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Conserved domains on  [gi|1034568326|ref|XP_016871765|]
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leucine-rich repeat-containing protein 18 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886   196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886   196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-188 1.14e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 1.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  49 LSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYI-DKLPESIGQMTSLLYLNVSNNRLTSnGLPVELKQLKNIRAV 126
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWI 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568326 127 NLGLNHLD-SVPTTLGALKELHEVGL-HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:PLN00113  218 YLGYNNLSgEIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF 281
LRR_8 pfam13855
Leucine rich repeat;
54-108 6.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034568326  54 ELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-198 1.92e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  55 LDLSRNLIRKIpDSISKFQNLRWLDLHSNYIDKL----------------------------PESI-GQMTSLLYLNVSN 105
Cdd:cd21340    51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLaALSNSLRVLNISG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 106 NRLTSnglPVELKQLKNIRAVNLGLNHLDSvpttlgaLKELHEVglhdnllnnipvsISKLPKLKKLNIKRNPF---PKP 182
Cdd:cd21340   130 NNIDS---LEPLAPLRNLEQLDASNNQISD-------LEELLDL-------------LSSWPSLRELDLTGNPVckkPKY 186

                         170
                  ....*....|....*.
gi 1034568326 183 GESeiFIDSIRRLENL 198
Cdd:cd21340   187 RDK--IILASKSLEVL 200
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 1.93e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.56  E-value: 1.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886   116 ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 110 SngLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886   196 D--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-179 6.56e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 6.56e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886   139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 110 SngLPVELKQLKNIRAVNLGLNHLDSVPtTLGALKELHEVGLHDNLLNNIPvSISKLPKLKKLNIKRNPF 179
Cdd:COG4886   219 D--LPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-179 2.07e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 2.07e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  46 ILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSngLPVELKQLKNIRA 125
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTD--LPEELGNLTNLKE 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034568326 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPF 179
Cdd:COG4886   187 LDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-177 6.03e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 91.15  E-value: 6.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  46 ILRLSDMDELDLSRNlirkipDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRLTSngLPVELKQLKNIRA 125
Cdd:COG4886    92 LGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD--LPEPLGNLTNLKS 163

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034568326 126 VNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:COG4886   164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGN 215
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-188 1.14e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 85.28  E-value: 1.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  49 LSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYI-DKLPESIGQMTSLLYLNVSNNRLTSnGLPVELKQLKNIRAV 126
Cdd:PLN00113  139 IPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLvGKIPNSLTNLTSLEFLTLASNQLVG-QIPRELGQMKSLKWI 217

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568326 127 NLGLNHLD-SVPTTLGALKELHEVGL-HDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:PLN00113  218 YLGYNNLSgEIPYEIGGLTSLNHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF 281
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-192 1.27e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.27e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPEsIGQMTSLLYLNVSNNRLT 109
Cdd:COG4886   185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLT 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 110 SngLPvELKQLKNIRAVNLGLNHLDSVP-TTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGESEIF 188
Cdd:COG4886   264 D--LP-PLANLTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340


                  ....
gi 1034568326 189 IDSI 192
Cdd:COG4886   341 ALSL 344
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
19-224 9.41e-11

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.64  E-value: 9.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  19 RNCIKitfDGKKRLDLSKMGITTFPKCILRlsDMDELDLSRNLIRKIPDSISKfqNLRWLDLHSNYIDKLPE----SIGQ 94
Cdd:PRK15370  173 RDCLK---NNKTELRLKILGLTTIPACIPE--QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPAtlpdTIQE 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  95 M---------------TSLLYLNVSNNRLTS--NGLPVELKQL----KNIRAVNL----GLNHLDSVPTTLGALKELHEV 149
Cdd:PRK15370  246 MelsinritelperlpSALQSLDLFHNKISClpENLPEELRYLsvydNSIRTLPAhlpsGITHLNVQSNSLTALPETLPP 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 150 GLH-----DNLLNNIPVSISklPKLKKLNIKRNP---FPK---PGESEIFIDsirrlENLYVVEEKDLCAAcLRKCQNAR 218
Cdd:PRK15370  326 GLKtleagENALTSLPASLP--PELQVLDVSKNQitvLPEtlpPTITTLDVS-----RNALTNLPENLPAA-LQIMQASR 397


