NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034603763|ref|XP_016881163|]
View 

microtubule cross-linking factor 1 isoform X19 [Homo sapiens]

Protein Classification

SOGA and DUF4482 domain-containing protein( domain architecture ID 13530637)

protein containing domains SMC_prok_B, SOGA, and DUF4482

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF4482 pfam14818
Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately ...
 973-1096 7.28e-51

Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.


:

Pssm-ID: 464333 [Multi-domain]  Cd Length: 138  Bit Score: 176.03  E-value: 7.28e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  973 MDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR------------GGSFLCDQKDGNVR 1040
Cdd:pfam14818    1 MDLRWQLQHTEKNWHREKMELLDRFDRERQEWESQKKIMQKKIEQLQREVSLRRkinmnerakvidGEKFVPDQKESSSP 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034603763 1041 PFPHQGSLRMPR--PVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDD 1096
Cdd:pfam14818   81 PFPDSGQCEFPRmnHPGSLSKSDSDEESFLDEGNQKLKEQKRCKASENLFLDALSLDN 138
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 167-261 3.21e-37

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


:

Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 135.50  E-value: 3.21e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  167 DSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANI 246
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSDSSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  247 LGRKIVELEVENRGL 261
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 296-388 1.07e-36

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


:

Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 133.96  E-value: 1.07e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  296 SSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGA--GGGAPLQEELKSARLQISE 373
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSdsSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  374 LSGKVLKLQHENHAL 388
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 9-322 1.65e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    9 LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK 88
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   89 AEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKtfnqqnggmerpgncrpatKTQRKLAPRRKDDS 168
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRI-------------------AATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  169 ADLRCQLQFAKEEaflmrkkMAKLGREKDELEQELQKYKSLYGDVDSPLptgeaggppstreAELKLRLKLVEEEANILG 248
Cdd:TIGR02168  848 EELSEDIESLAAE-------IEELEELIEELESELEALLNERASLEEAL-------------ALLRSELEELSEELRELE 907

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034603763  249 RKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLEsstELRRHLQFVEEEAELLRRSISEIE 322
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLE---EAEALENKIEDDEEEARRRLKRLE 978
 
Name Accession Description Interval E-value
DUF4482 pfam14818
Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately ...
 973-1096 7.28e-51

Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.


Pssm-ID: 464333 [Multi-domain]  Cd Length: 138  Bit Score: 176.03  E-value: 7.28e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  973 MDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR------------GGSFLCDQKDGNVR 1040
Cdd:pfam14818    1 MDLRWQLQHTEKNWHREKMELLDRFDRERQEWESQKKIMQKKIEQLQREVSLRRkinmnerakvidGEKFVPDQKESSSP 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034603763 1041 PFPHQGSLRMPR--PVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDD 1096
Cdd:pfam14818   81 PFPDSGQCEFPRmnHPGSLSKSDSDEESFLDEGNQKLKEQKRCKASENLFLDALSLDN 138
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 167-261 3.21e-37

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 135.50  E-value: 3.21e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  167 DSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANI 246
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSDSSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  247 LGRKIVELEVENRGL 261
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 296-388 1.07e-36

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 133.96  E-value: 1.07e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  296 SSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGA--GGGAPLQEELKSARLQISE 373
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSdsSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  374 LSGKVLKLQHENHAL 388
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 9-322 1.65e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    9 LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK 88
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   89 AEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKtfnqqnggmerpgncrpatKTQRKLAPRRKDDS 168
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRI-------------------AATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  169 ADLRCQLQFAKEEaflmrkkMAKLGREKDELEQELQKYKSLYGDVDSPLptgeaggppstreAELKLRLKLVEEEANILG 248
Cdd:TIGR02168  848 EELSEDIESLAAE-------IEELEELIEELESELEALLNERASLEEAL-------------ALLRSELEELSEELRELE 907

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034603763  249 RKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLEsstELRRHLQFVEEEAELLRRSISEIE 322
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLE---EAEALENKIEDDEEEARRRLKRLE 978
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-208 1.13e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEqkslkvAETGQVDGELIRSLEQDLKVAKDvsvRLHHELKTVEEKRAKAEDENE 94
Cdd:COG4913    256 PIRELAERYAAARERLAELEYLRAALR------LWFAQRRLELLEAELEELRAELA---RLEAELERLEARLDALREELD 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVE-ISKQALQNELERLKESSLKRRSTREMYKEKktfnQQNGGMERPGNcRPATKTQRKLAPRRKDDSADLRC 173
Cdd:COG4913    327 ELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEAL----LAALGLPLPAS-AEEFAALRAEAAALLEALEEELE 401

