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Conserved domains on  [gi|1034595692|ref|XP_016879071|]
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protein NDRG4 isoform X3 [Homo sapiens]

Protein Classification

NDRG family protein( domain architecture ID 11140417)

N-myc downstream-regulated gene (NDRG) family protein may be involved in cellular differentiation events; similar to Homo sapiens protein NDRG1, which is a stress-responsive protein involved in hormone responses, cell growth, and differentiation; belongs to the alpha/beta hydrolase superfamily

CATH:  3.40.50.1820
PubMed:  12369917|19508187|20667976|37582413|31545554
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 58-340 4.55e-167

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


:

Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 468.76  E-value: 4.55e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692  58 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 137
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 138 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 210
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 211 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 290
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034595692 291 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMP 340
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 58-340 4.55e-167

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 468.76  E-value: 4.55e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692  58 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 137
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 138 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 210
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 211 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 290
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034595692 291 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMP 340
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 106-335 2.86e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 47.69  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 106 MQEITKHFVVCHVDAPGQqvGASQFPQGYqfPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLV 185
Cdd:COG0596    43 IPALAAGYRVIAPDLRGH--GRSDKPAGG--YTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 186 LVNidpngkgwidwaatklsgltstlpdtvlshlfsqeelvnntELVQSYRQQIgnVVNQANLQLFWNMYNSRRDLDInr 265
Cdd:COG0596   119 LVD-----------------------------------------EVLAALAEPL--RRPGLAPEALAALLRALARTDL-- 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034595692 266 pgtVPNAKTLRCPVMLVVGDN---APAEDG--VVECNSKldpttTTFLKMADSGGLPQVTQPGKLTEAFKYFLQG 335
Cdd:COG0596   154 ---RERLARITVPTLVIWGEKdpiVPPALArrLAELLPN-----AELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
 
Name Accession Description Interval E-value
Ndr pfam03096
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ...
 58-340 4.55e-167

Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).


Pssm-ID: 397285 [Multi-domain]  Cd Length: 285  Bit Score: 468.76  E-value: 4.55e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692  58 EHDIETPYGLLHVVIRGSPKGNRPAILTYHDVGLNHKLCFNTFFNFEDMQEITKHFVVCHVDAPGQQVGASQFPQGYQFP 137
Cdd:pfam03096   1 EHIIETPCGSVHVTVYGDPEGKKPPILTYHDLGLNHKSCFQGLFNSESMQEILENFCIYHVDAPGQEDGAASFPGGYPYP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 138 SMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLVLVNIDPNGKGWIDWAATKLS-------GLTST 210
Cdd:pfam03096  81 SMDDLADMLPVVLDHFRLKSVIGMGVGAGAYILARFALKHPERVEGLVLINPTPKAAGWIEWFYNKLSskllyyyGMTDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 211 LPDTVLSHLFSQEELVNNTELVQSYRQQIGNVVNQANLQLFWNMYNSRRDLDINRPGTvpnakTLRCPVMLVVGDNAPAE 290
Cdd:pfam03096 161 AKDYLLAHYFGKEELSNNSDIVQEYRKFLKERLNPKNLQLYLEAYNSRRDLTIERPGL-----ETKCPVLLVVGDNSPHV 235

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034595692 291 DGVVECNSKLDPTTTTFLKMADSGGLPQVTQPGKLTEAFKYFLQGMGYMP 340
Cdd:pfam03096 236 DAVVECNTKLDPTKTTLLKVADCGGLVQQEQPGKLTESFKLFLQGMGYYP 285
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 106-335 2.86e-06

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 47.69  E-value: 2.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 106 MQEITKHFVVCHVDAPGQqvGASQFPQGYqfPSMEQLAAMLPSVVQHFGFKYVIGIGVGAGAYVLAKFALIFPDLVEGLV 185
Cdd:COG0596    43 IPALAAGYRVIAPDLRGH--GRSDKPAGG--YTLDDLADDLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595692 186 LVNidpngkgwidwaatklsgltstlpdtvlshlfsqeelvnntELVQSYRQQIgnVVNQANLQLFWNMYNSRRDLDInr 265
Cdd:COG0596   119 LVD-----------------------------------------EVLAALAEPL--RRPGLAPEALAALLRALARTDL-- 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034595692 266 pgtVPNAKTLRCPVMLVVGDN---APAEDG--VVECNSKldpttTTFLKMADSGGLPQVTQPGKLTEAFKYFLQG 335
Cdd:COG0596   154 ---RERLARITVPTLVIWGEKdpiVPPALArrLAELLPN-----AELVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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