|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
48-461 |
0e+00 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 632.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRpitlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysFLLMSDFVVLA 287
Cdd:cd17424 161 LILGGFVLNLCVCGALMR---------------------------------------------------FLLMPDFLVLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCL 367
Cdd:cd17424 190 VSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYFCYLFAVGMDGLCCLFL 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 368 PMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCG 447
Cdd:cd17424 270 PILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSG 349
|
410
....*....|....
gi 1034568216 448 FSMIFSSVLLGFAR 461
Cdd:cd17424 350 FSMIFSSLLLGSAR 363
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
48-461 |
2.41e-120 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 357.63 E-value: 2.41e-120
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRpitlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysFLLMSDFVVLA 287
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR---------------------------------------------------LLKDPTFVLLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQyvCYLFAVGMDGLCYLCL 367
Cdd:cd17352 190 LGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLY--LYIFTLLILGLSLLAF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 368 PMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCG 447
Cdd:cd17352 268 PLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCG 347
|
410
....*....|....
gi 1034568216 448 FSMIFSSVLLGFAR 461
Cdd:cd17352 348 ACLLLSGVLLFLLP 361
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
42-481 |
1.09e-103 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 318.22 E-value: 1.09e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 42 PPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLG 121
Cdd:TIGR00892 11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 122 GLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQF 201
Cdd:TIGR00892 91 GLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 202 SWRGALLILGGFVLNLCVCGALMRPItlkedhtTPEQnhvcRTQKEDIKRVSPYSSLTKEWAQTCLCCCLQQEYSFLLMS 281
Cdd:TIGR00892 171 GWRGSFLILGGLLLHCCVCGALMRPV-------GPSQ----RVSKSKSKEGLPPDGSTKKLSKKSTAEKINRFLDFSLFT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 282 D--FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyQYVCYLFAVGM 359
Cdd:TIGR00892 240 HrgFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKWIR--PHVQYLFSFAL 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 360 --DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTG 437
Cdd:TIGR00892 318 lfNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATK 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1034568216 438 SYTAAFLLCGFSMIFSSVLL--GFARLIKRMRKTQLQFIAKE--SDPK 481
Cdd:TIGR00892 398 NYKYIFYASGSIVVSAGLFLaiGNYINYRLLAKEQKAALEREgaRDKK 445
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
48-458 |
2.44e-89 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 278.89 E-value: 2.44e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPITLKEDhttpeqnhvcrtqkedikRVSPYSSLTKEWaqtclccclqqEYSFLLMSDFVVLA 287
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPLALPGD------------------PPAPPRSLSAAF-----------GLSLLTHRAFLRYA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyqyVCYLFAV--GMDGLCYL 365
Cdd:cd17423 212 LATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLR----LLHLLVLwtALTGLSLL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 366 CLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLL 445
Cdd:cd17423 288 LLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLV 367
|
410
....*....|....
gi 1034568216 446 CG-FSMIFSSVLLG 458
Cdd:cd17423 368 AGsFLLLGSLILLT 381
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
48-460 |
2.45e-78 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 250.03 E-value: 2.45e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPITLKedhttpeqnhVCRTQkedikrvspyssltkewaqtclccclqqeysfllmsDFVVLA 287
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPLDFS----------VFRDR------------------------------------GFVIYT 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyQYVCYLFAVGM--DGLCYL 365
Cdd:cd17430 195 IAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLLSILGFIDIFARPACGVVAGLKWVR--PRVVYLFSFAMlfNGLTDL 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 366 CLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLL 445
Cdd:cd17430 273 CSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYL 352
|
410
....*....|....*
gi 1034568216 446 CGFSMIFSSVLLGFA 460
Cdd:cd17430 353 AGSEVVLSALFLALG 367
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
48-461 |
2.61e-71 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 231.56 E-value: 2.61e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPItlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqQEYSFLLMSDFvvla 287
Cdd:cd17422 161 LVVGALQLNIVVCGALLRVL---------------------------------------------KEPGFICYALF---- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 vsVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYqYVCYLFAVGMdGLCYLCL 367
Cdd:cd17422 192 --GLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKI-YIELICVILL-CVVLLLF 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 368 PMLQSLPLLVPFSCTFGYFDGAYV-TLIPVVTTE-IVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLL 445
Cdd:cd17422 268 PFAYGFWSLLVCSIFYGFMFGTVAgTHIPLLAEDdVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYS 347
|
410
....*....|....*.
gi 1034568216 446 CGFSMIFSSVLLGFAR 461
Cdd:cd17422 348 CAAGMALGAVFLALVR 363
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
48-457 |
2.10e-66 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 218.91 E-value: 2.10e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPITLKEDHttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysfllmSDFVVLA 287
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPLGPLFKH-----------------------------------------------RGFLIYL 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCL 367
Cdd:cd17427 194 SGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLLC 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 368 PMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCG 447
Cdd:cd17427 274 PLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCG 353
|
410
....*....|
gi 1034568216 448 FSMIFSSVLL 457
Cdd:cd17427 354 AIVIVASIWL 363
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
48-460 |
5.21e-66 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 217.72 E-value: 5.21e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPItlkedhttpeqnhvCRTQKedikrvspyssltkewaqtclccclqqeysfllmsdFVVLA 287
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRPF--------------CSNTR------------------------------------YQIYT 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCL 367
Cdd:cd17425 191 LGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLLSILGFINIFMRPLAGLLSGLPVFKGRRIYLFSLALLLNGLSNLIC 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 368 PMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCG 447
Cdd:cd17425 271 AISASFPVLLVYCLLYSISMSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASS 350
|
410
....*....|...
gi 1034568216 448 FSMIFSSVLLGFA 460
Cdd:cd17425 351 IFVVSAALFMGLS 363
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
48-465 |
2.46e-62 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 208.14 E-value: 2.46e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIgTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGL-TFALAPFTQLLLDEYDWQGAL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPItlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqEYSFLLMSDFVVLA 287
Cdd:cd17421 160 LIFGGIMLNLVASGMLLRPI----------------------------------------------DFSLLKDPFFCIYT 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQY-VCYLFAVGMDGLcyLC 366
Cdd:cd17421 194 WSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQNWIKKYHYhKAYLILCGVTNL--LA 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 367 lPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLC 446
Cdd:cd17421 272 -PLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLA 350
|
410
....*....|....*....
gi 1034568216 447 GFSMIFSSVLLGFARLIKR 465
Cdd:cd17421 351 GGCYLLSSVSFFLEPLARR 369
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
48-457 |
9.43e-60 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 201.64 E-value: 9.43e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPITLKedhttpeqnhvcrtqkedikrvsPYSSLTkewaqtclcccLQQEYSFLLMSDFVVLA 287
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRPIGPK-----------------------PFLDLT-----------LFTHRGFLLYLSGNVIM 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFmaygcSPLfVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyQYVCYLFAVGM--DGLCYL 365
Cdd:cd17426 207 FFGLF-----APL-VFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANTKWVR--PRIQYFFAASVlyNGVCHL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 366 CLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLL 445
Cdd:cd17426 279 LAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWA 358
|
410
....*....|..
