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Conserved domains on  [gi|1034609330|ref|XP_016882735|]
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zinc finger protein OZF isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 9.58e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 9.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330   1 MSHLSQQRIYSGENPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKS 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFVCKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 148 KIHIGEKPFKC--SECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1034609330 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 2.25e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....*
gi 1034609330 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 9.58e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 9.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330   1 MSHLSQQRIYSGENPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKS 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFVCKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 148 KIHIGEKPFKC--SECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1034609330 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 74-178 2.27e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  74 CNECGKSFSQKEnLLTHQKIHtgEKPFECKdCGkAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKS----------NL 143
Cdd:PLN03086  456 CEKCGQAFQQGE-MEKHMKVF--HEPLQCP-CG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034609330 144 TEHEKIhIGEKPFKCSECGtafgqKKYLIKHQNIH 178
Cdd:PLN03086  531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
zf-H2C2_2 pfam13465
Zinc-finger double domain;
114-138 5.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.97e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609330 114 NLIRHQRTHTGEKPFVCKECGKTFS 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 2.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....*
gi 1034609330 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
1-260 9.58e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 9.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330   1 MSHLSQQRIYSGENPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIKHQNTHTGEKLFECNECGKS 80
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  81 FSQKENLLTHQKIHTGE-------KPFECKDCGKAFIQKSNLIRHQRT--HTGE--KPFVCKE--CGKTFSGKSNLTEHE 147
Cdd:COG5048   264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 148 KIHIGEKPFKC--SECGTAFGQKKYLIKHQNIH-----TGEKPYEC--NECGKAFSQRTSLIVHVRIHSGDKPYECN--V 216
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpP 423

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1034609330 217 CGKAFSQSSSLTVHVRSHTgEKPYGCNECGKAFSQFSTLALHLR 260
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-211 2.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  70 KLFECNECGKSFSQKENLLTHQKIHTGEKPFECKD--CGKAFIQKSNLIRHQRTHTGEKPFVC-KECGKTFSGKSNLTEH 146
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034609330 147 EKIHIGEKPFKCSECGTAFGQKKYLIK--HQNIHTGEKPYE-CNECGKAFSQRTSLIVHVRIHSGDKP 211
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSKD 179
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 74-178 2.27e-05

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 45.63  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  74 CNECGKSFSQKEnLLTHQKIHtgEKPFECKdCGkAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKS----------NL 143
Cdd:PLN03086  456 CEKCGQAFQQGE-MEKHMKVF--HEPLQCP-CG-VVLEKEQMVQHQASTCPLRLITCRFCGDMVQAGGsamdvrdrlrGM 530

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034609330 144 TEHEKIhIGEKPFKCSECGtafgqKKYLIKHQNIH 178
Cdd:PLN03086  531 SEHESI-CGSRTAPCDSCG-----RSVMLKEMDIH 559
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-291 2.81e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  62 HQNTHTGEKLFECNECGKSFSQKENLLTHQKIHTGEKPFECKDCGKAFIQKSNLIRHQRTHTGEKPFVCKECGKTFSGKS 141
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 142 NLTEHEKIHIGE-------KPFKCSECGTAFGQKKYLIKHQN--IHTGE--KPYECNE--CGKAFSQRTSLIVHVRIHSG 208
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 209 DKPYEC--NVCGKAFSQSS-----SLTVHVRSHTGEKPYGC--NECGKAFSQFSTLALHLRIHTGKKPYQC--SECGKAF 277
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSF 428

                         250
                  ....*....|....
gi 1034609330 278 SQKSHHIRHQKIHT 291
Cdd:COG5048   429 NRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
14-292 1.14e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  14 NPFACKVCGKVFSHKSNLTEHEHFHTREKPFECNECGKAFSQKQYVIK--HQNTHTGEKLFEC----------------N 75
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNskslplsnskasssslS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330  76 ECGKSFSQKENL---LTHQKIHTGEKPFECKDC--GKAFIQKSNLIRHQRTHTGEKPFVC--KECGKTFSGKSNLTEHEK 148
Cdd:COG5048   112 SSSSNSNDNNLLsshSLPPSSRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLHPPLpaNSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 149 IHIGEKPFKCSECGTAFGQKKYLIKHQNIHTGEKPYECNECGKAF------SQRTSLIVHVRIHSGDKPYECNVCGKAFS 222
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034609330 223 QSSSLTVHVRSHTG-EKPYGCNECGKAFSQFSTLALHLR--IHTGK--KPYQCSE--CGKAFSQKSHHIRHQKIHTH 292
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-292 5.89e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 5.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034609330 209 DKPYECNVCGKAFSQSSSLTVHVRS--HTGE--KPYGCNE--CGKAFSQFSTLALHLRIHTGKKPYQC--SECGKAFSQK 280
Cdd:COG5048   287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPL 366

                          90
                  ....*....|..
gi 1034609330 281 SHHIRHQKIHTH 292
Cdd:COG5048   367 LNNEPPQSLQQY 378
zf-H2C2_2 pfam13465
Zinc-finger double domain;
114-138 5.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 5.97e-04
                          10        20
                  ....*....|....*....|....*
gi 1034609330 114 NLIRHQRTHTGEKPFVCKECGKTFS 138
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
86-111 1.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609330  86 NLLTHQKIHTGEKPFECKDCGKAFIQ 111
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 100-122 1.94e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 1.94e-03
                          10        20
                  ....*....|....*....|...
gi 1034609330 100 FECKDCGKAFIQKSNLIRHQRTH 122
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
255-279 2.25e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.25e-03
                          10        20
                  ....*....|....*....|....*
gi 1034609330 255 LALHLRIHTGKKPYQCSECGKAFSQ 279
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
170-195 4.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 4.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609330 170 YLIKHQNIHTGEKPYECNECGKAFSQ 195
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
198-223 6.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 6.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034609330 198 SLIVHVRIHSGDKPYECNVCGKAFSQ 223
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-271 9.37e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.37  E-value: 9.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034609330 209 DKPYECNVCGKAFSQSSSLTVHVRSHTGEKPYGCN--ECGKAFSQFSTLALHLRIHTGKKPYQCS 271
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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