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Conserved domains on  [gi|1034580566|ref|XP_016875121|]
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integrator complex subunit 13 isoform X2 [Homo sapiens]

Protein Classification

integrator complex subunit 13( domain architecture ID 10562943)

integrator complex subunit 13, a crucial regulator of the mitotic cell cycle and development, is a DUF2151 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mat89Bb pfam10221
Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle ...
4-692 0e+00

Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. It is a component of INT (Integrator) complex, being involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Mat89Bb is also required for the correct dynein-dynactin perinuclear localization. Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.


:

Pssm-ID: 463006  Cd Length: 683  Bit Score: 1174.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566   4 FSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDS 83
Cdd:pfam10221   1 FPRNHKTVFVLDHTPYFGESCNQTIDFDIFTKQRKQGVIPLAPISKSLWTCSVEASFEYCRIVWDVFPGGKLIRFIVSDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566  84 GAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICI 163
Cdd:pfam10221  81 MAHMLNSWKQEQQSLSHLMNALAAVGPPPRSTQNTDCSVIHGLRAAIEALAECTEEQHEYRTRLYEPAPKVENRGRVICI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 164 TNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRhL 243
Cdd:pfam10221 161 TSLKDDSHMKSLEEEVAELLTQQNKIAASSDTLLPITSCHLVIVNTYPVGEESLVTTRPLKELSPLLKSEVHSVKAGR-L 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 244 ATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGS--REGSFKETITLKWCTP 321
Cdd:pfam10221 240 ANKLHSLLQKHFDLASTTVTGIPMKEEQNASSSANYDVELFHSSDAHTELLKTNLIDTAGVStkREGVTYETVTLKWCTP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 322 R-TNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPP 400
Cdd:pfam10221 320 RgCNSLELHYCTAAYRITPVDVNSRPSSCLTNFLLNGRSVMLEMPKKSGGKLVSHLLSAHGGEIFIHTLDTMRSVLEDPP 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 401 SISEGCGGRVTDYRITDFGEFMRENRLTPFldpRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVV-PLAS 479
Cdd:pfam10221 400 SISEGCGGRVTDYRITDFGELMKKNRLVPL---KRKLKKWTGLPIERAKKRLERITKYWPMTISDTFIFNVKQKLePLLT 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 480 VIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMA 559
Cdd:pfam10221 477 LITKEELTEEDVLQCKKVIYNLVQMESKGESLPLPNVGTRGKGPKREEQYRLMWNELETLLRKHVTTSERHKEVLKCLME 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 560 CRSKPPEEEERKKRGRKREDKEDKSEKavKDYEQEKSWQDSERLKGILERGKEELAEAEIikDSPDSPEPPNKKPLVEMD 639
Cdd:pfam10221 557 CRGKDKEEEDKMFVKRPFFDKEDKPEL--KLRELDSSWQDSERNKKEEDAERASVIRATT--DSPMSPPPLNKAPLLSEM 632
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034580566 640 EtpQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEE 692
Cdd:pfam10221 633 S--SIEKSKGPRSLLDLWANRCERANSQKRPEFVGRLESHGNKAPLYPNLKEK 683
 
Name Accession Description Interval E-value
Mat89Bb pfam10221
Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle ...
4-692 0e+00

Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. It is a component of INT (Integrator) complex, being involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Mat89Bb is also required for the correct dynein-dynactin perinuclear localization. Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.


Pssm-ID: 463006  Cd Length: 683  Bit Score: 1174.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566   4 FSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDS 83
Cdd:pfam10221   1 FPRNHKTVFVLDHTPYFGESCNQTIDFDIFTKQRKQGVIPLAPISKSLWTCSVEASFEYCRIVWDVFPGGKLIRFIVSDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566  84 GAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICI 163
Cdd:pfam10221  81 MAHMLNSWKQEQQSLSHLMNALAAVGPPPRSTQNTDCSVIHGLRAAIEALAECTEEQHEYRTRLYEPAPKVENRGRVICI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 164 TNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRhL 243
Cdd:pfam10221 161 TSLKDDSHMKSLEEEVAELLTQQNKIAASSDTLLPITSCHLVIVNTYPVGEESLVTTRPLKELSPLLKSEVHSVKAGR-L 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 244 ATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGS--REGSFKETITLKWCTP 321
Cdd:pfam10221 240 ANKLHSLLQKHFDLASTTVTGIPMKEEQNASSSANYDVELFHSSDAHTELLKTNLIDTAGVStkREGVTYETVTLKWCTP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 322 R-TNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPP 400
Cdd:pfam10221 320 RgCNSLELHYCTAAYRITPVDVNSRPSSCLTNFLLNGRSVMLEMPKKSGGKLVSHLLSAHGGEIFIHTLDTMRSVLEDPP 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 401 SISEGCGGRVTDYRITDFGEFMRENRLTPFldpRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVV-PLAS 479
Cdd:pfam10221 400 SISEGCGGRVTDYRITDFGELMKKNRLVPL---KRKLKKWTGLPIERAKKRLERITKYWPMTISDTFIFNVKQKLePLLT 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 480 VIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMA 559
Cdd:pfam10221 477 LITKEELTEEDVLQCKKVIYNLVQMESKGESLPLPNVGTRGKGPKREEQYRLMWNELETLLRKHVTTSERHKEVLKCLME 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 560 CRSKPPEEEERKKRGRKREDKEDKSEKavKDYEQEKSWQDSERLKGILERGKEELAEAEIikDSPDSPEPPNKKPLVEMD 639
Cdd:pfam10221 557 CRGKDKEEEDKMFVKRPFFDKEDKPEL--KLRELDSSWQDSERNKKEEDAERASVIRATT--DSPMSPPPLNKAPLLSEM 632
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034580566 640 EtpQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEE 692
Cdd:pfam10221 633 S--SIEKSKGPRSLLDLWANRCERANSQKRPEFVGRLESHGNKAPLYPNLKEK 683
 
