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Conserved domains on  [gi|1034591138|ref|XP_016877851|]
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membrane progestin receptor gamma isoform X1 [Homo sapiens]

Protein Classification

hemolysin III family protein( domain architecture ID 10503285)

hemolysin III family protein is an integral membrane protein that may have hemolytic and cytotoxic activity against a broad range of species and cell types

Gene Ontology:  GO:0016020|GO:0015267
TCDB:  1.C.113

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 43-269 7.83e-57

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


:

Pssm-ID: 427098  Cd Length: 222  Bit Score: 183.63  E-value: 7.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138  43 FQMTNETLNIWTHLLPFWFF--AWRFVTALYMTDIkNDSYSWPMLVYMCTSCVYPLVSSCAHTFSSMSKNARHICYFLDY 120
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFiaLLIFLLALATIDS-QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 121 GAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNTILSTGLSCYSRfleiqkpRLCKVIRVLAFAYPYTWDSLPI 200
Cdd:pfam03006  80 SGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSK-------PAPRWLRTAVYILMGWSGIIPI 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 201 FYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHMQM 269
Cdd:pfam03006 153 AHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 43-269 7.83e-57

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 183.63  E-value: 7.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138  43 FQMTNETLNIWTHLLPFWFF--AWRFVTALYMTDIkNDSYSWPMLVYMCTSCVYPLVSSCAHTFSSMSKNARHICYFLDY 120
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFiaLLIFLLALATIDS-QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 121 GAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNTILSTGLSCYSRfleiqkpRLCKVIRVLAFAYPYTWDSLPI 200
Cdd:pfam03006  80 SGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSK-------PAPRWLRTAVYILMGWSGIIPI 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 201 FYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHMQM 269
Cdd:pfam03006 153 AHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
 
Name Accession Description Interval E-value
HlyIII pfam03006
Haemolysin-III related; Members of this family are integral membrane proteins. This family ...
 43-269 7.83e-57

Haemolysin-III related; Members of this family are integral membrane proteins. This family includes a protein with hemolytic activity from Bacillus cereus. It has been proposed that YOL002c encodes a Saccharomyces cerevisiae protein that plays a key role in metabolic pathways that regulate lipid and phosphate metabolism. In eukaryotes, members are seven-transmembrane pass molecules found to encode functional receptors with a broad range of apparent ligand specificities, including progestin and adipoQ receptors, and hence have been named PAQR proteins. The mammalian members include progesterone binding proteins. Unlike the case with GPCR receptor proteins, the evolutionary ancestry of the members of this family can be traced back to the Archaea. This family belongs to the CREST superfamily, which are distantly related to GPCRs.


Pssm-ID: 427098  Cd Length: 222  Bit Score: 183.63  E-value: 7.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138  43 FQMTNETLNIWTHLLPFWFF--AWRFVTALYMTDIkNDSYSWPMLVYMCTSCVYPLVSSCAHTFSSMSKNARHICYFLDY 120
Cdd:pfam03006   1 FQIHNETLNIWTHLLGAILFiaLLIFLLALATIDS-QLSAVLPFLIFLLSACLCLGCSALYHTFSCHSEKVRKLFRKLDY 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 121 GAVNLFSLGSAIAYSAYTFPDALMCTTFHDYYVALAVLNTILSTGLSCYSRfleiqkpRLCKVIRVLAFAYPYTWDSLPI 200
Cdd:pfam03006  80 SGIFLLIAGSYTPVIYYAFYCAPKLGTIYLSFIWALAILGIISKLLWCFSK-------PAPRWLRTAVYILMGWSGIIPI 152

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034591138 201 FYRLFLFPG-ESAQNEATSYHQKHMIMTLLASFLYSAHLPERLAPGRFDYIGHSHQLFHVCVILATHMQM 269
Cdd:pfam03006 153 AHRALALGGaGEALEIALVLLVLGGVLYIIGAVFYALRVPERLFPGKFDIVGGSHQIFHVFVVLAALCHY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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