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1034603763  174 QLQfakEEAFLMRKKMAKLGREKDELEQELQKYKS 208
Cdd:COG4913    402 ALE---EALAEAEAALRDLRRELRELEAEIASLER 433
PTZ00121 PTZ00121
MAEBL; Provisional
 1-207 4.39e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 4.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    1 MEEMRDSYLEEDVYQLQELRREldranKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELK 80
Cdd:PTZ00121  1594 IEEVMKLYEEEKKMKAEEAKKA-----EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   81 TVEEKRAKAEdenETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKE---KKTFNQQNGGMERPGncRPATKTQ 157
Cdd:PTZ00121  1669 KAEEDKKKAE---EAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAeelKKAEEENKIKAEEAK--KEAEEDK 1743

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034603763  158 RKLAPRRKDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYK 207
Cdd:PTZ00121  1744 KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 15-205 1.14e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.05  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNcriLQYRLRKAEQKSLKVAETGQVD----GELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAE 90
Cdd:pfam07111  482 ELEQLREERNRLDAE---LQLSAHLIQQEVGRAREQGEAErqqlSEVAQQLEQELQRAQESLASVGQQLEVARQGQQEST 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   91 DENETLRQQMI-EVEISKQALQN---ELE-RLKE--SSLKRR---STREMYKEKKTFNQqnggmerpgncrpatkTQRKl 160
Cdd:pfam07111  559 EEAASLRQELTqQQEIYGQALQEkvaEVEtRLREqlSDTKRRlneARREQAKAVVSLRQ----------------IQHR- 621

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034603763  161 APRRKDDSADL-RCQLQFAKEEAFLMRKKMAKLGREKDELEQELQK 205
Cdd:pfam07111  622 ATQEKERNQELrRLQDEARKEEGQRLARRVQELERDKNLMLATLQQ 667
 
Name Accession Description Interval E-value
DUF4482 pfam14818
Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately ...
 973-1096 7.28e-51

Domain of unknown function (DUF4482); This family is found in eukaryotes, and is approximately 140 amino acids in length. The family is found in association with pfam11365.


Pssm-ID: 464333 [Multi-domain]  Cd Length: 138  Bit Score: 176.03  E-value: 7.28e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  973 MDLRWQIHHSEKNWNREKVELLDRLDRDRQEWERQKKEFLWRIEQLQKENSPRR------------GGSFLCDQKDGNVR 1040
Cdd:pfam14818    1 MDLRWQLQHTEKNWHREKMELLDRFDRERQEWESQKKIMQKKIEQLQREVSLRRkinmnerakvidGEKFVPDQKESSSP 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034603763 1041 PFPHQGSLRMPR--PVAMWPCADADSIPFEDRPLSKLKESDRCSASENLYLDALSLDD 1096
Cdd:pfam14818   81 PFPDSGQCEFPRmnHPGSLSKSDSDEESFLDEGNQKLKEQKRCKASENLFLDALSLDN 138
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 167-261 3.21e-37

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 135.50  E-value: 3.21e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  167 DSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANI 246
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSDSSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  247 LGRKIVELEVENRGL 261
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SOGA pfam11365
Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, ...
 296-388 1.07e-36

Protein SOGA; The SOGA (suppressor of glucose by autophagy) family consists of proteins SOGA1, SOGA2, and SOGA3. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin and insulin dependent manner.


Pssm-ID: 463264 [Multi-domain]  Cd Length: 95  Bit Score: 133.96  E-value: 1.07e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  296 SSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKFKFEPPREPGWLGEGASPGA--GGGAPLQEELKSARLQISE 373
Cdd:pfam11365    1 SSAELRRQLQFVEEEAELLRRSLSEIEDHNKQLTNELNKYKSKYGPDESSLSDGEGGGSdsSREAELQEELKLARLQINE 80

                           90
                   ....*....|....*
gi 1034603763  374 LSGKVLKLQHENHAL 388
Cdd:pfam11365   81 LSGKVMKLQYENRVL 95
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 9-322 1.65e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.69  E-value: 1.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    9 LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK 88
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEE 786

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   89 AEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKtfnqqnggmerpgncrpatKTQRKLAPRRKDDS 168
Cdd:TIGR02168  787 LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRI-------------------AATERRLEDLEEQI 847

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  169 ADLRCQLQFAKEEaflmrkkMAKLGREKDELEQELQKYKSLYGDVDSPLptgeaggppstreAELKLRLKLVEEEANILG 248
Cdd:TIGR02168  848 EELSEDIESLAAE-------IEELEELIEELESELEALLNERASLEEAL-------------ALLRSELEELSEELRELE 907

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034603763  249 RKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLEsstELRRHLQFVEEEAELLRRSISEIE 322
Cdd:TIGR02168  908 SKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLE---EAEALENKIEDDEEEARRRLKRLE 978
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 58-382 4.44e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 58.53  E-value: 4.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   58 IRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKESSlkRRSTREMYKEKKTF 137
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEV--EQLEERIAQLSKEL 756