gi 1034568216 446 CGFSMIFSSVLL 457
Cdd:cd17426 359 CGIVLIISSIYL 370
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
48-448 |
8.57e-51 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 177.33 E-value: 8.57e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPITLKEdhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysfllmsdFVVLA 287
Cdd:cd17429 161 FIQGAVSLNLCVCGALMRLFTNKV---------------------------------------------------FVAFI 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRRCLKNYQyvCYLFAVGMDGLCYLC 366
Cdd:cd17429 190 FWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSIIAIVHIFGKVILGIICDLPCISVWN--VFILANFTLGVCILI 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 367 LPMLQSLPLLVPFSCTFGYFDGaYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLC 446
Cdd:cd17429 268 LPLMHTYTGLAIVCALIGFSSG-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVC 346
|
..
gi 1034568216 447 GF 448
Cdd:cd17429 347 GL 348
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
48-457 |
6.59e-41 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 151.27 E-value: 6.59e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSivdcVTMLCAPLGSVVSNHLSCQVGI----MLGGL 123
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFT----VGLLAFGLAQPFVGRLLDRFGPrrvmLLGLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 124 LASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMV-GKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFS 202
Cdd:cd17355 77 LLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVaAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 203 WRGALLILGGFVLNLCVCGALMRPitlkeDHTTPEQNHVCRTQKEdikrVSPYSSLTKEWAqtclccclqqeysfllMSD 282
Cdd:cd17355 157 WRTALLVLALLALLVLVPVLLLLR-----RRPADLALRAYDDASP----ASPGSTLKEALR----------------SAS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 283 FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRrclknYQYVCYLFAV-GMDG 361
Cdd:cd17355 212 FWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDR-----YSPRRLLAASyALRA 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 362 LCYLCLPMLQSLPL-LVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYT 440
Cdd:cd17355 287 LGLALLLLLPFPPLaLLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYT 366
|
410
....*....|....*..
gi 1034568216 441 AAFLLCGFSMIFSSVLL 457
Cdd:cd17355 367 AAWALAVALGLIAALLV 383
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
86-459 |
1.44e-38 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 145.36 E-value: 1.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 86 QTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVG 165
Cdd:cd17420 44 KAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGAAVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 166 KYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPItlkedHTTPEQNHVCRTQ 245
Cdd:cd17420 124 HYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPL-----HPSPEDPKSKPGR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 246 KEDIKRVspYSSLTKEWaqtclccclqqEYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSIL 325
Cdd:cd17420 199 RTLHSRI--NLFLRKIF-----------NVEIFKRKRYVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCI 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 326 GVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMdGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTT 405
Cdd:cd17420 266 GITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSI-GLMSMMIPLCNSFGILISVCLVMGLFDGCFISIMAPIAFELVGPS 344
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1034568216 406 SLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGF 459
Cdd:cd17420 345 GASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
48-460 |
1.07e-37 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 141.88 E-value: 1.07e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPItlkedhttpeQNHVcrtqkedikrvspyssltkewaqtclccclqqeysfllmsdFVVLA 287
Cdd:cd17428 161 LIVGALALNLLACGSLMRLF----------KNRV-----------------------------------------FSALF 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRRCLkNYQYVcYLFAVGMDGLCYLC 366
Cdd:cd17428 190 IAILLFDIGAFPPSLLMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLADFKWV-NSLYL-YVLTLIGMGAALLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 367 LPMLQSLPLLVPFSCTFGYFDGAYvTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLC 446
Cdd:cd17428 268 IPFAKSYLTLAVLSAILGFLSGNW-SIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFS 346
|
410
....*....|....
gi 1034568216 447 GFSMIFSSVLLGFA 460
Cdd:cd17428 347 GFCVLLGGFLLLLA 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
49-456 |
2.02e-37 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 141.98 E-value: 2.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 49 WMIVAGCFLVTICTRAVTrCISIFFVEFQTYFTQDYAQTAWIHSI-VDCVTMLCAPLGSVVSNhLSCQVGIMLGGLLAST 127
Cdd:cd17353 3 WLVLLGAVLMHLILGYQY-AWSVFNPPLSSALGWSLASVALAFTLtIVFLAISAPFAGRLVDR-GGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17353 81 GFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILG-GFVLNLCVCGALMRpitLKEDHTTPEQNHVCRTQKEDIKRVSPYSSLTKEwaqtclccclqqeysfllmSDFVVL 286
Cdd:cd17353 161 LILGiIFLIIIVIGAFLIR---DPPKGWVPPGVDPLANNAENSPRDYTPREMLRT-------------------PTFWLL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 287 AVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNyqyvCYLFAVGMDGLCYL 365
Cdd:cd17353 219 WLMFFLNATAGLMLIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKN----TLSIAFLIQGVAMF 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 366 CLPMLQSLP-LLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRlVDTTGSYTAAFL 444
Cdd:cd17353 295 LLPFIGSVAvLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAY-VLYTGGYNAAFI 373
|
410
....*....|..
gi 1034568216 445 LCGFSMIFSSVL 456
Cdd:cd17353 374 IAAALSLVALAL 385
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-468 |
1.56e-35 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 136.15 E-value: 1.56e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 41 SPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIML 120
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 121 GGLLASTGLILSSFATSLKHLYLTLgVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIE 199
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 200 QFSWRGALLILGGFVLnlcvcgalmrpitlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysFLL 279
Cdd:COG2271 160 AFGWRAAFLILGLPGL-------------------------------------------------------------LLA 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 280 MSDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRrcLKNYQYVCYLFAVG 358
Cdd:COG2271 179 LLRFWLLALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLL 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 359 MDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGs 438
Cdd:COG2271 257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG- 335
|
410 420 430
....*....|....*....|....*....|
gi 1034568216 439 YTAAFLLCGFSMIFSSVLLGFarLIKRMRK 468
Cdd:COG2271 336 YQAAFLLLAALALLAALLALL--LLRETRK 363
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
49-465 |
3.95e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.39 E-value: 3.95e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 49 WMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVdcvtMLCAPLGSVVSNHLSCQVG----IMLGGLL 124
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIP----VLVGALLRIPLGFLVDRFGprrvLLIGLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 125 ASTGLILSSFATSLKHLyLTLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSW 203
Cdd:COG2223 80 LGIGLLLLALAVSYWLL-LLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGW 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 204 RGALLILGGFVLNLCVCGALMrpITLKEDHTTPEQNHVCRTQKEDIKRVspyssltkewaqtclccclqqeysfllmsDF 283
Cdd:COG2223 159 RNAFLILGILLLVVAVLAWLF--LRDPPAGAAAAAKASLRDQLEALRDP-----------------------------RF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 284 VVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNyqyVCYLFAVGMDGL 362
Cdd:COG2223 208 WLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR---VLLIVFALMALG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 363 CYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAA 442
Cdd:COG2223 285 LLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAA 364
|
410 420
....*....|....*....|...
