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Conserved domains on  [gi|1034571892|ref|XP_016872657|]
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leucine-rich repeat-containing protein 56 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-196 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  84 SLGNfgvhLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLE 163
Cdd:COG4886   200 PLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034571892 164 VLDLEGNSVEDLgQVRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886   276 TLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 201-466 1.86e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  201 PAPGPTNKVPRGYNYRAEVRKLIPQLqvldeVPAAHTGPPAPPRL-----SQDWLAVKEAIKKGNGLPPLDCP----RGA 271
Cdd:PHA03247  2494 AAPDPGGGGPPDPDAPPAPSRLAPAI-----LPDEPVGEPVHPRMltwirGLEELASDDAGDPPPPLPPAAPPaapdRSV 2568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  272 PIRRLDPELSLPETQSRASRPWPFSLLVRG-----------GPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGN------- 333
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPrapvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHppptvpp 2648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  334 ---------PTKGLRERRHQCQAREPPEQLPQHRP---------------GDPAASTSTPEPDPADSSDFLALAGLRAWR 389
Cdd:PHA03247  2649 perprddpaPGRVSRPRRARRLGRAAQASSPPQRPrrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  390 EHGVRPLPYRH-PESQQEGAVAPWGPRRVPEEQVHQAEPKT------PSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSG 462
Cdd:PHA03247  2729 RQASPALPAAPaPPAVPAGPATPGGPARPARPPTTAGPPAPappaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808


                   ....
gi 1034571892  463 SSSP 466
Cdd:PHA03247  2809 AAVL 2812
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-196 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  84 SLGNfgvhLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLE 163
Cdd:COG4886   200 PLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034571892 164 VLDLEGNSVEDLgQVRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886   276 TLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-233 1.28e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  91 HLPNLDQLKLNGSHLGSLRDLGtSLGHLQVLWLARCGLADLDGIASLPALKELY-------------------------- 144
Cdd:cd21340    44 FLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGNRISVVEGLENLTNLEELHienqrlppgekltfdprslaalsnsl 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 145 ----ASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQV-RYLQLCPRLAMLTLEGNLVCLQPapgptnkvprgyNYRAEV 219
Cdd:cd21340   123 rvlnISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------KYRDKI 190

                         170
                  ....*....|....
gi 1034571892 220 RKLIPQLQVLDEVP 233
Cdd:cd21340   191 ILASKSLEVLDGKE 204
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-156 1.13e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.31  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034571892 117 HLQVLWLARCGLADLDGIASLPALKELYASYNN-ISDLSPL 156
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
PHA03247 PHA03247
large tegument protein UL36; Provisional
 201-466 1.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  201 PAPGPTNKVPRGYNYRAEVRKLIPQLqvldeVPAAHTGPPAPPRL-----SQDWLAVKEAIKKGNGLPPLDCP----RGA 271
Cdd:PHA03247  2494 AAPDPGGGGPPDPDAPPAPSRLAPAI-----LPDEPVGEPVHPRMltwirGLEELASDDAGDPPPPLPPAAPPaapdRSV 2568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  272 PIRRLDPELSLPETQSRASRPWPFSLLVRG-----------GPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGN------- 333
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPrapvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHppptvpp 2648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  334 ---------PTKGLRERRHQCQAREPPEQLPQHRP---------------GDPAASTSTPEPDPADSSDFLALAGLRAWR 389
Cdd:PHA03247  2649 perprddpaPGRVSRPRRARRLGRAAQASSPPQRPrrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  390 EHGVRPLPYRH-PESQQEGAVAPWGPRRVPEEQVHQAEPKT------PSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSG 462
Cdd:PHA03247  2729 RQASPALPAAPaPPAVPAGPATPGGPARPARPPTTAGPPAPappaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808


                   ....
gi 1034571892  463 SSSP 466
Cdd:PHA03247  2809 AAVL 2812
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 315-483 3.02e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 43.64  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 315 PEDNTSSLTHGAGQVLCGNPTK-GLRERRHQ---------CQAREPPEQLPQHRP-----GDPAASTSTPepdpadssdf 379
Cdd:TIGR01628 336 PEEANRAVTEMHGRMLGGKPLYvALAQRKEQrrahlqdqfMQLQPRMRQLPMGSPmggamGQPPYYGQGP---------- 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 380 LALAGLRAWREHGVRPLPYRHPESQQEGAV--APWGPRRVPEEQVHQAEPKTPSSPpslASEPSGTSSQHLVPSPPKHPR 457
Cdd:TIGR01628 406 QQQFNGQPLGWPRMSMMPTPMGPGGPLRPNglAPMNAVRAPSRNAQNAAQKPPMQP---VMYPPNYQSLPLSQDLPQPQS 482

                         170       180
                  ....*....|....*....|....*...
gi 1034571892 458 PRDSGSSSPRWSTDLQSR--GRRLRVLG 483
Cdd:TIGR01628 483 TASQGGQNKKLAQVLASAtpQMQKQVLG 510
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-196 3.73e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 3.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  84 SLGNfgvhLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPLCLLEQLE 163
Cdd:COG4886   200 PLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLK 275