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  138 NQQNGgmERPGNCRPATKTQRKLApRRKDDSADLRCQLQFAKEEaflmrkkMAKLGREKDELEQELQKYKSLYGDVdspl 217
Cdd:TIGR02168  757 TELEA--EIEELEERLEEAEEELA-EAEAEIEELEAQIEQLKEE-------LKALREALDELRAELTLLNEEAANL---- 822

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  218 ptgeaggppSTREAELKLRLKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHApsiptspfgdsLESS 297
Cdd:TIGR02168  823 ---------RERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAL-----------LNER 882

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  298 TELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSKfkfepprepgwlgegaspgagggapLQEELKSARLQISELSGK 377
Cdd:TIGR02168  883 ASLEEALALLRSELEELSEELRELESKRSELRRELEE-------------------------LREKLAQLELRLEGLEVR 937


                   ....*
gi 1034603763  378 VLKLQ 382
Cdd:TIGR02168  938 IDNLQ 942
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 83-384 4.29e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 55.07  E-value: 4.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   83 EEKRAKAEDENETLRQQMIEVEISKQALQNELERLKesslKRRSTREMYKEKKTFNQQNGGMERPGNCRPATKTQRKLAP 162
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLR----REREKAERYQALLKEKREYEGYELLKEKEALERQKEAIER 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  163 RRkddsADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSlygdvDSPLPTGEAGGPPSTREAELKLRLKLVEE 242
Cdd:TIGR02169  245 QL----ASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGE-----EEQLRVKEKIGELEAEIASLERSIAEKER 315

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  243 EANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHApsipTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIE 322
Cdd:TIGR02169  316 ELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKL----TEEYAELKEELEDLRAELEEVDKEFAETRDELKDYR 391

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034603763  323 DHNRQLTHELSKFKFEPPRepgwLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHE 384
Cdd:TIGR02169  392 EKLEKLKREINELKRELDR----LQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALE 449
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 10-338 1.17e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 53.91  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   10 EEDVYQLQELRRELDRANKNCRI-----LQYRLRKAEQKSLKVAETGQVDGELIRSLEQdLKVAKDVSVRLHHELktvEE 84
Cdd:TIGR02168  185 RENLDRLEDILNELERQLKSLERqaekaERYKELKAELRELELALLVLRLEELREELEE-LQEELKEAEEELEEL---TA 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   85 KRAKAEDENETLRQQMIEVEISKQALQNELERLKE--SSLKRRstREMYKEKKTFNQQNggmerpgncRPATKTQRKLAP 162
Cdd:TIGR02168  261 ELQELEEKLEELRLEVSELEEEIEELQKELYALANeiSRLEQQ--KQILRERLANLERQ---------LEELEAQLEELE 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  163 RRKD----DSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVdsplptgeaggppSTREAELKLRLK 238
Cdd:TIGR02168  330 SKLDelaeELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETL-------------RSKVAQLELQIA 396

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  239 LVEEEANILGRKIVELEVENRGLKAEMEDMRGQQERegpgrdHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSI 318
Cdd:TIGR02168  397 SLNNEIERLEARLERLEDRRERLQQEIEELLKKLEE------AELKELQAELEELEEELEELQEELERLEEALEELREEL 470

                          330       340
                   ....*....|....*....|
gi 1034603763  319 SEIEDHNRQLTHELSKFKFE 338
Cdd:TIGR02168  471 EEAEQALDAAERELAQLQAR 490
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-208 1.13e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.30  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEqkslkvAETGQVDGELIRSLEQDLKVAKDvsvRLHHELKTVEEKRAKAEDENE 94
Cdd:COG4913    256 PIRELAERYAAARERLAELEYLRAALR------LWFAQRRLELLEAELEELRAELA---RLEAELERLEARLDALREELD 326

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVE-ISKQALQNELERLKESSLKRRSTREMYKEKktfnQQNGGMERPGNcRPATKTQRKLAPRRKDDSADLRC 173
Cdd:COG4913    327 ELEAQIRGNGgDRLEQLEREIERLERELEERERRRARLEAL----LAALGLPLPAS-AEEFAALRAEAAALLEALEEELE 401

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1034603763  174 QLQfakEEAFLMRKKMAKLGREKDELEQELQKYKS 208
Cdd:COG4913    402 ALE---EALAEAEAALRDLRRELRELEAEIASLER 433
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
15-334 1.52e-05

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 49.13  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETgqvdgelIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENE 94
Cdd:COG4372     46 ELEQLREELEQAREELEQLEEELEQARSELEQLEEE-------LEELNEQLQAAQAELAQAQEELESLQEEAEELQEELE 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQQN-GGMERPGNCRPATKTQRKLAPRRKddsaDLRC 173
Cdd:COG4372    119 ELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEElAALEQELQALSEAEAEQALDELLK----EANR 194

