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Conserved domains on  [gi|1034571817|ref|XP_016872639|]
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BLOC-2 complex member HPS5 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
38-150 1.60e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571817   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319    250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034571817  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319    324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-150 1.60e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571817   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319    250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034571817  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319    324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
38-150 1.60e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 1.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571817   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNQerrgkPEQM 115
Cdd:COG2319    250 RSVAFSPdgRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA-FSPDGKLLASGSDDGTVRLWDLAT-----GKLL 323

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034571817  116 YVSSEHK-----------GRRV-------TALCWDTA---ILRVFVGdHAGKVSAI 150
Cdd:COG2319    324 RTLTGHTgavrsvafspdGKTLasgsddgTVRLWDLAtgeLLRTLTG-HTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
38-131 1.61e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571817   38 TSIAVSR--KWLALGSSGGGLHLIQKEGWKHRLFLSHREGAISQVAcCLHDDDYVAVATSQGLVVVWELNqerRGKPEQM 115
Cdd:COG2319    208 RSVAFSPdgKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-FSPDGRLLASGSADGTVRLWDLA---TGELLRT 283

                           90
                   ....*....|....*.
gi 1034571817  116 YvssEHKGRRVTALCW 131
Cdd:COG2319    284 L---TGHSGGVNSVAF 296
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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