|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
35-668 |
1.71e-143 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 440.29 E-value: 1.71e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 35 ADRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVI 114
Cdd:COG1643 48 LELGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 115 ILDEAHERTLTTDILFGLLKKLfQEKSpnRkEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCnligPRDR 194
Cdd:COG1643 128 IFDEFHERSLNADLLLALLLDL-QPAL--R-PDLKLLVMSATLDAERFARLLGDAPVIESSGRTYPVEVRYR----PLPA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 195 ENTAYIQAIVKVTMDIhLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMTTDQQRRI 274
Cdd:COG1643 200 DERDLEDAVADAVREA-LAEEPGDILVFLPGEREIRRTAEAL-------------RGRLPPDTEILPLYGRLSAAEQDRA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 275 FLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYS 354
Cdd:COG1643 266 FAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWS 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 355 KDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFP 434
Cdd:COG1643 346 EEDFAR-RPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLP 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 435 LPPHLTCAVIKAASLDCEDLLLPIAAMLSvenvfirpvdpeyqkeaEQRHRELAAKAggfnDFATLAVIFEQCKSsgapa 514
Cdd:COG1643 425 LDPRLARMLLAAAELGCLREAAILAALLS-----------------ERDPRRGAAGS----DLLARLNLWRRLRE----- 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 515 swCQKHWIHWRCLFSAFRVEAQLRELIRKLKQQsdfpketfEGPKHEVLRRCLCAGYFKNVA-RRSVGRTFCTMDGRGsp 593
Cdd:COG1643 479 --QQREFLSYLRLREWRDLARQLRRLLGEGANE--------EPADYEAIGLLLALAYPDRIArRRGEGGRYLLARGRG-- 546
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034601281 594 VHIHPSSALHeqetKLEWIIFHEvLVTTKVYARI--VCPIRYEWVRDLLPKL--HEFNAHdlSSVARREVRedARRRWT 668
Cdd:COG1643 547 AALFPGSPLA----KKEWLVAAE-LVGGAAEARIrlAAPIDPEWLEELAAHLikRYSEPH--WDKKRGRVV--ARERVR 616
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
28-649 |
9.66e-110 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 361.39 E-value: 9.66e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 28 RLSAVCIaDRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPN 107
Cdd:TIGR01967 98 QLPKICL-ELGRGSHGLIGHTQPRRLAARTVAQRIAEELGTPLGEKVGYKVRFHDQVSSNTLVKLMTDGILLAETQQDRF 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 108 LTKFSVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCN 187
Cdd:TIGR01967 177 LSRYDTIIIDEAHERSLNIDFLLGYLKQLLP-----RRPDLKIIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRP 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 188 LIGPRDRENTAYIQAIVKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLfqmaesvdydydvQDTTLDGLLILPCYGSMT 267
Cdd:TIGR01967 252 LVEEQEDDDLDQLEAILD-AVDELFAEGPGDILIFLPGEREIRDAAEIL-------------RKRNLRHTEILPLYARLS 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 268 TDQQRRIFLPPPPgiRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSG 347
Cdd:TIGR01967 318 NKEQQRVFQPHSG--RRIVLATNVAETSLTVPGIHYVIDTGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPG 395
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 348 KCFRIYSKDFWNQcMPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDR---SGHVT 424
Cdd:TIGR01967 396 ICIRLYSEEDFNS-RPEFTDPEILRTNLASVILQMLALRLGDIAAFPFIEAPDPRAIRDGFRLLEELGALDDdeaEPQLT 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 425 RLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPvdPEYQKEAEQRHRELAAKAGGFNDFATLAVIF 504
Cdd:TIGR01967 475 PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRERP--MEKQQAADQAHARFKDPRSDFLSRVNLWRHI 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 505 E---QCKSSGAPASWCQKHWIH------WRCLFSafrveaQLRELIRKLK-QQSDFPKEtfegpkHEVLRRCLCAGYFKN 574
Cdd:TIGR01967 553 EeqrQALSANQFRNACRKQYLNylrvreWQDIYR------QLTQVVKELGlKLNEEPAD------YDAIHKALLSGLLSQ 620
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034601281 575 VARRSVGRTFctmDG-RGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL---HEFNAH 649
Cdd:TIGR01967 621 IGMKDEKHEY---DGaRGRKFHIFPGSPLFKKPPK--WVMAAELVETSKLYARLVAKIEPEWVEPVAGHLikkNYFEPH 694
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
38-643 |
2.01e-101 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 338.57 E-value: 2.01e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 38 GFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILD 117
Cdd:PRK11131 114 GRGVKGLIGHTQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIID 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 118 EAHERTLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLIGPRDRENT 197
