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Conserved domains on  [gi|1034663517|ref|XP_016869682|]
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semaphorin-4D isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
31-501 0e+00

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


:

Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 981.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  31 TWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLN 110
Cdd:cd11259     1 TWEHKEVQLVHFHEPDVSNYSTLLLSEDKDVLYVGAREAVFALNALNISEKQHELYWKVSEDKRTKCAVKGKSKQTECRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 111 YIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
Cdd:cd11259    81 YIRVLQPLNDTFLYVCGTNAFQPTCDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 191 NSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKK 270
Cdd:cd11259   161 NSSQSPLRTEYAIPWLNEPSFVFADVIRADPDSPDGEDDKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGLRTLQKK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 271 WTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQ 350
Cdd:cd11259   241 WTSFLKARLICSIPDKNLVFNVVNDVFILKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFSKGKYMQSATVEQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 351 SHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQA 430
Cdd:cd11259   321 SHTKWVRYNGEVPKPRPGACINNEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNYTQIVVDRVQA 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034663517 431 LDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11259   401 LDGTIYDVMFISTDRGALHKAISLENEVHIIEETQLFPDFEPVQTLLLSSKKGRRFLYAGSNSGVVQSPLA 471
Ig_Sema4D_like cd05873
Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members ...
559-645 2.05e-44

Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane-bound form and/or its cleaved form.


:

Pssm-ID: 409457  Cd Length: 87  Bit Score: 154.59  E-value: 2.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 559 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMgRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 638
Cdd:cd05873     1 GDPRQRTFKLGGNAELKCSPKSNLARVVWKFQGKVLKAESPKYGLY-GDGLLIFNASEADAGRYQCLSVEKSKAKTFFQT 79

                  ....*..
gi 1034663517 639 VAKHVLE 645
Cdd:cd05873    80 VAKYVLE 86
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
503-554 8.82e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.02  E-value: 8.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034663517 503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSrGLIQEMSGDASVCP 554
Cdd:pfam01437   2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSKCP 52
 
Name Accession Description Interval E-value
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
31-501 0e+00

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 981.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  31 TWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLN 110
Cdd:cd11259     1 TWEHKEVQLVHFHEPDVSNYSTLLLSEDKDVLYVGAREAVFALNALNISEKQHELYWKVSEDKRTKCAVKGKSKQTECRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 111 YIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
Cdd:cd11259    81 YIRVLQPLNDTFLYVCGTNAFQPTCDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 191 NSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKK 270
Cdd:cd11259   161 NSSQSPLRTEYAIPWLNEPSFVFADVIRADPDSPDGEDDKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGLRTLQKK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 271 WTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQ 350
Cdd:cd11259   241 WTSFLKARLICSIPDKNLVFNVVNDVFILKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFSKGKYMQSATVEQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 351 SHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQA 430
Cdd:cd11259   321 SHTKWVRYNGEVPKPRPGACINNEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNYTQIVVDRVQA 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034663517 431 LDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11259   401 LDGTIYDVMFISTDRGALHKAISLENEVHIIEETQLFPDFEPVQTLLLSSKKGRRFLYAGSNSGVVQSPLA 471
Sema smart00630
semaphorin domain;
50-474 1.62e-132

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 401.36  E-value: 1.62e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517   50 YSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTN 129
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKGKDPPTDCVNYIRLLLDYNEDRLLVCGTN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  130 AFQPACDHLNLtsfkflgknedgkgrcpfdpahsytsvmvdGELYSGTSYNFLGSEPIISRNSSHSP--------LRTE- 200
Cdd:smart00630  81 AFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvsLRTVl 130
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  201 YAIPWLNEPSFVFADVIrkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Cdd:smart00630 131 YDSKWLNEPNFVYAFES----------GDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARLE 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  281 CSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWVRY- 358
Cdd:smart00630 201 CSVPgEDPFYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFN-GPFKEC---ETSTSQWLPYs 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  359 NGPVPKPRPGACIDSEAraanytSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGtvY 436
Cdd:smart00630 277 RGKVPYPRPGTCPNKPP------SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYllTSIAVDRVATDGN--Y 348
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 1034663517  437 DVMFVSTDRGALHKAISLE----HAVHIIEETQLFQDFEPVQ 474
Cdd:smart00630 349 TVLFLGTSDGRILKVVLSEssssSESVVLEEISVFPDGSPIS 390
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
293-480 6.09e-70

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 228.69  E-value: 6.09e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 293 LRDVFVLRSPG--LKVPVFYALFTPQL-NNVGLSAVCAYNLSTAEEVFShGKYMqstTVEQSHTKWVRYNGPVPKPRPGA 369
Cdd:pfam01403   1 LQDVFVLKPGAgdALDTVLYGVFTTQWsNSIGGSAVCAFSLSDINAVFE-GPFK---EQEKSDSKWLPYTGKVPYPRPGT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 370 CIDSEARaanytssLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTvYDVMFVSTDRGALH 449
Cdd:pfam01403  77 CINDPLR-------LDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDGN-YTVLFLGTDDGRLH 148
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034663517 450 KAISLE-HAVHIIEETQLFQDFEPVQTLLLSS 480
Cdd:pfam01403 149 KVVLVGsEESHIIEEIQVFPEPQPVLNLLLSS 180
Ig_Sema4D_like cd05873
Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members ...
559-645 2.05e-44

Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane-bound form and/or its cleaved form.


Pssm-ID: 409457  Cd Length: 87  Bit Score: 154.59  E-value: 2.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 559 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMgRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 638
Cdd:cd05873     1 GDPRQRTFKLGGNAELKCSPKSNLARVVWKFQGKVLKAESPKYGLY-GDGLLIFNASEADAGRYQCLSVEKSKAKTFFQT 79

                  ....*..
gi 1034663517 639 VAKHVLE 645
Cdd:cd05873    80 VAKYVLE 86
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
503-554 8.82e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.02  E-value: 8.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034663517 503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSrGLIQEMSGDASVCP 554
Cdd:pfam01437   2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
503-554 2.62e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 53.32  E-value: 2.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034663517  503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPsrglIQEMSGDasVCP 554
Cdd:smart00423   2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSR----RQNWLSG--GCP 47
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
569-634 2.80e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.96  E-value: 2.80e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  569 GGTAELKCSQKSNL-ARVFWKFQNGVLKAESPKYGLMGRKN---LLIFNLSEGDSGVYQCLSEERVKNKT 634
Cdd:smart00410   9 GESVTLSCEASGSPpPEVTWYKQGGKLLAESGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGSAS 78
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
562-639 1.64e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.33  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 562 RQHFFKHGGTAELKCSQKSN--LARVFWKFQNGVLKAES---PKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVF 636
Cdd:pfam00047   4 PTVTVLEGDSATLTCSASTGspGPDVTWSKEGGTLIESLkvkHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSATLS 83

                  ...
gi 1034663517 637 QVV 639
Cdd:pfam00047  84 TSL 86
 
Name Accession Description Interval E-value
Sema_4D cd11259
The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); ...
31-501 0e+00

The Sema domain, a protein interacting module, of semaphorin 4D (Sema4D, also known as CD100); Sema4D/CD100 is expressed in immune cells and plays critical roles in immune response; it is thus termed an "immune semaphorin". It is expressed by lymphocytes and promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. Sema4D/CD100 knock-out mice demonstrate that Sema4D is required for normal activation of B and T lymphocytes. Sema4D increases B-cell and DC function using either Plexin B1 or CD72 as receptors. The function of Sema4D in immune response implicates its role in infectious and noninfectious diseases. Sema4D belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200520 [Multi-domain]  Cd Length: 471  Bit Score: 981.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  31 TWEHREVHLVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLN 110
Cdd:cd11259     1 TWEHKEVQLVHFHEPDVSNYSTLLLSEDKDVLYVGAREAVFALNALNISEKQHELYWKVSEDKRTKCAVKGKSKQTECRN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 111 YIRVLQPLSATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISR 190
Cdd:cd11259    81 YIRVLQPLNDTFLYVCGTNAFQPTCDYLNLTSFRLLGKNEDGKGRCPFDPAQSYTSVMVDGELYSGTSYNFLGSEPIISR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 191 NSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKK 270
Cdd:cd11259   161 NSSQSPLRTEYAIPWLNEPSFVFADVIRADPDSPDGEDDKIYFFFTEVSVEYEFVGKLLIPRIARVCKGDQGGLRTLQKK 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 271 WTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQ 350
Cdd:cd11259   241 WTSFLKARLICSIPDKNLVFNVVNDVFILKSPTLKEPVIYGVFTPQLNNVGLSAVCAYNLSTVEEVFSKGKYMQSATVEQ 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 351 SHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQA 430
Cdd:cd11259   321 SHTKWVRYNGEVPKPRPGACINNEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIGNRPRLIKKDVNYTQIVVDRVQA 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034663517 431 LDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11259   401 LDGTIYDVMFISTDRGALHKAISLENEVHIIEETQLFPDFEPVQTLLLSSKKGRRFLYAGSNSGVVQSPLA 471
Sema_4 cd11240
The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 ...
42-501 0e+00

The Sema domain, a protein interacting module, of class 4 semaphorins (Sema4); Class 4 semaphorins (Sema4s) are transmembrane regulator molecules involved in the development of the nervous system, immune response, cytoskeletal organization, angiogenesis, and cell-cell interactions. There are 7 distinct subfamilies in class 4 semaphorins, named 4A to 4G. Several class 4 subfamilies play important roles in the immune system and are called "immune semaphorins". Sema4A plays critical roles in T cell-DC interactions in the immune response. Sema4D/CD100, expressed by lymphocytes, promotes the aggregation and survival of B lymphocytes and inhibits cytokine-induced migration of immune cells in vitro. It is required for normal activation of B and T lymphocytes. Sema4B negatively regulates basophil functions through T cell-basophil contacts and significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. Sema4s not only influence the activation state of cells but also modulate their migration and survival. The effects of Sema4s on nonlymphoid cells are mediated by plexin D1 and plexin Bs. The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex and are involved in neural tube closure and development of cerebellar granules cells through receptor plexin B2. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200501 [Multi-domain]  Cd Length: 456  Bit Score: 793.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNIS-EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
Cdd:cd11240     1 FSQEGIQNYSTLLLSEDEGTLYVGAREALFALNVSDIStELKDKIKWEASEDKKKECANKGKDNQTDCFNFIRILQFYNS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 121 TSLYVCGTNAFQPACDHLNLTSFKFL-GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLR 198
Cdd:cd11240    81 THLYVCGTFAFSPRCTYINLSDFSLSsIKFEDGKGRCPFDPAQRYTAIMVDGELYSATVNNFLGSEPVISRNhSEGNVLK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 199 TEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd11240   161 TENTLRWLNEPAFVGSAHIRESIDSPDGDDDKIYFFFTETAVEYDFYEKVTVSRVARVCKGDLGGQRTLQKKWTTFLKAQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTveqSHTKWVRY 358
Cdd:cd11240   241 LVCSQPDSGLPFNVLRDVFVLSPDSWDATIFYGVFTSQWNVSGLSAVCAYSLEDIKKVFS-GKYKEFNR---ETSKWSRY 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 359 NGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIdNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438
Cdd:cd11240   317 TGPVPDPRPGACITNSARSQGITSSLNLPDNVLTFVKDHPLMDEQVHPI-NRPLLVKSGVNYTRIAVHRVQALDGQTYTV 395
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 439 MFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGnrFVYAGSNSGVVQAPLA 501
Cdd:cd11240   396 LFLGTEDGFLHKAVSLDGGMHIIEEIQLFDQPQPVKNLLLSSSKG--VLYVGSSSGVVQVPLS 456
Sema_semaphorin cd11235
The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator ...
48-501 0e+00

