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Conserved domains on  [gi|1034584367|ref|XP_016876050|]
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importin subunit alpha-4 isoform X1 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-497 6.15e-178

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 509.82  E-value: 6.15e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367   1 MRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQNATSDNPVVQLSAVQAARKLLSSDR 79
Cdd:COG5064    25 LRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKET 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  80 NPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGN 159
Cdd:COG5064   104 SPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 160 IIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDT 238
Cdd:COG5064   184 IAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 239 VWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKI 318
Cdd:COG5064   264 CWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 319 NKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISG--RKDQVEYLVQQNVIPPFCNLL 396
Cdd:COG5064   344 RKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLL 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 397 SVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDED 469
Cdd:COG5064   424 DVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDE 503

                         490       500
                  ....*....|....*....|....*...
gi 1034584367 470 pcLIPEaTQGGTYNFDPTANLQtkeFNF 497
Cdd:COG5064   504 --LAPE-TAGNTFTFGSNVNQQ---GNF 525
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-497 6.15e-178

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 509.82  E-value: 6.15e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367   1 MRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQNATSDNPVVQLSAVQAARKLLSSDR 79
Cdd:COG5064    25 LRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKET 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  80 NPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGN 159
Cdd:COG5064   104 SPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 160 IIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDT 238
Cdd:COG5064   184 IAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 239 VWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKI 318
Cdd:COG5064   264 CWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 319 NKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISG--RKDQVEYLVQQNVIPPFCNLL 396
Cdd:COG5064   344 RKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLL 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 397 SVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDED 469
Cdd:COG5064   424 DVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDE 503

                         490       500
                  ....*....|....*....|....*...
gi 1034584367 470 pcLIPEaTQGGTYNFDPTANLQtkeFNF 497
Cdd:COG5064   504 --LAPE-TAGNTFTFGSNVNQQ---GNF 525
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 1-69 1.24e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 88.75  E-value: 1.24e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034584367   1 MRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDadfkAQNVTLEAILQNATSDNPVVQLSAVQ 69
Cdd:pfam01749  15 LRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES----QLLESLPEMVQGVNSDDPELQLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 250-288 1.18e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 1.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034584367  250 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIV 288
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 48-162 1.30e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367   48 TLEA-----ILQNATSDNPVVQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGT 122
Cdd:PLN03200   185 TLEAggvdiLVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQS 263

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034584367  123 SAQTQAVVQSNAVPLFLRLLRSPH----QNVCEQ-----AVWALGNIIG 162
Cdd:PLN03200   264 KEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
1-497 6.15e-178

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 509.82  E-value: 6.15e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367   1 MRRHRNEVTVELRKNKRDEHLLKKRN-VPQEESLEDSDVDADFKAQNvTLEAILQNATSDNPVVQLSAVQAARKLLSSDR 79
Cdd:COG5064    25 LRRRREEQQVELRKQKREELLNKRRNlADVSEEAESSFIPMEQQFYS-ELPQLTQQLFSDDIEQQLQAVYKFRKLLSKET 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  80 NPPIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGN 159
Cdd:COG5064   104 SPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLFIQLLSSTEDDVREQAVWALGN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 160 IIGDGPQCRDYVISLGVVKPLLSFI-SPSIPITFLRNVTWVIVNLCRNKDPPPPMETVQEILPALCVLIYHTDINILVDT 238
Cdd:COG5064   184 IAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKNPPPDWSNISQALPILAKLIYSRDPEVLVDA 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 239 VWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKI 318
Cdd:COG5064   264 CWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSDDQTQVIINCGALKAFRSLLSSPKENI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 319 NKEAVWFLSNITAGNQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLTISG--RKDQVEYLVQQNVIPPFCNLL 396
Cdd:COG5064   344 RKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNATSGGlnRPDIIRYLVSQGFIKPLCDLL 423

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 397 SVKDSQVVQVVLDGLKNIL-------IMAGDEASTIAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDED 469
Cdd:COG5064   424 DVVDNKIIEVALDAIENILkvgeqdrLRYGKNINIYAVYVEKAGGMDAIHGLQDSVNRTIYDKAYSIIEKFFGEEDAVDE 503

                         490       500
                  ....*....|....*....|....*...
gi 1034584367 470 pcLIPEaTQGGTYNFDPTANLQtkeFNF 497
Cdd:COG5064   504 --LAPE-TAGNTFTFGSNVNQQ---GNF 525
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 1-69 1.24e-21