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  174 QLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPST---REAELKLRLKLVEEEANILGRK 250
Cdd:COG4372    195 NAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEellEEVILKEIEELELAILVEKDTE 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  251 IVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTH 330
Cdd:COG4372    275 EEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELALAILLAELADLLQLLLVGLLDND 354


                   ....
gi 1034603763  331 ELSK 334
Cdd:COG4372    355 VLEL 358
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 60-561 3.26e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 48.89  E-value: 3.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   60 SLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENETLRQQMIEVE------ISKQALQNELERLKESSLKRRSTREMYKE 133
Cdd:TIGR00606  581 SKSKEINQTRDRLAKLNKELASLEQNKNHINNELESKEEQLSSYEdklfdvCGSQDEESDLERLKEEIEKSSKQRAMLAG 660

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  134 KKTFNQQ--NGGMERPGNCRPATKTQRKLAPRRKDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYG 211
Cdd:TIGR00606  661 ATAVYSQfiTQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIID 740

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  212 DVDSPLP-TGEAGGPPSTREAELKLRLklvEEEANILGRKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTSPF 290
Cdd:TIGR00606  741 LKEKEIPeLRNKLQKVNRDIQRLKNDI---EEQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVERKIAQQAAKLQG 817

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  291 GDSLESSTELRrhlQFVEEEAELLRRSISEIEDhNRQLTHELSKfkfepprepgwlgegaspGAGGGAPLQEELKSARLQ 370
Cdd:TIGR00606  818 SDLDRTVQQVN---QEKQEKQHELDTVVSKIEL-NRKLIQDQQE------------------QIQHLKSKTNELKSEKLQ 875

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  371 ISELSGKVLKLQHENHALLSNIQRCDLAAHLGLRAPSPRDSDAESDAGKKESDGEESRLPQPKREGPVggeSDSEEMFEK 450
Cdd:TIGR00606  876 IGTNLQRRQQFEEQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKV---NDIKEKVKN 952

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  451 TSGFGSGKPSEASEPCPTELL-KAREDSEYLVTLKHEAQRLERTVERLITDTDSFlhdaglrggaplpgpglqGEEEQGE 529
Cdd:TIGR00606  953 IHGYMKDIENKIQDGKDDYLKqKETELNTVNAQLEECEKHQEKINEDMRLMRQDI------------------DTQKIQE 1014

                          490       500       510
                   ....*....|....*....|....*....|..
gi 1034603763  530 GDQQEPQLLGTINAKMKAFKKELQAFLEQVNR 561
Cdd:TIGR00606 1015 RWLQDNLTLRKRENELKEVEEELKQHLKEMGQ 1046
PTZ00121 PTZ00121
MAEBL; Provisional
 1-207 4.39e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.60  E-value: 4.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    1 MEEMRDSYLEEDVYQLQELRREldranKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELK 80
Cdd:PTZ00121  1594 IEEVMKLYEEEKKMKAEEAKKA-----EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   81 TVEEKRAKAEdenETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKE---KKTFNQQNGGMERPGncRPATKTQ 157
Cdd:PTZ00121  1669 KAEEDKKKAE---EAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAeelKKAEEENKIKAEEAK--KEAEEDK 1743

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034603763  158 RKLAPRRKDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYK 207
Cdd:PTZ00121  1744 KKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRR 1793
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 15-275 5.13e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENE 94
Cdd:COG1196    240 ELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLE 319

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQQNggmerpgncrpATKTQRKLAPRRKDDSADLRcQ 174
Cdd:COG1196    320 ELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEA-----------LLEAEAELAEAEEELEELAE-E 387

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  175 LQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLpTGEAGGPPSTREAELKLRLKLVEEEANILG--RKIV 252
Cdd:COG1196    388 LLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL-AELEEEEEEEEEALEEAAEEEAELEEEEEAllELLA 466

                          250       260
                   ....*....|....*....|...
gi 1034603763  253 ELEVENRGLKAEMEDMRGQQERE 275
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEA 489
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 15-257 9.25e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 9.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETgqvdgelIRSLEQDLKVAKDvsvrlhhELKTVEEKRAKAEDENE 94
Cdd:COG4942     21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQ-------LAALERRIAALAR-------RIRALEQELAALEAELA 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVEISKQALQNELERLkesslkrrsTREMYKekktfNQQNGGMERPGNCRPATKTQR------KLAPRRKDDS 168
Cdd:COG4942     87 ELEKEIAELRAELEAQKEELAEL---------LRALYR-----LGRQPPLALLLSPEDFLDAVRrlqylkYLAPARREQA 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  169 ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAggppstREAELKLRLKLVEEEANILG 248
Cdd:COG4942    153 EELRADLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEK------ELAELAAELAELQQEAEELE 226