The Sema domain, a protein interacting module, of semaphorins; Semaphorins are regulator molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. They can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted proteins; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. The semaphorins exert their function through their receptors, the neuropilin and plexin families. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200496 [Multi-domain]  Cd Length: 437  Bit Score: 616.73  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  48 YNYSALLLSEDKDTLYIGAREAVFAVNALNIsEKQHEVYWKVSEDKKAKCAEKGKSKqTECLNYIRVLQPLSATSLYVCG 127
Cdd:cd11235     1 LKYHTKLLHEDRSTLYVGARDRVYLVDLDSL-YTEQKVAWPSSPDDVDTCYLKGKSK-DDCRNFIKVLEKNSDDSLLVCG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 128 TNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTEYA-IPW 205
Cdd:cd11235    79 TNAFNPSCRNYNVETFELVGKEESGRGKCPYDPDHNSTALFADGELYSGTSADFLGTDPVIYRTLGHNPpLRTEYHdSKW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 206 LNEPSFVFADVIRkspdspdgedDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP- 284
Cdd:cd11235   159 LNEPQFVGAFDIG----------DYVYFFFREIAVEYINCGKAVYSRVARVCKNDQGGSRSLEKKWTTFLKARLNCSVPg 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 285 DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEQSHTKWVRYNgpVPK 364
Cdd:cd11235   229 EFPFYFNELQDVFDLPSPSNKEKIFYAVFTTPYNSIPGSAVCAYSLSDIEAVFN-GPFKEQHSSNSAWLPVPDER--VPE 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 365 PRPGACidsearaanYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTVYDVMFVS 442
Cdd:cd11235   306 PRPGTC---------VDDSSPLPDDTLNFIKSHPLMDEAVTPILNRPLFIKTDVNYrfTKIAVDRVQAKLGQTYDVLFVG 376
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 443 TDRGALHKAISLEH----AVHIIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQAPLA 501
Cdd:cd11235   377 TDRGIILKVVSLPEqglqASNILEEMPVGPPPEPIQTMQLSRKR--RSLYVGSETGVLQVPLA 437
Sema_4E cd11260
The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed ...
42-501 0e+00

The Sema domain, a protein interacting module, of semaphorin 4E (Sema4E); Sema4E is expressed in the epithelial cells that line the pharyngeal arches in zebrafish. It may act as a guidance molecule to restrict the branchiomotor axons to the mesenchymal cells. Gain-of-function and loss-of-function studies demonstrate that Sema4E is essential for the guidance of facial axons from the hindbrain into their pharyngeal arch targets and is sufficient for guidance of gill motor axons. Sema4E guides facial motor axons by a repulsive action. Sema4E belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200521 [Multi-domain]  Cd Length: 456  Bit Score: 559.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSAT 121
Cdd:cd11260     1 FKEQGIWNYSTMLLREDLGLLVLGAREAVFALDLNDISVKRAKVLWEVTEEKQKDCTNKGKHADIDCHNYIRILHKMNDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 122 SLYVCGTNAFQPACDHLNLT--SFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSpLRT 199
Cdd:cd11260    81 RMYVCGTNAFSPTCDYISYDdgQLTLEGKQEDGKGKCPFDPFQRYSSVMVDQDLYSATSMNFLGSEPVIMRSSPIT-IRT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 200 EYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARL 279
Cdd:cd11260   160 EFKSSWLNEPNFIYMAAVPESEDSPEGDDDKIYLFFSETAVEYDFYNKLVVSRVARVCKGDLGGQRTLQKKWTSFLKARL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 280 ICSRPDSGLVFnVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYN 359
Cdd:cd11260   240 DCSVPEPSLPY-VIQDVFHVCHQDWRKCVFYAVFTSQSDSSQSSAVCAYNVTDISNVFSRGKFKTPVAVETSFVKWVMYS 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 360 GPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVM 439
Cdd:cd11260   319 GELPVPRPGACINNAARTSGIKKSLNLPDKTLQFVKDKPLMDQAVHPITGKPLLVKRGALFTRIVVDMVTAADGQSYPVM 398
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034663517 440 FVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKgnrfVYAGSNSGVVQAPLA 501
Cdd:cd11260   399 FIGTANGYVLKAVNYDGEMHIIEEVQLFEPEEPIDILRLSQNQ----LYAGSASGVVQMPVS 456
Sema_4G cd11262
The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and ...
49-500 0e+00

The Sema domain, a protein interacting module, of semaphorin 4G (Sema4G); The Sema4G and Sema4C genes are expressed in the developing cerebellar cortex. Sema4G and Sema4C proteins specifically bind to Plexin B2 expressed in the cerebellar granule cells. Sema4G and Sema4C are involved in neural tube closure and cerebellar granule cell development through Plexin B2.Sema4G belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200523 [Multi-domain]  Cd Length: 457  Bit Score: 528.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEK-QHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCG 127
Cdd:cd11262     9 NYSTLLLEDESGRLYVGARGAIFSLNASDISDSsALTIDWEASPEQKHQCLKKGKNNQTECFNHVRFLQRFNSTHLYTCG 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 128 TNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLgSEPIISRNSSHSPLRTEYA-IPWL 206
Cdd:cd11262    89 THAFRPLCAYIDAERFTLSSQFEEGKEKCPYDPAKGYTGLIVDGQLYTASQYEFR-SFPDIRRNSPQPTLRTEEApTRWL 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 207 NEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVE---YEFVFRVliPRIARVCKGDQGGLRTLQKKWTSFLKARLICSR 283
Cdd:cd11262   168 NDADFVGSVLVRESMNSSVGDDDKIYFFFTERSQEetaYFSQSRV--ARVARVCKGDRGGKKTLQRKWTSFLKARLVCYI 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 284 PDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQsttVEQSHTKWVRYNGPVP 363
Cdd:cd11262   246 PEYEFLFNVLRSVFVLWGSTPQDTVFYGIFGLEWKNVKASAICRYSLSDIQTAFE-GPYME---YQDSSSKWSRYTGKVP 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 364 KPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDVMFVST 443
Cdd:cd11262   322 EPRPGSCITDEHRSQGINSSQDLPDNVLDFVRRHPLMAEQVLPVEGRPLLFKRNVIYTKIAVQTVRGLDGRVYDVLFLGT 401
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034663517 444 DRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSGVVQAPL 500
Cdd:cd11262   402 DEGWLHKAVVIGSAVHIIEELQVFREPQPVENLVISKKQNS--LYVGARSGVVQVPL 456
Sema_4B cd11257
The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in ...
42-501 1.19e-165

The Sema domain, a protein interacting module, of semaphorin 4B (Sema4B); Sema4B, expressed in T and B cells, is an immune semaphorin. It functions as a negative regulatory of basophils through T cell-basophil contacts and it significantly inhibits IL-4 and IL-6 production from basophils in response to various stimuli, including IL-3 and papain. In addition, T cell-derived Sema4B suppresses basophil-mediated Th2 skewing and humoral memory responses. Sema4B may be also involved in lung cancer cell mobility by inducing the degradation of CLCP1 (CUB, LCCL-homology, coagulation factor V/VIII homology domains protein). Sema4B is characterized by a PDZ-binding motif at the carboxy-terminus, which mediates interaction with the post-synaptic density protein PSD-95/SAP90, which is thought to play a central role during synaptogenesis and in the structure and function of post-synaptic specializations of excitatory synapses. Sema4B belongs to class 4 transmembrane semaphorin family proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200518 [Multi-domain]  Cd Length: 464  Bit Score: 489.37  E-value: 1.19e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNIS--EKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
Cdd:cd11257     2 FEAEGVSNYTALLLSKDGNMLYVGARETLFALSSNDISptGEQQELTWSADEEKKQECSFKGKDPQRDCQNYIKILLRLN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 120 ATSLYVCGTNAFQPACDHLNLTSFKfLGKN-------EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN- 191
Cdd:cd11257    82 STHLFTCGTYAFSPICTYIVMTNFS-LERDekgepllEDGKGRCPFDPEYKSTAIMVDGELYTGTVSNFQGNDPIIYRSl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 192 SSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKW 271
Cdd:cd11257   161 GSGTPLKTENSLNWLQDPAFVGSAYIQESLPKLVGDDDKIYFFFSETGKEFDFFENTIVSRIARVCKGDEGGERVLQKRW 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 272 TSFLKARLICSRPDSGLVFNVLRDVFVLrSPGL---KVPVFYALFTPQLNN--VGLSAVCAYNLSTAEEVFShGKYMQst 346
Cdd:cd11257   241 TTFLKAQLLCSLPDDGFPFNVLQDVFVL-TPSPedwKDTLFYGVFTSQWHKgtAGSSAVCVFTMDQVQRAFN-GLYKE-- 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 347 tVEQSHTKWVRYNGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDdsvTPIDNRPRLIKKDVNYTQIVVD 426
Cdd:cd11257   317 -VNRETQQWYTYTHPVPEPRPGACITNSARERKINSSLHMPDRVLNFVKDHFLMD---GQVRSQPLLLQPQVRYTQIAVH 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034663517 427 RTQALDGTvYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKGnrFVYAGSNSGVVQAPLA 501
Cdd:cd11257   393 RVKGLHKT-YDVLFLGTDDGRLHKAVSVGPMVHIIEELQIFSEGQPVQNLLLDTHKG--LLYASSHSGVVQVPVA 464
Sema_4C cd11258
The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a ...
41-501 2.76e-161

The Sema domain, a protein interacting module, of semaphorin 4C (Sema4C); Sema4C acts as a Plexin B2 ligand to regulate the development of cerebellar granule cells and to modulate ureteric branching in the developing kidney. The binding of Sema4C to Plexin B2 results the phosphorylation of downstream regulator ErbB-2 and the plexin protein itself. The cytoplasmic region of Sema4C binds a neurite-outgrowth-related protein SFAP75, suggesting that Sema4C may also play a role in neural function. Sema4C belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200519 [Multi-domain]  Cd Length: 458  Bit Score: 478.14  E-value: 2.76e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  41 QFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNIsEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA 120
Cdd:cd11258     3 RFSQVGVSNYTTLTLAEHRGLLYVGAREAIFALSLSNI-ELQPPISWEAPAEKKTECAQKGKSNQTECFNYIRFLQPYNQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 121 TSLYVCGTNAFQPACDHLNLTSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLR 198
Cdd:cd11258    82 SHLYTCGTYAFQPKCAYINMLTFTLDRAEfEDGKGKCPYDPAKGHTGLIVDGELYSATLNNFLGTEPVILRNlGQHYSMK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 199 TEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd11258   162 TEYLAFWLNEPHFVGSAFVPESVGSFTGDDDKIYFFFSERAVEYDCDSEQVVARVARVCKGDLGGARTLQKKWTTFLKAR 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEQshtKWVRY 358
Cdd:cd11258   242 LLCSIPEWQLYFNQLKAVFTLEGASWRNTTFFAVFQARWGDMDVSAVCEYQLGEIQQVFE-GPYKEYSEQAQ---KWGRY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 359 NGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYDV 438
Cdd:cd11258   318 TDPVPSPRPGSCINNWHRDHGYTSSLELPDNTLNFVKKHPLMEDRVKPRLGRPLLVPCNSNFTHVVWTRVLGLDGETYSV 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 439 MFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQAPLA 501
Cdd:cd11258   398 LFIGTLDGWLIKAVSLGSWVHMIEELQVFDQEPPESLVVSQSSK--KLLFAGSRSELLQLPWA 458
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
49-501 8.32e-150

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 445.88  E-value: 8.32e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  49 NYSALLLSEDKDTLYIGAREAVFAVNALNI----SEKQHEVYWKVSEDKKAKCAeKGKSKQTECLNYIRVLQPLSA-TSL 123
Cdd:cd09295     1 DDDKILVSFRKDTIYVGAIARIYKVDGGGTrlllSCISPELNFGFNEDQKAFCP-LRRGKWTECINYIKVLQQKGDlDIL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 124 YVCGTNAFQPACDHLNLTSFKFLGKNE--DGKGRCPFDPAHSYTSVMVDGELYSGTSYNFL-GSEPIISRNSSHSP-LRT 199
Cdd:cd09295    80 AVCGSNAAQPSCGSYRLDVLVELGKVRwpSGRPRCPIDNKHSNMGVNVDSKLYSATDHDFKdGDRPALSRRSSNVHyLRI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 200 EYAIP-WLNEPSFVFADVIRKSpdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd09295   160 VVDSStGLDEITFVYAFVSGDD-------DDEVYFFFRQEPVEYLKKGMVYVPRIARVCKLDVGGCHRLKKKLTSFLKAD 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRPDSGLVFNVLRDVFVLRsPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFshgkymqsttveqshtkwvry 358
Cdd:cd09295   233 LNCSRPQSGFAFNLLQDATGDT-KNLIQDVKFAIFSSCLNKSVESAVCAYLFTDINNVF--------------------- 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 359 ngpvpkprpgacidsearaanytsslnlpdktlqfvkdhplmDDSVTPIDNRPRLIKK--DVNYTQIVVDRTQAlDGTVY 436
Cdd:cd09295   291 ------------------------------------------DDPVEAINNRPLYAHQnqRSRLTSIAVDATKQ-KSVGY 327
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034663517 437 DVMFVSTDRGALHKAISLE--HAVHIIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQAPLA 501
Cdd:cd09295   328 QVVFLGLKLGSLGKALAFFflYKGHIIEEWKVFKDSSRITNLDLSRPP--LYLYVGSESGVLGVPVQ 392
Sema_3 cd11239
The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins ...
50-503 3.10e-140