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 88.75  E-value: 1.24e-21
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034584367   1 MRRHRNEVTVELRKNKRDEHLLKKRNVPQEESLEDSDVDadfkAQNVTLEAILQNATSDNPVVQLSAVQ 69
Cdd:pfam01749  15 LRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSSSAES----QLLESLPEMVQGVNSDDPELQLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 429-475 2.66e-21

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 86.88  E-value: 2.66e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1034584367 429 IEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPCLIPE 475
Cdd:pfam16186   3 IEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEEDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 122-160 4.07e-10

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 54.77  E-value: 4.07e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034584367 122 TSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNI 160
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 105-160 1.24e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.91  E-value: 1.24e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034584367 105 PSLQFEAAWALTNIASGTSAQTQAVVQsNAVPLFLRLLRSPHQNVCEQAVWALGNI 160
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 250-289 5.33e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.69  E-value: 5.33e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034584367 250 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIVT 289
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 333-372 5.88e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.69  E-value: 5.88e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034584367 333 NQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLT 372
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 250-288 1.18e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.89  E-value: 1.18e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034584367  250 NEQIQMVIDSGVVPFLVPLLSHQEVKVQTAALRAVGNIV 288
Cdd:smart00185   2 DENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 80-120 2.65e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.76  E-value: 2.65e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034584367  80 NPPIDDLIKSGILPILVKCLeRDDNPSLQFEAAWALTNIAS 120
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLL-SSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 122-160 3.38e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 49.35  E-value: 3.38e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034584367  122 TSAQTQAVVQSNAVPLFLRLLRSPHQNVCEQAVWALGNI 160
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
HEAT COG1413
HEAT repeat [General function prediction only];
48-160 3.39e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 52.32  E-value: 3.39e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  48 TLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDDLIKSG-------------------ILPILVKCLeRDDNPSLQ 108
Cdd:COG1413    17 AVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPdpevraaaaealgrigdpeAVPALIAAL-KDEDPEVR 95

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034584367 109 FEAAWALTNIASgtsaqtqavvqSNAVPLFLRLLRSPHQNVCEQAVWALGNI 160
Cdd:COG1413    96 RAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 79-120 1.10e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 1.10e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034584367   79 RNPPIDDLIKSGILPILVKCLeRDDNPSLQFEAAWALTNIAS 120
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELL-KSEDEEVVKEAAWALSNLSS 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 92-160 1.73e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 48.87  E-value: 1.73e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034584367  92 LPILVKCLERDDNPSLQFEAAWALTNIASgtsaqtqavvqSNAVPLFLRLLRSPHQNVCEQAVWALGNI 160
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI 58
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 291-331 2.63e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.06  E-value: 2.63e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034584367 291 TDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 331
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
92-287 2.80e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.63  E-value: 2.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  92 LPILVKCLeRDDNPSLQFEAAWALTNIASGTsaqtqavvqsnAVPLFLRLLRSPHQNVCEQAVWALGNIigdgpqcrdyv 171
Cdd:COG1413    18 VPALIAAL-ADEDPDVRAAAARALGRLGDPR-----------AVPALLEALKDPDPEVRAAAAEALGRI----------- 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 172 islgvvkpllsfispsipitflrnvtwvivnlcrnKDPpppmetvqEILPALCVLIYHTDINILVDTVWALSYLTdggne 251
Cdd:COG1413    75 -----------------------------------GDP--------EAVPALIAALKDEDPEVRRAAAEALGRLG----- 106

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1034584367 252 qiqmviDSGVVPFLVPLLSHQEVKVQTAALRAVGNI 287
Cdd:COG1413   107 ------DPAAVPALLEALKDPDWEVRRAAARALGRL 136
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 291-331 9.47e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 9.47e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034584367  291 TDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITA 331
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 333-372 1.71e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 44.73  E-value: 1.71e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1034584367  333 NQQQVQAVIDAGLIPMIIHQLAKGDFGTQKEAAWAISNLT 372
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 378-414 6.86e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.13  E-value: 6.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1034584367 378 DQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNI 414
Cdd:pfam00514   3 ENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 48-162 1.30e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 44.71  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367   48 TLEA-----ILQNATSDNPVVQLSAVQAARKLLSSDRNPpIDDLIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGT 122
Cdd:PLN03200   185 TLEAggvdiLVKLLSSGNSDAQANAASLLARLMMAFESS-ISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQS 263