Cdd:PRK11131 194 EAHERSLNIDFILGYLKELL----PRRPD-LKVIITSATIDPERFSRHFNNAPIIEVSGRTYPVEVRYRPIVEEADDTER 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 198 AYIQAIVKvTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMaesvdydyDVQDTTldgllILPCYGSMTTDQQRRIFlp 277
Cdd:PRK11131 269 DQLQAIFD-AVDELGREGPGDILIFMSGEREIRDTADALNKL--------NLRHTE-----ILPLYARLSNSEQNRVF-- 332
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 278 PPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSK-D 356
Cdd:PRK11131 333 QSHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEdD 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 357 FWNQcmPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAI--DRSGHVTRL---GLSMV 431
Cdd:PRK11131 413 FLSR--PEFTDPEILRTNLASVILQMTALGLGDIAAFPFVEAPDKRNIQDGVRLLEELGAIttDEQASAYKLtplGRQLA 490
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 432 EFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPeyQKEAEQRHRELAAKAGGFNDFATL-AVIFEQCK-- 508
Cdd:PRK11131 491 QLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDK--QQASDEKHRRFADKESDFLAFVNLwNYLQEQQKal 568
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 509 SSGAPASWCQKHWIHWrclfsaFRVE------AQLRELIRKLkqqsDFPKETFEGPKHEVlRRCLCAGYFKNVARRSVGR 582
Cdd:PRK11131 569 SSNQFRRLCRTDYLNY------LRVRewqdiyTQLRQVVKEL----GIPVNSEPAEYREI-HTALLTGLLSHIGMKDAEK 637
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034601281 583 TFCTmDGRGSPVHIHPSSALHEQETKleWIIFHEVLVTTKVYARIVCPIRYEWVRDLLPKL 643
Cdd:PRK11131 638 QEYT-GARNARFSIFPGSGLFKKPPK--WVMVAELVETSRLWGRIAARIEPEWIEPLAQHL 695
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
38-174 |
1.21e-91 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 283.28 E-value: 1.21e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 38 GFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILD 117
Cdd:cd17984 42 GFSQHGMIGVTQPRRVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILD 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034601281 118 EAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17984 122 EAHERSLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
179-353 |
1.67e-70 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 227.42 E-value: 1.67e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 179 YPVREKFCNLIGPR-----DRENTAYIQAIVKVTMDIHLNEMAGDILVFLTGQFEIEKSCELLFQMAESVDydydvqdtt 253
Cdd:cd18791 1 FPVEVYYLEDILELlgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPD--------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 254 LDGLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSE 333
Cdd:cd18791 72 LGKLLVLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKAS 151
|
170 180
....*....|....*....|
gi 1034601281 334 ALQRSGRAGRTSSGKCFRIY 353
Cdd:cd18791 152 AEQRAGRAGRTRPGKCYRLY 171
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
42-492 |
3.01e-69 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 242.52 E-value: 3.01e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 42 HGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHE 121
Cdd:PRK11664 48 NGKIIMLEPRRLAARNVAQRLAEQLGEKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 122 RTLTTDILFGLLKKLfQEkspNRKEHLKVVVMSATMELAKLSAFFGNCPIFDIPGRLYPVREKFCNLiGPRDRENTAYIQ 201
Cdd:PRK11664 128 RSLQADLALALLLDV-QQ---GLRDDLKLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPVERRYQPL-PAHQRFDEAVAR 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 202 AIVKVtmdihLNEMAGDILVFLTGQFEIEKSCELLfqmAESVDYDYDvqdttldgllILPCYGSMTTDQQRRIFLPPPPG 281
Cdd:PRK11664 203 ATAEL-----LRQESGSLLLFLPGVGEIQRVQEQL---ASRVASDVL----------LCPLYGALSLAEQQKAILPAPAG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 282 IRKCVISTNISATSLTIDGIRYVVDGGFVKQLNHNPRLGLDILEVVPISKSEALQRSGRAGRTSSGKCFRIYSKDFWNQc 361
Cdd:PRK11664 265 RRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER- 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 362 MPDHVIPEIKRTSLTSVVLTLKCLAIHDVIRFPYLDPPNERLILEALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTC 441
Cdd:PRK11664 344 AAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAA 423
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034601281 442 AVIKAASLDceDLLLPIAAML-------------SVENVFIRPvDPEYQKEAEQRHRELAAKAG 492
Cdd:PRK11664 424 MLVAAKEDD--EAALATAAKLaaileepprsgssDLGVALSRK-QPHWQQRAQQLLKRLNVRGG 484
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
41-174 |
2.91e-67 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 218.48 E-value: 2.91e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 41 QHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAH 120