The Sema domain, a protein interacting module, of class 3 semaphorins; Class 3 semaphorins (Sema3s) are secreted regulator molecules involved in the development of the nervous system, vasculogenesis, angiogenesis,and tumorigenesis. There are 7 distinct subfamilies named Sema3A to 3G. Sema3s function as repellent signals during axon guidance by repelling neurons away from the source of Sema3s. However, Sema3s that are secreted by tumor cells play an inhibitory role in tumor growth and angiogenesis (specifically Sema3B and Sema3F). Sema3s functions by forming complexes with neuropilins and A-type plexins, where neuropilins serve as the ligand binding moiety and the plexins function as signal transduction component. Sema3s primarily inhibit the cell motility and migration of tumor and endothelial cells by inducing collapse of the actin cytoskeleton via neuropilins and plexins. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200500 [Multi-domain]  Cd Length: 471  Bit Score: 424.08  E-value: 3.10e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  50 YSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTN 129
Cdd:cd11239    10 YRSLLLDEDRDRLYVGGKDHILSLSLDNINQDPKKIYWPASPERIEECKMAGKDPNTECANFVRVLQPYNRTHLYACGTG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 130 AFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTE- 200
Cdd:cd11239    90 AFHPICAFINVgrrledPIFKLDDSSlESGRGKCPFDPNQPFASVLIDGELYSGTAIDFMGRDAAIFRSLGHRHyIRTEq 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 201 YAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Cdd:cd11239   170 YDSRWLNEPKFVGAYLI---PDSDNPDDDKVYFFFREKAVEAEGSGKAIYSRVGRICKNDVGGQRSLVNKWSTFLKARLV 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 281 CSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWVR 357
Cdd:cd11239   247 CSVPGPDGIdtyFDELEDVFLLPTRDPKNPLIYGVFTTSSNVFKGSAVCVYSMADIRAAFN-GPFAHK---EGPNYQWVE 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 358 YNGPVPKPRPGACiDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTv 435
Cdd:cd11239   323 YQGKVPYPRPGTC-PSKTYGPLYKSTKDFPDDVISFARSHPLMYNPVYPLHGRPLLIRTNVPYrlTQIAVDRVEAEDGQ- 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 436 YDVMFVSTDRGALHKAISLEHAVH-----IIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQAPLAFC 503
Cdd:cd11239   401 YDVLFIGTDSGTVLKVVSLPKENWemeevILEELQVFKHPSPITSMEISSKR--QQLYVGSAEGVVQLPLHRC 471
Sema_4A cd11256
The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed ...
42-501 3.73e-139

The Sema domain, a protein interacting module, of semaphorin 4A (Sema4A); Sema4A is expressed in immune cells and is thus termed an "immune semaphorin". It plays critical roles in T cell-DC interactions in the immune response. It has been reported to enhance activation and differentiation of T cells in vitro and generation of antigen-specific T cells in vivo. The function of Sema4A in the immune response implicates its role in infectious and noninfectious diseases. Sema4A exerts its function through three receptors, namely Plexin B, Plexin D1, and Tim-2. Sema4A belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. TThe Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200517 [Multi-domain]  Cd Length: 447  Bit Score: 420.47  E-value: 3.73e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFA--VNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS 119
Cdd:cd11256     2 FRQENVHNYDQLLLSPDETTLYVGARDNILAlgIRTPGPIRLKHQIPWPANDSKISECAFKKKSNETECFNFIRVLVPVN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 120 ATSLYVCGTNAFQPACDHLNLTSFKFLGKNE-----DGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SS 193
Cdd:cd11256    82 GTHLYTCGTYAFSPACTYIELDHFSLPPPNGtiitmDGKGQSPFDPQHNYTAILVDGELYTGTMNNFRGNEPIIFRNlGT 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 194 HSPLRTEYAIPWLN-EPSFVFAdvirkspdSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWT 272
Cdd:cd11256   162 KVSLKTDGFLRWLNaDAVFVAS--------FNPQGDSKVYFFFEETAREFDFFEKLTVARVARVCKNDVGGEKLLQKKWT 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 273 SFLKARLICSRPDSgLVFNVLRDVFVLRSPGLKVPVFYALFTP--QLNNVGLSAVCAYNLSTAEEVFShGKYMQsttVEQ 350
Cdd:cd11256   234 TFLKAQLTCSQQGH-FPFNVIHHVALLNQPDPNNSVFYAVFTSqwQLGGRRSSAVCAYKLNDIEKVFN-GKYKE---LNK 308
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 351 SHTKWVRYNGPVPKPRPGACidsearaanytSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQA 430
Cdd:cd11256   309 ESSRWTRYMGPVSDPRPGSC-----------SGGKSSDKALNFMKDHFLMDEVVLPGAGRPLLVKSNVQYTRIAVDSVQG 377
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034663517 431 LDGTVYDVMFVSTDRGALHKAISL-EHAVHIIEETQLFQDFEPVQTLLLSSKKGnrFVYAGSNSGVVQAPLA 501
Cdd:cd11256   378 VSGHNYTVMFLGTDKGFLHKAVLMgGSESHIIEEIELLTPPEPVENLLLAANEG--VVYIGYSAGVWRVPLA 447
Sema_4F cd11261
The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in ...
39-499 1.31e-138

The Sema domain, a protein interacting module, of semaphorin 4F (Sema4F); Sema4F plays role in heterotypic cell-cell contacts and controls cell proliferation and suppresses tumorigenesis. In neurofibromatosis type 1 (NF1) patients, reduced Sema4F level disrupts Schwann cell/axonal interactions. Experiments using a yeast two-hybrid system show that the extreme C-terminus of Sema4F interacts with the PDZ domains of post-synaptic density protein SAP90/PSD-95, indicating possible functional involvement of Semas4F at glutamatergic synapses. Recent work also suggests a role for Sema4F in the injury response of intramedullary axotomized motoneuron. Sema4F belongs to the class 4 transmembrane semaphorin family of proteins. Semaphorins are regulator molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200522 [Multi-domain]  Cd Length: 460  Bit Score: 419.68  E-value: 1.31e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  39 LVQFHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKsKQTECLNYIRVLQPL 118
Cdd:cd11261     3 LTRFSAPHTYNYSVLLVDPASHTLYVGARDAIFALTLPFSGERPRRIDWMVPEAHRQNCRKKGK-KEAECHNFIRILAIA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 119 SATSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-- 196
Cdd:cd11261    82 NASHLLTCGTFAFDPKCGVIDVSSFQQVERLESGRGKCPFEPAQRSAAIMAGGVLYAATVKNFLGTEPIISRAVGRAEew 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 197 LRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLK 276
Cdd:cd11261   162 IRTETLPSWLNAPAFVAAVFLSPAEWGDEDGDDEIYFFFTETAREYDSYERIKVPRVARVCAGDLGGRKTLQQRWTTFLK 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 277 ARLICSRPDSGLVFNVLRDVFVLRS-PGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQsttVEQSHTKW 355
Cdd:cd11261   242 ADLLCPGPEHGRASSILQDVTTLRPlPGAGTPIFYGIFSSQWEGASISAVCAFRPQDIRRVMN-GPFRE---FKHDCNRG 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 356 VRY-NGPVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGT 434
Cdd:cd11261   318 LPVmDSDVPQPRPGECITNNMKLLGFGSSLSLPDRVLTFVRDHPLMDRPVFPADGHPLLVTTDTAYLRVAAHRVTSLSGK 397
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034663517 435 VYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSskkgNRFVYAGSNSGVVQAP 499
Cdd:cd11261   398 EYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPEPQPVENLQLH----HNWLLVGSDTEVTQIN 458
Sema smart00630
semaphorin domain;
50-474 1.62e-132

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 401.36  E-value: 1.62e-132
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517   50 YSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTN 129
Cdd:smart00630   1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSKGKDPPTDCVNYIRLLLDYNEDRLLVCGTN 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  130 AFQPACDHLNLtsfkflgknedgkgrcpfdpahsytsvmvdGELYSGTSYNFLGSEPIISRNSSHSP--------LRTE- 200
Cdd:smart00630  81 AFQPVCRLRNL------------------------------GELYVGTVADFSGSDPAIPRSLSVRRlkgtsgvsLRTVl 130
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  201 YAIPWLNEPSFVFADVIrkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Cdd:smart00630 131 YDSKWLNEPNFVYAFES----------GDFVYFFFRETAVEDDNCGKAVHSRVARVCKNDVGGPRSLDKKWTSFLKARLE 200
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  281 CSRP-DSGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWVRY- 358
Cdd:smart00630 201 CSVPgEDPFYFNELQAAFLLPPGSESDDVLYGVFSTSSNPIPGSAVCAFSLSDINAVFN-GPFKEC---ETSTSQWLPYs 276
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  359 NGPVPKPRPGACIDSEAraanytSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGtvY 436
Cdd:smart00630 277 RGKVPYPRPGTCPNKPP------SSKDLPDETLNFIKSHPLMDEVVQPLTGRPLFVKTDSNYllTSIAVDRVATDGN--Y 348
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|..
gi 1034663517  437 DVMFVSTDRGALHKAISLE----HAVHIIEETQLFQDFEPVQ 474
Cdd:smart00630 349 TVLFLGTSDGRILKVVLSEssssSESVVLEEISVFPDGSPIS 390
Sema_3A cd11249
The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been ...
27-503 3.05e-120

The Sema domain, a protein interacting module, of semaphorin 3A (Sema3A); Sema3A has been reported to inhibit the growth of certain experimental tumors and to regulate endothelial cell migration and apoptosis in vitro, as well as arteriogenesis in the muscle, skin vessel permeability, and tumor angiogenesis in vivo. The function of Sema3A is mediated through receptors neuropilin-1 (NP1) and plexins, although little is known about the requirement of specific plexins in its receptor complex. It is known however that Plexin-A4 is the receptor for Sema3A in the Toll-like receptor- and sepsis-induced cytokine storm during immune response. Sema3A is a member of the Class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200510 [Multi-domain]  Cd Length: 493  Bit Score: 373.18  E-value: 3.05e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  27 IPRITWEHREV----HLVQFHE-PDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQhEVYWKVSEDKKAKCAEKG 101
Cdd:cd11249     4 VPRLKLSYKEMlesnNLITFNGlANSSSYHTFLLDEERGRLYVGAKDHIFSFNLVNIKDFQ-KIVWPVSPSRRDECKWAG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 102 KSKQTECLNYIRVLQPLSATSLYVCGTNAFQPACDHLNLTS------FKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELY 174
Cdd:cd11249    83 KDILKECANFIKVLKAYNQTHLYACGTGAFHPVCTYIEVGHhpedniFRLEDSHfENGRGKSPYDPKLLTASLLIDGELY 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 175 SGTSYNFLGSEPIISRN-SSHSPLRTE-YAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPR 252
Cdd:cd11249   163 SGTAADFMGRDFAIFRTlGHHHPIRTEqHDSRWLNDPRFISAHLI---PESDNPEDDKIYFFFRENAIDGEHTGKATHAR 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 253 IARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYN 329
Cdd:cd11249   240 IGQLCKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIdthFDELQDVFLMNSKDPKNPIVYAVFTTSSNIFKGSAVCMYS 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 330 LSTAEEVFShGKYMQSttvEQSHTKWVRYNGPVPKPRPGACidSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDN 409
Cdd:cd11249   320 MTDIRRVFL-GPYAHR---DGPNYQWVPFQGRVPYPRPGTC--PSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINN 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 410 RPRLIKKDVNY--TQIVVDRTQALDGTvYDVMFVSTDRGALHKAISLE----HAVH--IIEETQLFQDFEPVQTLLLSSK 481
Cdd:cd11249   394 RPIIIKTDVDYqfTQIVVDRVEAEDGQ-YDVMFIGTDMGTVLKVVSIPketwHDLEevLLEEMTVFREPTAISAMELSTK 472
                         490       500
                  ....*....|....*....|..
gi 1034663517 482 KGNrfVYAGSNSGVVQAPLAFC 503
Cdd:cd11249   473 QQQ--LYIGSAIGVSQLPLHRC 492
Sema_1A cd11237
The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a ...
54-503 2.19e-115