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1034571892 164 VLDLEGNSVEDLgQVRYLQLCPRLAMLTLEGNL 196
Cdd:COG4886   276 TLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-195 2.01e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 2.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  91 HLPNLDQLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADL-DGIASLPALKELYASYNNISDLS-PLCLLEQLEVLDLE 168
Cdd:COG4886   134 NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLS 213

                          90       100
                  ....*....|....*....|....*..
gi 1034571892 169 GNSVEDLGQVryLQLCPRLAMLTLEGN 195
Cdd:COG4886   214 GNQLTDLPEP--LANLTNLETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 91-233 1.28e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.28e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  91 HLPNLDQLKLNGSHLGSLRDLGtSLGHLQVLWLARCGLADLDGIASLPALKELY-------------------------- 144
Cdd:cd21340    44 FLTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGNRISVVEGLENLTNLEELHienqrlppgekltfdprslaalsnsl 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 145 ----ASYNNISDLSPLCLLEQLEVLDLEGNSVEDLGQV-RYLQLCPRLAMLTLEGNLVCLQPapgptnkvprgyNYRAEV 219
Cdd:cd21340   123 rvlnISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------KYRDKI 190

                         170
                  ....*....|....
gi 1034571892 220 RKLIPQLQVLDEVP 233
Cdd:cd21340   191 ILASKSLEVLDGKE 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-195 7.23e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 7.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  47 EQLVEEYLSPARLQALARVDDLRLVRTLEMCVDTREGSLGNFGVHLPNLDQLKLNGShlgslrDLGTSLGHLQVLWLARC 126
Cdd:COG4886    50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGN 123

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034571892 127 GLADL-DGIASLPALKELYASYNNISDL-SPLCLLEQLEVLDLEGNSVEDLGQVryLQLCPRLAMLTLEGN 195
Cdd:COG4886   124 QLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLTNLKELDLSNN 192
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 117-156 1.13e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.31  E-value: 1.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034571892 117 HLQVLWLARCGLADLDGIASLPALKELYASYNN-ISDLSPL 156
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 138-170 1.46e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.93  E-value: 1.46e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034571892 138 PALKELYASYNNISDLSPLCLLEQLEVLDLEGN 170
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
117-170 2.24e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 2.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034571892 117 HLQVLWLARCGLADLDGIA--SLPALKELYASYNNISDLSPLCL--LEQLEVLDLEGN 170
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfkGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGN 59
PHA03247 PHA03247
large tegument protein UL36; Provisional
 201-466 1.86e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.86e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  201 PAPGPTNKVPRGYNYRAEVRKLIPQLqvldeVPAAHTGPPAPPRL-----SQDWLAVKEAIKKGNGLPPLDCP----RGA 271
Cdd:PHA03247  2494 AAPDPGGGGPPDPDAPPAPSRLAPAI-----LPDEPVGEPVHPRMltwirGLEELASDDAGDPPPPLPPAAPPaapdRSV 2568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  272 PIRRLDPELSLPETQSRASRPWPFSLLVRG-----------GPLPEGLLSEDLAPEDNTSSLTHGAGQVLCGN------- 333
Cdd:PHA03247  2569 PPPRPAPRPSEPAVTSRARRPDAPPQSARPrapvddrgdprGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHppptvpp 2648

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  334 ---------PTKGLRERRHQCQAREPPEQLPQHRP---------------GDPAASTSTPEPDPADSSDFLALAGLRAWR 389
Cdd:PHA03247  2649 perprddpaPGRVSRPRRARRLGRAAQASSPPQRPrrraarptvgsltslADPPPPPPTPEPAPHALVSATPLPPGPAAA 2728

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  390 EHGVRPLPYRH-PESQQEGAVAPWGPRRVPEEQVHQAEPKT------PSSPPSLASEPSGTSSQHLVPSPPKHPRPRDSG 462
Cdd:PHA03247  2729 RQASPALPAAPaPPAVPAGPATPGGPARPARPPTTAGPPAPappaapAAGPPRRLTRPAVASLSESRESLPSPWDPADPP 2808


                   ....
gi 1034571892  463 SSSP 466
Cdd:PHA03247  2809 AAVL 2812
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 315-483 3.02e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 43.64  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 315 PEDNTSSLTHGAGQVLCGNPTK-GLRERRHQ---------CQAREPPEQLPQHRP-----GDPAASTSTPepdpadssdf 379
Cdd:TIGR01628 336 PEEANRAVTEMHGRMLGGKPLYvALAQRKEQrrahlqdqfMQLQPRMRQLPMGSPmggamGQPPYYGQGP---------- 405

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 380 LALAGLRAWREHGVRPLPYRHPESQQEGAV--APWGPRRVPEEQVHQAEPKTPSSPpslASEPSGTSSQHLVPSPPKHPR 457
Cdd:TIGR01628 406 QQQFNGQPLGWPRMSMMPTPMGPGGPLRPNglAPMNAVRAPSRNAQNAAQKPPMQP---VMYPPNYQSLPLSQDLPQPQS 482