gi 1034568216 443 FLLCGFSMIFSSVLLGFARLIKR 465
Cdd:COG2223 365 FLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
48-460 |
2.19e-31 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 124.83 E-value: 2.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 48 GWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLAST 127
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 128 GLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFVLNLCVCGALMRPitlkedhttpeqNHVCRTQKEdIKRVSPYSSLTKEWaqtclccclqqeysfLLMSDFVVLA 287
Cdd:cd17314 161 TILGILAAIVLSVVSLLGF------------KEPPDNQAR-LHVQKKKTQTMGEI---------------FRDKVFWILF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSVGVSHQQ-AAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMdGLCYLC 366
Cdd:cd17314 213 IAIFLVLIGGFLFIANMASLVRSLQLDAPSfVTKLMSIYGLFNAFGRLLWGIVADFFGGRLSTLSILLTILGL-GLCAFL 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 367 LPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLC 446
Cdd:cd17314 292 FLLKMTPVGLVLTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIY 371
|
410
....*....|....
gi 1034568216 447 GFSMIFSSVLLGFA 460
Cdd:cd17314 372 AVIVFLASAILLAV 385
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
86-459 |
2.40e-28 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 116.43 E-value: 2.40e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 86 QTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVG 165
Cdd:cd17464 44 KTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAAVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 166 KYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKedhttpeqnhvcRTQ 245
Cdd:cd17464 124 HYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPM------------KKD 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 246 KEDIKRVSPYSSLTKEWaqtclccclqqEYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSIL 325
Cdd:cd17464 192 KEGKKRKFKCPPLKKIF-----------NFNIWKSTGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMCI 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 326 GVIDIIGNITFGWLTDR--RCLKNYQYVCYLFAVgmdGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVG 403
Cdd:cd17464 261 GITSGIGRLIFGRVADYipGVKKVYLQVSSFFFI---GLMSMMIPLCHVFGGLIAVCLFMGLFDGCFISIMAPIAFELVG 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034568216 404 TTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGF 459
Cdd:cd17464 338 AQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCF 393
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
31-465 |
1.10e-27 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 114.59 E-value: 1.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 31 MAKVNRARSTSPPDGGWgwMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSN 110
Cdd:COG2807 1 MSTTSSSARRSRRAGRW--LLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 111 HLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTlGVLTGLGFALCYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFIL 190
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG-TALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 191 APVVQLLIEQFSWRGALLILGGfvlnLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKrvspySSLTkeWAQTClccc 270
Cdd:COG2807 158 AGLTVPLAAALGWRGALAVWAL----LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWR-----SPLA--WLLTL---- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 271 lqqeySFLLMSdfvvlavsvlFMAYGcspLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRclkNYQY 350
Cdd:COG2807 223 -----FFGLQS----------LLYYA---VVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL---GDRR 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 351 VCYLFAVGMDGLCYLCLpMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSAL-GVVYFLHAVPYLVSPPIA 429
Cdd:COG2807 282 PLLLLLGLLGLAGLLGL-LLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALsGMAQSVGYLLAALGPLLV 360
|
410 420 430
....*....|....*....|....*....|....*.
gi 1034568216 430 GRLVDTTGSYTAAFLLCgfsMIFSSVLLGFARLIKR 465
Cdd:COG2807 361 GALHDATGSWTAALLLL---AALAVLMLVAGLLAGR 393
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-420 |
2.76e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 106.60 E-value: 2.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 42 PPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLG 121
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 122 GLLASTGLILSSFATSLKHLYLtLGVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQ 200
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 201 FSWRGALLILGGfvlnLCVCGALMRPITLKEDHTTPEQNHvcrtqkedikrvspyssltkewaqtclcccLQQEYSFLLM 280
Cdd:COG2814 161 FGWRWVFLVNAV----LALLALLLLLRLLPESRPAARARL------------------------------RGSLRELLRR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 281 SDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAvgm 359
Cdd:COG2814 207 PRLLLLLLLAFLLGFGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL--- 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034568216 360 dGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAV 420
Cdd:COG2814 284 -ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
56-426 |
1.01e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 96.33 E-value: 1.01e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 56 FLVTICTRAVTRCISIFFVEF-QTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSF 134
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 135 ATSLKHLYLtLGVLTGLGFALCYSPAIAMVGKYFSR-RKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGF 213
Cdd:pfam07690 82 ASSLWLLLV-LRVLQGLGAGALFPAALALIADWFPPeERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 214 VLNLCVCGALMRPITLKedhttpeqnhvcrtqKEDIKRVSPYSSLTKEWaqtclccclqqeySFLLMSDFVVLAVSVLFM 293
Cdd:pfam07690 161 SLLAAVLLLLPRPPPES---------------KRPKPAEEARLSLIVAW-------------KALLRDPVLWLLLALLLF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 294 AYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMdGLCYLCLPMLQSL 373
Cdd:pfam07690 213 GFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA-ALGLLLLSLTLSS 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1034568216 374 PLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSP 426
Cdd:pfam07690 292 LWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
56-457 |
2.38e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 95.57 E-value: 2.38e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 56 FLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFA 135
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 136 TSLKHLYLTLgVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQ--FSWRGALLILGG 212
Cdd:cd06174 82 PSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 213 FVLNLCVCGALMRPiTLKEDHTTPEQNHVCRTQKEDIKRVspyssltkewaqtclccclqqeysfLLMSDFVVLAVSVLF 292
Cdd:cd06174 161 LALLAAILLLLVVP-DPPESARAKNEEASSKSVLKLLKRV-------------------------LKNPGLWLLLLAIFL 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 293 MAYGCSPLFVYLVPYALS-VGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYqyvCYLFAVGMDGLCYLCLPMLQ 371
Cdd:cd06174 215 VNLAYYSFSTLLPLFLLDlGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP---LLLIGLLLMALGLALLLLAP 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 372 SLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMI 451
Cdd:cd06174 292 SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLL 371
|
....*.