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034584367  123 SAQTQAVVQSNAVPLFLRLLRSPH----QNVCEQ-----AVWALGNIIG 162
Cdd:PLN03200   264 KEAKQAIADAGGIPALINATVAPSkefmQGEFAQalqenAMGALANICG 312
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 208-247 8.76e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 37.05  E-value: 8.76e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034584367 208 DPPPPMETVQE-ILPALCVLIYHTDINILVDTVWALSYLTD 247
Cdd:pfam00514   1 SPENKQAVIEAgAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Adaptin_N pfam01602
Adaptin N terminal region; This family consists of the N terminal region of various alpha, ...
 51-471 8.93e-04

Adaptin N terminal region; This family consists of the N terminal region of various alpha, beta and gamma subunits of the AP-1, AP-2 and AP-3 adaptor protein complexes. The adaptor protein (AP) complexes are involved in the formation of clathrin-coated pits and vesicles. The N-terminal region of the various adaptor proteins (APs) is constant by comparison to the C-terminal which is variable within members of the AP-2 family; and it has been proposed that this constant region interacts with another uniform component of the coated vesicles.


Pssm-ID: 396262 [Multi-domain]  Cd Length: 523  Bit Score: 41.84  E-value: 8.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  51 AILQNATSDNPVVQLSAVQAARKLLSSDrnppiDDLIKSGIlPILVKCLErDDNPSlqfeaawaltniasgtsaqtqavV 130
Cdd:pfam01602 118 DIKKLLVDRSPYVRKKAALAILKLYRKS-----PDLVRDFV-PELKELLS-DKDPG-----------------------V 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 131 QSNAVPLFLRLLRSPHQNVceQAVWALGNIIGDGpqcrdyvisLGVVKPLLSfispsipITFLRnvtwVIVNLCRNkDPP 210
Cdd:pfam01602 168 QSAAVALLYEICKNDRLYL--KLLPLLFRRLCNL---------LGVLNPWLQ-------VKILR----LLTRLAPL-DPL 224

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 211 PPMETVQEILPalcvLIYHTDINILVDTVWALSYLtDGGNEQIQMVIDSgvvpfLVPLLSHQEVKVQTAALRAVGNIVTG 290
Cdd:pfam01602 225 LPKELLEDLLN----LLQNSNNAVLYETANTIVHL-APAPELIVLAVNA-----LGRLLSSPDENLRYVALRNLNKIVMK 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 291 TdeqTQVVLNCDVLSHFpnLLSHPKEKINKEAVWFLSNItaGNQQQVQAVIDagLIPMIIHQLAKGDFgtQKEAAWAISN 370
Cdd:pfam01602 295 E---PKAVQHLDLIIFC--LKTDDDISIRLRALDLLYAL--VNESNVKEIVK--ELLKYVHEIADPDF--KIELVRAIGR 363

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367 371 LTI-SGRKdqveylvQQNVIPPFCNLLSVKDSQVVQVVLDGLKNILIMAgdeASTIAEIIEECgglekIEVLQQHENEDI 449
Cdd:pfam01602 364 LAEkFPTD-------AEWYLDVLLDLLSLAGSYVVDEIVEVIRDIIQNV---PELREYILEHL-----CELLEDIESPEA 428

                         410       420
                  ....*....|....*....|..
gi 1034584367 450 YKLAFEIIDQYfsGDDIDEDPC 471
Cdd:pfam01602 429 LAAALWILGEY--GELIPNGSS 448
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 378-414 1.39e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 36.25  E-value: 1.39e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034584367  378 DQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDGLKNI 414
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 165-205 2.94e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034584367 165 PQCRDYVISLGVVKPLLSFI-SPSIPItfLRNVTWVIVNLCR 205
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLsSPDEEV--QEEAAWALSNLAA 41
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 49-158 4.96e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.16  E-value: 4.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034584367  49 LEAILQNATSD-NPVVQLSAVQAarklLSSDRNPpiddliksGILPILVKCLeRDDNPSLQFEAAWALTNIASgtsaqtq 127
Cdd:pfam13646   1 LPALLQALLRDpDPEVRAAAIRA----LGRIGDP--------EAVPALLELL-KDEDPAVRRAAAEALGKIGD------- 60

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1034584367 128 avvqSNAVPLFLRLLRS-PHQNVCEQAVWALG 158
Cdd:pfam13646  61 ----PEALPALLELLRDdDDDVVRAAAAEALA 88
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 239-287 6.71e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.04  E-value: 6.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1034584367 239 VWALSYLTDGGNEQIQMVIDSgVVPFLVPLLSHQEVKVQTAALRAVGNI 287
Cdd:pfam13513   8 ALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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