|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
21-516 |
0e+00 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 659.01 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 21 RAFIFILTFLLYASFHLSRKPISIVKGELHKYCTAWDEAdvrfssqnrksgsaaPHQLPDNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKPISIVKSVLHPNCSALIPP---------------PNIVLNNTTWCGWAPFDGKNGTELLG 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 101 ALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCL 180
Cdd:cd17344 66 ALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACV 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 181 GNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvthskg 260
Cdd:cd17344 146 GNWFGKGKRGLIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP--------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 261 yengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAK 340
Cdd:cd17344 211 ------------------------------------------------------------------PGVIEFSLCLFFAK 224
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 341 LVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLE 420
Cdd:cd17344 225 LVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYFGQVSMT 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 421 ATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPSGWSNVFYMLMF 500
Cdd:cd17344 305 TNIVLLIVCGLLVNGPYALITTAVSADLGTHKSLKGNARALATVTAIIDGTGSIGAALGPLLAGLISSRGWNNVFYMLIA 384
|
490
....*....|....*.
gi 1034627307 501 ADACALLFLIRLIHKE 516
Cdd:cd17344 385 ADVCAGLLLTRLVYKE 400
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
21-513 |
5.75e-96 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 296.92 E-value: 5.75e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 21 RAFIFILTFLLYASFHLSRKPISIVKgelhkyctawdeadVRFSSQNRKSGSAAPHQLPDNETDCGWAPFDKNNYQQLLG 100
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVK--------------PSISAEWTPSNSNTSIELHEETWNANPLFPSQDDAALFLG 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 101 ALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGL----GYFYNIHsfgFYVVTQVINGLVQTTGWPSV 176
Cdd:cd17342 67 VLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVltewLHFYNKY---LYCILWVLNGLLQSTGWPCV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 177 VTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvt 256
Cdd:cd17342 144 VAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP----------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 257 hskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCL 336
Cdd:cd17342 213 ----------------------------------------------------------------------PGVIPYSLAY 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 337 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFS-TVS 415
Cdd:cd17342 223 ACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYShSPS 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 416 KMGLEATIamLLLSGALVSGPYTLITTAVSADLGTHKSLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPS-GWSNV 494
Cdd:cd17342 303 DKVLNAFV--MTITGFFIGGPANLISSAISADLGRQPQLRGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRlGWMWV 380
|
490
....*....|....*....
gi 1034627307 495 FYMLMFADACALLFLIRLI 513
Cdd:cd17342 381 FYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
21-513 |
6.22e-74 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 238.71 E-value: 6.22e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 21 RAFIFILTFLLYASFHLSRKPISIVKGELHkyctawdeadvrfssqnrksgsaapHQLPDNETDCGWapfdknnyqqllg 100
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIV-------------------------EEIGLSKDDLGI------------- 42
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 101 aLDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCL 180
Cdd:cd17312 43 -IGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFS-----TSLWFFAVLWGLNGLFQSMGWPPCVKLL 116
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 181 GNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvthsk 259
Cdd:cd17312 117 GNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYgWRAAFLVPGIVGLVVAIILFFFLRDSP-------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 260 gyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFA 339
Cdd:cd17312 183 -------------------------------------------------------------------PYVWVLSLAYAFV 195
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 340 KLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYIFSTVSKm 417
Cdd:cd17312 196 YIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPH- 274
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 418 GLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKslkgnahALSTVTAIIDGTGSVGAALGPLLAGLLSPS-GWSNVFY 496
Cdd:cd17312 275 NKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE-------AAGTATGFVGLFGYLGASLAGLPLGYIIDHyGWSTVFY 347
|
490
....*....|....*..
gi 1034627307 497 MLMFADACALLFLIRLI 513
Cdd:cd17312 348 FLISAALLSVLLLLSLW 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
105-515 |
5.32e-26 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 109.19 E-value: 5.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 105 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:COG2271 53 AFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF-----ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyen 263
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFgWRAAFLILGLPGLLLALLRFWLLA--------------------- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 264 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkipgviefsLCLLFAKLVS 343
Cdd:COG2271 187 ----------------------------------------------------------------------LAYFLVYFAL 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 344 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAS-TCGLMLLLAAPTLYIFSTVSkmGLEAT 422
Cdd:COG2271 197 YGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALLLLALLP--SPALA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 423 IAMLLLSGALVSGPYTLITTAVSADLGThkslkgnaHALSTVTAIIDGTGSVGAALGPLLA-GLLSPSGWSNVFYMLMFA 501
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAAL 346
|
410
....*....|....