gi 1034568216 452 FSSVLL 457
Cdd:cd06174 372 LAAILL 377
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
86-459 |
4.05e-19 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 89.09 E-value: 4.05e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 86 QTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVG 165
Cdd:cd17465 44 KTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 166 KYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLnlcvcgalmrpitlkedhttpeqnhvcrtq 245
Cdd:cd17465 124 HYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIGLAHTFQVLSLFMF------------------------------ 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 246 kedikrVSPYSSLTkewaqtclccclqqeYSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSIL 325
Cdd:cd17465 174 ------IQIFLSLT---------------YKVFRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCI 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 326 GVIDIIGNITFGWLTDR--RCLKNYQYVCYLFAVgmdGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVG 403
Cdd:cd17465 233 GASSGIGRLMSGKIGDLipGLKKIYLQVASFLLL---GIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVG 309
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034568216 404 TTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGF 459
Cdd:cd17465 310 PMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFF 365
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
49-459 |
2.25e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 83.39 E-value: 2.25e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 49 WMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTG 128
Cdd:cd17319 2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 129 LILSSFATSLKHLYLtLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 207
Cdd:cd17319 82 TALTGFATSLTSLYV-LRFLLGVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 208 LILGGFvlnlcvcGALMRPITlkedhttpeqnhvcrtqkedikrvspyssltkewaqtclccclqqeysFLLMSDFVVLA 287
Cdd:cd17319 161 IIEGLL-------GLLLAVLW------------------------------------------------WFYLRQVWGLA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 288 VSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYL-FAVGMDGLcyL 365
Cdd:cd17319 186 LGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIgLLLAAVGL--L 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 366 CLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFLL 445
Cdd:cd17319 264 LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLF 343
|
410
....*....|....
gi 1034568216 446 CGFSMIFSSVLLGF 459
Cdd:cd17319 344 LAAVALLAALLVLL 357
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
99-461 |
1.11e-15 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 78.77 E-value: 1.11e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 99 MLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLtLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYG 177
Cdd:cd17325 45 LLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL-ARFLQGLASAAVWPAAMALIADIApPEERGRAMG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 178 IAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLnlcvCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVspyss 257
Cdd:cd17325 124 IFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL----LALVLALLLLPEPRPPPNKRAVSAARLRSGLRL----- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 258 ltkewaqtclccclqqeysFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITF 336
Cdd:cd17325 195 -------------------LLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 337 GWLTDRRCLKnyqyvcYLFAVGM--DGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVV 414
Cdd:cd17325 256 GKLSDRIGRK------PLILIGLllSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1034568216 415 YFLHAVPYLVSPPIAGRLVDTTGsYTAAFLLCGFSMIFSSVLLGFAR 461
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
120-457 |
2.87e-12 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 68.03 E-value: 2.87e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 120 LGGLLASTGLILSSFATSLKHLYLTLgVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLI 198
Cdd:cd17475 66 VGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGSVQPGGGRAIMRWFPpRERGLAMGIRQTGVPLGGALAAALLPPLA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 199 EQFSWRGALLILGGfvlnLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRVspyssltkewaqtclccclqqeysfL 278
Cdd:cd17475 145 LHYGWRAAFVVAGL----VSILAAVLFWLFYREPPAASAATESASTLLRSLKEV-------------------------L 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 279 LMSDFVVLAVSVLFMAYGCSPLFVYLVPYALS-VGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQ--YVCYLF 355
Cdd:cd17475 196 RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRpvLVITAA 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 356 AVGMDGLCYLCLPMLQSLPLLVPFSCTFGYF----DGAYVTLIpvvtTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGR 431
Cdd:cd17475 276 IAAAALLVLSLLSPGTPLWLLVLLLILLGLFaigwNGLYLTLV----AESAGPEQAGTALGLANTINFIGIAIGPPLFGL 351
|
330 340
....*....|....*....|....*.
gi 1034568216 432 LVDTTGSYTAAFLLCGFSMIFSSVLL 457
Cdd:cd17475 352 LVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
89-461 |
3.89e-11 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 64.52 E-value: 3.89e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 89 WIHSIVDCVTMLCAPLGSVVSNHLScQVGIMLGGLLAST-GLILSSFATSLKHLYLTLGVLtGLGFALCYSPAIAMVGKY 167
Cdd:cd17473 39 LLLTLPALFIALFAPLAGWLADRFG-RKRLLIAGLLLYGiGGVAGLFLDSLYALLASRALL-GIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 168 FS---RRKALAY-GIAMSGSGIgtfILAPVVQLLIEqFSWRGALLI-LGGFVLNLCVCGALMRPitlKEDHTTPEQNHVC 242
Cdd:cd17473 117 FEgeeRAKMLGLqSAAMSLGGV---VFLLLGGALAE-IGWRAPFLVyLLALPVLILVLLFLPEP---ARKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 243 RTQKEDIKRVSPYSsltkewaqtclccclqqeysfllmsdFVVLAVSVLFMAygcspLFVYLVPYALSVG-VSHQQAAFL 321
Cdd:cd17473 190 TAAALPWKRVLPIY--------------------------FLAFLAMLLFYV-----IPIQLPFLLQERGgGSAALIGLA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 322 MSILGVIDIIGNITFGWLTDRRCLKNyqyvCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEI 401
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRR----LLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSL 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034568216 402 VGTTSLSSALGVV---YFLHAvpyLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLLGFAR 461
Cdd:cd17473 315 VPPELRGRAMGIVtsaFFLGQ---FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
76-470 |
1.56e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.87 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 76 FQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLkHLYLTLGVLTGLGFAL 155
Cdd:COG0738 34 LKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY-PLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 156 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ---FSWRGALLILGGFVLnlcVCGALMRPITLKED 232
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLL---LLALLFLRSKLPEI 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 233 HTTPEQNHVCRTQKEDIKRVSPyssltkewaqtclccclqqeysFLLMSDFVVLAVSVLFMAYGCSPLFVylvpyALSVG 312
Cdd:COG0738 190 EEEEEEAAGSAASLKSLLKNPR----------------------LLLGGLAIFLYVGAEGAIGDWLPLYL-----KDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 313 VSHQQAAFLMSILGVIDIIGNITFGWLTDRRclkNYQYVCYLFAVGMdGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVT 392