The Sema domain, a protein interacting module, of semaphorin 1A (Sema1A); Sema1A is a transmembrane protein. It has been shown to mediate the defasciculation of motor axon bundles at specific choice points. Sema1A binds to its receptor plexin A (PlexA), which in turn triggers downstream signaling events involving the receptor tyrosine kinase Otk, the evolutionarily conserved flavoprotein monooxygenase molecule interacting with CasL (MICAL), and the A kinase anchoring protein Nervy, leading to repulsive growth-cone response. Sema1A has also been shown to be involved in synaptic formation. It is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200498 [Multi-domain]  Cd Length: 446  Bit Score: 358.95  E-value: 2.19e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  54 LLSEDKDTLYIGAREAVFavnalNIS----EKQHEVYWKVSEDKKAKCAEKGKSKqTECLNYIRVLQPLSATSLYVCGTN 129
Cdd:cd11237     9 LLDQDGNSLLVGARNAVY-----NISlsdlTENQRIEWPSSDAHREMCLLKGKSE-DDCQNYIRVLAKKSAGRLLVCGTN 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 130 AFQPACDHLNLTSFKFLGKNE-DGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNsshsPLRTE-YAIPWLN 207
Cdd:cd11237    83 AYKPLCREYTVKDGGYRVEREfDGQGLCPYDPKHNSTAVYADGQLYSATVADFSGADPLIYRE----PLRTErYDLKQLN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 208 EPSFV--FADvirkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRP- 284
Cdd:cd11237   159 APNFVssFAY------------GDYVYFFFRETAVEYINCGKAIYSRVARVCKNDKGGPHPFRDRWTSFLKARLNCSVPg 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 285 DSGLVFNVLR---DVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTtveqSHTKWVRYNGP 361
Cdd:cd11237   227 EYPFYFNEIQstsDIVEGGYGGKSAKLIYGVFTTPVNSISGSAVCAFSLQDILEVFDGSFKEQQD----INSNWLPVPSN 302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 362 -VPKPRPGACIDsearaanytSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVD-RTQALDGTVYD 437
Cdd:cd11237   303 kVPEPRPGQCVN---------DSRTLPDVTVNFIKSHPLMDEAVPSFFGRPILVRTSLQYrfTQIAVDpQVKALDGKYYD 373
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 438 VMFVSTDRGALHKAISLEHAVH-------IIEETQLFQDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLAFC 503
Cdd:cd11237   374 VLFIGTDDGKVLKAVNIASADTvdkvspvVIEETQVFPRGVPIRNLLIVRGKDDGRLVVVSDDEIVSIPLHRC 446
Sema_3F cd11254
The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is ...
49-503 2.45e-114

The Sema domain, a protein interacting module, of semaphorin 3F (Sema3F); Sema3F is coexpressed with semaphorin3B. Both Sema3B and Sema3F proteins are candidate tumor suppressors that are down-regulated in highly metastatic tumors. Two receptor families, the neuropilins and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3F is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200515 [Multi-domain]  Cd Length: 470  Bit Score: 356.83  E-value: 2.45e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGT 128
Cdd:cd11254     9 DYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWPASPQRIEECILSGKGSNGECGNFIRLIQPWNRTHLYVCGT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 129 NAFQPACDHLN--LTSFKFL-----GKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRTE 200
Cdd:cd11254    89 GAYNPVCAYINrgRRAEDYMfrlepDKLESGKGKCPYDPKQDSVSALINGELYAGVYIDFMGTDAAIFRTMGKQPaMRTD 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 201 -YAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLiPRIARVCKGDQGGLRTLQKKWTSFLKARL 279
Cdd:cd11254   169 qYNSRWLNDPAFVHAHLI---PDSSEKNDDKLYFFFREKSLEAPQSPAVL-SRIGRVCLNDDGGHCCLVNKWSTFLKARL 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 280 ICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWV 356
Cdd:cd11254   245 VCSVPGADGIethFDELRDVFIQPTQDTKNPVIYAVFSTSGSVFKGSAVCVYSMADIRMVFN-GPFAHK---EGPNYQWM 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 357 RYNGPVPKPRPGACIDSEArAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGT 434
Cdd:cd11254   321 PYTGKIPYPRPGTCPGGTF-TPSMKSTKDYPDEVINFMRTHPLMYNAVYPVHRRPLVVRTNVNYrfTTIAVDQVDAADGR 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034663517 435 vYDVMFVSTDRGALHKAISL-----EHAVHIIEETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSGVVQAPLAFC 503
Cdd:cd11254   400 -YEVLFLGTDRGTVQKVIVLpkddlETEELTLEEVEVFKVPAPIKTMKISSKRQQ--LYVSSAVGVTHLSLHRC 470
Sema_3B cd11250
The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is ...
50-503 4.78e-114

The Sema domain, a protein interacting module, of semaphorin 3B (Sema3B); Sema3B is coexpressed with semaphorin 3F and both proteins are candidate tumor suppressors. Both Sema3B and Sema3F show high levels of expression in normal tissues and low-grade tumors but are down-regulated in highly metastatic tumors in the lung, melanoma cells, bladder carcinoma cells and prostate carcinoma. They are upregulated by estrogen and inhibit cell motility and invasiveness through decreased FAK phosphorylation and inhibition of MMP-2 and MMP-9 expression. Two receptor families, the neuropilins (NP) and plexins, have been implicated in mediating the actions of semaphorins 3B and 3F. Sema3B is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200511 [Multi-domain]  Cd Length: 471  Bit Score: 356.14  E-value: 4.78e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  50 YSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGTN 129
Cdd:cd11250    10 YDALLLDEERGRLFVGAKNYLASLSLDNISKQEKKIYWPAPVEWREECNWAGKDINTDCMNYVKILHHYNRTHLYACGTG 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 130 AFQPACDHLNL------TSFKF-LGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRTE- 200
Cdd:cd11250    90 AFHPTCAFVEVgqrmedHVFRLdPSRVEDGKGKSPYDPRHTAASVLVGDELYSGVATDLMGRDFTIFRSlGQRPSLRTEq 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 201 YAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Cdd:cd11250   170 HDSRWLNEPKFVKVFWI---PESENPDDDKIYFFFRETAVEAAGLGKQSYSRIGQICRNDMGGQRSLVNKWTTFLKARLV 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 281 CSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWVR 357
Cdd:cd11250   247 CSVPGNEGGdthFDELRDVFLLQTRDKRNPLIYAVFSTSSSVFQGSAVCVYTMNDVRRAFL-GPFAHK---EGPNYQWVS 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 358 YNGPVPKPRPGACidSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTv 435
Cdd:cd11250   323 YQGKVPYPRPGMC--PSKTFGSFESTKDFPDDVIQFARNHPLMFNPVLPLGGRPLFLRTGIPYtfTQIAVDRVAAADGH- 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034663517 436 YDVMFVSTDRGALHKAISL-----EHAVHII-EETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSGVVQAPLAFC 503
Cdd:cd11250   400 YDVMFIGTDVGSVLKVISVpkgswPSNEELLlEELHVFKDSSPITSMQISSKRQQ--LYVGSRSGVSQLPLHRC 471
Sema_3G cd11255
The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is ...
47-503 7.43e-112

The Sema domain, a protein interacting module, of semaphorin 3G (Sema3G); Semaphorin 3G is identified as a primarily endothelial cell- expressed class 3 semaphorin that controls endothelial and smooth muscle cell functions in autocrine and paracrine manners, respectively. It is mainly expressed in the lung and kidney, and a little in the brain. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200516 [Multi-domain]  Cd Length: 474  Bit Score: 350.75  E-value: 7.43e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  47 IYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVC 126
Cdd:cd11255     7 DLHLSAVYLDEYRDRLFLGGKDVLYSLRLDQTHPDAKEIHWPPLPGQREECIRKGKDPETECANFVRVLQPFNRTHLLAC 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 127 GTNAFQPACD------------HLNLTSFkflgknEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSH 194
Cdd:cd11255    87 GTGAFQPVCAlinvghrgehvfSLDPTTV------ESGRGRCPHEPKRPFASTFTGGELYTGLTADFLGRDSVIFRGFGT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 195 -SPLRTEYAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEF-VFRVLIPRIARVCKGDQGGLRTLQKKWT 272
Cdd:cd11255   161 rSPLRTETDQRLLHEPRFVAAHLI---PDNADRDNDKVYFFFTERATETAEdDDGAIHSRVGRLCANDAGGQRVLVNKWS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 273 SFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvE 349
Cdd:cd11255   238 TFIKARLVCSVPGPHGIqthFDQLEDVFLLRTKDGKSPEIYALFSTISNVFQGFAVCVYSMADIWEVFN-GPFAHK---D 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 350 QSHTKWVRYNGPVPKPRPGAC----IDSEARAanYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQI 423
Cdd:cd11255   314 GPDHQWGPYEGKVPYPRPGVCpskiTAQPGRA--FRSTKDYPDEVLQFARAHPLMWRPVYPSHRRPVLVKTGLPYrlTQI 391
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 424 VVDRTQALDGTvYDVMFVSTDRGALHKAISLEHAVH------IIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQ 497
Cdd:cd11255   392 VVDRVEAEDGY-YDVMFIGTDSGSVLKVIVLQKGNSaageevTLEELQVFKVPTPITEMEISVKR--QMLYVGSRTGVAQ 468

                  ....*.
gi 1034663517 498 APLAFC 503
Cdd:cd11255   469 VPLHRC 474
Sema_3D cd11252
The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted ...
49-503 3.32e-108

The Sema domain, a protein interacting module, of semaphorin 3D (Sema3D); Sema3D is a secreted semaphorin expressed during the development of the nervous system. In zebrafish, Sema3D is expressed in the ventral tectum. It guides retinal axons along the dorsoventral axis of the tectum and guides the laterality of retinal ganglion cell (RGC) projections. Both Sema3D knockdown or its ubiquitous overexpression induced aberrant ipsilateral projections. Proper balance of Sema3D is needed at the midline for the progression of RGC axons from the chiasm midline into the contralateral optic tract. Sema3D is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200513 [Multi-domain]  Cd Length: 474  Bit Score: 341.12  E-value: 3.32e-108
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGT 128
Cdd:cd11252     9 DFQTLLLDEERGRLLLGAKDHIYLLDLVDLNKNPKKIYWPAAKERVELCKLAGKDANTECANFIRVLHPYNRTHVYVCGT 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 129 NAFQPACDHLNL------TSFKFLGKN-EDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP----L 197
Cdd:cd11252    89 GAFHPTCGYIELgthkedRIFLLDTQNlESGRLKCPFDPQQPFASVMTDEYLYAGTASDFLGKDTTFTRSLGPTPdhhyI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 198 RTEYAIP-WLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLK 276
Cdd:cd11252   169 RTDISEHyWLNGAKFIGTFPI---PDTYNPDDDKIYFFFREASQDGSTSDKSVLSRVGRVCKNDVGGQRSLINKWTTFLK 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 277 ARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHT 353
Cdd:cd11252   246 ARLVCSIPGPDGAdthFDELQDIFLLPTRDERNPVVYGVFTTTSSIFKGSAVCVYSMADIRAVFN-GPYAHK---ESPDH 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 354 KWVRYNGPVPKPRPGACiDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQAL 431
Cdd:cd11252   322 RWVQYEGRIPYPRPGTC-PSKTYDPLIKSTKDFPDEVISFIKRHPLMYKSVYPLTGGPVFTRINVDYrlTQIVVDHVAAE 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034663517 432 DGTvYDVMFVSTDRGALHKAISLEHAVH-----IIEETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSGVVQAPLAFC 503
Cdd:cd11252   401 DGQ-YDVMFLGTDIGTVLKVVSITKEKWtmeevVLEELQIFKHPSPILNMELSLKQQQ--LYIGSRDGLVQLSLHRC 474
Sema_3C cd11251
The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted ...
49-503 4.71e-103