gi 1034627307 502 DACALLFLIRLIHK 515
Cdd:COG2271 347 ALLAALLALLLLRE 360
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
99-510 |
2.37e-25 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 108.10 E-value: 2.37e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 99 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYnIHSFGFYVVTQVINGLVQTTGWPSVVT 178
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSA-TSSVGLMFILLFLNGWFQGMGWPPSGR 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 179 CLGNWFGKGRRGLIMGVWN-SHTSVGNILGSLI---AGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstl 254
Cdd:cd17345 119 TMVHWFSKKERGTWTSIWNiSHNVGGGLVGPLAglgLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESE------ 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 255 vthskgyenGTNRLRlqkqILKSEKNKPLDPEMQCLLLSDGKgsihpnhvvilpgdggsgtaaISFTGALKIPGVIEFSL 334
Cdd:cd17345 193 ---------GLPPIE----EYKGDYPEEADGEEEEQELSAWE---------------------IFVKYVLKNKLLWYIAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 335 CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGLMLLLAAPTLYIFS 412
Cdd:cd17345 239 ANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 413 TVSKMGLEATIAMLLlsGALVSGPYTLI-----------TTAVSADL-GTHKSLKGNAHALSTVTAIIDGtgsvgaalgp 480
Cdd:cd17345 319 LAPNVLVDLIALIAL--GFLIYGPVMLIglqalelvpkkAAGTAAGLtGLFGYLGGSVLATALIGIIVDH---------- 386
|
410 420 430
....*....|....*....|....*....|
gi 1034627307 481 llagllspSGWSNVFYMLMFADACALLFLI 510
Cdd:cd17345 387 --------FGWNGGFIVLLASCILAIIFLA 408
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
99-461 |
5.04e-24 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 103.61 E-value: 5.04e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 99 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGlgyFYNihSFGFYVVTQVINGLVQTTGWPSVVT 178
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFG---FST--SLWVMAALWALNGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 179 CLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWV--STCWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsstlvt 256
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIaeLYSWHWVFIVPGIIAIIVSLICFLLLRDSP----------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 257 hskgyengtnrlrlqkqilKSEKNKPLDPEMqclllSDGKGSIHPNHvvilpgDGGSGTAAISFTGALKIPGVIEFSLCL 336
Cdd:TIGR00881 176 -------------------QSCGLPPAEEMP-----NEEPDGDAEKK------EEELTKKQIFLQYVLLNKVLWYISLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 337 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL--EKRASTCGLMLLLAAPTLYIFSTV 414
Cdd:TIGR00881 226 VFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLN 305
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1034627307 415 SKMGLEATIAMLLLSGALVSGPYTLITTAVSaDLGtHKSLKGNAHAL 461
Cdd:TIGR00881 306 PAANPLMDLICLFALGFLVYGPQMLIGVIAS-ELA-PKKAAGTAAGF 350
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
105-512 |
1.45e-17 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 84.16 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 105 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:cd17319 46 AFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGF-----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLiehpndvrcsstlvthskgyen 263
Cdd:cd17319 121 PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFgWRWAFIIEGLLGLLLAVLWWFYL---------------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 264 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAKLVS 343
Cdd:cd17319 179 ---------------------------------------------------------------RQVWGLALGYFGINYAL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 344 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLEATI 423
Cdd:cd17319 196 YGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 424 AMLLLSGALVSGPYTLITTaVSADLgthkslkGNAHALSTVTAIIDGTGSVGAALGPLL--AGLLSPSGWSNVFYMLMFA 501
Cdd:cd17319 276 ILLSLAGFGIGAASPVFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLigYLVDATGSYTAAFLFLAAV 347
|
410
....*....|.
