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Conserved domains on  [gi|1034628510|ref|XP_016884156|]
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ATPase MORC2 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-140 2.39e-61

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


:

Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 204.18  E-value: 2.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIyaaasFTERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDI-----FIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034628510   98 ESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 140
Cdd:cd16931     76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 500-547 9.50e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 9.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034628510  500 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 547
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 super family cl39387
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 244-456 3.99e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


The actual alignment was detected with superfamily member pfam17942:

Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  244 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 314
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  315 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 394
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034628510  395 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 456
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 625-740 4.96e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  625 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 704
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1034628510  705 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 740
Cdd:PHA03247  2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-140 2.39e-61

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 204.18  E-value: 2.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIyaaasFTERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDI-----FIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034628510   98 ESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 140
Cdd:cd16931     76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-174 2.42e-40

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 145.17  E-value: 2.42e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510   29 LFGALAELVDNARDADATRIDIYAaasftERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGN 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEV-----NKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGI 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034628510  108 GLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPVTDNVEKFAIET 174
Cdd:pfam13589   74 GLKLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 500-547 9.50e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 9.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034628510  500 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 547
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 244-456 3.99e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  244 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 314
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  315 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 394
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034628510  395 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 456
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 625-740 4.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  625 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 704
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1034628510  705 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 740
Cdd:PHA03247  2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PTZ00121 PTZ00121
MAEBL; Provisional
 290-369 6.56e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 6.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  290 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 369
Cdd:PTZ00121  1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
 
Name Accession Description Interval E-value
HATPase_MORC-like cd16931
Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger ...
 18-140 2.39e-61

Histidine kinase-like ATPase domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains; This family includes the histidine kinase-like ATPase (HATPase) domain of human microrchidia (MORC) family CW-type zinc finger proteins MORC1-4, and related domains. In addition to the HATPase domain, MORC family proteins have a CW-type zinc finger domain containing four conserved cysteines and two conserved tryptophans, and coiled-coil domains at the carboxy-terminus. MORC1 has cross-species differential methylation in association with early life stress, and genome-wide association with major depressive disorder (MDD). MORC2 is involved in several nuclear processes, including transcription modulation and DNA damage repair, and exhibits a cytosolic function in lipogenesis, adipogenic differentiation, and lipid homeostasis by increasing the activity of ACLY. MORC3 regulates p53, and is an antiviral factor which plays an important role during HSV-1 and HCMV infection, and is a positive regulator of influenza virus transcription. MORC4 is highly expressed in a subset of diffuse large B-cell lymphomas and has potential as a lymphoma biomarker.


Pssm-ID: 340408 [Multi-domain]  Cd Length: 118  Bit Score: 204.18  E-value: 2.39e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510   18 YLHTNSTTHEFLFGALAELVDNARDADATRIDIyaaasFTERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP 97
Cdd:cd16931      1 FLHSNSTTHSWPFGAVAELVDNARDADATRLDI-----FIDDINLLRGGFMLSFLDDGNGMTPEEAHHMISFGFSDKRSD 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034628510   98 ESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFH 140
Cdd:cd16931     76 DHDHIGRYGNGFKSGSMRLGRDVIVFTKKDESQSCGLLSQTFL 118
HATPase_c_3 pfam13589
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, ...
 29-174 2.42e-40

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.


Pssm-ID: 433332 [Multi-domain]  Cd Length: 135  Bit Score: 145.17  E-value: 2.42e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510   29 LFGALAELVDNARDADATRIDIYAaasftERREDlrGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTP-ESTQIGQYGN 107
Cdd:pfam13589    1 LEGALAELIDNSIDADATNIKIEV-----NKNRG--GGTEIVIEDDGHGMSPEELINALRLATSAKEAKrGSTDLGRYGI 73

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034628510  108 GLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGiDEVIVPLPTWnartREPVTDNVEKFAIET 174
Cdd:pfam13589   74 GLKLASLSLGAKLTVTSKKEGKSSTLTLDRDKISNEN-DWLLPLLTPA----PIENFDELDKDAHGT 135
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 500-547 9.50e-17

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 74.65  E-value: 9.50e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1034628510  500 TTIQCDLCLKWRTLPFQLSSVEKdyPDTWVCSMNPDPEQDRCEASEQK 547
Cdd:pfam07496    1 YWVQCDSCLKWRRLPTEIDPYEL--PEPWYCSMNPDPKYNSCDAPEEI 46
Morc6_S5 pfam17942
Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. ...
 244-456 3.99e-12

Morc6 ribosomal protein S5 domain 2-like; This domain is found in MORC6 proteins in eukaryotes. Arabidopsis microrchidia (MORC) ATPase family proteins are conserved among plants and animals and are involved in transcriptional silencing. In Arabidopsis, MORC6/DMS11 was reported to function in the condensation of pericentromeric heterochromatin, thereby facilitating transcriptional silencing. Further studies demonstrate that MORC6 and its homologs MORC1 and MORC2 form a complex which associates with SUVH9, required for Pol V occupancy in the RdDM (RNA-directed DNA methylation) pathway.


Pssm-ID: 465579  Cd Length: 139  Bit Score: 64.49  E-value: 3.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  244 SFRAYAAVLY--IDPRMRIFIHGHKVQTKRLS-------CCLYKPrmykytssrfktraeqevkkaeHVARIAEEKArea 314
Cdd:pfam17942    2 SLRAYASILYlrLPPNFQIILRGKKVEHHNIAddlkypeKITYKP----------------------QVGGGKEVVV--- 56

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  315 eskartlEVRLGgdltrdsrvmlrqvqnraitlrreadvkkRIKEAKQralkepkeLNfVFGVNIEHRDldgmfiyncsR 394
Cdd:pfam17942   57 -------ITTIG-----------------------------FLKEAPH--------IN-VHGFNVYHKN----------R 81

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034628510  395 LIKMYEKVGPQ-----------LEGGmacggvvgvvdvpylVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYW 456
Cdd:pfam17942   82 LIKPFWRVGNQagskgrgvigvLEAN---------------FIEPTHDKQDFERTSLYQRLEARLKQMLKEYW 139
PHA03247 PHA03247
large tegument protein UL36; Provisional
 625-740 4.96e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  625 AVIRNAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAstsrllqpPEAPRKPANTLVKTASRPAPLVQQLSPSL 704
Cdd:PHA03247  2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPA--------PAPPAAPAAGPPRRLTRPAVASLSESRES 2797

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1034628510  705 LPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPS 740
Cdd:PHA03247  2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTS 2833
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 638-744 5.46e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 5.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  638 PTPRPASQPRKAPVISSTPKLPalaareeaSTSRLLQPPEAPRKPAN--TLVKTASRPAPLVQQL-----SPSLLPNSKS 710
Cdd:PTZ00449   561 PGPAKEHKPSKIPTLSKKPEFP--------KDPKHPKDPEEPKKPKRprSAQRPTRPKSPKLPELldipkSPKRPESPKS 632

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1034628510  711 PREVPSPKVIKTPvvKKTESPikLSPATPSRKRS 744
Cdd:PTZ00449   633 PKRPPPPQRPSSP--ERPEGP--KIIKSPKPPKS 662
PHA03247 PHA03247
large tegument protein UL36; Provisional
 629-743 1.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.08  E-value: 1.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  629 NAPSRPPSLPTPrPASQPRKAPVISSTPKLPALA------AREEASTSRLLQPPEAPRKPANTLVKTASRPAPLV----- 697
Cdd:PHA03247  2755 ARPARPPTTAGP-PAPAPPAAPAAGPPRRLTRPAvaslseSRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLpppts 2833

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1034628510  698 -QQLSPSLLPNSKSPREVPSPKVIKTPVVKK--TESPIKLSPATPSRKR 743
Cdd:PHA03247  2834 aQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRrpPSRSPAAKPAAPARPP 2882
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 630-745 2.61e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 44.08  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  630 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEASTSRLLQPPEAPRKPANTLVKtASRPAPLVQQLSPSLLPNSK 709
Cdd:PHA02682   102 APAPAVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQCPPAPPLPTPKPAP-AAKPIFLHNQLPPPDYPAAS 180

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1034628510  710 SPREVPSPKVikTPVVkKTESPIKLSPATPSRKRSV 745
Cdd:PHA02682   181 CPTIETAPAA--SPVL-EPRIPDKIIDADNDDKDLI 213
PHA03247 PHA03247
large tegument protein UL36; Provisional
 630-739 2.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 2.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  630 APSRPPSLPTPRPASQPRKAPVISSTPKLPALA-----------AREEASTSRLLQPPEAPRKPantlvktASRP--APL 696
Cdd:PHA03247  2623 APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDpapgrvsrprrARRLGRAAQASSPPQRPRRR-------AARPtvGSL 2695

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034628510  697 VQQLSPSllPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATP 739
Cdd:PHA03247  2696 TSLADPP--PPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736
PHA03247 PHA03247
large tegument protein UL36; Provisional
 601-746 4.08e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 4.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  601 EVTTRPSTEEPVRRPQRPRSPPLPAVIRNAPSRPP-SLPTPRPASQPRKAPvisSTPKLPALAAREEASTSRLLQPPEAP 679
Cdd:PHA03247  2861 DVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTeSFALPPDQPERPPQP---QAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034628510  680 RKPANTLVKTASRPAPLVQQLSPSLLPNSKSPREVPSPKVIKTPVVKKTESPiklSPATPSRKRSVA 746
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAP---ASSTPPLTGHSL 3001
HATPase_MutL-MLH-PMS-like cd16926
Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, ...
 35-88 7.59e-04

Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains; This family includes the histidine kinase-like ATPase (HATPase) domains of Escherichia coli MutL, human MLH1 (mutL homolog 1), human PMS1 (PMS1 homolog 1, mismatch repair system component), human MLH3 (mutL homolog 3), and human PMS2 (PMS1 homolog 2, mismatch repair system component). MutL homologs (MLH/PMS) participate in MMR (DNA mismatch repair), and in addition have role(s) in DNA damage signaling and suppression of homologous recombination (recombination between partially homologous parental DNAs). The primary role of MutL in MMR is to mediate protein-protein interactions during mismatch recognition and strand removal; a ternary complex is formed between MutS, MutL, and the mismatched DNA, which activates the MutH endonuclease.


Pssm-ID: 340403 [Multi-domain]  Cd Length: 188  Bit Score: 41.65  E-value: 7.59e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034628510   35 ELVDNARDADATRIDIyaaasfterreDLRGGfMLCFL---DDGAGMDPSDAASVIQ 88
Cdd:cd16926     20 ELVENSIDAGATRIDV-----------EIEEG-GLKLIrvtDNGSGISREDLELAFE 64
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 630-740 1.55e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  630 APSRPPSLPT-PRPASQPRKAPVISSTPKLPALAAREEASTSrLLQPPEAPRKPANTLVKTASRPAplvqqlSPSLLPNS 708
Cdd:PRK14951   376 AEKKTPARPEaAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-PAAAPPAPVAAPAAAAPAAAPAA------APAAVALA 448

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1034628510  709 KSPREVPSPKVIKTPVVKKTESPIKLSPATPS 740
Cdd:PRK14951   449 PAPPAQAAPETVAIPVRVAPEPAVASAAPAPA 480
PHA03247 PHA03247
large tegument protein UL36; Provisional
 628-740 2.22e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  628 RNAPSrPPSLPTPRPASQPRKAPVISSTPKLPA-LAAREE-ASTSRLLQPPEAPRKPANTLVKTASR-PAPLVQQLSPSL 704
Cdd:PHA03247  2653 RDDPA-PGRVSRPRRARRLGRAAQASSPPQRPRrRAARPTvGSLTSLADPPPPPPTPEPAPHALVSAtPLPPGPAAARQA 2731

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1034628510  705 LPnsKSPREVPSPKVIKTPVVKKTESPIKlSPATPS 740
Cdd:PHA03247  2732 SP--ALPAAPAPPAVPAGPATPGGPARPA-RPPTTA 2764
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 629-736 2.37e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 41.84  E-value: 2.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  629 NAPSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREE------ASTSRL--------LQPPEAPRKPANTLVKTASRPA 694
Cdd:PLN03209   322 KIPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEppqpkaVVPRPLspytayedLKPPTSPIPTPPSSSPASSKSV 401

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034628510  695 PLVQQL-SPSLLPNSKSPREVPSPKVIktPVVKKTESPikLSP 736
Cdd:PLN03209   402 DAVAKPaEPDVVPSPGSASNVPEVEPA--QVEAKKTRP--LSP 440
PTZ00121 PTZ00121
MAEBL; Provisional
 290-369 6.56e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.51  E-value: 6.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  290 KTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRLGGDLTRDSrvmlrQVQNRAITLRREADVKKRIKEAKQRALKEPK 369
Cdd:PTZ00121  1397 KKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKA-----EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 626-727 6.66e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 6.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  626 VIRNAPSRPPSLPTPRPASQPR--KAPVISSTPKLPALAAREEastsrLLQPPEAPRKPANTlvKTASRPAPLVQQLSPS 703
Cdd:PTZ00449   574 TLSKKPEFPKDPKHPKDPEEPKkpKRPRSAQRPTRPKSPKLPE-----LLDIPKSPKRPESP--KSPKRPPPPQRPSSPE 646

                           90       100
                   ....*....|....*....|....*...
gi 1034628510  704 LlPNS----KSPREVPSPKVIKTPVVKK 727
Cdd:PTZ00449   647 R-PEGpkiiKSPKPPKSPKPPFDPKFKE 673
PHA03247 PHA03247
large tegument protein UL36; Provisional
 630-749 9.32e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 9.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  630 APSRPP-----SLPTPRPASQPRKAPVIS--STPKLPALAAREEA----STSRLLQPPEAPRKPANT-LVKTASRPAPLV 697
Cdd:PHA03247  2556 PPAAPPaapdrSVPPPRPAPRPSEPAVTSraRRPDAPPQSARPRApvddRGDPRGPAPPSPLPPDTHaPDPPPPSPSPAA 2635

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034628510  698 QQL---SPSLLPNSKSPREVPSPKVIKTPVVKKTESPIKLSPATPSRKRSVAVSD 749
Cdd:PHA03247  2636 NEPdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARP 2690
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 630-715 9.38e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 39.70  E-value: 9.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034628510  630 APSRPPSLPTPRPASQPRKAPVISSTPKLPALAAREEAStsrllqPPEAPRKPANTLVKTASRPAPLVQQLSPSLLPNSK 709
Cdd:PRK14951   413 APAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAP------PAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAA 486


                   ....*.
gi 1034628510  710 SPREVP 715
Cdd:PRK14951   487 RLTPTE 492
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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