                   ....*....
gi 1034603763  249 RKIVELEVE 257
Cdd:COG4942    227 ALIARLEAE 235
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 15-205 1.14e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 47.05  E-value: 1.14e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNcriLQYRLRKAEQKSLKVAETGQVD----GELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAE 90
Cdd:pfam07111  482 ELEQLREERNRLDAE---LQLSAHLIQQEVGRAREQGEAErqqlSEVAQQLEQELQRAQESLASVGQQLEVARQGQQEST 558

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   91 DENETLRQQMI-EVEISKQALQN---ELE-RLKE--SSLKRR---STREMYKEKKTFNQqnggmerpgncrpatkTQRKl 160
Cdd:pfam07111  559 EEAASLRQELTqQQEIYGQALQEkvaEVEtRLREqlSDTKRRlneARREQAKAVVSLRQ----------------IQHR- 621

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1034603763  161 APRRKDDSADL-RCQLQFAKEEAFLMRKKMAKLGREKDELEQELQK 205
Cdd:pfam07111  622 ATQEKERNQELrRLQDEARKEEGQRLARRVQELERDKNLMLATLQQ 667
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 13-328 1.16e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.04  E-value: 1.16e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   13 VYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQ--VDGELIRSLEQDlkvaKDVSVRLHHELKTVEEKRA--- 87
Cdd:pfam17380  277 IVQHQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRklEEAEKARQAEMD----RQAAIYAEQERMAMEREREler 352

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   88 -KAED---ENETLRQQMIEVEISK----QALQNEL----ERLKESSLKRRSTREMYKEK-KTFNQQNGGME--RPGNCRP 152
Cdd:pfam17380  353 iRQEErkrELERIRQEEIAMEISRmrelERLQMERqqknERVRQELEAARKVKILEEERqRKIQQQKVEMEqiRAEQEEA 432

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  153 ATKTQRKLAPRRKDDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLptgeaggppstrEAE 232
Cdd:pfam17380  433 RQREVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKIL------------EKE 500

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  233 LKLRLKLVEEEANilGRKIVELEVENRGLKAEMEDMRGQQEREgpGRDHAPSIPTSPFGDSLESSTELRRHLQFVEEEAE 312
Cdd:pfam17380  501 LEERKQAMIEEER--KRKLLEKEMEERQKAIYEEERRREAEEE--RRKQQEMEERRRIQEQMRKATEERSRLEAMERERE 576

                          330
                   ....*....|....*.
gi 1034603763  313 LLRRsISEIEDHNRQL 328
Cdd:pfam17380  577 MMRQ-IVESEKARAEY 591
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 15-334 1.30e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 1.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNcRILQYRLRKAEQKSLKVAetgqvdgelIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENE 94
Cdd:COG1196    201 QLEPLERQAEKAERY-RELKEELKELEAELLLLK---------LRELEAELEELEAELEELEAELEELEAELAELEAELE 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   95 TLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQQNggMERpgncrpATKTQRKLAPRRKDDSAdlrcQ 174
Cdd:COG1196    271 ELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEER--LEE------LEEELAELEEELEELEE----E 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  175 LQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDsplptgeaggppSTREAELKLRLKLVEEEANILgRKIVEL 254
Cdd:COG1196    339 LEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE------------EELEELAEELLEALRAAAELA-AQLEEL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  255 EVENRGLKAEMEDMRGQQEREGpgrdhapsiptspfGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHELSK 334
Cdd:COG1196    406 EEAEEALLERLERLEEELEELE--------------EALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
16-336 3.42e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.44  E-value: 3.42e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   16 LQELRRELDRankncrilqyrlRKAEQKSLkVAETGQVDgELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENET 95
Cdd:PRK03918   167 LGEVIKEIKR------------RIERLEKF-IKRTENIE-ELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKE 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   96 L---RQQMIEVEISKQALQNELERLKEsslKRRSTREMYKEKKtfnqqnggmerpgncrpatKTQRKLAPRRKDDSadlr 172
Cdd:PRK03918   233 LeelKEEIEELEKELESLEGSKRKLEE---KIRELEERIEELK-------------------KEIEELEEKVKELK---- 286

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  173 cQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAggpPSTREAELKLRLKLVEEEANILGRKIV 252
Cdd:PRK03918   287 -ELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEE---KEERLEELKKKLKELEKRLEELEERHE 362

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  253 ELEVenrgLKAEMEDMRGQQEREGPgrdhapsiptspfgdslESSTELRRHLQFVEEEAELLRRSISEIEDHNRQLTHEL 332
Cdd:PRK03918   363 LYEE----AKAKKEELERLKKRLTG-----------------LTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEI 421