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRF---GPVRLLRLSALLA-AVGLLLALLAPGPWLALIGLALVGLGLSLMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034568216 393 LIPVVTTEIVGTTSlSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTAAFLLcgfSMIFSSVLLGFARLIKRMRKTQ 470
Cdd:COG0738 319 TIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLADAFG-LRAAFLV---PLVCYLLILLLALALKRKRRKK 391
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
80-459 |
6.68e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 80 FTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLyLTLGVLTGLGFALCYSP 159
Cdd:cd17474 29 LGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALL-LAGRALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 160 AIAMVGKYFS---RRKALAYGIAMSGSGIGTFilaPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHTTP 236
Cdd:cd17474 108 ALTLIGDLFEggeRAKAMGLYEAALGLGIAVG---PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 237 EqnhvcrtqkedIKRVSPYSSLTKEWaqtclccclqqeysfllmsdFVVLAVSVLFMAYGCSPLFVYL-VPYALSVGVSH 315
Cdd:cd17474 185 A-----------TKLRDLKKALRGRG--------------------LLTFLVSAFLYFFLYFAFLTYLpFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 316 QQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyQYVCYLFAVGMdGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIP 395
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRFGA--RRILVIGLLLY-ALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLT 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568216 396 VVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTAAFLLCGFSMIFSSVLLGF 459
Cdd:cd17474 311 TLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG-LSAPFLVGAAIALAAAVLLAL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
85-384 |
6.98e-09 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 57.56 E-value: 6.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 85 AQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLyLTLGVLTGLGFALCYSPAIAMV 164
Cdd:cd17324 34 AQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALL-LLARALAGLAHGGFWAIAAAYA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 165 GKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGgfVLNLCVCGALMRpitlkedhTTPEQNHVCR 243
Cdd:cd17324 113 ADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA--VLALLAALLLWR--------LLPSLPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 244 TQKEDIKRvspyssltkewaqtclccclqqeYSFLLMSDFVVLAVSVLFMAYGC-SPLFVYLVPYALSV-GVSHQQAAFL 321
Cdd:cd17324 183 GSLGLLSS-----------------------LLLLLRNPRLRLAYLITFLLFGGfFALYTYLAPFLTDVpGFSSSAIIGL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034568216 322 MSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFG 384
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF 302
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
34-433 |
1.39e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 56.98 E-value: 1.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 34 VNRARSTSPPDGGWgWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFTQDYAQTAWIHSIvdcvTMLCAPLGSVVSNHLS 113
Cdd:TIGR00895 2 VQNNIRKQPLSRYQ-WRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSA----GLIGMAFGALFFGPLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 114 CQVG---IMLGG-LLASTGLILSSFATSLKHLyLTLGVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTF 188
Cdd:TIGR00895 77 DRIGrrrVLLWSiLLFSVFTLLCALATNVTQL-LILRFLAGLGLGGLMPNLNALVSEYAPkRFRGTAVGLMFCGYPIGAA 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 189 ILAPVVQLLIEQFSWRGALLIlgGFVLNLCVCGALMRPITLKEDHT---TPEQNHVCRTQKEDIKRVSPYSSLTKEWAQT 265
Cdd:TIGR00895 156 VGGFLAGWLIPVFGWRSLFYV--GGIAPLLLLLLLMRFLPESIDFLvskRPETVRRIVNAIAPQMQAEAQSALPEQKSTQ 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 266 clccclQQEYSF--LLMSDFVVLAVSVLFMAYGCSPLFVYLV----PYALS-VGVSHQQAAFLMSILGVIDIIGNITFGW 338
Cdd:TIGR00895 234 ------GTKRSVfkALFQGKTARITVLLWLLYFMLLVGVYFLtnwlPKLMVeLGFSLSLAATGGALFNFGGVIGSIIFGW 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 339 LTDRRCLKNYQYVCYLFAVgmdgLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLH 418
Cdd:TIGR00895 308 LADRLGPRVTALLLLLGAV----FAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIG 383
|
410
....*....|....*
gi 1034568216 419 AVPYLVSPPIAGRLV 433
Cdd:TIGR00895 384 RLGAIIGPILAGYLL 398
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
76-457 |
1.42e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.80 E-value: 1.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 76 FQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLkHLYLTLGVLTGLGFAL 155
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNY-WLLLLLVALAGIGSAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 156 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGtFILAPVVQLLIEQFSWRGALLILGGFVLnlcVCGALMrpitlkedhtt 235
Cdd:cd17478 101 FHPEGARLASQAAGGRRGLAMSIFSVGGNLG-FALGPLIAAALVALFGGLGLLILLIIPG---LAVALL----------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 236 peqnhvCRTQKEDIKRVSPYSSLTKEWAQTclcccLQQEYSFLLMSDFVVLAVSVLFMAygcspLFVYLVPYALSVGVSH 315
Cdd:cd17478 166 ------LLRLRPLKKPEAKKAAAKSSARST-----LKGVWRALLLLLIIVFLRSWVLSS-----LTTFLPFYLVQRGYSL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 316 QQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMDGLCylclpMLQSLPLLVPFSCTFGYFDGAYVTLIP 395
Cdd:cd17478 230 VFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF-----LLTPGIWSYILLVLAGFLLFASFPVTV 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034568216 396 VVTTEIV-GTTSLSSAL--GVVYFLHAvpylVSPPIAGRLVDTTGsYTAAFLLCGFSMIFSSVLL 457
Cdd:cd17478 305 VLAQELLpGNVGLASGLmmGLSFGLGG----IGAPVLGALADAFG-LESVLLILALLPLLGALLA 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
286-461 |
2.70e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 55.50 E-value: 2.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 286 LAVSVLFMAYGCSPLFVYLVPY-ALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKnyqyVCYLFAVGMDGLCY 364
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLlAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR----RVLLIGLLLFALGL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 365 LCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTAAFL 444
Cdd:pfam07690 77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFL 155
|
170
....*....|....*..
gi 1034568216 445 LCGFSMIFSSVLLGFAR 461
Cdd:pfam07690 156 ILAILSLLAAVLLLLPR 172
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
284-461 |
3.30e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 3.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 284 VVLAVSVLFMAYGCspLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYqyvcYLFAVGMDGLC 363
Cdd:cd17325 1 LSLALFLDMLGYGI--IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRL----LLLGLLLLAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 364 YLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTAAF 443
Cdd:cd17325 75 TLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPF 153
|
170
....*....|....*...
gi 1034568216 444 LLCGFSMIFSSVLLGFAR 461
Cdd:cd17325 154 LVCAALALLALVLALLLL 171
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
283-459 |
7.71e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 54.21 E-value: 7.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 283 FVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYqyvcYLFAVGMDGL 362
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV----LLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 363 CYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTAA 442
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-WRWV 166
|
170
....*....|....*..