Name Accession Description Interval E-value
Mat89Bb pfam10221
Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle ...
4-692 0e+00

Cell cycle and development regulator Mat89Bb; This is entry represents the cell cycle regulator Mat89b (also known as protein asunder), which plays an evolutionarily conserved role as a crucial regulator of both cell cycle and development. It is a component of INT (Integrator) complex, being involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1 and U5. Mat89Bb is also required for the correct dynein-dynactin perinuclear localization. Mat89Bb is a PNG kinase substrate, that is essential for S-M cycles of early Drosophila embryogenesis, Xenopus embryonic cell cycles and morphogenesis, and cell division in cultured mammalian cells.


Pssm-ID: 463006  Cd Length: 683  Bit Score: 1174.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566   4 FSESHKTVFVVDHCPYMAESCRQHVEFDMLVKNRTQGIIPLAPISKSLWTCSVESSMEYCRIMYDIFPFKKLVNFIVSDS 83
Cdd:pfam10221   1 FPRNHKTVFVLDHTPYFGESCNQTIDFDIFTKQRKQGVIPLAPISKSLWTCSVEASFEYCRIVWDVFPGGKLIRFIVSDS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566  84 GAHVLNSWTQEDQNLQELMAALAAVGPPNPRADPECCSILHGLVAAVETLCKITEYQHEARTLLMENAERVGNRGRIICI 163
Cdd:pfam10221  81 MAHMLNSWKQEQQSLSHLMNALAAVGPPPRSTQNTDCSVIHGLRAAIEALAECTEEQHEYRTRLYEPAPKVENRGRVICI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 164 TNAKSDSHVRMLEDCVQETIHEHNKLAANSDHLMQIQKCELVLIHTYPVGEDSLVSDRSKKELSPVLTSEVHSVRAGRhL 243
Cdd:pfam10221 161 TSLKDDSHMKSLEEEVAELLTQQNKIAASSDTLLPITSCHLVIVNTYPVGEESLVTTRPLKELSPLLKSEVHSVKAGR-L 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 244 ATKLNILVQQHFDLASTTITNIPMKEEQHANTSANYDVELLHHKDAHVDFLKSGDSHLGGGS--REGSFKETITLKWCTP 321
Cdd:pfam10221 240 ANKLHSLLQKHFDLASTTVTGIPMKEEQNASSSANYDVELFHSSDAHTELLKTNLIDTAGVStkREGVTYETVTLKWCTP 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 322 R-TNNIELHYCTGAYRISPVDVNSRPSSCLTNFLLNGRSVLLEQPRKSGSKVISHMLSSHGGEIFLHVLSSSRSILEDPP 400
Cdd:pfam10221 320 RgCNSLELHYCTAAYRITPVDVNSRPSSCLTNFLLNGRSVMLEMPKKSGGKLVSHLLSAHGGEIFIHTLDTMRSVLEDPP 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 401 SISEGCGGRVTDYRITDFGEFMRENRLTPFldpRYKIDGSLEVPLERAKDQLEKHTRYWPMIISQTTIFNMQAVV-PLAS 479
Cdd:pfam10221 400 SISEGCGGRVTDYRITDFGELMKKNRLVPL---KRKLKKWTGLPIERAKKRLERITKYWPMTISDTFIFNVKQKLePLLT 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 480 VIVKESLTEEDVLNCQKTIYNLVDMERKNDPLPISTVGTRGKGPKRDEQYRIMWNELETLVRAHINNSEKHQRVLECLMA 559
Cdd:pfam10221 477 LITKEELTEEDVLQCKKVIYNLVQMESKGESLPLPNVGTRGKGPKREEQYRLMWNELETLLRKHVTTSERHKEVLKCLME 556
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034580566 560 CRSKPPEEEERKKRGRKREDKEDKSEKavKDYEQEKSWQDSERLKGILERGKEELAEAEIikDSPDSPEPPNKKPLVEMD 639
Cdd:pfam10221 557 CRGKDKEEEDKMFVKRPFFDKEDKPEL--KLRELDSSWQDSERNKKEEDAERASVIRATT--DSPMSPPPLNKAPLLSEM 632
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034580566 640 EtpQVEKSKGPVSLLSLWSNRINTANSRKHQEFAGRLNSVNNRAELYQHLKEE 692
Cdd:pfam10221 633 S--SIEKSKGPRSLLDLWANRCERANSQKRPEFVGRLESHGNKAPLYPNLKEK 683
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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