gi 1034627307 502 DACALLFLIRL 512
Cdd:cd17319 348 ALLAALLVLLL 358
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
67-466 |
1.70e-17 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 84.69 E-value: 1.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 67 NRKSGSAAphqLPD--NETDcgwapFDKNNyqqlLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALF 144
Cdd:cd17343 18 NRKSFSFV---LPSlmNELG-----LDKSD----LGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 145 GlgYFYNIHSFGFYvvtQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWV-STCWGLSF 223
Cdd:cd17343 86 S--GSSSVWVFSIL---WFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLAlSYGWRSTL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 224 VVPGAIVAAMGIVCFLFLIEHPNDVRCSSTLVTHSKGyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnh 303
Cdd:cd17343 161 SISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKG------------------------------------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 304 vvilpGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILA 383
Cdd:cd17343 198 -----KKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAA 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 384 GVISDRLEKRASTCG----------LMLLLAAPTLYIFS-TVSKMGLEATIAML-LLSGALVSGPYTLIttAVSADLGTH 451
Cdd:cd17343 273 GYLSDWAVAKHGSSSrgnprmplalVFMAGLTVSLHLFRvHITSDSSELFILLLgFLIGFSLYGPIAIF--GVIANESAP 350
|
410
....*....|....*
gi 1034627307 452 KSLKGNAHALSTVTA 466
Cdd:cd17343 351 SHLCGTSHAIVALAA 365
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
98-453 |
2.70e-17 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 83.24 E-value: 2.70e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 98 LLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVV 177
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF-----ASSLWLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 178 TCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVS-TCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstlvt 256
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlFGWRAAFLILAILSLLAAVLLLLPRPPPESKR-------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 257 hskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvviLPGDGGSGTAAISFTGALKIPGVIEFSLCL 336
Cdd:pfam07690 180 --------------------------------------------------PKPAEEARLSLIVAWKALLRDPVLWLLLAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 337 LFAKLVSYTFLFWLPLYITnVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSK 416
Cdd:pfam07690 210 LLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLT 288
|
330 340 350
....*....|....*....|....*....|....*..
gi 1034627307 417 MGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKS 453
Cdd:pfam07690 289 LSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEER 325
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
105-451 |
2.26e-16 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 80.40 E-value: 2.26e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 105 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:COG2814 53 AYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL-----APSLWLLLAARFLQGLGAGALFPAALALIADLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRcsstlvthskgyen 263
Cdd:COG2814 128 PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFgWRWVFLVNAVLALLALLLLLRLLPESRPAAR-------------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 264 gtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgdggsGTAAISFTGALKIPGVIEFSLCLLFAKLVS 343
Cdd:COG2814 194 --------------------------------------------------ARLRGSLRELLRRPRLLLLLLLAFLLGFGF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 344 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL-EKRASTCGLMLLLAAPTLYIFSTvskmGLEAT 422
Cdd:COG2814 224 FALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFgRRRLLLIGLLLLALGLLLLALAG----SLWLL 299
|
330 340
....*....|....*....|....*....
gi 1034627307 423 IAMLLLSGALVSGPYTLITTAVSADLGTH 451
Cdd:COG2814 300 LLALFLLGFGFGLLFPLLQALVAELAPPE 328
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
105-510 |
3.67e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 80.16 E-value: 3.67e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 105 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:cd06174 39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF-----APSFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVStCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVrcsstlvthskgyeng 264
Cdd:cd06174 114 PERERGRALGLLQAFGSVGGILGPLLGGILAS-SLGFGWRAVFLIAAALALLAAILLLLVVPDP---------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 265 tnrlrlqkqilkseknkpldpemqclllsdgkgsihPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSY 344
Cdd:cd06174 177 ------------------------------------PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYY 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 345 TFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSkmGLEATIA 424
Cdd:cd06174 221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAP--SLLLLLL 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 425 MLLLSGALVSGPYTLITTAVSADLgthksLKGNAHALSTVTAIIDGTGSVGAALGPLLAGLLSPsGWSNVFYMLMFADAC 504
Cdd:cd06174 299 LLLLLGFGLGGLLPLSFALIAELF-----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF-GLTGAFLVLAVLLLL 372
|
....*.
gi 1034627307 505 ALLFLI 510
Cdd:cd06174 373 AAILLL 378
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
109-432 |
7.01e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 76.46 E-value: 7.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 188
Cdd:COG2223 52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA-----VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 189 RGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSSTlvthskgyengtNR 267
Cdd:COG2223 127 RGLALGLAAGGGNLGAAVAAFLAPLLIAAFgWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK------------AS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 268 LRLQKQILKSeknkpldpemqclllsdgkgsihpnhvvilpgdggsgtaaisftgalkiPGVIEFSLCLLFAKLVSYTFL 347
Cdd:COG2223 195 LRDQLEALRD-------------------------------------------------PRFWLLSLLYFGTFGSFIGFS 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 348 FWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLeATIAMLL 427
Cdd:COG2223 226 SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWL-FLVLFLL 304
|
....*
gi 1034627307 428 LSGAL 432
Cdd:COG2223 305 LGLAL 309
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
98-458 |
6.06e-13 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 70.89 E-value: 6.06e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 98 LLGALdysFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVV 177
Cdd:PRK11663 62 LLATL---FYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS-----SSLWAFALLWVLNAFFQGWGWPVCA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 178 TCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVST-CWGLSFVVPGAIVAAMGIVCFLFLIEHPndvrcsSTLVT 256
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIALHyGWRYGMMIAGIIAIVVGLFLCWRLRDKP------QAMGL 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 257 HSKGyengtnrlrlqkqilkSEKNKPLDPEMQclllSDGKGSIHpnhvvilpgdggsgtAAISFTGALKIPGVIEFSLCL 336
Cdd:PRK11663 208 PSVG----------------EWRHDALELAQQ----QEGAGLSR---------------KEILTKYVLLNPYIWLLSFSY 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 337 LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKraSTCGLMLLLAAptLYIFSTVSK 416
Cdd:PRK11663 253 VLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN--GNRGPMNLIFA--AGILLSVGS 328
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1034627307 417 MGLEATIAMLLLSGAL------VSGPYTLITTAvsADLGTHKSLKGNA 458
Cdd:PRK11663 329 LWLMPFASYVMQAACFftigffVFGPQMLIGMA--AAECSHKEAAGAA 374
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
68-245 |
1.43e-12 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 68.97 E-value: 1.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 68 RKSGSAAphqLPDNETDCGwapFDKNNyqqlLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLG 147
Cdd:cd17488 19 RKSFNAA---MPAMLADLG---LDKSD----IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 148 yfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVST-CWGLSFVVP 226
Cdd:cd17488 89 -----SSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTyGWRAGMYVP 163
|
170
....*....|....*....
