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Conserved domains on  [gi|1034606628|ref|XP_016881918|]
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leucine-rich repeat LGI family member 4 isoform X1 [Homo sapiens]

Protein Classification

LRR 8 and EPTP domain-containing protein( domain architecture ID 10509911)

LRR (Leucine rich repeat) 8 and EPTP (Epitempin) domain-containing protein, similar to Homo sapiens leucine-rich glioma inactivated-1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 224-265 1.42e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 224 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 265
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 179-220 2.82e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 2.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 179 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 220
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 42-78 5.03e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034606628  42 FQTV-GESALSVEPFSYQGEPHIVLAqPFAGRCLILSW 78
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 269-308 5.44e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034606628 269 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 329-358 9.20e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 33.60  E-value: 9.20e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034606628 329 APRAFAHITMAGRRFLFAACFKGPTQIYQH 358
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 224-265 1.42e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 224 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 265
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 179-220 2.82e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 2.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 179 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 220
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 42-78 5.03e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034606628  42 FQTV-GESALSVEPFSYQGEPHIVLAqPFAGRCLILSW 78
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 269-308 5.44e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034606628 269 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 329-358 9.20e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 33.60  E-value: 9.20e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034606628 329 APRAFAHITMAGRRFLFAACFKGPTQIYQH 358
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 224-265 1.42e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 1.42e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 224 RFERRTDIPEAeDVYATRHFQAGGDVFLCLTRYIGDSMVMRW 265
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 179-220 2.82e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 40.91  E-value: 2.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1034606628 179 GFYPHQSLHAWhRDTDAEALELDGRPHLLLASASQRPVLFHW 220
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 42-78 5.03e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.45  E-value: 5.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034606628  42 FQTV-GESALSVEPFSYQGEPHIVLAqPFAGRCLILSW 78
Cdd:pfam03736   5 YQTIpTRGARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 269-308 5.44e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 37.06  E-value: 5.44e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034606628 269 MFRLLQQLPSRGAHVFQPLLIARDQLAILGSDFAFSQVLR 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 329-358 9.20e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 33.60  E-value: 9.20e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034606628 329 APRAFAHITMAGRRFLFAACFKGPTQIYQH 358
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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