gi 1034568216 443 FLLCGFSMIFSSVLLGF 459
Cdd:COG2814 167 FLVNAVLALLALLLLLR 183
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
275-457 |
7.87e-08 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 54.14 E-value: 7.87e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 275 YSFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRclkNYQYVCY 353
Cdd:cd17316 171 LALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLV 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 354 LFAVGMDGLCY-LCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRL 432
Cdd:cd17316 248 IGLILSGILALpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
170 180
....*....|....*....|....*
gi 1034568216 433 VDTTGSYTAAFLLCGFSMIFSSVLL 457
Cdd:cd17316 328 LASTGGTGVPALILALLAIVALIVA 352
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
118-466 |
9.97e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 9.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 118 IMLGGLLASTGLIL----SSFATSLKHLYLTLG-VLTGLGFALCYSPAIAMVGKYFS--RRKALAYGIAMSGSGIGTFIL 190
Cdd:COG2211 84 ILIGAIPLALSFVLlftaPDLSPTGKLIYALVTyLLLGLAYTLVNIPYSALGAELTPdyEERTRLSSWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 191 APVVQLLIEQFS------WRGALLILGGfvlnLCVCGALMRPITLKEDHTTPEQNHvcrTQKEDIKrvspyssltkewaq 264
Cdd:COG2211 164 SVLPPPLVAAFGgdaalgYRLTALIFAV----LGLLAFLLTFFGTKERPVPEEEKV---SLKESLK-------------- 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 265 tclccclqqeySFLLMSDFVVLAVSVLF--MAYGC-SPLFVYLVPYALsvGVSHQQAAFLMSILGVIDIIGNITFGWLTD 341
Cdd:COG2211 223 -----------ALLKNRPFLLLLLAYLLffLALALvAALLLYYFKYVL--GLSAALVGLLLALYFLAALLGAPLWPRLAK 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 342 RRCLKNyqyvCYLFAVGMDGLCYLCLPMLQ--SLPLLVPFSCTFGYFDGAYVTLIPVVTTEIV-------GTTSLSSALG 412
Cdd:COG2211 290 RFGKKK----AFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydewktGRRREGLYFG 365
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034568216 413 VVYFLHAVPYLVSPPIAGRLVD--------------TTGSYTAAFLLCGFSMIFSSVLLGFARLIKRM 466
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLLLAlfgyvagaaqspsaLTGIRLLFFLLPAVLLLLAALLLLFYPLTRER 433
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
76-462 |
1.04e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 53.86 E-value: 1.04e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 76 FQTYFTQDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKhLYLTLGVLTGLGFAL 155
Cdd:cd17333 22 LEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIY-LFVVLMFLAGLGAGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 156 CYSPAIAMVGKYFSRRKALAYGIAMSGSGIGTFILAPVVQLLIEQ-FSWRGALLILGGFVLNLCVCgaLMRPITLKEDHT 234
Cdd:cd17333 101 LDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAIL--ILLTLFPELPSA 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 235 tpeQNHVCRTQKEdikrvsPYSSLTKEWaqtclccclqqeysfllmSDFVVLAVSVLFMAYGCSPLFVYLVP-YAL-SVG 312
Cdd:cd17333 179 ---RNPQQSVGAF------SASASRLLR------------------NPSIILGALALFLYVGAETAFSSWVPsYLVeKKH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 313 VSHQQAAFLMSILGVIDIIGNITFGWLTDRrclknYQYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTF-GYFDGAYV 391
Cdd:cd17333 232 VSDGLAGYLLSGFWVGITIGRLLGGPISRR-----IKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALlGLFMAALF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034568216 392 TLIPVVTTEIVGTTSlSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAafLLCGfsMIFSSVLLGFARL 462
Cdd:cd17333 307 PTILSLGISNLPYAK-GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTA--MLLI--TILYAIIFVLALL 372
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
284-457 |
3.73e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.16 E-value: 3.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 284 VVLAVSVLFMAYGCSPLFVYlvpYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVgmdgLC 363
Cdd:cd17370 205 YLLAVALFALGNFSFAFLIL---RAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLA----LA 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 364 YLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTgSYTAAF 443
Cdd:cd17370 278 YLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI-SPSAAF 356
|
170
....*....|....
gi 1034568216 444 LLCGFSMIFSSVLL 457
Cdd:cd17370 357 LFSAVLALIALLLL 370
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
85-447 |
5.98e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 51.43 E-value: 5.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 85 AQTAWIHSIvdcvTMLCAPLGSVVSNHLSCQVG----IMLGGLLASTGLILSSFATSLKHLYLtLGVLTGLGFALCYSPA 160
Cdd:cd17365 34 AQLGPVGSA----ALFGMAIGALLAGPLADRFGrkrvLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 161 IAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLnlcVCGALMRpITLKedhttpeqn 239
Cdd:cd17365 109 ITLVSEYAPaRRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPL---ILLPLLR-GTLL--------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 240 hvcrtqkedikrvspyssltkewaqtcLCCClqqeySFLlmsdfvvlavsVLFMAYGcspLFVYLvPYAL-SVGVSHQQA 318
Cdd:cd17365 176 ---------------------------LWVT-----FFM-----------GLLLVYL---LNSWL-PKLMvEAGYSLSQA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 319 AFLMSILGVIDIIGNITFGWLTDRRCLKNyqyVCYLFAVGMdGLCYLCLPM-LQSLPLLVPFSCTFGYFDGAYVTLIPVV 397
Cdd:cd17365 209 LTITLLLNIGGVIGSLLLGWLADRFGPKR---VLALFFALG-AVSLALLGVsPASLVLLYVLVFLAGACVNGAQVGLYAL 284
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1034568216 398 TTEIVGT----TSLSSALGVVyFLHAVpylVSPPIAGRLVDTTGSYTAAFLLCG 447
Cdd:cd17365 285 AARFYPTevraTGVGWALGVG-RLGAI---LGPLLGGLLLAAGLGPESVFLALA 334
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
69-215 |
7.18e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.97 E-value: 7.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 69 ISIFFVEFQTYFTQDYAQTAWIHSivdcVTMLCAPLGSVVSNHLSCQVG----IMLGGLLASTGLILSSFATSLKHLYLt 144
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVS----AYLLGRAIGLLLFGRLGDRYGrkrvLLIGLLLFGLASLLCGLAPSPELLIA- 107
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034568216 145 LGVLTGLGFALCYSPAIAMVGKYFS-RRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVL 215
Cdd:COG0477 108 ARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
119-462 |
7.32e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 48.07 E-value: 7.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 119 MLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIAMVGKYFSR-RKALAYGIAMSGSGIGTFILAPVVQ-L 196
Cdd:cd06180 67 IRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHATAaGRGHLIGLLFAGVGLGIALSGLLVPaG 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 197 LIEQFSWRGALLILGGFVLNLCVCGALMRPiTLKEDHTTPEQNHVCRTQkedikrvspyssltkewaqtclccclqqeys 276
Cdd:cd06180 147 LGGGLSWRAGWLALALLSAVLLLLSFLLLR-RGPSAPTEASAAESAPGL------------------------------- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 277 fllmsdfvVLAVSVLFMAYGCSPL-----FVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNyqyv 351
Cdd:cd06180 195 --------NRPLWRLALAYGLFGFgyiitATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGALSDRWGTRR---- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 352 CYLFAVGMDGLCYLcLPMLQSLPLLVPFSCtFGYfdGAYVTLIPVVTTEIVGTTSLSS---ALGVVYFLHAVPYLVSPPI 428
Cdd:cd06180 263 ALAANLLVQAVGVL-LPLLSPGPAGLVLSA-VLF--GGTFMAITALVMALARELAPPAaprALALMTASFGVGQILGPLL 338
|
330 340 350
....*....|....*....|....*....|....
gi 1034568216 429 AGRLVDTTGSYTAAfLLCGFSMIFSSVLLGFARL 462
Cdd:cd06180 339 AGWLADATGGFAPA-LILAAAALVVAALLALLVL 371
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
119-457 |
9.32e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.65 E-value: 9.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 119 MLGGLLASTGL-ILSSFATSLkHLYLTLGVLTGLGFALCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIGTFILAPVVQL 196
Cdd:cd17312 71 MSAGLLLSALAnIFMGFSTSL-WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKErGTVYGIWSTSHNFGGILAPILAAS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 197 LIEQFSWRGALLILGgfvlnlcVCGALMRPITLKEDHTTPeqnhvcrtqkedikrvsPYssltkewaqtclccclqqeys 276
Cdd:cd17312 150 LASYYGWRAAFLVPG-------IVGLVVAIILFFFLRDSP-----------------PY--------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 277 fllmsdFVVLAVSVLFMaYGCSPLFVYLVPYALS--VGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKNYQYVCYL 354
Cdd:cd17312 185 ------VWVLSLAYAFV-YIVRYACLDWGPLYLYevKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 355 FAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGT-TSLSSALGVVYFLHAVPYLVSPPIAGRLV 433
Cdd:cd17312 258 YMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRkEAAGTATGFVGLFGYLGASLAGLPLGYII 337
|
330 340
....*....|....*....|....
gi 1034568216 434 DTTGSYTaAFLLCGFSMIFSSVLL 457
Cdd:cd17312 338 DHYGWST-VFYFLISAALLSVLLL 360
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
100-460 |
8.41e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 44.87 E-value: 8.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 100 LCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLGVLTGLGFALCYSPAIamVGKYFSRRKAL---AY 176
Cdd:cd17339 49 VFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGGIALLFLGTALAGAGIAVGNVLLPSL--IKRDFPRRVGLmtgLY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 177 GIAMS-GSGIGTFILAPVVQLLieQFSWRGALLILGGFVLnlcVCGALMRPITLKEDHTTPEQnhvcrtqkEDIKRVSPY 255
Cdd:cd17339 127 TTSMNlGAALASGLSVPLAQAL--GGGWRGALAIWALPAL---LALLIWLPQLRRRKRAAAAA--------APLTKISVW 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 256 SSltkewaqtclccclqqeysfllmsdfvVLAVSV-LFMayGCSPLFVY-----LVPYALSVGVSHQQAAFLMSILGVID 329
Cdd:cd17339 194 RS---------------------------PLAWQVtLFM--GLQSLLFYtlmawLPTILIDAGLSAATAGWLLSLFQLVG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 330 IIGNITFGWLTDRrcLKNYQYVCYLFAVGM-DGLCYLCLPMLQSLPLLVPF-----SCTFGYfdgaYVTLIPVVTTEIVG 403
Cdd:cd17339 245 IPASLLVPILATR--LKNQRPIVVLLAVLFiIGVLGLLFAPTALALLWAVLlglggGAAFSL----ALTLISLRSSDPAE 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034568216 404 TTSLSS-ALGVVYFLHAVpylvSPPIAGRLVDTTGSYTAAFLLcgfsMIFSSVLLGFA 460
Cdd:cd17339 319 AAALSGmAQSVGYLLAAL----GPLLFGVLHDLTGSWTAPLVL----LLALTVLQLVA 368
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
285-456 |
8.70e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 8.70e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 285 VLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRrclKNYQYVCYLFAVGMDGLCY 364
Cdd:cd17477 192 LALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADR---FDRRRVLLGCALLGALAAL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 365 LCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGSYTAAFL 444
Cdd:cd17477 269 LLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLF 348
|
170
....*....|..
gi 1034568216 445 LCGFSMIFSSVL 456
Cdd:cd17477 349 LAAVALLFLLFL 360
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
283-457 |
2.20e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 283 FVVLAVSVLFMAYGcsPLFVYLVPYALSV-GVSHQQAAFLMSILGVIDIIGNITFGWLTDRRclkNYQYVCYLFAVGMdG 361
Cdd:cd06173 212 LLLLALALFALLGG--ALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRR---RRGRLLLIGALLL-G 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 362 LCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTGsYTA 441
Cdd:cd06173 286 LALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALG-LSA 364
|
170
....*....|....*.
gi 1034568216 442 AFLLCGFSMIFSSVLL 457
Cdd:cd06173 365 VFLLAGALLLLAALLL 380
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
123-460 |
8.74e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 41.52 E-value: 8.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 123 LLASTGLILSSFATSLKHLyLTLGVLTGLGFALCYSPAIAMVGKYF-SRRKALAYGIAMSGSGIG----TFILAPVVQLL 197
Cdd:cd17371 72 LLFAVFTLLCGFAQNYWQL-LILRALAGLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGwllaTLLAALLFPLL 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 198 IEQFSWRGaLLILGGFVLNLCVcgaLMRPiTLKEdhtTPEQNHVCRTQKEDIKRVSPYSSLTKEWAQTCLCCCLqqeysf 277
Cdd:cd17371 151 PPEIAWRV-LFLLGALPALLVL---FIRR-FVKE---PPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASL------ 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 278 llmsdfvvLAVSVLFMAYGCSPLFVYLVPYALSVGVSHQQAAFLMSILGVIdiIGNITFGWLTD----RRCLKNYQYVCY 353
Cdd:cd17371 217 --------LATGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGF--LGYLAGGFLADrigrRNNFALFALGSA 286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 354 LFAvgmdgLCYLCLPMLQSLPLLVPFscTFGYFDGAYVTLIPVVTTEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGRLV 433
Cdd:cd17371 287 ISI-----LLYFFLPLSPTLILILGF--PLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLA 359
|
330 340
....*....|....*....|....*..
gi 1034568216 434 DTTGSYTAAFLLCGFSMIFSSVLLGFA 460
Cdd:cd17371 360 TSGSLGTAIAVFAAVYYIAGLVLALLL 386
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
100-437 |
9.73e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 41.59 E-value: 9.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 100 LCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKH---LYLTLGVLTGLGFALCYSpaiaMVGKYFSRRK-ALA 175
Cdd:TIGR00881 45 ISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVmaaLWALNGIFQGMGWPPCGR----TVTKWFSRSErGTW 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 176 YGIAMSGSGIGTFILAPVVQLLIEQF-SWRGALLILGGFVLNLC-VCGALMRPitlkedhttpeqnhvcRTQKEDIKRVS 253
Cdd:TIGR00881 121 VSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSlICFLLLRD----------------SPQSCGLPPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 254 PYSSLTKEWAQTCLCCCLQQEYSFLlmsDFVVLAVSVLFMAYGcsPLFVYLVPYAL----------SVGVSHQQAAFLMS 323
Cdd:TIGR00881 185 EMPNEEPDGDAEKKEEELTKKQIFL---QYVLLNKVLWYISLG--YVFVYVVRTGIldwsplyltqEKGFSKEKASWAFT 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 324 ILGVIDIIGNITFGWLTDRRCLKNYQYVCYLFAVGMD-GLCYLCLPMLQSLPLLVPFSCTFGYFDGAYVTLIPVVTTEIV 402
Cdd:TIGR00881 260 LYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIvSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIASELA 339
|
330 340 350
....*....|....*....|....*....|....*
gi 1034568216 403 GTTSLSSALGVVYFLHAVPYLVSPPIAGRLVDTTG 437
Cdd:TIGR00881 340 PKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
72-215 |
1.22e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 72 FFVEFQTYFtqDYAQTAWIHSIVDCVTMLCAPLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKHLYLTLgVLTGL 151
Cdd:cd17324 223 PFLTDVPGF--SSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGL-VLWGL 299
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034568216 152 GFALCYSPAIAMVGKYFSRRKALAYGIAMS----GSGIGTFILApvvqLLIEQFSWRGALLILGGFVL 215
Cdd:cd17324 300 GFFAAHSALQTRVLRLAPEARGLASSLYLAaynlGGALGAALGG----LVLDHGGWAGVGWVGAALLL 363
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
118-459 |
1.88e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 40.69 E-value: 1.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 118 IMLGGLLASTGLILSSFATSLKHLYLTLG-----VLTGLGFAL-------CYSPAIAMVGKYFS---RRKALAYGIAMSG 182
Cdd:cd17313 72 ILVGAPLAALGLILIPNAADIGLALGDGPrtwalVLFVLGIVLldfamnvCQGPVRALLPDLVPpeqRSKANGIINFMGG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 183 SG--IGTFILApVVQLLIEQFSWRGALL----ILGGFVLNLCVCGALmrpITLKEDHTTPEQnHVCRTQKEDIKRVSPYS 256
Cdd:cd17313 152 LGgvLGYLLGA-ILWDHNWFGFALGGNLkvpfYIGAIILLVCVLVTL---FFVKEPPLSPEA-GEHSENPSLGEVLKSLL 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 257 SLTKEWAQTCLCCCLQQEYSFllMSDFVVLAVSVLFMAYGcspLFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITF 336
Cdd:cd17313 227 KLLKIMPRSLLRLLLVIFFWW--IAFFPFELFFTDYMGEE---VYHGTSAASSHYGAGVRMGAWGLLIFSLAFLIFSLPI 301
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 337 GWLTDRRCLKnyqyVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFGYFDGA-YVTLIPVVTTEIVGTT-SLSSALGVV 414
Cdd:cd17313 302 GKLGKKIGRK----KVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATiNINPYPLVSDYHSESGrGQGTDTGLL 377
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1034568216 415 YFLHAVPYLVSPPIAGRLVDTTGsYTAAFLLCGFSMIFSSVLLGF 459
Cdd:cd17313 378 NLAISLAQILVSLLAGPIIDVKG-YGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_NIMT_like |
cd17409 |
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of ... |
103-446 |
3.90e-03 |
|
2-nitroimidazole transporter and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli 2-nitroimidazole transporter (NIMT), also called YeaN, and similar proteins. NIMT confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. The NIMT-like subfamily belongs to the 2-nitroimidazole and cyanate transporters like (NIMT/CynX-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340967 [Multi-domain] Cd Length: 374 Bit Score: 39.56 E-value: 3.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 103 PLGSVVSNHLSCQVGIMLGGLLASTGLILSSFATSLKhLYLTLGVLtGLGFALCYSPAIAMVGKYFSRRKAL---AYGIA 179
Cdd:cd17409 52 PLAAKLARRYGLERSLFAALLLIAAGIALRSTGSVWA-LYLGTAII-GAGIAIGNVLLPSLLKRDFPARVATltgAYALT 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 180 MS-GSGIGTFILAPVVQllIEQFSWRGALLILggFVLNLcVCGALMRPITlkEDHTTPEQNHVCRTQKEDIKRvspySSL 258
Cdd:cd17409 130 MGvGAALGSALVVPLAQ--VLAFGWQLALGAF--LVFPL-VAALIWLPQL--RRHTSPAADTAKPPHGGSVWR----SPL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 259 TkeWAQTclccclqqeysfllmsdfvvlavsvLFMAYGCsplFVYLV-----PYAL-SVGVSHQQAAFLMSILGVIDIIG 332
Cdd:cd17409 199 A--WQVT-------------------------LFLGLNS---FIYYVlvgwlPSILtDAGYSAAQAGSLHGLLQLATAVP 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 333 NITFG----WLTDRRCLKnyQYVCYLFAVGMDGLCYLclPMLQSLpllvpFSCTFGYFDGAYVTL----IPVVTTEIVGT 404
Cdd:cd17409 249 GLLLIpvlaRMKDQRLLA--VLVSLLGAVGLIGLLLA--PSLAIL-----WVILFGFGSGAGFILglafIGLRTSSAHQA 319
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1034568216 405 TSLSS-ALGVVYFLHAVpylvSPPIAGRLVDTTGSYTAAFLLC 446
Cdd:cd17409 320 AALSGmAQCVGYLLAAT----GPMLVGALHDLTGSWSVPLLLC 358
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
118-457 |
7.97e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 38.71 E-value: 7.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 118 IMLGGL----LASTGLILSSFATSLkhlyLTLGVLTGLGFALCYSPAIAMVGKYFSRRK-ALAYGIAMSGSGIgTFILAP 192
Cdd:cd17320 66 VLLAGLllfiLASLLCALASSIEQL----LIARFLQGLGAAAGSVVARAIVRDLYSGAElAKIFSLLMMILAI-APALAP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 193 VV-QLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDHTTPEQNHVCRTQKEDIKRvspyssltkewaqtclcccl 271
Cdd:cd17320 141 LLgGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKN-------------------- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 272 qqeySFLLMSDFVVLAVSVLFMAY-GCSPlFVYLVPYalsvGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKN--Y 348
Cdd:cd17320 201 ----RRFLGYALALGLSFAGLFAYlAAAP-FIYIEQL----GLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRllR 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 349 QYVCYLFAVGMDGLCYLCLPMLQSLPLLVPFSCTFgyfdGAYVTLIPVVTT-------EIVGTTslSSALGVVYFLHAVp 421
Cdd:cd17320 272 LGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIF----FGFGLIFPNATSlalepfpHVAGTA--SALLGFLQFLIGA- 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 1034568216 422 yLVSPPIAGRLVDTTGSYTAAFLLCGFSMIFSSVLL 457
Cdd:cd17320 345 -LAGALVGLLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
116-215 |
8.25e-03 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 38.39 E-value: 8.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568216 116 VGIMLGGLLASTGLILSSFATSLKHlYLTLGVLTGLGFALcYSPAIAMVGKYFSRRK-----ALAYGIAMSGSGIGTFIL 190
Cdd:cd17341 66 VFIASLLLLLIPLLALALAVSSYWG-LLVLGFLLGFAGAN-FASGQPWASFWFPKEKiggaaGGIAGAGNMGVAVSQLLA 143
|
90 100
....*....|....*....|....*...
gi 1034568216 191 APVVQLLIEQ---FSWRGALLILGGFVL 215
Cdd:cd17341 144 PLIAGAIVFDggfVGWRNAFFVPGILLA 171
|
|
| |