The Sema domain, a protein interacting module, of semaphorin 3C (Sema3C); Sema3C is a secreted semaphorin expressed in and adjacent to cardiac neural crest cells, and causes impaired migration of neural crest cells to the developing cardiac outflow tract, resulting in the interruption of the aortic arch and persistent truncus arteriosus. It has been proposed that Sema3C acts as a guidance molecule, regulating migration of neural crest cells that express semaphorin receptors such as plexin A2. Sema3C may also participate in tumor progression. The cleavage of Sema3C induced by ADAMTS1 promotes the migration of breast cancer cells. Sema3C is a member of the class 3 semaphorin family of secreted proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200512 [Multi-domain]  Cd Length: 470  Bit Score: 327.62  E-value: 4.71e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  49 NYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSATSLYVCGT 128
Cdd:cd11251     9 DYRILFMDEDQDRIYVGSKDHILSLNINNISQDALSIFWPASASKVEECKMAGKDPTHGCGNFVRVIQPYNRTHLYVCGS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 129 NAFQPACDHLNLTS------FKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRT-E 200
Cdd:cd11251    89 GAFSPVCVYVNRGRrseeqvFHIDSKAESGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSlTKRNAVRTdQ 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 201 YAIPWLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLI 280
Cdd:cd11251   169 HNSKWLSEPIFVDAHLI---PDGTDPNDAKLYFFLKERLTDNSGSTKQIHSMIARVCPNDTGGQRSLVNKWTTFLKARLV 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 281 CSRPD---SGLVFNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFsHGKYMQSttvEQSHTKWVR 357
Cdd:cd11251   246 CSVMDedgTETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKGSAVCVYHMSDIQTVF-NGPFAHK---EGPNHQLIA 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 358 YNGPVPKPRPGACiDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIK--KDVNYTQIVVDRTQALDGTv 435
Cdd:cd11251   322 YQGRIPYPRPGTC-PGGAFTPNMQSTKEFPDDVVTFIRNHPLMFNPIYPIGRRPLLVRtgTDYKYTKIAVDRVNAADGR- 399
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 436 YDVMFVSTDRGALHKAISLE-----HAVHIIEETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSGVVQAPLAFC 503
Cdd:cd11251   400 YHVLFLGTDKGTVQKVVVLPtngslSGELILEELEVFKNHAPITNMKISSKKQQ--LYVSSEEGISQVSLHRC 470
Sema_3E cd11253
The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted ...
41-503 2.75e-102

The Sema domain, a protein interacting module, of semaphorin 3E (Sema3E); Sema3E is a secreted molecule implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. It is also highly expressed in metastatic cancer cells. Sema3E signaling, through its high affinity functional receptor Plexin D1, drives cancer cell invasiveness and metastatic spreading. Sema3E is a member of the class 3 semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200514 [Multi-domain]  Cd Length: 471  Bit Score: 325.27  E-value: 2.75e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  41 QFHEPDIYNYSaLLLSEDKDTLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKqTECLNYIRVLQPLSA 120
Cdd:cd11253     2 HSPFGFLDLHT-MLLDEYQERLFVGGRDLLYSLSLERISANYKEIHWPSTQLQVEDCIMKGRDK-PECANYIRVLHHYNR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 121 TSLYVCGTNAFQPAC----------DHL-NLTSFKFlgknEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIIS 189
Cdd:cd11253    80 THLLACGTGAFDPVCafirvgrgseDHLfQLESDKF----ERGRGRCPFDPNSSFISTLIGGELFVGLYSDYWGRDAAIF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 190 RNSSH-SPLRTEYAIP-WLNEPSFVFADVIrksPDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTL 267
Cdd:cd11253   156 RTMNHlAHIRTEHDDErLLKEPKFVGSYMI---PDNEDPDDNKVYFFFTEKALEAEGGNHAIYTRVGRVCANDQGGQRML 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 268 QKKWTSFLKARLICSRPDSGLV---FNVLRDVFVLRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQ 344
Cdd:cd11253   233 VNKWSTFLKTRLICSVPGPNGIdthFDELEDVFLLRTRDNKNPEIFGLFSTTSNIFKGYAICVYHMASIRAAFN-GPFAH 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 345 SttvEQSHTKWVRYNGPVPKPRPGACIdSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQ 422
Cdd:cd11253   312 K---EGPEYHWSVYEGKVPYPRPGSCA-SKVNGGHYGTTKDYPDEALRFARSHPLMYQAVKPVHKRPILVKTDGKYnlKQ 387
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 423 IVVDRTQALDGTvYDVMFVSTDRGALHKAI--------SLEHAvhIIEETQLFQDFEPVQTLLLSSKKGNrfVYAGSNSG 494
Cdd:cd11253   388 IAVDRVEAEDGQ-YDVLFIGTDNGIVLKVItiynqeteTMEEV--ILEELQVFKVPVPIISMEISSKRQQ--LYIGSESG 462

                  ....*....
gi 1034663517 495 VVQAPLAFC 503
Cdd:cd11253   463 VAQIRFHQC 471
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
60-471 1.66e-98

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 315.22  E-value: 1.66e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  60 DTLYIGAREAVFAVNaLNISEKQHEVY-----WKVSEDKKAKCAEKGKSKQtECLNYIRVLQPLSATSLYVCGTNAFQPA 134
Cdd:cd11242    19 RTLYIAARDHVYTVD-LDASHTEEIVPskkltWRSRQADVENCRMKGKHKD-ECHNFIKVLVPRNDETLFVCGTNAFNPV 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 135 CDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFV 212
Cdd:cd11242    97 CRNYRIDTLEQDGEEISGMARCPFDAKQANVALFADGKLYSATVTDFLASDAVIYRSLGDSPtLRTvKYDSKWLKEPHFV 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 213 FAdvIRKSpdspdgedDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVF 290
Cdd:cd11242   177 HA--VEYG--------DYVYFFFREIAVEYNTLGKVVFSRVARVCKNDMGGSpRVLEKQWTSFLKARLNCSVPgDSHFYF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 291 NVLRDVF-VLRSPGlkVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEQSHTkwvryngP-----VPK 364
Cdd:cd11242   247 DVLQAVTdVIRING--RPVVLGVFTTQYNSIPGSAVCAFDMDDIEKVFE-GRFKEQKSPDSAWT-------PvpedrVPK 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 365 PRPGACIDSeARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDrTQALDGTVYDVMFVS 442
Cdd:cd11242   317 PRPGCCAGS-GSAEKYKTSNDFPDDTLNFIKTHPLMDEAVPSIINRPWFTRTMVRYrlTQIAVD-NAAGPYQNYTVVFLG 394
                         410       420
                  ....*....|....*....|....*....
gi 1034663517 443 TDRGALHKAISLEHAvHIIEETQLFQDFE 471
Cdd:cd11242   395 SEAGTVLKFLARIGP-SGSNGSVFLEEID 422
Sema_6D cd11269
The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed ...
54-501 1.84e-85

The Sema domain, a protein interacting module, of semaphorin 6D (Sema6D); Sema6D is expressed predominantly in the nervous system during embryogenesis and it uses Plexin-A1 as a receptor. It displays repellent activity for dorsal root ganglion axons. Sema6D also acts as a regulator of late phase primary immune responses. In addition, Sema6D is overexpressed in gastric carcinoma, indicating that it may have an important role in the occurrence and development of the cancer. Sema6D is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200530 [Multi-domain]  Cd Length: 465  Bit Score: 280.76  E-value: 1.84e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  54 LLSEDKDTLYIGAREAVFAVNaLNISEKQH-----EVYWKVSEDKKAKCAEKGKSKQtECLNYIRVLQPLSATSLYVCGT 128
Cdd:cd11269    13 LMLKIRDTLYIAGRDQVYTVN-LNEVPKTEvtpsrKLTWRSRQQDRENCAMKGKHKD-ECHNFIKVFVPRNDEMVFVCGT 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 129 NAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWL 206
Cdd:cd11269    91 NAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSmGDGSALRTiKYDSKWI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 207 NEPSFVFAdvirkspdspDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP- 284
Cdd:cd11269   171 KEPHFLHA----------IEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGsQRVLEKHWTSFLKARLNCSVPg 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 285 DSGLVFNVLRDVF-VLRSPGlkVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFsHGKYMQSTTVEqshTKWVRY-NGPV 362
Cdd:cd11269   241 DSFFYFDVLQSITdIIEING--IPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVF-KGRFKEQKTPD---SVWTAVpEDKV 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 363 PKPRPGACIdSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTqALDGTVYDVMF 440
Cdd:cd11269   315 PKPRPGCCA-KHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPSIIEEPWFTKTRVRYrlTAIAVDHA-AGPHQNYTVIF 392
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034663517 441 VSTDRGALHKAI------SLEHAVhIIEETQLF-------QDFEPVQTLLLSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11269   393 VGSEAGVVLKILaktspfSLNDSV-LLEEIEAYnhakcsaENEEDRRVISLQLDRDHHALFVAFSSCVVRIPLS 465
Sema_2A cd11238
The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted ...
50-501 6.46e-85

The Sema domain, a protein interacting module, of semaphorin 2A (Sema2A); Sema2A, a secreted semaphorin, signals through its receptor plexin B (PlexB) to regulate central and peripheral axon pathfinding. In the Drosophila embryo, Sema2A secreted by oenocytes interacts with PlexB to guide sensory axons. Sema2A is a member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200499 [Multi-domain]  Cd Length: 452  Bit Score: 278.92  E-value: 6.46e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  50 YSALLLSEDKDTLYIGAREAVFAVNALNISEKQH---EVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLS-ATSLYV 125
Cdd:cd11238     3 YRTLLLDEKRNALYVGAMDRVFRLNLYNINDTGNncaRDELTLSPSDVSECVSKGKDEEYECRNHVRVIQPMGdGQTLYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 126 CGTNAFQP---ACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDG-------ELYSGTSYNFLGSEPIISR----N 191
Cdd:cd11238    83 CSTNAMNPkdrVLDANLLHLPEYVPGPGNGIGKCPYDPDDNSTAVWVEWgnpgdlpALYSGTRTEFTKANTVIYRpplyN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 192 SS----HSPLRT-EYAIPWLNEPSFVFA-DVirkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLR 265
Cdd:cd11238   163 NTkgrhESFMRTlKYDSKWLDEPNFVGSfDI-----------GDYVYFFFRETAVEYINCGKVVYSRVARVCKKDTGGKN 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 266 TLQKKWTSFLKARLICSRPDS-GLVFNVLRDVFvlRSPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQ 344
Cdd:cd11238   232 VLRQNWTTFLKARLNCSISGEfPFYFNEIQSVY--KVPGRDDTLFYATFTTSENGFTGSAVCVFTLSDINAAFDTGKFKE 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 345 STTveqSHTKWVRY-NGPVPKPRPGACIDsearaanytSSLNLPDKTLQFVKDHPLMDDSVTpiDNRPRLIKKDVNYTQI 423
Cdd:cd11238   310 QAS---SSSAWLPVlSSEVPEPRPGTCVN---------DSATLSDTVLHFARTHPLMDDAVS--HGPPLLYLRDVVFTHL 375
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 424 VVDRTQAlDGTVYDVMFVSTDRGALHKAISLEHAVHiiEETQLFQDF-----EPVQTLLLSSKKgnrFVYAGSNSGVVQA 498
Cdd:cd11238   376 VVDKLRI-DDQEYVVFYAGSNDGKVYKIVHWKDAGE--SKSNLLDVFeltpgEPIRAMELLPGE---FLYVASDHRVSQI 449

                  ...
gi 1034663517 499 PLA 501
Cdd:cd11238   450 DLA 452
Sema_6A cd11266
The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, ...
61-450 7.03e-83

The Sema domain, a protein interacting module, of semaphorins 6A (Sema6A); In the cerebellum, Sema6A-plexin A2 signaling modulates granule cell migration by controlling centrosome positioning. Besides plexin A2, plexin A4 is also found to be a receptor of Sema6A. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. It is required for the clustering of boundary cap cells at the PNS/CNS interface and thus, prevents motoneurons from streaming out of the ventral spinal cord. At the dorsal root entry site, it organizes the segregation of dorsal roots. Sema6A may also be involved in axonal pathfinding processes in the periinfarct and homotopic contralateral cortex. Sema6A is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200527 [Multi-domain]  Cd Length: 466  Bit Score: 273.83  E-value: 7.03e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  61 TLYIGAREAVFAVNaLNISEKQhEVY------WKVSEDKKAKCAEKGKSKQtECLNYIRVLQPLSATSLYVCGTNAFQPA 134
Cdd:cd11266    20 TLYIAARDHIYTVD-IDTSHTE-EIYfskkltWKSRQADVDTCRMKGKHKD-ECHNFIKVLLKRNDDTLFVCGTNAFNPS 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 135 CDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFV 212
Cdd:cd11266    97 CRNYKMDTLEFFGDEFSGMARCPYDAKHANVALFADGKLYSATVTDFLAIDAVIYRSLGDSPtLRTvKHDSKWLKEPYFV 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 213 FAdvirkspdspDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-DSGLVF 290
Cdd:cd11266   177 QA----------VDYGDYIYFFFREIAVEYNSMGKVVFPRVAQVCKNDMGGsQRVLEKQWTSFLKARLNCSVPgDSHFYF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 291 NVLRDVF-VLRSPGLKVPVfyALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEQSHTKWVryNGPVPKPRPGA 369
Cdd:cd11266   247 NILQAVTdVIHINGRDVVL--ATFSTPYNSIPGSAVCAYDMLDIASVFT-GRFKEQKSPDSTWTPVP--DERVPKPRPGC 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 370 CIDSeARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDrTQALDGTVYDVMFVSTDRGA 447
Cdd:cd11266   322 CAGS-SSLEKYATSNEFPDDTLNFIKTHPLMDEAVPSIINRPWFLRTMVRYrlTKIAVD-NAAGPYQNHTVVFLGSEKGI 399