gi 1034627307 227 GAIVAAMGIVCFLFLIEHP 245
Cdd:cd17488 164 GIIAILMGIVLCWRLRDRP 182
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
97-444 |
8.96e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 63.79 E-value: 8.96e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 97 QLLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSV 176
Cdd:cd17328 34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSF-----APNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 177 VTCLGNWFGKGRRGLIMGVWNSHTSVGNILG----SLIAGYWVStcWGLSFVVPGAIVAAMGIVCFLFLIEHP-NDVRCS 251
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGyvvgGLVAQATGG--WRWAFRVTGVLGVLLAILLLLFVREPPrGAAEGG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 252 STLVTHSKGYENGTnrlrlqKQILKSeknkpldPEMQCLLLsdgkgsihpnhvvilpgdggsGTAAISFTGalkipgvie 331
Cdd:cd17328 187 VMAKSTATSFLADL------KALAKN-------PSFILSTL---------------------GFTAVSFVT--------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 332 fslcllfaklvsYTFLFWLPLYITNVDHLDAKKAGELSTLFD----VGGIFGGILAGVISDRLEKRAST-----CGLMLL 402
Cdd:cd17328 224 ------------GALAFWAPTFFLRAFGVGDLSSADVGLIFGaitcIAGVLGVLLGGILADRLRRKTPRadplvCAVGLL 291
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1034627307 403 LAAPTLYIFSTVSKMGLEATIAMLLLSGALVSGPYTLITTAV 444
Cdd:cd17328 292 AAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAIL 333
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
99-444 |
2.30e-10 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 62.76 E-value: 2.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 99 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTGWPSVVT 178
Cdd:PRK09556 66 LGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGSVSLGLMIALWALSGFFQSTGGPCSYS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 179 CLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLS----FVVPGAIVAAMGIVCFLFLIEHPNdvrcsstl 254
Cdd:PRK09556 146 TITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGANYFFDGHvigmFIFPSIIALIIGFIGLRYGSDSPE-------- 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 255 vthskgyENGTNRLrlqkQILKSEKNKPLDPEMQCLLLSdgKGSIHPNHVvilpgdggsgtaaisftgaLKIPGVieFSL 334
Cdd:PRK09556 218 -------ELGWGKA----EEIFGEPISEEDKETESTDMT--KWQIFVEYV-------------------LKNPVI--WLL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 335 CL--LFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR---ASTCGLMLLLAAPTLY 409
Cdd:PRK09556 264 CFanIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANGRralVACIALALIIFTLGVY 343
|
330 340 350
....*....|....*....|....*....|....*
gi 1034627307 410 IFSTVSKMGLeatiAMLLLSGALVSGPYTLITTAV 444
Cdd:PRK09556 344 QHATSEYMYL----ASLFALGFLVFGPQLLIGVAA 374
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
109-440 |
1.27e-09 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 60.49 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfYNIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 188
Cdd:PRK11273 75 AYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFVP-WATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 189 RGLIMGVWN-SHTSVGNILGSL-IAGYWVSTCWGLSFVVPGAivAAMGIVCFLFLIEHPNDVRCSSTLVTHSK-----GY 261
Cdd:PRK11273 154 RGGIVSVWNcAHNVGGGLPPLLfLLGMAWFNDWHAALYMPAF--AAILVALFAFAMMRDTPQSCGLPPIEEYKndypdDY 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 262 ENGTNRLRLQKQILkseknkpldpeMQCLLlsdgkgsihPNHVVILpgdggsgtaaISFTGAlkipgviefslcllFAKL 341
Cdd:PRK11273 232 NEKHEQELTAKQIF-----------MQYVL---------PNKLLWY----------IAIANV--------------FVYL 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 342 VSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEK--RASTCGL-MLLLAAPTL-YIFSTVSKM 417
Cdd:PRK11273 268 LRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATGVFfMTLVTIATIvYWLNPAGNP 347
|
330 340
....*....|....*....|...