Cdd:cd17917 31 GKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAH 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1034601281 121 ERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17917 111 ERSLDTDFLLGLLKDLLR-----KRPDLKVILMSATLDAEKFSSYFGGAPVIHI 159
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
36-174 |
5.89e-62 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 204.90 E-value: 5.89e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 36 DRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVII 115
Cdd:cd17978 40 EAGFARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVII 119
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034601281 116 LDEAHERTLTTDILFGLLKKLFQEKSPNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17978 120 LDEAHERTVHTDVLFGLVKSAQRRRKEQKLSPLKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
38-174 |
5.74e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 202.31 E-value: 5.74e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 38 GFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILD 117
Cdd:cd17983 42 GYTDYGMIGCTQPRRVAAMSVAKRVSEEMGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMD 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034601281 118 EAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17983 122 EAHERSLNTDVLFGLLREVVA-----RRRDLKLIVTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
34-175 |
3.24e-60 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 200.40 E-value: 3.24e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 34 IADRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSV 113
Cdd:cd17971 43 LAEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSV 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034601281 114 IILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDIP 175
Cdd:cd17971 123 IMLDEAHERTIHTDVLFGLLKKTVQ-----KRPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
44-174 |
1.93e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 182.62 E-value: 1.93e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 44 MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERT 123
Cdd:cd17973 62 LVACTQPRRVAAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERT 141
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1034601281 124 LTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17973 142 LATDILMGLLKEVVR-----RRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
38-174 |
7.84e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 177.69 E-value: 7.84e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 38 GFSQHGM-IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIIL 116
Cdd:cd17974 42 GYTKGGGkIGCTQPRRVAAMSVAARVAEEMGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMII 121
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034601281 117 DEAHERTLTTDILFGLLKKLfqekSPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17974 122 DEAHERTLHTDILFGLVKDI----ARFRPD-LKLLISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
34-166 |
2.15e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 163.02 E-value: 2.15e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 34 IADRGFSQHG-MIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK-ETAIKYMTDGCLLKHILGDPNLTKF 111
Cdd:cd17980 38 LAEAGWTAGGrVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKY 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1034601281 112 SVIILDEAHERTLTTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFF 166
Cdd:cd17980 118 SVIMLDEAHERTLYTDILIGLLKKIQK-----KRGDLRLIVASATLDAEKFRDFF 167
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
35-175 |
4.52e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 162.52 E-value: 4.52e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 35 ADRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKcTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVI 114
Cdd:cd17982 44 GSPESDNPGMIGITQPRRVAAVSMAKRVAEELN-VFGKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVI 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034601281 115 ILDEAHERTLTTDILFGLL-------KKLFqeKSPNRKEHLKVVVMSATMelaKLSAFFGNCPIFDIP 175
Cdd:cd17982 123 IIDEAHERSVNTDILIGMLsrivplrAKLY--LQDQTVKPLKLVIMSATL---RVEDFTENKLLFPRP 185
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
28-174 |
1.82e-41 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 149.14 E-value: 1.82e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 28 RLSAVCIaDRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPN 107
Cdd:cd17989 33 QLPKICL-ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRY 111
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034601281 108 LTKFSVIILDEAHERTLTTDILFGLLKKLFqeksPNRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17989 112 LRAYDTIIIDEAHERSLNIDFLLGYLKQLL----PRRPD-LKVIITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
43-172 |
2.03e-35 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 132.07 E-value: 2.03e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 43 GMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHER 122
Cdd:cd17990 47 GKIIVLEPRRVAARAAARRLATLLGEAPGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHER 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1034601281 123 TLTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMELAKLSAFFGNCPIF 172
Cdd:cd17990 127 SLDADLALALLLEVQQL----LRDDLRLLAMSATLDGDGLAALLPEAPVV 172
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
45-174 |
5.05e-32 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 122.17 E-value: 5.05e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 45 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 124
Cdd:cd17979 46 IACTQPRRIACISLAKRVAFESLNQYGSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHL 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 1034601281 125 TTDILFGLLKKLFQekspnRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17979 126 HGDFLLGVLRCLLR-----LRPDLKLILMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
45-167 |
3.39e-31 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 120.30 E-value: 3.39e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 45 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHERTL 124
Cdd:cd17988 51 IVVTQPRRIAAISIARRVSQEREWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQ 130
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1034601281 125 TTDILFGLLKKLFQEKSpnrkEHLKVVVMSATMELAKLSAFFG 167
Cdd:cd17988 131 ELDFLLLVVRRLLRTNS----RHVKIILMSATISCKEFADYFT 169
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
37-174 |
3.91e-31 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 119.95 E-value: 3.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 37 RGFSQHGMIGVTQPRKVAAISVAQRVAEEM--KCTLGSKVGYQVRFDDCSSKETA-IKYMTDGCLLKHILGDPNLTKFSV 113
Cdd:cd17981 45 RGKGSSCRIVCTQPRRISAISVAERVAAERaeSCGLGNSTGYQIRLESRKPRKQGsILYCTTGIVLQWLQSDPHLSNVSH 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034601281 114 IILDEAHERTLTTDILFGLLKKLFqekspNRKEHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17981 125 LVLDEIHERNLQSDVLMGIVKDLL-----PFRSDLKVILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
41-174 |
1.08e-30 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 118.77 E-value: 1.08e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 41 QHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAH 120
Cdd:cd17977 48 QHGVVVCTQVHKQTAVWLALRVADEMDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAH 127
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1034601281 121 ERTLTTDILFGLLKKLFQEkspnRKEhLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17977 128 ERTVSTDVLLGLLKDVLLS----RPE-LKLVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
37-174 |
1.12e-29 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 115.77 E-value: 1.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 37 RGFsQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIIL 116
Cdd:cd17986 46 RGF-QKGQVTVTQPHPLAARSLALRVADEMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVL 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034601281 117 DEAHERTLTTDILFGLLKKLFQEkspnRKEHLKVVVMSATMElAKLSAFFGNCPIFDI 174
Cdd:cd17986 125 DEAQERSVASDSLLGLLKDVRLQ----RPELRVVVVTSPALE-PKLRAFWGNPPVVHV 177
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
37-174 |
4.96e-29 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 113.78 E-value: 4.96e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 37 RGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNLTKFSVIIL 116
Cdd:cd17985 45 GPPLPVANIICTQPRRISAISVAERVAQERAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIV 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034601281 117 DEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17985 125 DEVHERTEESDFLLLVLKDLMVQRP-----DLKVILMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
37-171 |
1.04e-28 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 112.96 E-value: 1.04e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 37 RGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDD-CSSKETAIKYMTDGCLLKHILGDPNLTKFSVII 115
Cdd:cd17976 45 RGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRRNVGYQVRLESrPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVI 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034601281 116 LDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPI 171
Cdd:cd17976 125 VDEVHERDVNTDFLLILLKGVLQLNP-----ELRVVLMSATGDNQRLSRYFGGCPV 175
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
34-174 |
1.54e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 106.92 E-value: 1.54e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 34 IADRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKCTLG-----SKVGYQVRFDDCSSKETAIKYMTDGCLLKHILGDPNL 108
Cdd:cd17975 43 LLNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESGpggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLL 122
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034601281 109 TKFSVIILDEAHERTLTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17975 123 SSISHIIVDEVHERSVQSDFLLIILKEILHKRS-----DLHLILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
48-174 |
2.12e-25 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 103.37 E-value: 2.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 48 TQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLKHIL-GDPNLTKFSVIILDEAHERTLTT 126
Cdd:cd17987 54 TQPRRLAAIAVAERVAAERGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMaGDSALSTVTHVIVDEVHERDRFS 133
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 1034601281 127 DILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17987 134 DFLLTKLRDILQKHP-----NLKLILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
45-174 |
4.89e-22 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 95.67 E-value: 4.89e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 45 IGVTQPRKVAAISVAQRVAEEMKCTLGSKVGYQVRFDDCSSK-ETAIKYMTDGCLLKHIlgDPNLTKFSVIILDEAHERT 123
Cdd:cd17972 111 IVVTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRpHASILFCTVGVLLRKL--EAGIRGISHVIVDEIHERD 188
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1034601281 124 LTTDILFGLLKKLFQEKSpnrkeHLKVVVMSATMELAKLSAFFGNCPIFDI 174
Cdd:cd17972 189 INTDFLLVVLRDVVQAYP-----DLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
407-491 |
7.91e-19 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 82.29 E-value: 7.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 407 ALKQLYQCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRPVDPEYQKEAEQRHRE 486
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLDPRSAAKAARRR 80
|
....*
gi 1034601281 487 LAAKA 491
Cdd:pfam04408 81 RRAAD 85
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
563-643 |
8.23e-19 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 81.53 E-value: 8.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 563 LRRCLCAGYFKNVARR-SVGRTFCTMDGrGSPVHIHPSSAL-HEQETKLEWIIFHEVLVTTKVYARIVCPIRYEWVRDLL 640
Cdd:pfam07717 1 LRAALAAGLYPNVARRdPKGKGYTTLSD-NQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFA 79
|
...
gi 1034601281 641 PKL 643
Cdd:pfam07717 80 PHI 82
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
413-501 |
4.24e-17 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 76.54 E-value: 4.24e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 413 QCDAIDRSGHVTRLGLSMVEFPLPPHLTCAVIKAASLDCEDLLLPIAAMLSVENVFIRpvdpEYQKEAEQRHRELAAKAG 492
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPRPK----EKREDADAARRRFADPES 76
|
....*....
gi 1034601281 493 gfnDFATLA 501
Cdd:smart00847 77 ---DHLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
40-180 |
4.47e-16 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 77.53 E-value: 4.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 40 SQHGMIGVTQPRKVAAISVAQRVAEEMKCTLGSKVGY------QVRFDDCSSKETAIKYMTDGCLLKHILGDP-NLTKFS 112
Cdd:smart00487 52 GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKVVGLyggdskREQLRKLESGKTDILVTTPGRLLDLLENDKlSLSNVD 131
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034601281 113 VIILDEAHERT--LTTDILFGLLKKLfqekspnrKEHLKVVVMSATM--ELAKLSAFFGNCPIFDIPGRLYP 180
Cdd:smart00487 132 LVILDEAHRLLdgGFGDQLEKLLKLL--------PKNVQLLLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
256-343 |
4.08e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 59.53 E-value: 4.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 256 GLLILPCYGSMTTDQQRRIFLPPPPGIRKCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEAL 335
Cdd:smart00490 11 GIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPASYI 72
|
....*...