                   ....
gi 1034603763  333 SKFK 336
Cdd:PRK03918   422 KELK 425
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
15-225 3.88e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   15 QLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAkdvsvRLHHELKTVEEKRAKAEDEN- 93
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVA-----SAEREIAELEAELERLDASSd 685

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   94 --ETLRQQMIEVEISKQALQNELERLKEsslkRRSTREmyKEKKTFNQQnggmerpgncRPATKTQRKLAPRRKDDSADL 171
Cdd:COG4913    686 dlAALEEQLEELEAELEELEEELDELKG----EIGRLE--KELEQAEEE----------LDELQDRLEAAEDLARLELRA 749

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034603763  172 RCQLQFAKEEAFLMRKKM------------AKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGP 225
Cdd:COG4913    750 LLEERFAAALGDAVERELrenleeridalrARLNRAEEELERAMRAFNREWPAETADLDADLESLP 815
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 2-285 4.84e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 45.11  E-value: 4.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    2 EEMRDSYLEedvyqLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQvdgELIRSLeQDLKVAKDvsvRLHHELKT 81
Cdd:pfam15921  597 KEINDRRLE-----LQEFKILKDKKDAKIRELEARVSDLELEKVKLVNAGS---ERLRAV-KDIKQERD---QLLNEVKT 664

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   82 VEEKRAKAEDENETL----RQQMIEVEISKQALQNELerlkesslkRRSTREMYKEKKTFNQQNGGmerPGNC-RPATKT 156
Cdd:pfam15921  665 SRNELNSLSEDYEVLkrnfRNKSEEMETTTNKLKMQL---------KSAQSELEQTRNTLKSMEGS---DGHAmKVAMGM 732

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  157 QRKLAPRRKDDSAdLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVdsplptgeAGGPPSTREAELKLR 236
Cdd:pfam15921  733 QKQITAKRGQIDA-LQSKIQFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEKNKM--------AGELEVLRSQERRLK 803

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034603763  237 LKLVEEEANILGRKIVELEVENRGLKAEMEDMRGQ-------QEREGPGRDHAPSI 285
Cdd:pfam15921  804 EKVANMEVALDKASLQFAECQDIIQRQEQESVRLKlqhtldvKELQGPGYTSNSSM 859
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 16-327 5.12e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 5.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   16 LQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENET 95
Cdd:TIGR02169  704 LDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALND 783

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   96 L-----RQQMIEVEISKQALQNELERLK------ESSLKRRSTREMYKEKKTFNQQNGgmerpgncRPATKTQRKLAPRR 164
Cdd:TIGR02169  784 LearlsHSRIPEIQAELSKLEEEVSRIEarlreiEQKLNRLTLEKEYLEKEIQELQEQ--------RIDLKEQIKSIEKE 855

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  165 KDDS------------------ADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLptGEAGGPP 226
Cdd:TIGR02169  856 IENLngkkeeleeeleeleaalRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKL--EALEEEL 933

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  227 STREAELKLRLKLVEEEANI--LGRKIVELEVENRGLkaEMEDMRGQQEREgpgrdhapsiptspfgDSLESSTELRRHL 304
Cdd:TIGR02169  934 SEIEDPKGEDEEIPEEELSLedVQAELQRVEEEIRAL--EPVNMLAIQEYE----------------EVLKRLDELKEKR 995

                          330       340
                   ....*....|....*....|...
gi 1034603763  305 QFVEEEAELLRRSISEIEDHNRQ 327
Cdd:TIGR02169  996 AKLEEERKAILERIEEYEKKKRE 1018
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
9-336 6.46e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 44.67  E-value: 6.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    9 LEEDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQVDGELIRSLEQdLKVAKDVSVRLHHELKTVEEKRAK 88
Cdd:PRK03918   233 LEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELKE-LKEKAEEYIKLSEFYEEYLDELRE 311

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   89 AEDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQQ-NGGMERPGNCRpatKTQRKLAPRRKDD 167
Cdd:PRK03918   312 IEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELyEEAKAKKEELE---RLKKRLTGLTPEK 388

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  168 SADLRCQLQFAKEEaflMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAGGPPSTREAELKLRLKLVEEEANIL 247
Cdd:PRK03918   389 LEKELEELEKAKEE---IEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKELLEEYTAELKRIE 465

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  248 GRKIvELEVENRGLKAEMEDMRGQQEREgpgRDHAPSIPTSPFGDSLESSTEL--RRHLQFVEEEAELLRRSISEIEDHN 325
Cdd:PRK03918   466 KELK-EIEEKERKLRKELRELEKVLKKE---SELIKLKELAEQLKELEEKLKKynLEELEKKAEEYEKLKEKLIKLKGEI 541