gi 1034627307 418 GLEatIAMLLLSGALVSGPYTLI 440
Cdd:PRK11273 348 TVD--MACMIVIGFLIYGPVMLI 368
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-512 |
7.98e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.59 E-value: 7.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 188
Cdd:cd17325 43 AQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA-----TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 189 RGLIMGVWNSHTSVGNILGSLIAGYWVSTcwgLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrl 268
Cdd:cd17325 118 RGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLAL-------------------------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 269 rlqkqILKSEKNKPldpemqclllsdgkgsihPNHVVILPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSYtflf 348
Cdd:cd17325 169 -----LLLPEPRPP------------------PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF---- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 349 wLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRaSTCGLMLLLAAPTLYIFSTVSkmgleaTIAMLLL 428
Cdd:cd17325 222 -LPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT------SFWLLLL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 429 SGALVSGPYTLITTAVSADLG--THKSLKGNAHAL-STVTAIIDGTGSVGAALGPLLAgllspsGWSNVFYML-MFADAC 504
Cdd:cd17325 294 LLALLGLGLGLVFPATLALLAdiVPPEGRGTAMGLfNTAFSLGMVLGPLLGGFLYDAF------GFATPFLAAaALLLLA 367
|
....*...
gi 1034627307 505 ALLFLIRL 512
Cdd:cd17325 368 AVLFLLLR 375
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
99-458 |
1.69e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.79 E-value: 1.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 99 LGALDYSFLCAYAVGMYLSGIIGERLPIRyyltFGMLASGAFTALfGLGYFYNIHSFGFYVVTQVI----NGLVQTTGWP 174
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYK----RGLLLGLLLMAL-GLLLFALAPSYPLLLLALFLlglgLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 175 SVVTClgnwfGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstl 254
Cdd:COG0738 120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFL------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 255 vthskgyengtnRLRLQKQILKSEKNKPldpemqclllsdgkgsihpnhvvilpgdggsgtAAISFTGALKIPGVIEFSL 334
Cdd:COG0738 183 ------------RSKLPEIEEEEEEAAG---------------------------------SAASLKSLLKNPRLLLGGL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 335 CLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLeKRASTCGLMLLLAAPTLYIFSTV 414
Cdd:COG0738 218 AIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLA 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1034627307 415 SkmGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNA 458
Cdd:COG0738 297 P--GPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSA 338
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
87-445 |
5.01e-08 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 54.94 E-value: 5.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 87 WAPFDKNNYQ----QLLGALDYSFLcAYAVGMYLSGIIGERLPIRYYLTFGMLASGAftALFGLGYFYNI-HSFGFYVVT 161
Cdd:cd17475 18 LAPFLQEDLHlslaQVGLLLSALNL-GVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYpVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 162 QVINGLVQTTGWPSVVTclgnWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLF 240
Cdd:cd17475 95 GAGYGSVQPGGGRAIMR----WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYgWRAAFVVAGLVSILAAVLFWLF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 241 LIEHPndvrcsstlvthskgyengtnrlrlqkqilksekNKPLDPEMQCLLLSDGKGSIhpnhvvilpgdGGSGTAAISF 320
Cdd:cd17475 171 YREPP----------------------------------AASAATESASTLLRSLKEVL-----------RNRDVWLIAI 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 321 TGALkipgviefsLCllfakLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE--KRASTCG 398
Cdd:cd17475 206 AGAL---------LV-----APQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFggRRRPVLV 271
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1034627307 399 LMLLLAAPTLYIFSTVSKMGLEATIAMLL-LSGALVSGPYTLITTAVS 445
Cdd:cd17475 272 ITAAIAAAALLVLSLLSPGTPLWLLVLLLiLLGLFAIGWNGLYLTLVA 319
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
106-249 |
3.46e-07 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 52.64 E-value: 3.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 106 FLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFG 185
Cdd:cd17327 50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAA-----VKNFGGLIALRFFLGLFESGVFPGFILYLGMWYK 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034627307 186 KGRRGLIMGVWNSHTSVGNILGSLIAgYWVSTC--------WGLSFVVPGAIVAAMGIVCFLFLIEHPNDVR 249