                         170       180
                  ....*....|....*....|....*...
gi 1034571892 458 PRDSGSSSPRWSTDLQSR--GRRLRVLG 483
Cdd:TIGR01628 483 TASQGGQNKKLAQVLASAtpQMQKQVLG 510
LRR_9 pfam14580
Leucine-rich repeat;
97-230 3.51e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.67  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  97 QLKLNGSHLGSLRDLGTSLGHLQVLWLARCGLADLDGIASLPALKELYASYNNISDLSPlcLLEQ----LEVLDLEGNSV 172
Cdd:pfam14580  23 ELDLRGYKIPIIENLGATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGE--GLGEalpnLTELILTNNNL 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034571892 173 EDLGQVRYLQLCPRLAMLTLEGNLVCLQPapgptnkvprgyNYRAEVRKLIPQLQVLD 230
Cdd:pfam14580 101 QELGDLDPLASLKKLTFLSLLRNPVTNKP------------HYRLYVIYKVPQLRLLD 146
LRR_8 pfam13855
Leucine rich repeat;
138-197 5.50e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.50e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034571892 138 PALKELYASYNNISDLSPLCL--LEQLEVLDLEGNSVEDLGQvRYLQLCPRLAMLTLEGNLV 197
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 54-186 5.54e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  54 LSPARLQALArvDDLRLVRTLEMcVDTREGSLGNFGV--------HLPNLDQLKLNGShlgSLRDLG--------TSLGH 117
Cdd:cd00116   149 LEGASCEALA--KALRANRDLKE-LNLANNGIGDAGIralaeglkANCNLEVLDLNNN---GLTDEGasalaetlASLKS 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892 118 LQVLWLARCGLADLdGIASL--------PALKELYASYNNISDLSPLCLLE------QLEVLDLEGNSV--EDLGQVRYL 181
Cdd:cd00116   223 LEVLNLGDNNLTDA-GAAALasallspnISLLTLSLSCNDITDDGAKDLAEvlaekeSLLELDLRGNKFgeEGAQLLAES 301


                  ....*
gi 1034571892 182 QLCPR 186
Cdd:cd00116   302 LLEPG 306
PHA03247 PHA03247
large tegument protein UL36; Provisional
 201-513 6.68e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 6.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  201 PAPGPTNKVPRGYNYRAEvrkliPQLQVLDEVPAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPEL 280
Cdd:PHA03247  2742 PAVPAGPATPGGPARPAR-----PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAA 2816

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  281 SLPETQSRAS-RPWPFSLLVRGGPLPEGLLSEDLAPEDNTSS----LTHGAGQVLCGNPTKGLR-----------ERRHQ 344
Cdd:PHA03247  2817 ALPPAASPAGpLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAPARppvrrlarpavSRSTE 2896

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  345 CQAREPPEQLPQHRPGDPAASTSTPE------PDPADSSDFLALAGLRAWREHGVRPLPYRHPESQQEGAVAPwGPRRVP 418
Cdd:PHA03247  2897 SFALPPDQPERPPQPQAPPPPQPQPQpppppqPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVP-GRVAVP 2975

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  419 EEQVHQAEPKTP---SSPPSLASEP-SGTSSQ------HLVPSPPK-------HPrPRDSGSSSPRWSTDLQSRGRRLRV 481
Cdd:PHA03247  2976 RFRVPQPAPSREapaSSTPPLTGHSlSRVSSWasslalHEETDPPPvslkqtlWP-PDDTEDSDADSLFDSDSERSDLEA 3054

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1034571892  482 LGSWGPGLGDGVAAVPVLRALEVASRLSPRAQ 513
Cdd:PHA03247  3055 LDPLPPEPHDPFAHEPDPATPEAGARESPSSQ 3086
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 233-484 7.75e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 7.75e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  233 PAAHTGPPAPPRLSQDWLAVKEAIKKGNGLPPLDCPRGAPIRRLDPELSLPETQSRASRPWPFSLLVRGGPLPEGLLSED 312
Cdd:PHA03307   159 PAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  313 LAPEDntSSLTHGAGQVLCGNPTKG---LRERRHQCQAREPPEQLPQHRPGDPAASTSTPEPDPADSSDflalaglrawR 389
Cdd:PHA03307   239 SSSSE--SSGCGWGPENECPLPRPApitLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGS----------G 306

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034571892  390 EHGVRPLPYRHPESQQEGAVAPWGPRRVPEEQVHQAEPKTPSSPPSLASEPSGTSSqhlvPSPPKHPRPRDSGSSSPRWS 469
Cdd:PHA03307   307 PAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP----SSPRKRPRPSRAPSSPAASA 382

                          250
                   ....*....|....*
gi 1034571892  470 TDLQSRGRRLRVLGS 484
Cdd:PHA03307   383 GRPTRRRARAAVAGR 397
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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