                  ...
gi 1034663517 448 LHK 450
Cdd:cd11266   400 ILK 402
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
42-501 2.31e-82

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 271.47  E-value: 2.31e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQhEVYWKVSEDKKAKCAEKGKSKQtECLNYIRVLQpLSAT 121
Cdd:cd11264     1 FTYPGVRDFSQLALDLNRNQLIVGARNYLFRLSLHNVSLIQ-ATEWGSDEDTRRSCQSKGKTEE-ECQNYVRVLI-VYGK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 122 SLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVD-GELYSGTSYNFLGSEPIISRN-SSHSPLRT 199
Cdd:cd11264    78 KVFTCGTNAFSPVCTSRQVGNLSKVIERINGVARCPYDPRHNSTAVITSrGELYAATVIDFSGRDPAIYRSlGSVPPLRT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 200 -EYAIPWLNEPSFVFADVIRKSpdspdgeddrVYFFFTEVSVEYEfVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd11264   158 aQYNSKWLNEPNFIAAYDIGLF----------TYFFFRENAVEHD-CGKTVYSRVARVCKNDIGGRFLLEDTWTTFMKAR 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRP-DSGLVFNVLRDVFVLRSPGLkvpvFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQsttvEQSHTKWVR 357
Cdd:cd11264   227 LNCSRPgEIPFYYNELQSTFYLPEQDL----IYGVFTTNVNSIAASAVCAFNLSAITQAFNGPFRYQ----ENPRSAWLP 298
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 358 YNGPVPKPRPGACIDSearaanyTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDgTVYD 437
Cdd:cd11264   299 TANPIPNFQCGTLSDD-------SPNENLTERSLQDAQRLFLMNDVVQPVTVDPLVTQDSVRFSKLVVDIVQGKD-TLYH 370
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034663517 438 VMFVSTDRGALHKAISL-EHAVH--IIEETQLFQD--FEPVQTLLLssKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11264   371 VMYIGTEYGTILKALSTtNRSLRscYLEEMQILPPgqREPIRSLQI--LHSDRSLFVGLNNGVLKIPLE 437
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
42-500 5.33e-82

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 270.58  E-value: 5.33e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQHeVYWKVSEDKKAKCAEKGKSKQtECLNYIRVLQpLSAT 121
Cdd:cd11241     1 FEIEYVSDFSRLVLDPTHDQLIVGARNYLFRLRLQSLSLLQA-VPWNSDEDTKRQCQSKGKSVE-ECQNYVRVLL-VVGK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 122 SLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRN-SSHSPLRT 199
Cdd:cd11241    78 NLFTCGTYAFSPVCTIRKLSNLTQILDTISGVARCPYSPAHNSTALISaSGELYAGTVYDFSGRDPAIYRSlGGKPPLRT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 200 -EYAIPWLNEPSFVFADVIrkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd11241   158 aQYNSKWLNEPNFVGSYEI----------GNHTYFFFRENAVEHQDCGKTVYSRIARVCKNDIGGRFLLEDTWTTFMKAR 227
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRP-DSGLVFNVLRDVFVLRSPGLkvpvFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSHTKWVR 357
Cdd:cd11241   228 LNCSLPgEFPFYYNEIQGTFYLPETDL----IYAVFTTNVNGIAGSAICAFNLSAINQAFN-GPFKYQ---ENNGSAWLP 299
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 358 YNGPVPKPRPGACIDSearaanyTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTVYD 437
Cdd:cd11241   300 TPNPHPNFQCTTSIDR-------GQPANTTERDLQDAQKYQLMAEVVQPVTKIPLVTMDDVRFSKLAVDVVQGRGTQLVH 372
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034663517 438 VMFVSTDRGALHKAISLEHAVH--IIEETQLFQDF--EPVQTLLLSskKGNRFVYAGSNSGVVQAPL 500
Cdd:cd11241   373 IFYVGTDYGTILKMYQPHRSQKscTLEEIKILPAMkgEPITSLQFL--KSEKSLFVGLETGVLRIPL 437
Sema_6B cd11267
The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as ...
61-501 2.25e-79

The Sema domain, a protein interacting module, of semaphorin 6B (Sema6B); Sema6B functions as repellents for axon growth; this repulsive activity is mediated by its receptor Plexin A4. Sema6B is expressed in CA3, and repels mossy fibers in a Plexin A4 dependent manner. In human, it was shown that peroxisome proliferator-activated receptors (PPARs) and 9-cis-retinoic acid receptor (RXR) regulate human semaphorin 6B (Sema6B) gene expression. Sema6B is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200528 [Multi-domain]  Cd Length: 466  Bit Score: 264.39  E-value: 2.25e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  61 TLYIGAREAVFAVNALNISEK----QHEVYWKVSEDKKAKCAEKGKsKQTECLNYIRVLQPLSATSLYVCGTNAFQPACD 136
Cdd:cd11267    20 TLYIGDRDNLYRVELDPTAGTemryHKKLTWRSNKNDINVCRMKGK-HEGECRNFIKVLLLRDYGTLFVCGTNAFNPVCA 98
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 137 HLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRNSSHSP-LRT-EYAIPWLNEPSFVFA 214
Cdd:cd11267    99 NYSIDTLEPVGDNISGMARCPYDPKHANVALFADGMLFTATVTDFLAIDAVIYRSLGDSPaLRTvKHDSKWFKEPYFVHA 178
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 215 dVIRKSpdspdgeddRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGG-LRTLQKKWTSFLKARLICSRP-DSGLVFNV 292
Cdd:cd11267   179 -VEWGS---------HVYFFFREIAMEFNYLEKVVVSRVARVCKNDMGGsQRVLEKQWTSFLKARLNCSVPgDSHFYFNV 248
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 293 LRDVF-VLRSPGLkvPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEqshTKWVRY-NGPVPKPRPGAC 370
Cdd:cd11267   249 LQAVSdILNLGGR--PVVLAVFSTPTNSIPGSAVCAFDMTQVAAVFE-GRFREQKSPE---SIWTPVpEELVPRPRPGCC 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 371 IdseARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTvYDVMFVSTDRGAL 448
Cdd:cd11267   323 A---APGMRYNSSSTLPDEVLNFVKTHPLMDEAVPSLGHAPWIVRTMTRYqlTHMVVDTEAGPHGN-HTVVFLGSTRGTV 398
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034663517 449 HK--------AISLEHAVHIIEETQLFQ------DFEPVQTLL-LSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11267   399 LKfliipnasSSEISNQSVFLEELETYNpercgwDSPQAQKLLsLELDKGSGGLLLAFPSCVVRVPVA 466
Sema_5A cd11263
The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse ...
42-500 2.57e-76

The Sema domain, a protein interacting module, of semaphorin 5A (Sema5A); Originally, mouse Sema5A was identified as a protein that induces inhibitory responses during optic nerve development. Recent studies show that Sema5A controls innate immunity in mice. It also has been identified as a candidate gene for causing idiopathic autism in humans. Plexin B3 functions as a binding partner and receptor for Sema5A. Furthermore, Sema5A is also implicated in cancer. The role of the Drosophila Sema5A ortholog, Dsema-5C, in tumorigenicity and metastasis has been reported. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Sema5A belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200524 [Multi-domain]  Cd Length: 436  Bit Score: 255.34  E-value: 2.57e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVNALNISEKQhEVYWKVSEDKKAKCAEKGKSKQtECLNYIRVLQpLSAT 121
Cdd:cd11263     1 FRAENAVDFSQLTFDPGQKELIVGARNYLFRLQLEDLSLIQ-AVEWECDEATKKACYSKGKSKE-ECQNYIRVLL-VGGD 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 122 SLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMV-DGELYSGTSYNFLGSEPIISRN-SSHSPLRT 199
Cdd:cd11263    78 RLFTCGTNAFTPICTNRTLNNLTEIHDQISGMARCPYSPQHNSTALLTsSGELYAATAMDFPGRDPAIYRSlGILPPLRT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 200 -EYAIPWLNEPSFVFADVIrkspdspdgeDDRVYFFFTEVSVEYEfVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKAR 278
Cdd:cd11263   158 aQYNSKWLNEPNFVSSYDI----------GNFTYFFFRENAVEHD-CGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKAR 226
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 279 LICSRP-DSGLVFNVLRDVFVLrsPGLKvpVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHG-KYMqsttvEQSHTKWV 356
Cdd:cd11263   227 LNCSRPgEIPFYYNELQSTFFL--PELD--LIYGIFTTNVNSIAASAVCVFNLSAISQAFNGPfKYQ-----ENSRSAWL 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 357 ryngPVPKPRPgaciDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDgTVY 436
Cdd:cd11263   298 ----PYPNPNP----NFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTPVPYFMEDNSRFSHVAVDVVQGKD-MLF 368
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034663517 437 DVMFVSTDRGALHKAISLEHAVH---IIEETQLF--QDFEPVQTLLLSSKKGNRFVyaGSNSGVVQAPL 500
Cdd:cd11263   369 HIIYLATDYGTIKKVLAPLNQSSsscLLEEIELFpkRQREPIRSLQILHSQSVLFV--GLQEHVIKIPL 435
Sema_7A cd11243
The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); ...
35-501 1.46e-73

The Sema domain, a protein interacting module, of semaphorin 7A (Sema7A, also called CD108); Sema7A plays regulatory roles in both immune and nervous systems. Unlike other semaphorins, which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Sema7A also plays a critical role in the negative regulation of T cell activation and function. Sema7A is a membrane-anchored member of the semaphorin family of proteins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200504 [Multi-domain]  Cd Length: 414  Bit Score: 247.07  E-value: 1.46e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  35 REVHLVQFHEPDiynysalllsedKDTLYIGAREAVFAVNALNISEKQhevywKVSEDKKAKCAEKGKSKQTECLNYIRV 114
Cdd:cd11243     1 KESYPVFFHEAG------------SSSVYVGGQGALYLLDFTGSAVIV-----KKIPDEKTEKDCKKRATLDDCENYITL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 115 LQPLSaTSLYVCGTNAFQPACDHLNLTSFKFLGkneDGKGRCPFDPAHSyTSVMVDG-ELYS---GTSYNFlgsePIISR 190
Cdd:cd11243    64 IKKLD-YRLLVCGTNAGSPKCWFLVNQTLVTLS---ADRGVAPFLPDEN-SLVLIEGnNVYStisGKKGNI----PRFRR 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 191 NSSHSPLRTEYAipWLNEPSFVFADVIrkspDSPDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQ-K 269
Cdd:cd11243   135 YGGKKELYTSDT--VMQKPQFVKATLL----PEDEQYQDKIYYFFREDNEDKGPEAEPNISRVARLCKEDQGGTSSLStS 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 270 KWTSFLKARLICSRPDSGLVFNVLRDVFVLRSPGLKVPVFYALFTpqlNNVGLSAVCAYNLSTAEEVFSHGKYMQsttve 349
Cdd:cd11243   209 KWSTFLKARLVCGDPATPMNFNRLQDVFLLPKEEWREAVVYGVFS---NTWGSSAVCSYSLGDIDKVFRTSSLKG----- 280
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 350 qshtkwvrYNGPVPKPRPGACIDSEAraanytsslNLPDKTLQFVKDHPLMDDSVTPIDNRPR-LIKKDVNYTQIVVDRT 428
Cdd:cd11243   281 --------YSGSLPNPRPGTCVPPEQ---------THPSETFSFADEHPELDDRIEPDEPRKLpVFQNKDHYQKVVVDEV 343
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 429 QALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSSKKgnRFVYAGSNSGVVQAPLA 501
Cdd:cd11243   344 RASDGVSYDVLYLATDKGKIHKVVESKGQTHNIMEIQPFKEQEPIQSMILDAER--SHLYVGTKAEVTRLPLD 414
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
293-480 6.09e-70

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 228.69  E-value: 6.09e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 293 LRDVFVLRSPG--LKVPVFYALFTPQL-NNVGLSAVCAYNLSTAEEVFShGKYMqstTVEQSHTKWVRYNGPVPKPRPGA 369
Cdd:pfam01403   1 LQDVFVLKPGAgdALDTVLYGVFTTQWsNSIGGSAVCAFSLSDINAVFE-GPFK---EQEKSDSKWLPYTGKVPYPRPGT 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 370 CIDSEARaanytssLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNYTQIVVDRTQALDGTvYDVMFVSTDRGALH 449
Cdd:pfam01403  77 CINDPLR-------LDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRVQALDGN-YTVLFLGTDDGRLH 148
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034663517 450 KAISLE-HAVHIIEETQLFQDFEPVQTLLLSS 480
Cdd:pfam01403 149 KVVLVGsEESHIIEEIQVFPEPQPVLNLLLSS 180
Sema_6E cd11270
The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed ...
61-501 4.78e-69

The Sema domain, a protein interacting module, semaphorin 6E (sema6E); Sema6E is expressed predominantly in the nervous system during embryogenesis. It binds Plexin A1 and might utilize it as a receptor to repel axons of specific types during development. Sema6E acts as a repellent to dorsal root ganglion axons as well as sympathetic axons. Sema6E is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200531 [Multi-domain]  Cd Length: 462  Bit Score: 236.16  E-value: 4.78e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  61 TLYIGAREAVFAVNALNISEK---QHEVYWKVSEdkKAKCAEKGKSKQtECLNYIRVLQPLSATSLYVCGTNAFQPACDH 137
Cdd:cd11270    20 MVYIAARDHVFAINLSASLERivpQQKLTWKTKD--VEKCTVRGKNSD-ECYNYIKVLVPRNDETLFACGTNAFNPTCRN 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 138 LNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSP-LRT-EYAIPWLNEPSFVFA 214
Cdd:cd11270    97 YKMSSLEQDGEEVIGQARCPFESRQSNVGLFAGGDFYSATMTDFLASDAVIYRSlGESSPvLRTvKYDSKWLREPHFLHA 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 215 DVIrkspdspdgeDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFNV 292
Cdd:cd11270   177 IEY----------GNYVYFFLSEIAVEYTTLGKVVFSRVARVCKNDNGGSpRVLERYWTSFLKARLNCSVPgDSFFYFDV 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 293 LRDVFVLRSPGLKvPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSTTVEQSHTKWVRynGPVPKPRPGACId 372
Cdd:cd11270   247 LQSLTNVMQINHR-PAVLGVFTTQANSITGSAVCAFYMDDIEKVFN-GKFKEQRNSESAWTPVPD--EAVPKPRPGSCA- 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 373 SEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY--TQIVVDRTQALDGTvYDVMFVSTDRGALHK 450
Cdd:cd11270   322 GDGPAAGYKSSTNFPDETLTFIKSYPLMDEAVPSVNNRPCFTRTTSRFklTQIAVDTAAGPYKN-YTVVFLGSENGHVLK 400
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 451 AISLEHAVHIIeETQLFQDF------------EPVQTLLLSSKKGNRFVYAGSNSGVVQAPLA 501
Cdd:cd11270   401 VLASMHPNSSY-STQVLEDIdvynpnkcnvrgEDRRILGLELDKDHHALFVAFTGCVIRVPLS 462
Sema_6C cd11268
The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called ...
61-452 4.44e-66

The Sema domain, a protein interacting module, of semaphorin 6C (Sema6C, also called semaphorin Y); Sema6C is highly expressed in adult brain and skeletal muscle and it shows growth cone collapsing activity. It may play a role in the maintenance and remodelling of neuronal connections. In adult skeletal muscle, this role includes prevention of motor neuron sprouting and uncontrolled motor neuron growth. The expression of Sema6C in adult skeletal muscle is down-regulated following denervation. Sema6C is a member of the class 6 semaphorin family of proteins, which are membrane associated semaphorins. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200529 [Multi-domain]  Cd Length: 465  Bit Score: 228.43  E-value: 4.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  61 TLYIGAREAVFAVNALNISEKQHEV-----YWKvSEDKKaKCAEKGKSKQtECLNYIRVLQPLSATSLYVCGTNAFQPAC 135
Cdd:cd11268    20 TLLVAARDHVFSFDLQAEEEGEGLVpnkylTWR-SQDVE-NCAVRGKLTD-ECYNYIRVLVPWDSQTLLACGTNSFSPVC 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 136 DHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYNFLGSEPIISRN-SSHSPLRT-EYAIPWLNEPSFVF 213
Cdd:cd11268    97 RSYGITSLQQEGEELSGQARCPFDATQSNVAIFAEGSLYSATAADFQASDAVVYRSlGPQPPLRSaKYDSKWLREPHFVQ 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 214 AdvirkspdspDGEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGL-RTLQKKWTSFLKARLICSRP-DSGLVFN 291
Cdd:cd11268   177 A----------LEHGDHVYFFFREVSVEDARLGRVQFSRVARVCKRDMGGSpRALDRHWTSFLKLRLNCSVPgDSTFYFD 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 292 VLRdvfvlrspGLKVPV-------FYALFTPQLNNVGLSAVCAYNLSTAEEVFsHGKYMQSTTVEQSHTKwvRYNGPVPK 364
Cdd:cd11268   247 VLQ--------ALTGPVnlhgrsaLFGVFTTQTNSIPGSAVCAFYLDEIERGF-EGKFKEQRSLDGAWTP--VSEDRVPS 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 365 PRPGACIdSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRL-IKKDVNYTQIVVDRTQALDGTVyDVMFVST 443
Cdd:cd11268   316 PRPGSCA-GVGGAALFSSSRDLPDDVLTFIKAHPLLDPAVPPVTHQPLLtLTSRALLTQVAVDGMAGPHSNI-TVMFLGS 393

                  ....*....
gi 1034663517 444 DRGALHKAI 452
Cdd:cd11268   394 NDGTVLKVL 402
Sema_5C cd11265
The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, ...
42-450 1.76e-64

The Sema domain, a protein interacting module, of semaphorin 5C (sema5C); In Drosophila, Sema5C was identified as an early development gene, which is expressed in stage 2 embryos with a striped pattern emerging at later stages. Sema5c may play a role in odor-guided behavior and in tumorigenesis. Sema5C belongs to class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200526 [Multi-domain]  Cd Length: 433  Bit Score: 222.73  E-value: 1.76e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  42 FHEPDIYNYSALLLSEDKDTLYIGAREAVFAVnALNISEKQHEVYWKVSEDKKAKCAEKGKSKQtECLNYIRVLQPlSAT 121
Cdd:cd11265     1 FSDPEVTSYSQMLFDVARNQVIVGARDNLYRL-SLDGLELLERASWPAAESKVALCQNKGQSEE-DCHNYVKVLLS-YGK 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 122 SLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVM-VDGELYSGTSYNFLGSEPIISRN---SSHSPL 197
Cdd:cd11265    78 QLFACGTNAFSPRCSWREMENLTSVTEWDSGVAKCPYSPHANITALLsSSGQLFVGSPTDFSGSDSAIYRTlgtSNKSFL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 198 RT-EYAIPWLNEPSFV--FAdvirkspdspdgEDDRVYFFFTEVSVEYEFVFRVLIPRIARVCKGDQGGLRTLQK-KWTS 273
Cdd:cd11265   158 RTkQYNSKWLNEPQFVgsFE------------TGNFVYFLFRESAVEYMNCGKVIYSRIARVCKNDVGGGTMLLKdNWTT 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 274 FLKARLICSRP-DSGLVFNVLRDVFVLRSPGLkvpvFYALFTPQLNNVGLSAVCAYNLSTAEEVFShGKYMQSttvEQSH 352
Cdd:cd11265   226 FLKARLNCSLPgEYPFYFDEIQGMTYLPDEGI----LYATFTTPENSIAGSAVCAFNLSSINAAFD-GPFKHQ---ESSG 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 353 TKWVRYN-------GPVPKPRPGACIDSEAraanytsslnlpdktlqfvkdHPLMDDSVTPIDNRPRLIKKDVNYTQIVV 425
Cdd:cd11265   298 AAWERVNvnhrdhfNQCSSSSSSHLLESSR---------------------YQLMDEAVQPITLEPLHHAKLERFSHIAV 356
                         410       420
                  ....*....|....*....|....*
gi 1034663517 426 DRTQALDGTVYDVMFVSTDRGALHK 450
Cdd:cd11265   357 DVIPTKIHQSVHVLYVATTGGLIKK 381
Ig_Sema4D_like cd05873
Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members ...
559-645 2.05e-44

Immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain of semaphorin 4D (Sema4D) and similar proteins. Sema4D is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4D has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4D plays a part in the development of GABAergic synapses. Sema4D in addition is an immune semaphorin. It is abundant on resting T cells; its expression is weak on resting B cells and antigen presenting cells (APCs), but is upregulated by various stimuli. The receptor used by Sema4D in the immune system is CD72. Sem4D enhances the activation of B cells and DCs through binding CD72, perhaps by reducing CD72s inhibitory signals. The receptor used by Sema4D in the non-lymphatic tissues is plexin-B1. Sem4D is anchored to the cell surface but its extracellular domain can be released from the cell surface by a metalloprotease-dependent process. Sem4D may mediate its effects in its membrane-bound form and/or its cleaved form.


Pssm-ID: 409457  Cd Length: 87  Bit Score: 154.59  E-value: 2.05e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 559 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPKYGLMgRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQV 638
Cdd:cd05873     1 GDPRQRTFKLGGNAELKCSPKSNLARVVWKFQGKVLKAESPKYGLY-GDGLLIFNASEADAGRYQCLSVEKSKAKTFFQT 79

                  ....*..
gi 1034663517 639 VAKHVLE 645
Cdd:cd05873    80 VAKYVLE 86
Ig_Semaphorin_C cd04979
Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are ...
559-645 3.86e-30

Immunoglobulin (Ig)-like domain at the C-terminus of semaphorins; The members here are composed of the immunoglobulin (Ig)-like domain in semaphorins. Semaphorins are transmembrane protein that have important roles in a variety of tissues. Functionally, semaphorins were initially characterized for their importance in the development of the nervous system and in axonal guidance. Later they have been found to be important for the formation and functioning of the cardiovascular, endocrine, gastrointestinal, hepatic, immune, musculoskeletal, renal, reproductive, and respiratory systems. Semaphorins function through binding to their receptors and transmembrane semaphorins also serves as receptors themselves. Although molecular mechanism of semaphorins is poorly understood, the Ig-like domains may be involved in ligand binding or dimerization.


Pssm-ID: 409368  Cd Length: 88  Bit Score: 114.09  E-value: 3.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 559 GSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAE-SPKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVkNKTVFQ 637
Cdd:cd04979     1 TSFKQISVKEGDTVILSCSVKSNNAPVTWIHNGKKVPRYrSPRLVLKTERGLLIRSAQEADAGVYECHSGERV-LGSTLR 79

                  ....*...
gi 1034663517 638 VVAKHVLE 645
Cdd:cd04979    80 SVTLHVLE 87
Sema cd09295
The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins ...
228-560 7.34e-19

The Sema domain, a protein interacting module, of semaphorins and plexins; Both semaphorins and plexins have a Sema domain on their N-termini. Plexins function as receptors for the semaphorins. Evolutionarily, plexins may be the ancestor of semaphorins. Semaphorins are regulatory molecules in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems, and cancer. Semaphorins can be divided into 7 classes. Vertebrates have members in classes 3-7, whereas classes 1 and 2 are known only in invertebrates. Class 2 and 3 semaphorins are secreted; classes 1 and 4 through 6 are transmembrane proteins; and class 7 is membrane associated via glycosylphosphatidylinositol (GPI) linkage. Plexins are a large family of transmembrane proteins, which are divided into four types (A-D) according to sequence similarity. In vertebrates, type A plexins serve as co-receptors for neuropilins to mediate the signalling of class 3 semaphorins. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B plexins. This family also includes the MET and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves to recognize and bind receptors.