Cdd:cd17327 125 REEQAKRIAFFYAAAGLGSIFGGLLA-YGVFKIlgvgglagWRWLFIIEGLITIIIGLVIFFWLPDNPSKAW 195
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
99-390 |
5.61e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.94 E-value: 5.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 99 LGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGL----VQTTGWP 174
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFAT-----PSIYLFVVLMFLAGLgagiLDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 175 SVVTclgnwFGKGRRGLIMGVWNSHTSVGNILGSLIAGY--WVSTCWGLSFVVPGAIVAAMGIVCFLFLIEHPNDVRCSs 252
Cdd:cd17333 108 FVGA-----LFEESSATRLNVLHGFFGLGALIGPLIATSllTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNP- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 253 tlvthskgyengtnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilpgDGGSGTAAISFTGALKIPGVIEF 332
Cdd:cd17333 182 ---------------------------------------------------------QQSVGAFSASASRLLRNPSIILG 204
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627307 333 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRL 390
Cdd:cd17333 205 ALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRI 262
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
105-243 |
6.12e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.35 E-value: 6.12e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 105 SFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:COG0477 57 AYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL-----APSPELLIAARALQGIGAGGLMPGALALIAELF 131
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVpGAIVAAMGIVCFLFLIE 243
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAALgWRWIFLI-NAPLGLLALVLRLRLPE 190
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
109-428 |
7.26e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 7.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTG---WPSVVTclgNWFG 185
Cdd:COG2807 65 AFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSL-----APSVALLLAGTALIGAGIAVGnvlLPGLIK---RWFP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 186 KgRRGLIMGVWNSHTSVGNILGSLIAGYWV-STCWGLSFVVpGAIVAAMGIVCFLFLIEHPndvrcsstlvthskgyeng 264
Cdd:COG2807 137 D-RVGLMTGLYTAAMGLGAALAAGLTVPLAaALGWRGALAV-WALLALLALLLWLPLLRRR------------------- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 265 tnrlrlqkqilkseknkpldpemqclllsdgkgsihpnhvvilPGDGGSGTAAISFTGALKIPGVIEFSLCLLFAKLVSY 344
Cdd:COG2807 196 -------------------------------------------PAAAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYY 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 345 TFLFWLPLYITNVdHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKR---------ASTCGLMLLLAAPT--LYIFST 413
Cdd:COG2807 233 AVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplllllglLGLAGLLGLLLAPGslPWLWAV 311
|
330
....*....|....*
gi 1034627307 414 VSKMGLEATIAMLLL 428
Cdd:COG2807 312 LLGLGQGGLFPLALT 326
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-445 |
7.29e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 51.40 E-value: 7.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGR 188
Cdd:cd17324 46 GYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA-----PSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 189 RGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLSFVVpgAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrl 268
Cdd:cd17324 121 RGRAIGLVFSGLTLGLVLGRPLGG-LLGQLLGWRAAF--LAIAVLALLAALLLW-------------------------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 269 rlqkqilkseknkpldpemqcLLLSDGKgsihpnhvvilPGDGGSGTAAISFTGALKIPGVIE---FSLCLLFAKLVSYT 345
Cdd:cd17324 172 ---------------------RLLPSLP-----------PKKPGSLGLLSSLLLLLRNPRLRLaylITFLLFGGFFALYT 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 346 FLfwlPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAptlYIFSTVSKMGLEATIAM 425
Cdd:cd17324 220 YL---APFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAA---LLLLTLLGPSPLLLLVG 293
|
330 340
....*....|....*....|
gi 1034627307 426 LLLSGALVSGPYTLITTAVS 445
Cdd:cd17324 294 LVLWGLGFFAAHSALQTRVL 313
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
333-446 |
1.41e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 333 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAsTCGLMLLLAAPTLYIFS 412
Cdd:cd17316 183 ILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKK-TLVIGLILSGILALPLF 261
|
90 100 110
....*....|....*....|....*....|....