                          330
                   ....*....|.
gi 1034603763  326 RQLTHELSKFK 336
Cdd:PRK03918   542 KSLKKELEKLE 552
PTZ00121 PTZ00121
MAEBL; Provisional
 10-275 7.55e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 7.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   10 EEDVYQLQELRRELDRANKncrilQYRLRKAEQK----SLKVAETGQVDGELIRSLE----QDLKVAKDVsvRLHHELKT 81
Cdd:PTZ00121  1493 EEAKKKADEAKKAAEAKKK-----ADEAKKAEEAkkadEAKKAEEAKKADEAKKAEEkkkaDELKKAEEL--KKAEEKKK 1565

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   82 VEEKRAKAEDENETLRQqmieVEISKQAlqnELERLKESSLKRRSTREMYKEKktFNQQNGGMERPGNCRPATKTQRKLA 161
Cdd:PTZ00121  1566 AEEAKKAEEDKNMALRK----AEEAKKA---EEARIEEVMKLYEEEKKMKAEE--AKKAEEAKIKAEELKKAEEEKKKVE 1636

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  162 PRRKDDSADLRCQLQFAKEEaflmRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEAggppSTREAELKLRLKLVE 241
Cdd:PTZ00121  1637 QLKKKEAEEKKKAEELKKAE----EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEA----LKKEAEEAKKAEELK 1708

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1034603763  242 EEANILGRKIVELEVENRGLKAEMEDMRGQQERE 275
Cdd:PTZ00121  1709 KKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED 1742
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 10-391 1.93e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 43.09  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   10 EEDVYQLQELRRELDRANKNCRILQYRLR--KAEQKSLKvaetGQVDGELIRSLEQDLKVAKDVSVRLHHELKTVEEKRA 87
Cdd:TIGR04523  263 NKIKKQLSEKQKELEQNNKKIKELEKQLNqlKSEISDLN----NQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIIS 338

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   88 KAEDENETLRQQMIEVEISKQALQNELERlKESSLKRrstreMYKEKKTFNQQNggmerpgncrpatktqRKLaprrKDD 167
Cdd:TIGR04523  339 QLNEQISQLKKELTNSESENSEKQRELEE-KQNEIEK-----LKKENQSYKQEI----------------KNL----ESQ 392

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  168 SADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYKSLYGDVDSPLPTGEaggppsTREAELKLRLKLVEEEANIL 247
Cdd:TIGR04523  393 INDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLT------NQDSVKELIIKNLDNTRESL 466

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  248 GRKIVELEVENRGLKAEMEDMrgQQEREGPGRDHapSIPTSPFGDSLESSTELRRHLQFVEEEAELLRRSISEIEDHNRQ 327
Cdd:TIGR04523  467 ETQLKVLSRSINKIKQNLEQK--QKELKSKEKEL--KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISD 542

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034603763  328 LTHELSKFKFepprepgwlgegaspgagggaplqeELKSARL--QISELSGKVLKLQHENHALLSN 391
Cdd:TIGR04523  543 LEDELNKDDF-------------------------ELKKENLekEIDEKNKEIEELKQTQKSLKKK 583
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1-140 4.15e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 4.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    1 MEEMRDSYLEEDVYQLQELRRELDRANKN--CRILQYRLRKAEQKSLKVAETgQVDGELIRSLEQDLKVAKDVSVRLHHE 78
Cdd:pfam17380  407 LEEERQRKIQQQKVEMEQIRAEQEEARQRevRRLEEERAREMERVRLEEQER-QQQVERLRQQEEERKRKKLELEKEKRD 485

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034603763   79 LKTVEEKRAKA-EDENETLRQQMIEVEISKQALQNELE----------RLKESSLKRRSTREMyKEKKTFNQQ 140
Cdd:pfam17380  486 RKRAEEQRRKIlEKELEERKQAMIEEERKRKLLEKEMEerqkaiyeeeRRREAEEERRKQQEM-EERRRIQEQ 557
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 166-394 4.80e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 41.29  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  166 DDSADLRCQLQFAKEEAFLMRKKMAKLGREKDELEQELQKYkslygdvdsplptgeaggppSTREAELKLRLKLVEEEAN 245
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAAL--------------------ERRIAALARRIRALEQELA 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  246 ILGRKIVELEVENRGLKAEMEDMRGQQER-----EGPGRDHAPSIPTSP--FGDSLESSTELRRHLQFVEEEAELLRRSI 318
Cdd:COG4942     80 ALEAELAELEKEIAELRAELEAQKEELAEllralYRLGRQPPLALLLSPedFLDAVRRLQYLKYLAPARREQAEELRADL 159

