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Conserved domains on  [gi|1034599498|ref|XP_016880058|]
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sperm-egg fusion protein TMEM95 isoform X5 [Homo sapiens]

Protein Classification

TMEM95 domain-containing protein( domain architecture ID 10633569)

TMEM95 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM95 pfam15203
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-154 3.13e-93

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


:

Pssm-ID: 464560  Cd Length: 151  Bit Score: 267.42  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599498  17 CVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKL 96
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWKECEASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKTKL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034599498  97 PEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGA 154
Cdd:pfam15203  81 PEYTREALCAPACRGSTTLYNCSTCEGVEVSCWPRKRCFPGSHDLWEARILLLSVSGA 138
 
Name Accession Description Interval E-value
TMEM95 pfam15203
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-154 3.13e-93

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


Pssm-ID: 464560  Cd Length: 151  Bit Score: 267.42  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599498  17 CVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKL 96
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWKECEASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKTKL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034599498  97 PEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGA 154
Cdd:pfam15203  81 PEYTREALCAPACRGSTTLYNCSTCEGVEVSCWPRKRCFPGSHDLWEARILLLSVSGA 138
 
Name Accession Description Interval E-value
TMEM95 pfam15203
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-154 3.13e-93

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


Pssm-ID: 464560  Cd Length: 151  Bit Score: 267.42  E-value: 3.13e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599498  17 CVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKL 96
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWKECEASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKTKL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034599498  97 PEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGA 154
Cdd:pfam15203  81 PEYTREALCAPACRGSTTLYNCSTCEGVEVSCWPRKRCFPGSHDLWEARILLLSVSGA 138
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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