gi 1034627307 413 tvskMGLEATIAMLLLSGALVSGPYTLITTAVSA 446
Cdd:cd17316 262 ----YLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
90-437 |
2.60e-06 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 50.13 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 90 FDKNNYQQ--LLGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGYfynIHSFGFYVVTQVINGL 167
Cdd:TIGR00894 67 KNPNFKWSgaLQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAA---GGGIALVVFCRVIQGL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 168 vqttGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGY------WVSTCWGLSFVVPGAIVAAMGIVCFLFL 241
Cdd:TIGR00894 144 ----AQGSVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPisgwlcESWGGWPMIFYVFGIVGCAWSLLWFVFP 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 242 IEHPNDVRCSStlvthskgyengtnrLRLQKQILKSeknkpldpemqclllsdgkgsihpnhvviLPGDGGSGTAAISFT 321
Cdd:TIGR00894 220 ADDPSIHPCIS---------------KFEKKYINSS-----------------------------LQGQKGSTRQSLPIK 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 322 GALKIPGVIEFSLClLFAKLVSYTFLF-WLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISD------RLEKRA 394
Cdd:TIGR00894 256 AIPKSLPVWAIWFA-IFGHFWLYTILPtYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADflksskTLSLTA 334
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1034627307 395 ST---CGLMLLLAAPTLYIFSTVSKmGLEATIAMLLLSGALVSGPY 437
Cdd:TIGR00894 335 ARkifNGIGGLGPGIFAYALPYLSA-AFYLTIIILTLANAVSSGPL 379
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
111-438 |
4.70e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 48.89 E-value: 4.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 111 AVGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHSFGFYvvtQVINGLVQTTGWPSVVTCLGNWFGKGRRG 190
Cdd:TIGR00895 66 AFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLIL---RFLAGLGLGGLMPNLNALVSEYAPKRFRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 191 LIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIVAAMGIVCFLFLIEhpndvrcsSTLVTHSKGYENGTNRLr 269
Cdd:TIGR00895 141 TAVGLMFCGYPIGAAVGGFLAGWLIPVFgWRSLFYVGGIAPLLLLLLLMRFLPE--------SIDFLVSKRPETVRRIV- 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 270 lqkqilkseknKPLDPEMQCLLLSdgkgsihpnHVVILPGDGGSGTAAIS--FTGALkipGVIEFSL-CLLFAKLVSYTF 346
Cdd:TIGR00895 212 -----------NAIAPQMQAEAQS---------ALPEQKSTQGTKRSVFKalFQGKT---ARITVLLwLLYFMLLVGVYF 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 347 LF-WLPlYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRAStcGLMLLLAAPTLYI-FSTVSKMGLEATia 424
Cdd:TIGR00895 269 LTnWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVT--ALLLLLGAVFAVLvGSTLFSPTLLLL-- 343
|
330
....*....|....
gi 1034627307 425 MLLLSGALVSGPYT 438
Cdd:TIGR00895 344 LGAIAGFFVNGGQS 357
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
333-453 |
3.74e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 46.01 E-value: 3.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 333 SLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFS 412
Cdd:cd17321 174 VLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL 253
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 1034627307 413 TVSKMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKS 453
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKA 294
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
116-440 |
3.90e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 46.01 E-value: 3.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 116 LSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVvTCLGNWFGKGRRGLIMGV 195
Cdd:cd17478 50 LFGYLADRKPRRYLLPLGPLLTGLGLSLLGF-----APNYWLLLLLVALAGIGSAAFHPEG-ARLASQAAGGRRGLAMSI 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 196 WNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAMGIVCFLFLIehpndvrcsstlvthskgyengtnrlRLQKQIL 275
Cdd:cd17478 124 FSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLR--------------------------PLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 276 KSEKNKPLDPEmqclllsdgKGSIHPNHVVILpgdggsgtAAISFTGALKIPGVIEFSLCLLFAKLVSYTFlfwlplyit 355
Cdd:cd17478 178 KKAAAKSSARS---------TLKGVWRALLLL--------LIIVFLRSWVLSSLTTFLPFYLVQRGYSLVF--------- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 356 nvdhldakkAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTvskmGLEATIAMLLLSGALVSG 435
Cdd:cd17478 232 ---------AGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLT----PGIWSYILLVLAGFLLFA 298
|
....*
gi 1034627307 436 PYTLI 440
Cdd:cd17478 299 SFPVT 303
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
111-240 |
1.47e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 44.10 E-value: 1.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 111 AVGMYLSG-IIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRR 189
Cdd:cd17474 248 ALGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGF-----VPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEER 322
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1034627307 190 GLIMGVWNSHTSVGNILGSLIAGYWVSTcWGLS--FVVPGAIVAAMGIVCFLF 240
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEI-FGLSapFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
94-208 |
1.67e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.95 E-value: 1.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 94 NYQQLLGALDYSFLCA-YAVGMYLSGIIGERLPIRYYLTFGMLasGAFTALFGLGYFYNIHSFGFYVVTQVINGLVQTTG 172
Cdd:pfam07690 231 GLSALLAGLLLGLGGLlGAIGRLLLGRLSDRLGRRRRLLLALL--LLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLV 308
|
90 100 110
....*....|....*....|....*....|....*.