gi 1034601281 336 QRSGRAGR 343
Cdd:smart00490 73 QRIGRAGR 80
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
107-356 |
1.08e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 61.92 E-value: 1.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 107 NLTKFSVIILDEAHERTLTTDILFGLLKKLfqeksPNRKEHLkvVVMSATME--LAKLSAFFGNcPIF-DIPG-RLYPVR 182
Cdd:PHA02653 288 KLFDYGTVIIDEVHEHDQIGDIIIAVARKH-----IDKIRSL--FLMTATLEddRDRIKEFFPN-PAFvHIPGgTLFPIS 359
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 183 EKFC-NLIGPRDR------ENTAYIQAIVKVTMDihlNEMAGDILVFLTGQfeieksCELLFQMAESVDYDYDV-----Q 250
Cdd:PHA02653 360 EVYVkNKYNPKNKrayieeEKKNIVTALKKYTPP---KGSSGIVFVASVSQ------CEEYKKYLEKRLPIYDFyiihgK 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 251 DTTLDGLLilpcygsmttdqqRRIFLPPPPGIrkcVISTNISATSLTIDGIRYVVDGG--FVKQlnhnPRLGLDILevvp 328
Cdd:PHA02653 431 VPNIDEIL-------------EKVYSSKNPSI---IISTPYLESSVTIRNATHVYDTGrvYVPE----PFGGKEMF---- 486
|
250 260
....*....|....*....|....*...
gi 1034601281 329 ISKSEALQRSGRAGRTSSGKCFRIYSKD 356
Cdd:PHA02653 487 ISKSMRTQRKGRVGRVSPGTYVYFYDLD 514
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
204-343 |
6.37e-08 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 51.06 E-value: 6.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 204 VKVTMDIHLNEMAGDILVFLTGQFEIEksCELLFQmaesvdydydvqdttLDGLLILPCYGSMTTDQQRRIFLPPPPGIR 283
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLE--AELLLE---------------KEGIKVARLHGDLSQEEREEILEDFRKGKI 65
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 284 KCVISTNISATSLTIDGIRYVVDGGFvkqlnhnprlgldilevvPISKSEALQRSGRAGR 343
Cdd:pfam00271 66 DVLVATDVAERGLDLPDVDLVINYDL------------------PWNPASYIQRIGRAGR 107
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
86-157 |
2.59e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 39.15 E-value: 2.59e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034601281 86 KETAIKYMTDGCLLKHILGDPNLTKFSVIILDEAHErtlTTDILFG-LLKKLFQEKSPNRkehlKVVVMSATM 157
Cdd:pfam00270 93 KGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAHR---LLDMGFGpDLEEILRRLPKKR----QILLLSATL 158
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
110-235 |
5.19e-03 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 40.21 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 110 KFSVIILDEAH----ERTLTTDILFGLlkklfqeKSPNRkehlkvVVMSAT-MELaKLSAFFGncpIFDI--PGRLYPV- 181
Cdd:COG0553 358 DWDLVILDEAQhiknPATKRAKAVRAL-------KARHR------LALTGTpVEN-RLEELWS---LLDFlnPGLLGSLk 420
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1034601281 182 --REKFCNLIGPRDRENTAYIQAIVKVTMdihLNEMAGDILVFLTGQFEIEKSCEL 235
Cdd:COG0553 421 afRERFARPIEKGDEEALERLRRLLRPFL---LRRTKEDVLKDLPEKTEETLYVEL 473
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
34-156 |
8.40e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 37.38 E-value: 8.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034601281 34 IADRGFSQHGMIGVTQPRKVAAISVAQRVAEEMKctLGSKVGYQVRFDDCSSKETAIK------YMTDGCLLKHILGD-- 105
Cdd:cd00046 22 ALLLLLKKGKKVLVLVPTKALALQTAERLRELFG--PGIRVAVLVGGSSAEEREKNKLgdadiiIATPDMLLNLLLREdr 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1034601281 106 PNLTKFSVIILDEAHERTLTTDILFGLLKKLFQEKSPNrkehLKVVVMSAT 156
Cdd:cd00046 100 LFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLKN----AQVILLSAT 146
|
|
| |