Pssm-ID: 200495 [Multi-domain]  Cd Length: 392  Bit Score: 89.57  E-value: 7.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 228 DDRVYFFFTEVSVeyefvfrvLIPRIARVCKGDQGGLRTLqkkwtsflkarLICSRPDSGLVFNVLRDV-FVLRSPGLKV 306
Cdd:cd09295     2 DDKILVSFRKDTI--------YVGAIARIYKVDGGGTRLL-----------LSCISPELNFGFNEDQKAfCPLRRGKWTE 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 307 PVFYALFTPQLNNVGLSAVCAYNLSTaeevFSHGKYMQSTTVEQSHTKWvryngpvPKPRPGACIDseARAANYTSSLnl 386
Cdd:cd09295    63 CINYIKVLQQKGDLDILAVCGSNAAQ----PSCGSYRLDVLVELGKVRW-------PSGRPRCPID--NKHSNMGVNV-- 127
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 387 pDKTLQFVKDHPLMDDSvtpidnRPRLIKK--DVNYTQIVVDRTQALDGTVYDVMFVSTDRgalhkaislehavhiIEET 464
Cdd:cd09295   128 -DSKLYSATDHDFKDGD------RPALSRRssNVHYLRIVVDSSTGLDEITFVYAFVSGDD---------------DDEV 185
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 465 QLFQDFEPVQTLllssKKGnrFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSRGLIQ 544
Cdd:cd09295   186 YFFFRQEPVEYL----KKG--MVYVPRIARVCKLDVGGCHRLKKKLTSFLKADLNCSRPQSGFAFNLLQDATGDTKNLIQ 259
                         330
                  ....*....|....*..
gi 1034663517 545 EMS-GDASVCPDKSKGS 560
Cdd:cd09295   260 DVKfAIFSSCLNKSVES 276
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
503-554 8.82e-10

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 55.02  E-value: 8.82e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034663517 503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSrGLIQEMSGDASVCP 554
Cdd:pfam01437   2 CSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACGAPE-GNCEEWEQASSKCP 52
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
503-554 2.62e-09

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 53.32  E-value: 2.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034663517  503 CGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPsrglIQEMSGDasVCP 554
Cdd:smart00423   2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSR----RQNWLSG--GCP 47
Ig_Sema4B_like cd05872
Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are ...
574-636 1.63e-08

Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B; The members here are composed of the immunoglobulin (Ig)-like domain of Sema4B and similar proteins. Sema4B is a Class IV semaphorin. Semaphorins are classified based on structural features additional to the Sema domain. Sema4B has extracellular Sema and Ig domains, a transmembrane domain, and a short cytoplasmic domain. Sema4B has been shown to preferentially regulate the development of the postsynaptic specialization at the glutamatergic synapses. This cytoplasmic domain includes a PDZ-binding motif upon which the synaptic localization of Sem4B is dependent. Sema4B is a ligand of CLCP1. CLCP1 was identified in an expression profiling analysis, which compared a highly metastic lung cancer subline with its low metastic parental line. Sema4B was shown to promote CLCP1 endocytosis and their interaction is a potential target for therapeutic intervention of metastasis.


Pssm-ID: 409456  Cd Length: 86  Bit Score: 52.44  E-value: 1.63e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663517 574 LKCSQKSNLARVFWKFQNGVLKAESPKYgLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVF 636
Cdd:cd05872    16 LPCQLRSNLASPVWLFNGTPLNAQFSYL-RLGTDGLLILVTSPEHSGTYRCYSEEEGFQQLVA 77
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
145-538 2.76e-07

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 54.17  E-value: 2.76e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 145 FLGKNEDGKG---------RCPFDPAhsyTSVMVDGELYSgtsyNFLGSepIISRNSSHSPLRTEYAIPWL---NEPSFV 212
Cdd:cd11272   146 FIGTAVDGKQdyfptlssrKLPRDPE---SSAMLDYELHS----DFVSS--LIKIPSDTLALVSHFDIFYIygfASGNFV 216
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 213 -FADVIRKSPD--SPDGEDDrvyFFFTEvsveyefvfrvlipRIARVCKGDqgglrtlqKKWTSFLKARLICSRpdSGLV 289
Cdd:cd11272   217 yFLTVQPETPEgvSINSAGD---LFYTS--------------RIVRLCKDD--------PKFHSYVSLPFGCVR--GGVE 269
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 290 FNVLRDVFvlrspglkvpvfyalftpqLNNVGLSAVCAYNLSTAEEV----FSHGK--YMQSTTVEQSHTKWVRYNGPVP 363
Cdd:cd11272   270 YRLLQAAY-------------------LSKPGEVLARSLNITAQEDVlfaiFSKGQkqYHHPPDDSALCAFPIRAINAQI 330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 364 KPRPGACIDSEARAanytsSLN-LPDKTLQFVKDHPLMDDSVTPID-NRP----RLIKKDVNYTQiVVDRTQALDGTVYD 437
Cdd:cd11272   331 KERLQSCYQGEGNL-----ELNwLLGKDVQCTKAPVPIDDNFCGLDiNQPlggsTPVEGVTLYTS-SRDRLTSVASYVYN 404
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 438 ---VMFVSTDRGALHK--AISLEHAVHIIEETQLFQDFEPVQTLLLSSKKgNRFVYAGSNSGVVQAPLAFCGKHGTCEDC 512
Cdd:cd11272   405 gysVVFVGTKSGKLKKirADGPPHGGVQYEMVSVFKDGSPILRDMAFSID-HKYLYVMSERQVSRVPVESCEQYTTCGEC 483
                         410       420
                  ....*....|....*....|....*.
gi 1034663517 513 VLARDPYCAWspptatCVaLHQTESP 538
Cdd:cd11272   484 LSSGDPHCGW------CA-LHNMCSR 502
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
569-634 2.80e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.96  E-value: 2.80e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  569 GGTAELKCSQKSNL-ARVFWKFQNGVLKAESPKYGLMGRKN---LLIFNLSEGDSGVYQCLSEERVKNKT 634
Cdd:smart00410   9 GESVTLSCEASGSPpPEVTWYKQGGKLLAESGRFSVSRSGStstLTISNVTPEDSGTYTCAATNSSGSAS 78
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
52-337 1.81e-05

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 48.10  E-value: 1.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  52 ALLLSEDKDTLYIGAREAVFAVNA-LNIsekQHEVYWKVSED-----KKAKCAEKGKSKQTEclNYIRVLQPL-SATSLY 124
Cdd:cd11236     4 HLAVDNSTGRVYVGAVNRLYQLDSsLLL---EAEVSTGPVLDsplclPPGCCSCDHPRSPTD--NYNKILLIDySSGRLI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 125 VCGTnAFQPACDHLNLTSFKFLGKNEDGKGRCPfDPAHSYTSVMVDGE------LYSGTSYNFLGSEPIISRNSSHSPLR 198
Cdd:cd11236    79 TCGS-LYQGVCQLRNLSNISVVVERSSTPVAAN-DPNASTVGFVGPGPynnenvLYVGATYTNNGYRDYRPAVSSRSLPP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 199 TeyaiPWLNEPSFVFADVIRKSPDSPDGE----------DDRVYFffteVSVEYEFVFRVL--IPRIARVCKGDqgglrt 266
Cdd:cd11236   157 D----DDFNAGSLTGGSAISIDDEYRDRYsikyvygfssGGFSYF----VTVQRKSVDDESpyISRLVRVCQSD------ 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 267 lqKKWTSFLKARLICSRPDSGLvFNVLRDVFV-------LRSPGLKV--PVFYALFTPQLNNV----GLSAVCAYNLSTA 333
Cdd:cd11236   223 --SNYYSYTEVPLQCTGGDGTN-YNLLQAAYVgkagsdlARSLGISTddDVLFGVFSKSKGPSaepsSKSALCVFSMKDI 299

                  ....
gi 1034663517 334 EEVF 337
Cdd:cd11236   300 EAAF 303
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
61-450 1.97e-04

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 44.92  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517  61 TLYIGAREAVFAVNalniSEKQHEVYWKVSEDKKA-KC------AEKGKSKQTECLNYIRVLQPLSATsLYVCGTnAFQP 133
Cdd:cd11245    13 RLYLGAVNGLFQLS----PNLQLESRADTGPKKDSpQClppitaAECPQAKETDNFNKLLLVNSANGT-LVVCGS-LFQG 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 134 ACDHLNLTSFKFLGKNEDGKGRCPFDPAH--SYTSVMVDGELYSGTSYNFLGsEPIISRNSSHSPLRTEYAIpWLNEPSF 211
Cdd:cd11245    87 VCELRNLNSVNKPLYRPETPGDKQYVAANepSVSTVGLISYFKDGLSLLFVG-RGYTSSLSGGIPPITTRLL-QEHGEMD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 212 VFA----------DVIRKSPD--SPDGEDDRVYFFFTEVSVEYEFVFRVLIpriARVCKGDQgglrtlqkKWTSFLKARL 279
Cdd:cd11245   165 AFSneveaklvvgSASRYHHDfvYAFADNGYIYFLFSRRPGTADSTKRTYI---SRLCENDH--------HYYSYVELPL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 280 ICSRPDSGlVFNVLRDVFVlrSPGLKV---PVFYALFT----PQLNNVGLSAVCAYNLSTAEEVFSHgkymqstTVEQSH 352
Cdd:cd11245   234 NCTVNQEN-TYNLVQAAYL--AKPGKVlngKVLFGVFSadeaSTAAPDGRSALCMYPLSSVDARFER-------TRESCY 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 353 TKWVRynGPVPKPRPGACIDSEARAAnytsslNLPDKTlqfVKDHPLMDDSV-TPIDNRPRLIKKDVnYTQivVDRTQAL 431
Cdd:cd11245   304 TGEGL--EDDKPETAYIEYNVKSICK------TLPDKN---VKAYPCGAEHTpSPLASRYPLAAKPI-LTR--NDMLTAV 369
                         410       420
                  ....*....|....*....|..
gi 1034663517 432 DGTVYD---VMFVSTDRGALHK 450
Cdd:cd11245   370 AVAVENghtIAFLGDSGGQLHK 391
Ig_Sema3 cd05871
Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed ...
569-645 1.17e-03

Immunoglobulin (Ig)-like domain of class III semaphorin Sema3; The members here are composed of the immunoglobulin (Ig)-like domain of Sema3 and similar proteins. Semaphorins are classified based on structural features additional to the Sema domain. Sema3 is a Class III semaphorin that is secreted. It is a vertebrate class having a Sema domain, an Ig domain, a short basic domain. They have been shown to be axonal guidance cues and have a part in the regulation of the cardiovascular, immune, and respiratory systems. Sema3A, the prototype member of this class III subfamily, induces growth cone collapse and is an inhibitor of axonal sprouting. In perinatal rat cortex, it acts as a chemoattractant and functions to direct the orientated extension of apical dendrites. It may play a role, prior to the development of apical dendrites, in signaling the radial migration of newborn cortical neurons towards the upper layers. Sema3A selectively inhibits vascular endothelial growth factor receptor (VEGF)-induced angiogenesis and induces microvascular permeability. This group also includes Sema3B, -C, -D, -E, -G.


Pssm-ID: 409455  Cd Length: 92  Bit Score: 38.87  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 569 GGTAELKCSQKSNLARVFWKFQ-NGVLKAESPKYG----LMGRkNLLIFNLSEGDSGVYQCLSEERvknkTVFQVVAK-- 641
Cdd:cd05871    12 GNSTFLECLPKSPQATVKWLFQrGGDQRKEEVKSEerliVTDR-GLLLRSLQRSDAGVYTCQAVEH----GFSQTLVKir 86

                  ....*
gi 1034663517 642 -HVLE 645
Cdd:cd05871    87 lHVIE 91
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
562-639 1.64e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.33  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663517 562 RQHFFKHGGTAELKCSQKSN--LARVFWKFQNGVLKAES---PKYGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVF 636
Cdd:pfam00047   4 PTVTVLEGDSATLTCSASTGspGPDVTWSKEGGTLIESLkvkHDNGRTTQSSLLISNVTKEDAGTYTCVVNNPGGSATLS 83

                  ...
gi 1034663517 637 QVV 639
Cdd:pfam00047  84 TSL 86
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
572-633 4.42e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 36.54  E-value: 4.42e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034663517 572 AELKCS-QKSNLARVFWKFQNGVLK--AESPKYGLMGRKNLLIFNLSEGDSGVYQClseeRVKNK 633
Cdd:cd00096     1 VTLTCSaSGNPPPTITWYKNGKPLPpsSRDSRRSELGNGTLTISNVTLEDSGTYTC----VASNS 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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