gi 1034627307 173 WPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGS 208
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
109-240 |
2.72e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 43.37 E-value: 2.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIR----YYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWF 184
Cdd:cd06173 252 AFGVGALLGALLLGRLSKRrrrgRLLLIGALLLGLALLVLGL-----SPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034627307 185 GKGRRGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLS--FVVPGAIVAAMGIVCFLF 240
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAG-LLADALGLSavFLLAGALLLLAALLLLLL 383
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
90-240 |
7.25e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 41.84 E-value: 7.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 90 FDKNNYQQllGALDYSFLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALfgLGYFYNIHsFGFYVVTQVINGLVQ 169
Cdd:cd17318 51 FDWSEKTQ--GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLL--TPLAARGG-YGALIVLRILQGLAQ 125
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034627307 170 TTGWPSVVTCLGNWFGKGRRGLIMGVWNSHTSVGNILGSLIAGYWVSTC-WGLSFVVPGAIvaamGIVCFLF 240
Cdd:cd17318 126 GVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLgWPSIFYIFGGL----GLLWCLL 193
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
344-448 |
4.05e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.59 E-value: 4.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 344 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRASTCGLMLLLAAPTLYIFSTVSKMGLEATI 423
Cdd:cd17367 240 YTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGIGGTLATVPLLSALDHTDSPYTA 319
|
90 100
....*....|....*....|....*
gi 1034627307 424 AMLLLSGALVSGPYTLITTAVSADL 448
Cdd:cd17367 320 FALVLVGLVFLSGYTSINAVVKAEL 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
106-206 |
5.04e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.19 E-value: 5.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 106 FLCAYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLgyfynIHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFG 185
Cdd:COG2814 252 FGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL-----AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
90 100
....*....|....*....|.
gi 1034627307 186 KGRRGLIMGVWNSHTSVGNIL 206
Cdd:COG2814 327 PEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
344-510 |
6.25e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 39.14 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 344 YTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLEKRastcglmlllaaptlYIFSTVSKMGLEATI 423
Cdd:cd17318 216 YTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSR---------------GILSTTTVRKLFTSI 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 424 AMLLLSGALVSGPY---------TLITTAVSADLGTHKSLKGNAHALS-----TVTAIIDGTGSVG-----AALGPLLAG 484
Cdd:cd17318 281 GFLGPGVFLIALGYlgsnatlavVFLTLSVGLSGACYSGFLVNHLDLApnyagTLMGITNTAATIAgiispLIVGAIVKN 360
|
170 180
....*....|....*....|....*..
gi 1034627307 485 LLSPSGWSNVFYMLMFADA-CALLFLI 510
Cdd:cd17318 361 DQTIGQWRIVFFISAAIYIlGAIFYLI 387
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
109-242 |
6.53e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.12 E-value: 6.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 109 AYAVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFglgYFYNIHSFGFYVVTQVINGLVQTTGWPSVVTCL------GN 182
Cdd:COG2211 276 AALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL---FFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdyDE 352
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034627307 183 W-FGKGRRGLIMGVWNSHTSVGNILGSLIAGyWVSTCWGLSFVVPGAIVAAMGIVCFLFLI 242
Cdd:COG2211 353 WkTGRRREGLYFGIFTFAIKLGQALAGALAG-LLLALFGYVAGAAQSPSALTGIRLLFFLL 412
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
322-458 |
7.31e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 7.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 322 GALKIPGVIEFSLCLLFAKLVSYTFLFWLPLYITNVDHLDAKKAGELSTLFDVGGIFGGILAGVISDRLE-KRASTCGLM 400
Cdd:cd17503 173 RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGpRLLLLAGLL 252
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034627307 401 LLLAAptLYIFSTVS-KMGLEATIAMLLLSGALVSGPYTLITTAVSADLGTHKSLKGNA 458
Cdd:cd17503 253 LLALG--TLLLAFLTpDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATA 309
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
111-245 |
9.45e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 38.32 E-value: 9.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034627307 111 AVGMYLSGIIGERLPIRYYLTFGMLASGAFTALFGLGyfyniHSFGFYVVTQVINGLVQTTGWPSVVTCLGNWFGKGRRG 190
Cdd:cd17474 48 AVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS-----DSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERA 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1034627307 191 LIMGVWNSHTSVGNILGSLIAGYWVSTCWGLSFVVPGAIVAAmGIVCFLFLIEHP 245
Cdd:cd17474 123 KAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPV-AFLAILFLLPEP 176
|
|
| |