                  ....*.
gi 1034568326 219 DNLNRI 224
Cdd:PRK15370  398 NNLVRL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-139 5.75e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 5.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGIT-TFPKCILRLSDMDELDLSRNLIR-KIPDSISKFQNLRWLDL-HSNYIDKLPESIGQMTSLLYLNVSNN 106
Cdd:PLN00113  478 ENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQN 557

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1034568326 107 RLtSNGLPVELKQLKNIRAVNLGLNHLD-SVPTT 139
Cdd:PLN00113  558 QL-SGEIPKNLGNVESLVQVNISHNHLHgSLPST 590
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-177 7.62e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 7.62e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  32 LDLSKMGITTFPKCILRLSDMDELDLSRNLIRKIPDSISKFQNLRWLDLHSNYIDKLPESIGQMTSLLYLNVSNNRltsn 111
Cdd:COG4886    32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE---- 107

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034568326 112 glpvELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:COG4886   108 ----ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNN 169
PLN03150 PLN03150
hypothetical protein; Provisional
 52-167 1.65e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  52 MDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYID-KLPESIGQMTSLLYLNVSNNRLtsNGlpvelkqlkniravnlg 129
Cdd:PLN03150  420 IDGLGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSF--NG----------------- 480

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034568326 130 lnhldSVPTTLGALKELHEVGLHDNLLN-NIPVSISKLP 167
Cdd:PLN03150  481 -----SIPESLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
PLN03150 PLN03150
hypothetical protein; Provisional
 26-117 1.74e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  26 FDGKKR------LDLSKMGITTF-PKCILRLSDMDELDLSRNLIR-KIPDSISKFQNLRWLDLHSNYID-KLPESIGQMT 96
Cdd:PLN03150  411 FDSTKGkwfidgLGLDNQGLRGFiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLT 490

                          90       100
                  ....*....|....*....|.
gi 1034568326  97 SLLYLNVSNNRLtSNGLPVEL 117
Cdd:PLN03150  491 SLRILNLNGNSL-SGRVPAAL 510
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-198 9.54e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.46  E-value: 9.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  43 PKCILRLSDMDELDLSRN-LIRKIPDSISKFQNLRWLDLHSN-YIDKLPESIGQMTSLLYLNVSNNRLtSNGLPVELKQL 120
Cdd:PLN00113  277 PPSIFSLQKLISLDLSDNsLSGEIPELVIQLQNLEILHLFSNnFTGKIPVALTSLPRLQVLQLWSNKF-SGEIPKNLGKH 355

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 121 KNIRAVNLGLNHL-------------------------DSVPTTLGALKELHEVGLHDN--------------------- 154
Cdd:PLN00113  356 NNLTVLDLSTNNLtgeipeglcssgnlfklilfsnsleGEIPKSLGACRSLRRVRLQDNsfsgelpseftklplvyfldi 435

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034568326 155 ----LLNNIPVSISKLPKLKKLNIKRNPFpkPGESEIFIDSiRRLENL 198
Cdd:PLN00113  436 snnnLQGRINSRKWDMPSLQMLSLARNKF--FGGLPDSFGS-KRLENL 480
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-179 3.91e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 3.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  50 SDMDELDLS-RNLIRKIPDSISKFQNLRWLDLHSNYID-KLPESIGQMT-SLLYLNVSNNRLTSnglPVELKQLKNIRAV 126
Cdd:PLN00113   69 SRVVSIDLSgKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTG---SIPRGSIPNLETL 145

