 760.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916   1 MGPAGSLLGSGQMQITLWGSLAAVAIFFVITFLIFLCSSCDREKKPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPAS 80
Cdd:pfam15347   1 MGPVGSLLSSGQVQIILWGSLAAVTTFLLLTFLIFLCSSCDREKKPKQQSGDHENLMNVPSDKEVFSHSVTSLATDAPAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916  81 SEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAVDTMLTARSVDGDQGLGM 159
Cdd:pfam15347  81 SEQNGALTNGDILSEDSTGTCMQPYEEVQTSASDLLDSQDSTGKSlKCHQSRELPRIPPNSALETILPARSVENDQGLGM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 160 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQTEGKAEFAEYASVDRNKKCRQS 239
Cdd:pfam15347 161 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVGAPAGLEKGHNGRSKSAPAPKELQGPVSAGKAESAEYASVDRNKKSRQS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 240 VNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAEEsATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSS 319
Cdd:pfam15347 241 ANAESVLGNSADPEEEAPPPVPVKLLDENENVQEKEMEEAGE-ATEGTSETNKRLSSLSYKSREEDPTLTEEEISAMYSS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 320 VNKPGQLVNksgqsltVPESTYTSIQ-GDPQRSPSSCNDLYATVKDFEKTPNS--TLPPAGRPSEEPEPDYEAIQTLNRE 396
Cdd:pfam15347 320 VNKPGQSVN-------VPESDYTCIQeIAPQRSPSSCNDLYATVRDFEKTPNSttTPPPAERPNGEPEPDYEAIQTLSRE 392
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1034660916 397 EEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL 432
Cdd:pfam15347 393 EERTTLGPNGGHALFPKENDYESIGDLQQGRDITRL 428
 
Name Accession Description Interval E-value
PAG pfam15347
Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding ...
1-432 0e+00

Phosphoprotein associated with glycosphingolipid-enriched; PAG, or Cbp/PAG (Csk binding protein/phospho-protein associated with glycosphingolipid-enriched microdomains) is a transmembrane family that has a negative regulatory role in T-cell activation through being an adapter for C-terminal Src kinase, Csk. This family of proteins is found in eukaryotes.


Pssm-ID: 434654  Cd Length: 428  Bit Score: 760.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916   1 MGPAGSLLGSGQMQITLWGSLAAVAIFFVITFLIFLCSSCDREKKPRQHSGDHENLMNVPSDKEMFSRSVTSLATDAPAS 80
Cdd:pfam15347   1 MGPVGSLLSSGQVQIILWGSLAAVTTFLLLTFLIFLCSSCDREKKPKQQSGDHENLMNVPSDKEVFSHSVTSLATDAPAS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916  81 SEQNGALTNGDILSEDSTLTCMQHYEEVQTSASDLLDSQDSTGKP-KCHQSRELPRIPPESAVDTMLTARSVDGDQGLGM 159
Cdd:pfam15347  81 SEQNGALTNGDILSEDSTGTCMQPYEEVQTSASDLLDSQDSTGKSlKCHQSRELPRIPPNSALETILPARSVENDQGLGM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 160 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVAAAAHLEKGHSGKAKSTSASKELPGPQTEGKAEFAEYASVDRNKKCRQS 239
Cdd:pfam15347 161 EGPYEVLKDSSSQENMVEDCLYETVKEIKEVGAPAGLEKGHNGRSKSAPAPKELQGPVSAGKAESAEYASVDRNKKSRQS 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 240 VNVESILGNSCDPEEEAPPPVPVKLLDENENLQEKEGGEAEEsATDTTSETNKRFSSLSYKSREEDPTLTEEEISAMYSS 319
Cdd:pfam15347 241 ANAESVLGNSADPEEEAPPPVPVKLLDENENVQEKEMEEAGE-ATEGTSETNKRLSSLSYKSREEDPTLTEEEISAMYSS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660916 320 VNKPGQLVNksgqsltVPESTYTSIQ-GDPQRSPSSCNDLYATVKDFEKTPNS--TLPPAGRPSEEPEPDYEAIQTLNRE 396
Cdd:pfam15347 320 VNKPGQSVN-------VPESDYTCIQeIAPQRSPSSCNDLYATVRDFEKTPNSttTPPPAERPNGEPEPDYEAIQTLSRE 392
                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1034660916 397 EEKATLGTNGHHGLVPKENDYESISDLQQGRDITRL 432
Cdd:pfam15347 393 EERTTLGPNGGHALFPKENDYESIGDLQQGRDITRL 428
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH