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Conserved domains on  [gi|1034569199|ref|XP_016872028|]
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inhibitory synaptic factor 2A isoform X1 [Homo sapiens]

Protein Classification

FAM196 domain-containing protein( domain architecture ID 11238133)

FAM196 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FAM196 pfam15265
FAM196 family; This protein family is a domain of unknown function. This family of proteins is ...
1-479 0e+00

FAM196 family; This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.


:

Pssm-ID: 464603 [Multi-domain]  Cd Length: 491  Bit Score: 751.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199   1 MVSKDTGKCIL--TTSESEVEPAACLalEMKYALDPNRQ-IKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKP 77
Cdd:pfam15265   1 MVSKEVRPCLLkrNSLESDVEPAASL--EMKYALDPNRQpIKKRNKALQVRFKDICEAQNEQRDAELDAAQDPALKGKKS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199  78 VSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGN-LKSLPAADPFKSQNNGFLTDAKEKNEAGPM 156
Cdd:pfam15265  79 ISYKVAYRKYMTVPARRSIPNVTKSTGVQTSPDLRKHYPTFPLDRKKGTtSKSLAEVPTFKSQNNGFVSDAKDKKDQSSG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 157 EEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPE--PLSYGEAA--LQNSTRPPSEEPDYQLLG-RAKQD 231
Cdd:pfam15265 159 EASVSEKATASTQVPELIHHSNELSNTIDQLSSSNCSEGCPSPDssLLSSESESpcLCLSATSSLEEPNYQSGSvKAKHD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 232 RGRP-NSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCP----ADDERRRATHLNGLQAPSETALA 306
Cdd:pfam15265 239 PELLlPKDDSNPKSKGPLSKTEKATCYLPPSTPSSPGPCAWNSLTQVEWGLCSdspaVSNDRKRLVQLNGLQASTKSAPA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 307 CSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQEL 386
Cdd:pfam15265 319 CSEQTQCQSPECSNSTLQPSSLPREEIQPQSNAVEISEINQQILPHGELCDLKAQLQSMENLISSSQETIKVLLGVIQEL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 387 EKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKT 466
Cdd:pfam15265 399 EKGEALREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLKRLHPAEETQVPPLPYSQEAYTSTPKKKSKT 478
                         490
                  ....*....|...
gi 1034569199 467 ESKKHGRWKLWFL 479
Cdd:pfam15265 479 ESKKHKRWKLWFL 491
 
Name Accession Description Interval E-value
FAM196 pfam15265
FAM196 family; This protein family is a domain of unknown function. This family of proteins is ...
1-479 0e+00

FAM196 family; This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.


Pssm-ID: 464603 [Multi-domain]  Cd Length: 491  Bit Score: 751.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199   1 MVSKDTGKCIL--TTSESEVEPAACLalEMKYALDPNRQ-IKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKP 77
Cdd:pfam15265   1 MVSKEVRPCLLkrNSLESDVEPAASL--EMKYALDPNRQpIKKRNKALQVRFKDICEAQNEQRDAELDAAQDPALKGKKS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199  78 VSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGN-LKSLPAADPFKSQNNGFLTDAKEKNEAGPM 156
Cdd:pfam15265  79 ISYKVAYRKYMTVPARRSIPNVTKSTGVQTSPDLRKHYPTFPLDRKKGTtSKSLAEVPTFKSQNNGFVSDAKDKKDQSSG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 157 EEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPE--PLSYGEAA--LQNSTRPPSEEPDYQLLG-RAKQD 231
Cdd:pfam15265 159 EASVSEKATASTQVPELIHHSNELSNTIDQLSSSNCSEGCPSPDssLLSSESESpcLCLSATSSLEEPNYQSGSvKAKHD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 232 RGRP-NSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCP----ADDERRRATHLNGLQAPSETALA 306
Cdd:pfam15265 239 PELLlPKDDSNPKSKGPLSKTEKATCYLPPSTPSSPGPCAWNSLTQVEWGLCSdspaVSNDRKRLVQLNGLQASTKSAPA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 307 CSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQEL 386
Cdd:pfam15265 319 CSEQTQCQSPECSNSTLQPSSLPREEIQPQSNAVEISEINQQILPHGELCDLKAQLQSMENLISSSQETIKVLLGVIQEL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 387 EKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKT 466
Cdd:pfam15265 399 EKGEALREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLKRLHPAEETQVPPLPYSQEAYTSTPKKKSKT 478
                         490
                  ....*....|...
gi 1034569199 467 ESKKHGRWKLWFL 479
Cdd:pfam15265 479 ESKKHKRWKLWFL 491
 
Name Accession Description Interval E-value
FAM196 pfam15265
FAM196 family; This protein family is a domain of unknown function. This family of proteins is ...
1-479 0e+00

FAM196 family; This protein family is a domain of unknown function. This family of proteins is found in eukaryotes and are typically between 441 and 534 amino acids in length.


Pssm-ID: 464603 [Multi-domain]  Cd Length: 491  Bit Score: 751.97  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199   1 MVSKDTGKCIL--TTSESEVEPAACLalEMKYALDPNRQ-IKKRNKALQVRFKDICEAQNEQRDTQLSSGQLGEKREAKP 77
Cdd:pfam15265   1 MVSKEVRPCLLkrNSLESDVEPAASL--EMKYALDPNRQpIKKRNKALQVRFKDICEAQNEQRDAELDAAQDPALKGKKS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199  78 VSCRAAYRKYMTVPARRSIPNVTKSTGVQTSPDLKKCYQTFPLDRKKGN-LKSLPAADPFKSQNNGFLTDAKEKNEAGPM 156
Cdd:pfam15265  79 ISYKVAYRKYMTVPARRSIPNVTKSTGVQTSPDLRKHYPTFPLDRKKGTtSKSLAEVPTFKSQNNGFVSDAKDKKDQSSG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 157 EEARPCGAGRVHKTTALVFHSNQHMNTVDQPLGVNCTEPCKSPE--PLSYGEAA--LQNSTRPPSEEPDYQLLG-RAKQD 231
Cdd:pfam15265 159 EASVSEKATASTQVPELIHHSNELSNTIDQLSSSNCSEGCPSPDssLLSSESESpcLCLSATSSLEEPNYQSGSvKAKHD 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 232 RGRP-NSEEPAPPALRRVFKTEVATVYAPALSARAPEPGLSDSAAASQWSLCP----ADDERRRATHLNGLQAPSETALA 306
Cdd:pfam15265 239 PELLlPKDDSNPKSKGPLSKTEKATCYLPPSTPSSPGPCAWNSLTQVEWGLCSdspaVSNDRKRLVQLNGLQASTKSAPA 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 307 CSPPMQCLSPECSEQPSQTHTPPGLGNQPSPTAVAAGEECQRIVPHTEVVDLKAQLQMMENLISSSQETIKVLLGVIQEL 386
Cdd:pfam15265 319 CSEQTQCQSPECSNSTLQPSSLPREEIQPQSNAVEISEINQQILPHGELCDLKAQLQSMENLISSSQETIKVLLGVIQEL 398
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034569199 387 EKGEAHREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLRKLHPIEETQVIPSPYSQETYSSTPKQKSKT 466
Cdd:pfam15265 399 EKGEALREGLSYRTGQDTANCDTCRNSACIIYSVELDFKQQEDKLQPVLKRLHPAEETQVPPLPYSQEAYTSTPKKKSKT 478
                         490
                  ....*....|...
gi 1034569199 467 ESKKHGRWKLWFL 479
Cdd:pfam15265 479 ESKKHKRWKLWFL 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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