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034568326 127 NLGLNHLD-SVPTTLGALKELHEVGLHDN-LLNNIPVSISKLPKLKKLNIKRNPF 179
Cdd:PLN00113  146 DLSNNMLSgEIPNDIGSFSSLKVLDLGGNvLVGKIPNSLTNLTSLEFLTLASNQL 200
LRR_8 pfam13855
Leucine rich repeat;
54-108 6.90e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034568326  54 ELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRL 108
Cdd:pfam13855   5 SLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-177 2.60e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  55 LDLSRN-LIRKIPDSiSKFQNLRWLDLHSNYIDK-LPESIGQMTSLLYLNVSNNRLTSNgLPVELKQLKNIraVNLGLNH 132
Cdd:PLN00113  457 LSLARNkFFGGLPDS-FGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLSGE-IPDELSSCKKL--VSLDLSH 532

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034568326 133 ldsvpttlgalkelhevglhDNLLNNIPVSISKLPKLKKLNIKRN 177
Cdd:PLN00113  533 --------------------NQLSGQIPASFSEMPVLSQLDLSQN 557
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-198 1.92e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  55 LDLSRNLIRKIpDSISKFQNLRWLDLHSNYIDKL----------------------------PESI-GQMTSLLYLNVSN 105
Cdd:cd21340    51 LYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVeglenltnleelhienqrlppgekltfdPRSLaALSNSLRVLNISG 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 106 NRLTSnglPVELKQLKNIRAVNLGLNHLDSvpttlgaLKELHEVglhdnllnnipvsISKLPKLKKLNIKRNPF---PKP 182
Cdd:cd21340   130 NNIDS---LEPLAPLRNLEQLDASNNQISD-------LEELLDL-------------LSSWPSLRELDLTGNPVckkPKY 186

                         170
                  ....*....|....*.
gi 1034568326 183 GESeiFIDSIRRLENL 198
Cdd:cd21340   187 RDK--IILASKSLEVL 200
LRR_8 pfam13855
Leucine rich repeat;
73-133 2.35e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 2.35e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034568326  73 QNLRWLDLHSNYIDKL-PESIGQMTSLLYLNVSNNRLTSNGlPVELKQLKNIRAVNLGLNHL 133
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
19-206 2.83e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  19 RNCIKitfDGKKRLDLSKMGITTFPKCI------LRLSD------------MDELDLSRNLIRKIPDSISKFQNLRWLDL 80
Cdd:PRK15387  196 RACLN---NGNAVLNVGESGLTTLPDCLpahittLVIPDnnltslpalppeLRTLEVSGNQLTSLPVLPPGLLELSIFSN 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  81 HSNYIDKLPESI-------GQMTSLLYL-------NVSNNRLTSngLPVELKQLKNIRAVNlglNHLDSVPTTLGALKEL 146
Cdd:PRK15387  273 PLTHLPALPSGLcklwifgNQLTSLPVLppglqelSVSDNQLAS--LPALPSELCKLWAYN---NQLTSLPTLPSGLQEL 347

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034568326 147 hevGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPK-PGESEIFIDSIRRLENLYVV--EEKDL 206
Cdd:PRK15387  348 ---SVSDNQLASLPTLPSELYKLWAYNNRLTSLPAlPSGLKELIVSGNRLTSLPVLpsELKEL 407
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-206 4.75e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.07  E-value: 4.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326  30 KRLDLSKMGITTFPKcILRLSDMDELDLSRNLIRKIPDSiSKFQNLRWLDLHSNYI-----DKLPESIGQMTSLLYLNVS 104
Cdd:COG4886   231 ETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLtdlklKELELLLGLNSLLLLLLLL 308

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568326 105 NNRLTSNGLPVELKQLKNIRAVNLGLNHLDSVPTTLGALKELHEVGLHDNLLNNIPVSISKLPKLKKLNIKRNPFPKPGE 184
Cdd:COG4886   309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                         170       180
                  ....*....|....*....|..
gi 1034568326 185 SEIFIDSIRRLENLYVVEEKDL 206
Cdd:COG4886   389 LLLLLLTTTAGVLLLTLALLDA 410
LRR_8 pfam13855
Leucine rich repeat;
30-85 3.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.19  E-value: 3.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034568326  30 KRLDLSKMGITTF-PKCILRLSDMDELDLSRNLIRKI-PDSISKFQNLRWLDLHSNYI 85
Cdd:pfam13855   4 RSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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