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034603763  319 SEIEDHNRQLTHELSKfkfepprepgwLGEGASPGAGGGAPLQEELKSARLQISELSGKVLKLQHENHALLSNIQR 394
Cdd:COG4942    160 AELAALRAELEAERAE-----------LEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEE 224
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
11-328 4.87e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 41.68  E-value: 4.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   11 EDVYQLQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGqvdgELIRSLEQDLKVAKDVSVRLHHELKTVEEKRAK-A 89
Cdd:COG4717    122 EKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELE----EELEELEAELAELQEELEELLEQLSLATEEELQdL 197

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   90 EDENETLRQQMIEVEISKQALQNELERLKESSLKRRSTREMYKEKKTFNQQN-------GGMERPGNCRPATKTQRKLAP 162
Cdd:COG4717    198 AEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARlllliaaALLALLGLGGSLLSLILTIAG 277

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  163 RRKDDSADLRCQLQFAKEEAFLMRKKMAKLGR--EKDELEQ-ELQKYKSLYGdVDSPLPTGEAGGPPST----------- 228
Cdd:COG4717    278 VLFLVLGLLALLFLLLAREKASLGKEAEELQAlpALEELEEeELEELLAALG-LPPDLSPEELLELLDRieelqellrea 356

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763  229 REAELKLRLKLVEEEANILG-----------RKIVELEVENRGLKAEMEDMRGQQEREGPGRDHAPSIPTspfGDSLES- 296
Cdd:COG4717    357 EELEEELQLEELEQEIAALLaeagvedeeelRAALEQAEEYQELKEELEELEEQLEELLGELEELLEALD---EEELEEe 433

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1034603763  297 STELRRHLQFVEEEAELLRRSISEIEDHNRQL 328
Cdd:COG4717    434 LEELEEELEELEEELEELREELAELEAELEQL 465
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 16-143 5.58e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.59  E-value: 5.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   16 LQELRRELDRANKNCRILQYRLRKAEQKslkvaetgqvdgelIRSLEQDLKVAKDVSVRLHHELKTVEEKRAKAEDENET 95
Cdd:TIGR02169  394 LEKLKREINELKRELDRLQEELQRLSEE--------------LADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQ 459

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034603763   96 LRQQMIEVEISKQALQNELERL-KESSLKRRSTREMYKEKKTFNQQNGG 143
Cdd:TIGR02169  460 LAADLSKYEQELYDLKEEYDRVeKELSKLQRELAEAEAQARASEERVRG 508
DUF4201 pfam13870
Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. ...
 16-119 8.15e-03

Domain of unknown function (DUF4201); This is a family of coiled-coil proteins from eukaryotes. The function is not known.


Pssm-ID: 464008 [Multi-domain]  Cd Length: 177  Bit Score: 39.13  E-value: 8.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   16 LQELRRELDRANKNCRILQYRLRKAEQKSLKVAETGQ----VD-----------GELIRSLEQDLKVAKDVSVRLHHELK 80
Cdd:pfam13870    1 MRAKRNELSKLRLELITLKHTLAKIQEKLEQKEELGEgltmIDflqlqienqalNEKIEERNKELKRLKLKVTNTVHALT 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034603763   81 TVEEKRAKAEDENETLRQQMIEVEISKQALQNELERLKE 119
Cdd:pfam13870   81 HLKEKLHFLSAELSRLKKELRERQELLAKLRKELYRVKL 119
Rootletin pfam15035
Ciliary rootlet component, centrosome cohesion;
31-133 8.38e-03

Ciliary rootlet component, centrosome cohesion;


Pssm-ID: 464459 [Multi-domain]  Cd Length: 190  Bit Score: 39.25  E-value: 8.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763   31 RILQYRLRKAEQKSLKVAETGQVDGELIRSLEQDL-----KVAKDVSVRLHHELKTVEEKRAKAED---ENETLRQQMIE 102
Cdd:pfam15035   24 KVLQYKKRCSELEQQLLEKTSELEKTELLLRKLTLeprlqRLEREHSADLEEALIRLEEERQRSESlsqVNSLLREQLEQ 103

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1034603763  103 VEISKQALQNELERL-------------KESSLKRRstREMYKE 133
Cdd:pfam15035  104 ASRANEALREDLQKLtndwerareeleqKESEWRKE--EEAFNE 145
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
2-125 9.44e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.05  E-value: 9.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034603763    2 EEMRDSYLEEDVYQLQELRRELDRANKncrilqyRLRKAEQKSLKVAetgqvdgELIRSLEQDLKVAKDVSVRLHHELKt 81
Cdd:COG4913    326 DELEAQIRGNGGDRLEQLEREIERLER-------ELEERERRRARLE-------ALLAALGLPLPASAEEFAALRAEAA- 390

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1034603763   82 veEKRAKAEDENETLRQQMIEVEISKQALQNELERLKE--SSLKRR 125
Cdd:COG4913    391 --ALLEALEEELEALEEALAEAEAALRDLRRELRELEAeiASLERR 434
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH