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Conserved domains on  [gi|1039727579|ref|XP_017171326|]
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fibronectin isoform X5 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.41e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 5.41e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.97e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 1.97e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.34e-19

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1039727579 1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.87e-18

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 4.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 9.59e-18

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 9.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401     54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401    134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401    284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401    362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401    438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                          490
                   ....*....|...
gi 1039727579 1458 DITANSFTVHWVA 1470
Cdd:COG3401    518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.91e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1904-1984 1.14e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1904 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1981 KSEP 1984
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.84e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 9.84e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039727579  811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.79e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.79e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
232-271 1.27e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.46e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1723 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1799
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1800 TSRP 1803
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2131-2172 1.51e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.51e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039727579  2131 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2172
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2086-2130 2.40e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.40e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579  2086 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2130
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.61e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.61e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.39e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.39e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
1815-1894 9.05e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1815 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1891 RSSP 1894
Cdd:pfam00041   81 EGPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
698-1027 1.12e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401    212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401    290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401    370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401    450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                          330       340
                   ....*....|....*....|
gi 1039727579 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401    523 APDGTPNVTGASPVTVGAST 542
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.28e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.28e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.96e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.96e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2174-2213 9.58e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 9.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579 2174 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2213
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
619-688 1.13e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.13e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039727579  619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.65e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1039727579   142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.90e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.90e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
2000-2055 7.94e-07

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.94e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 2000 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2055
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.75e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.41e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 5.41e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.97e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 1.97e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 2.17e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.17e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039727579  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.66e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.60  E-value: 2.66e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039727579  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 2.22e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 2.22e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.34e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1039727579 1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 5.11e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 5.11e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.87e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 4.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 9.59e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 9.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401     54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401    134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401    284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401    362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401    438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                          490
                   ....*....|...
gi 1039727579 1458 DITANSFTVHWVA 1470
Cdd:COG3401    518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.91e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1904-1984 1.14e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1904 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1981 KSEP 1984
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.84e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 9.84e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039727579  811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1358-1439 1.98e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 1.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1904-1984 2.41e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1904 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1981 KSEP 1984
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 3.07e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 3.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1039727579  886 QESTPVFIQQETT 898
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1240-1803 4.26e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 4.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1240 LEYNVSVYTVKDDKESAPISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1319
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1320 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIE-LTNLLVRYSPVKNE 1398
Cdd:COG3401    102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1399 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDITANSFTVHWVAPRAP 1474
Cdd:COG3401    180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTES 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1475 -ITGYII-RHHAEHS----VGRPRQdrvppsrNSITLTNLNPGTEYVVSIIAVNGR-EESPPLIGQQATVSDI----PRD 1543
Cdd:COG3401    260 dATGYRVyRSNSGDGpftkVATVTT-------TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTppaaPSG 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1544 LEVIASTPTSLLISWEPPA-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSK 1622
Cdd:COG3401    333 LTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSE 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1623 PVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTpkNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSV 1702
Cdd:COG3401    412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAA--VLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1703 YAQNRNGESQPLVQTAVTTIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGL 1782
Cdd:COG3401    490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSG 569

                          570       580
                   ....*....|....*....|.
gi 1039727579 1783 MVATKYEVSVYALKDTLTSRP 1803
Cdd:COG3401    570 NLYLITTLGGSLLTTTSTNTN 590
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.79e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.79e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1721 1.06e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1039727579 1710 ESQPLVQTAVTT 1721
Cdd:cd00063     82 ESPPSESVTVTT 93
fn1 pfam00039
Fibronectin type I domain;
232-271 1.27e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.36e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.36e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039727579   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.46e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1723 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1799
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1800 TSRP 1803
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2131-2172 1.51e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.51e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039727579  2131 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2172
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2086-2130 2.40e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.40e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579  2086 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2130
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.61e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.61e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.39e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.39e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 5.70e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1526 ESPP 1529
Cdd:cd00063     82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1621 7.20e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1039727579 1618 PASS 1621
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
1815-1894 9.05e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1815 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1891 RSSP 1894
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 1.12e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401    212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401    290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401    370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401    450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                          330       340
                   ....*....|....*....|
gi 1039727579 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401    523 APDGTPNVTGASPVTVGAST 542
fn1 pfam00039
Fibronectin type I domain;
561-599 1.36e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.36e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
2086-2125 1.99e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.18  E-value: 1.99e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2086 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2125
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.28e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.28e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 3.99e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.99e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
187-226 1.25e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.87  E-value: 1.25e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.77e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.77e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579   810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039727579   885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 1.92e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.92e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1436 ES 1437
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
726-797 3.79e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.79e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579  726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.98e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.35  E-value: 3.98e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.96e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.96e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1904-1982 8.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1904 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1981 KS 1982
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2174-2213 9.58e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 9.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579 2174 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2213
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 1.13e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.18  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
619-688 1.13e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.13e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039727579  619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.14e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1436 ESIP 1439
Cdd:cd00063     82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.65e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1039727579   142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 1.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039727579  1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 2.03e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.03e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 3.18e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1616 DS 1617
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 3.58e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.58e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1449 DSPTGFDSSDITANSFTVHWVAPRAP-ITGYIIRHHAEHSVGRPRQDRV--PPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1526 ES 1527
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.90e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.90e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 6.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1039727579  984 ESNPLTAQQTT 994
Cdd:cd00063     82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2084-2128 7.99e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.88  E-value: 7.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579 2084 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2128
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2131-2168 8.02e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 8.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2131 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2168
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.73e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 1.73e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2175-2215 2.45e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.36  E-value: 2.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579  2175 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2215
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
524-555 4.44e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.55  E-value: 4.44e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039727579  524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 5.82e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 5.82e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061      1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 8.63e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 8.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039727579  142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1810 1.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1723 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1799
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1039727579 1800 TSRPAQGVITT 1810
Cdd:cd00063     82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.56e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.03  E-value: 1.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1895 1.83e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1815 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1890
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 1039727579 1891 RSSPV 1895
Cdd:cd00063     82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.10e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.66  E-value: 2.10e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2130-2171 3.16e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.26  E-value: 3.16e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579 2130 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2171
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 3.09e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 3.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061      1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1723-1794 5.64e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.64e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579  1723 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1794
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn1 pfam00039
Fibronectin type I domain;
2175-2210 6.16e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.39  E-value: 6.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2175 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2210
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 8.48e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 8.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061      1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.53e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.53e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579   907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579   984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 2.03e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 2.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1889 2.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.44e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1815 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1889
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
fn3 pfam00041
Fibronectin type III domain;
2000-2055 7.94e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.94e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 2000 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2055
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579   616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.75e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.86e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.70  E-value: 3.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061      2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.82e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.82e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063      4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 353-401 5.41e-24

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 96.60  E-value: 5.41e-24
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   353 GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 413-461 1.97e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 1.97e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1039727579   413 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 354-401 2.17e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.17e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039727579  354 NSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 414-461 2.66e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.60  E-value: 2.66e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039727579  414 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:cd00062      1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn2 pfam00040
Fibronectin type II domain;
360-401 2.22e-20

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 86.08  E-value: 2.22e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  360 CVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFC 401
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1541-1620 2.34e-19

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 84.39  E-value: 2.34e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEG 82


                   ...
gi 1039727579 1618 PAS 1620
Cdd:pfam00041   83 PPS 85
fn2 pfam00040
Fibronectin type II domain;
420-461 5.11e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 82.23  E-value: 5.11e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  420 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFC 461
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1633-1713 4.87e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 80.54  E-value: 4.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1710 ESQP 1713
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
993-1470 9.59e-18

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 89.68  E-value: 9.59e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  993 TTKLDAPTNLQFVNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPG--SEYTVTLVAVKG 1070
Cdd:COG3401     54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSpaVGTATTATAVAG 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1071 NQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGgeapreVTSDSGSIVVSGLTPGVEYTY 1150
Cdd:COG3401    134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLT------VTSTTLVDGGGDIEPGTTYYY 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1151 TIQVLRDGQERDAPIVNRVV---TPLSPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVvhaD 1227
Cdd:COG3401    208 RVAATDTGGESAPSNEVSVTtptTPPSAPTGLTATADTPGSV-TLSWDPVTESDATGYRVYRSNSGDGPFTKVATV---T 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1228 QSSCTFENLNPGLEYNVSVYTVKDDKESAPISDTV-------VPEVPQltDLSFVDITDSSIGLRWTPLNSSTIIGYRIT 1300
Cdd:COG3401    284 TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVsvttdltPPAAPS--GLTATAVGSSSITLSWTASSDADVTGYNVY 361

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1301 VVAAGEGIPifeDFVDSSVG--YYTVTGLEPGIDYDISVITLINGG-ESAPTTLTQQTAVPPPTDLRFTNiGPDTMRVTW 1377
Cdd:COG3401    362 RSTSGGGTY---TKIAETVTttSYTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTA-SVDAVPLTD 437

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1378 APPPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSS 1457
Cdd:COG3401    438 VAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAA 517

                          490
                   ....*....|...
gi 1039727579 1458 DITANSFTVHWVA 1470
Cdd:COG3401    518 AAVGGAPDGTPNV 530
fn3 pfam00041
Fibronectin type III domain;
1449-1529 3.91e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 78.23  E-value: 3.91e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1526 ESPP 1529
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1904-1984 1.14e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 77.15  E-value: 1.14e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1904 DAPSNLRFLTTTPNSLLVSWQAPR---ARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1981 KSEP 1984
Cdd:cd00063     82 ESPP 85
fn3 pfam00041
Fibronectin type III domain;
811-882 9.84e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.99  E-value: 9.84e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039727579  811 DAPPDPTVDQVDDTSIVVRWSRP---QAPITGYRIVYSPSVEGS-STELNLPETANSVTLSDLQPGVQYNITIYAV 882
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1358-1439 1.98e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 1.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1358 PPPTDLRFTNIGPDTMRVTWAPPP--SIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1436 ESIP 1439
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1904-1984 2.41e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 73.22  E-value: 2.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1904 DAPSNLRFLTTTPNSLLVSWQAPRAR---ITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1981 KSEP 1984
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 810-898 3.07e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.91  E-value: 3.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  810 PDAPPDPTVDQVDDTSIVVRWSRPQ---APITGYRIVYSPSVEGSSTELNLPE-TANSVTLSDLQPGVQYNITIYAVEEN 885
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1039727579  886 QESTPVFIQQETT 898
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1240-1803 4.26e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 4.26e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1240 LEYNVSVYTVKDDKESAPISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV 1319
Cdd:COG3401     22 AVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSG 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1320 GYYTVTGlePGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPPPSIE-LTNLLVRYSPVKNE 1398
Cdd:COG3401    102 SVGGATN--TGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAgAGVVVSPDTSATAA 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1399 EDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPLRGRQKTGL----DSPTGFDSSDITANSFTVHWVAPRAP 1474
Cdd:COG3401    180 VATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPttppSAPTGLTATADTPGSVTLSWDPVTES 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1475 -ITGYII-RHHAEHS----VGRPRQdrvppsrNSITLTNLNPGTEYVVSIIAVNGR-EESPPLIGQQATVSDI----PRD 1543
Cdd:COG3401    260 dATGYRVyRSNSGDGpftkVATVTT-------TSYTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTppaaPSG 332

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1544 LEVIASTPTSLLISWEPPA-VSVRYYRItYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPASSK 1622
Cdd:COG3401    333 LTATAVGSSSITLSWTASSdADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSE 411

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1623 PVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTpkNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSV 1702
Cdd:COG3401    412 EVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAA--VLADGGDTGNAVPFTTTSSTVTATTTDTTTANL 489

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1703 YAQNRNGESQPLVQTAVTTIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGL 1782
Cdd:COG3401    490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSG 569

                          570       580
                   ....*....|....*....|.
gi 1039727579 1783 MVATKYEVSVYALKDTLTSRP 1803
Cdd:COG3401    570 NLYLITTLGGSLLTTTSTNTN 590
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 187-231 4.79e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.84  E-value: 4.79e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNR 231
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1633-1721 1.06e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 71.37  E-value: 1.06e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1633 DKPSQMQVTDVQDNSISVRWLPST---SPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNG 1709
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1039727579 1710 ESQPLVQTAVTT 1721
Cdd:cd00063     82 ESPPSESVTVTT 93
fn1 pfam00039
Fibronectin type I domain;
232-271 1.27e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 69.65  E-value: 1.27e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKC 271
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 232-275 1.36e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.69  E-value: 1.36e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039727579   232 CNDQDTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHA 275
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
fn3 pfam00041
Fibronectin type III domain;
1723-1803 1.46e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.46e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1723 PAPTNLKFSQVTPTSFTAQWIAP---SVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1799
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1800 TSRP 1803
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2131-2172 1.51e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.51e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039727579  2131 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHE 2172
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2086-2130 2.40e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.92  E-value: 2.40e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579  2086 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW 2130
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 561-604 3.61e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.53  E-value: 3.61e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   561 CQDSETRTFYQIGDSWEK-FVHGVRYQCYCYGRGIGEWHCQPLQT 604
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1591-1975 3.95e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 78.12  E-value: 3.95e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1591 STATINNIKPGADYTITLYAVTGRGDSPASSKPVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTPKN 1670
Cdd:COG3401     30 GGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNT 109

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1671 GLGPSKTK----TASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTTIPAPTNLKFSQVTPTSFTAQWIAPS 1746
Cdd:COG3401    110 GLTSSDEVpspaVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTS 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1747 VQLTGYRVRVNPkektgpmkeinlspdsssvivsglmvATKYEVSVYALKDTLTSRPAQGVITTLENVSP--PRRARVTD 1824
Cdd:COG3401    190 TTLVDGGGDIEP--------------------------GTTYYYRVAATDTGGESAPSNEVSVTTPTTPPsaPTGLTATA 243

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1825 ATETTITISWRTKTET-ITGFQvdaipangqtpVQRSISPDVR----------SYTITGLQPGTDYKIHLYTLNDNARSS 1893
Cdd:COG3401    244 DTPGSVTLSWDPVTESdATGYR-----------VYRSNSGDGPftkvatvtttSYTDTGLTNGTTYYYRVTAVDAAGNES 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1894 P--VIIDASTAI---DAPSNLRFLTTTPNSLLVSWQAPR-ARITGYIIKYEKPGSPPREVVPRPRPGvTEATITGLEPGT 1967
Cdd:COG3401    313 ApsNVVSVTTDLtppAAPSGLTATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGT 391


                   ....*...
gi 1039727579 1968 EYTIYVIA 1975
Cdd:COG3401    392 TYYYKVTA 399
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 470-513 4.39e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 68.15  E-value: 4.39e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQ 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1449-1529 5.70e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.45  E-value: 5.70e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1449 DSPTGFDSSDITANSFTVHWVAPR---APITGYIIRHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1526 ESPP 1529
Cdd:cd00063     82 ESPP 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1541-1621 7.20e-14

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 69.06  E-value: 7.20e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1541 PRDLEVIASTPTSLLISWEPPAVS---VRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDS 1617
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....
gi 1039727579 1618 PASS 1621
Cdd:cd00063     84 PPSE 87
fn3 pfam00041
Fibronectin type III domain;
1815-1894 9.05e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 68.60  E-value: 9.05e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1815 SPPRRARVTDATETTITISWRTKTE---TITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1890
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1039727579 1891 RSSP 1894
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
698-1027 1.12e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.58  E-value: 1.12e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  698 TTSASTPVTSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNI 776
Cdd:COG3401    212 TDTGGESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTD 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  777 PDLLPGRKY---IVNVYQISEEGKQSLILS-TSQTTAPDAPPDPTVDQVDDTSIVVRWS-RPQAPITGYRIVYSPSVEGS 851
Cdd:COG3401    290 TGLTNGTTYyyrVTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGT 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  852 STELNLPETANSVTLSDLQPGVQYNITIYAV----EENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWT 927
Cdd:COG3401    370 YTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAAS 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  928 PPDSVVSGYRVEVLPVSLPgehgqrlPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNE 1007
Cdd:COG3401    450 NPGVSAAVLADGGDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGG 522

                          330       340
                   ....*....|....*....|
gi 1039727579 1008 TDRTVLVTWTPPRARIAGYR 1027
Cdd:COG3401    523 APDGTPNVTGASPVTVGAST 542
fn1 pfam00039
Fibronectin type I domain;
561-599 1.36e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.57  E-value: 1.36e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  561 CQDSETRTFYQIGDSWEKFVH-GVRYQCYCYGRGIGEWHC 599
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQrGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1267-1349 1.99e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.44  E-value: 1.99e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1267 PQLTDLSFVDITDSSIGLRWTPL--NSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1344
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 1039727579 1345 ESAPT 1349
Cdd:pfam00041   81 EGPPS 85
fn1 pfam00039
Fibronectin type I domain;
2086-2125 1.99e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 66.18  E-value: 1.99e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2086 CFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRC 2125
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 518-560 2.28e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.28e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   518 CIVDD--ITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPIDQ 560
Cdd:smart00058    1 CFDEEtgTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
470-508 3.99e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.99e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  470 CTTNE-GVMYRIGDQWDKQHDLGHMMRCTCVGNGRGEWAC 508
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
807-1297 6.43e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 74.27  E-value: 6.43e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  807 TTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQ 886
Cdd:COG3401     54 TLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAG 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  887 ESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGqrlpvnrntfaeitGL 966
Cdd:COG3401    134 GAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGG--------------DI 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  967 SPGVTYLFKVFAVHQGRESNP----LTAQQTTKLDAPTNLQFVNETDRTVLVTWTP-PRARIAGYRLTAGLTRGGQPKQY 1041
Cdd:COG3401    200 EPGTTYYYRVAATDTGGESAPsnevSVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKV 279

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1042 NVGPLASkYPLRNLQPGSEYTVTLVAVKGN-QQSPKATGVFTTLQPLRSIPPYN---TEVTETTIVITWTPAP---RIGF 1114
Cdd:COG3401    280 ATVTTTS-YTDTGLTNGTTYYYRVTAVDAAgNESAPSNVVSVTTDLTPPAAPSGltaTAVGSSSITLSWTASSdadVTGY 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1115 KLGVRPSQGGEAPREVTSDSG-SIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA-------NPD 1186
Cdd:COG3401    359 NVYRSTSGGGTYTKIAETVTTtSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTAsvdavplTDV 438

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1187 TGVLTVSWERSTTPD---------ITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAP 1257
Cdd:COG3401    439 AGATAAASAASNPGVsaavladggDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAA 518

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|
gi 1039727579 1258 ISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGY 1297
Cdd:COG3401    519 AVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSAS 558
fn1 pfam00039
Fibronectin type I domain;
187-226 1.25e-12

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 63.87  E-value: 1.25e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579  187 CFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITC 226
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1174-1257 1.72e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1174 SPPTNLHL-EANPDTgvLTVSWERSTTP--DITGYRITTTPTNGQQGTsLEEVVHADQSSCTFENLNPGLEYNVSVYTVK 1250
Cdd:pfam00041    1 SAPSNLTVtDVTSTS--LTVSWTPPPDGngPITGYEVEYRPKNSGEPW-NEITVPGTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 1039727579 1251 DDKESAP 1257
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 810-888 1.77e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.77e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579   810 PDAPPDPTVDQVDDTSIVVRWSRPQ-----APITGYRIVYSPSvEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039727579   885 NQES 888
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1358-1437 1.92e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.94  E-value: 1.92e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1358 PPPTDLRFTNIGPDTMRVTWAPPPSIELTNLLVRYSPVKNEED--VAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1436 ES 1437
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
997-1075 2.49e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 2.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  997 DAPTNLQFVNETDRTVLVTWTPPRAR---IAGYRLTAGLTRGGQPKQ-YNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGngpITGYEVEYRPKNSGEPWNeITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1039727579 1073 QSP 1075
Cdd:pfam00041   81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
726-797 3.79e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.97  E-value: 3.79e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579  726 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGK 797
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 559-602 3.98e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 62.35  E-value: 3.98e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  559 DQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGrGIGEWHCQPL 602
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 98-141 5.96e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.98  E-value: 5.96e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579    98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISCTIANR 141
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
907-987 7.28e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 63.20  E-value: 7.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  907 PPPTDLQFVELTDVKVTIMWTPP---DSVVSGYRVEVLPVSLpGEHGQRLPVNRNTF-AEITGLSPGVTYLFKVFAVHQG 982
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 1039727579  983 RESNP 987
Cdd:pfam00041   80 GEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1904-1982 8.86e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.02  E-value: 8.86e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1904 DAPSNLRFLTTTPNSLLVSWQAP-RARITGYIIKY--EKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQ 1980
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYrvEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1981 KS 1982
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2174-2213 9.58e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 61.58  E-value: 9.58e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579 2174 TCYDD--GKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNC 2213
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
98-136 1.13e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 61.18  E-value: 1.13e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   98 CFDKYTGNTYKVGDTYERPKDS-MIWDCTCIGAGRGRISC 136
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
619-688 1.13e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.43  E-value: 1.13e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039727579  619 TPSQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:pfam00041    9 TDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1358-1439 1.14e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.14e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1358 PPPTDLRFTNIGPDTMRVTWAPPPSI--ELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQH 1435
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....
gi 1039727579 1436 ESIP 1439
Cdd:cd00063     82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 142-185 1.65e-11

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 60.83  E-value: 1.65e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 1039727579   142 CHEG--GQSYKIGDKWRRPHEtGGYMLECLCLGNGKGEWTCKPIAE 185
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1633-1711 1.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 1.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1633 DKPSQMQVTDVQDNSISVRWLP-----STSPVTGYRVTTTPKNGlgPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNR 1707
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPppddgITGYIVGYRVEYREEGS--EWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039727579  1708 NGES 1711
Cdd:smart00060   80 AGEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 96-137 2.03e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.42  E-value: 2.03e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579   96 ETCFDKYTGNTYKVGDTYERPKDSMIWDCTCIGaGRGRISCT 137
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1541-1617 3.18e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.48  E-value: 3.18e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1541 PRDLEVIASTPTSLLISWEPPAVS-----VRYYRITYGETGGNspVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRG 1615
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1616 DS 1617
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 997-1083 3.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 3.21e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  997 DAPTNLQFVNETDRTVLVTWTPPR---ARIAGYRLTAGLTRGGQPKQYNVGPL-ASKYPLRNLQPGSEYTVTLVAVKGNQ 1072
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGsETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1039727579 1073 QSPKATGV-FTT 1083
Cdd:cd00063     82 ESPPSESVtVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1449-1527 3.58e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 3.58e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1449 DSPTGFDSSDITANSFTVHWVAPRAP-ITGYIIRHHAEHSVGRPRQDRV--PPSRNSITLTNLNPGTEYVVSIIAVNGRE 1525
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579  1526 ES 1527
Cdd:smart00060   82 EG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-90 5.90e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 59.27  E-value: 5.90e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   53 CFDN--GKHYQINQQWERTYLGNALVCTCYGGSRGFNCES 90
Cdd:cd00061      3 CFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 907-994 6.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 6.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  907 PPPTDLQFVELTDVKVTIMWTPPD---SVVSGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1039727579  984 ESNPLTAQQTT 994
Cdd:cd00063     82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2084-2128 7.99e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 58.88  E-value: 7.99e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579 2084 DSCFDPYTVSHYAIGEEWERLSDaGFKLTCQCLGfGSGHFRCDSS 2128
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
2131-2168 8.02e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.86  E-value: 8.02e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2131 CHDN--GVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKC 2168
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 185-228 1.73e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 57.73  E-value: 1.73e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  185 EKCFDHAAGTSYVVGETWEKPYQGwMMVDCTCLGeGNGRITCTS 228
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2175-2215 2.45e-10

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 57.36  E-value: 2.45e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579  2175 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRCDNCRR 2215
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1174-1263 2.85e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.05  E-value: 2.85e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1174 SPPTNLHLEANPDTGVlTVSWERSTTP--DITGYRITTTPTNGQQGTSLEeVVHADQSSCTFENLNPGLEYNVSVYTVKD 1251
Cdd:cd00063      2 SPPTNLRVTDVTSTSV-TLSWTPPEDDggPITGYVVEYREKGSGDWKEVE-VTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|..
gi 1039727579 1252 DKESAPISDTVV 1263
Cdd:cd00063     80 GGESPPSESVTV 91
fn1 pfam00039
Fibronectin type I domain;
524-555 4.44e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 56.55  E-value: 4.44e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039727579  524 TYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKC 555
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1264-1355 4.77e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.28  E-value: 4.77e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1264 PEVPQltDLSFVDITDSSIGLRWTP--LNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLI 1341
Cdd:cd00063      1 PSPPT--NLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....
gi 1039727579 1342 NGGESAPTTLTQQT 1355
Cdd:cd00063     79 GGGESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 468-511 5.82e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 5.82e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  468 EICTTNE-GVMYRIGDQWDKQHDlGHMMRCTCVGNgRGEWACIPY 511
Cdd:cd00061      1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
142-180 8.63e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 8.63e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039727579  142 CHE--GGQSYKIGDKWRRPHETGgYMLECLCLGNGKGEWTC 180
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1723-1810 1.37e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1723 PAPTNLKFSQVTPTSFTAQWIAPS---VQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTL 1799
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1039727579 1800 TSRPAQGVITT 1810
Cdd:cd00063     82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 230-274 1.56e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.03  E-value: 1.56e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  230 NRCNDQDTRTSYRIGDTWSKKDNrGNLLQCVCTGNgRGEWKCERH 274
Cdd:cd00061      1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1815-1895 1.83e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.74  E-value: 1.83e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1815 SPPRRARVTDATETTITISW---RTKTETITGFQVDAIPANGQTPVQ-RSISPDVRSYTITGLQPGTDYKIHLYTLNDNA 1890
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 1039727579 1891 RSSPV 1895
Cdd:cd00063     82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 53-93 2.10e-09

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 54.66  E-value: 2.10e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579    53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNCESKPE 93
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
704-898 2.58e-09

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 62.66  E-value: 2.58e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  704 PVTSNTVTGETAPYSPVVATSESVTEITassfvVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPG 782
Cdd:COG4733    528 PPQWPPVNVTTSESLSVVAQGTAVTTLT-----VSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAG 597

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  783 RkYIVNVYQISEEGKQSLILSTSQTTA---PDAPPDPTVDQV--DDTSIVVRWSRPQ-APITGYRIVYSPSVEGSSTELN 856
Cdd:COG4733    598 D-YEVRVRAINALGVSSAWAASSETTVtgkTAPPPAPTGLTAtgGLGGITLSWSFPVdADTLRTEIRYSTTGDWASATVA 676

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039727579  857 LPE-TANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETT 898
Cdd:COG4733    677 QALyPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2130-2171 3.16e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 54.26  E-value: 3.16e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579 2130 WCHDN--GVNYKIGEKWDRQGEnGQRMSCTCLGNgKGEFKCDPH 2171
Cdd:cd00061      2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 997-1074 4.03e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.03e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579   997 DAPTNLQFVNETDRTVLVTWTPP-----RARIAGYRLTaGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGN 1071
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVE-YREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1039727579  1072 QQS 1074
Cdd:smart00060   81 GEG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
600-940 1.58e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.02  E-value: 1.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  600 QPLQTYPGTTGPVQVI-ITETPSQPNSHPIQWNAPEPSHITKYILrWRPKTSTGRWKE-ATIPGhlNSYTIKGLTPGVIY 677
Cdd:COG3401    222 NEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDATGYRV-YRSNSGDGPFTKvATVTT--TSYTDTGLTNGTTY 298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  678 EgqlisiqqYGhreVTRFDFTTSASTPvtSNTVTGETAPYSPVVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELS 756
Cdd:COG3401    299 Y--------YR---VTAVDAAGNESAP--SNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTS 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  757 EEGdEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAP 836
Cdd:COG3401    366 GGG-TYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAA 444

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  837 ITGYR--IVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQF 914
Cdd:COG3401    445 ASAASnpGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAP 524

                          330       340
                   ....*....|....*....|....*.
gi 1039727579  915 VELTDVKVTIMWTPPDSVVSGYRVEV 940
Cdd:COG3401    525 DGTPNVTGASPVTVGASTGDVLITDL 550
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1711-2054 2.01e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 59.63  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1711 SQPLVQTAVTTIPAPTNLKFSQVTPTSFTAQW-IAPSVQLTGYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYE 1789
Cdd:COG3401     38 VYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTgGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEV 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1790 VSVYALKDTLTSRPAQGVITTLENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANGQTpvQRSISPDVRSYT 1869
Cdd:COG3401    118 PSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATT--SLTVTSTTLVDG 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1870 ITGLQPGTDYKIHLYTLNDNARSSPV----IIDASTAIDAPSNLRFLTTTPNSLLVSWQA-PRARITGYIIKYEKPGSPP 1944
Cdd:COG3401    196 GGDIEPGTTYYYRVAATDTGGESAPSnevsVTTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGP 275

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1945 REVVPRPRpgVTEATITGLEPGTEYTIYVIALKNN----QKSEPLIGrkKTGQEAL-------------SQTTISWTPFQ 2007
Cdd:COG3401    276 FTKVATVT--TTSYTDTGLTNGTTYYYRVTAVDAAgnesAPSNVVSV--TTDLTPPaapsgltatavgsSSITLSWTASS 351

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039727579 2008 ES--SEYIIscqpVGTDEEPLQFQV---PGTSTSATLTGLTRGVTYNIIVEA 2054
Cdd:COG3401    352 DAdvTGYNV----YRSTSGGGTYTKiaeTVTTTSYTDTGLTPGTTYYYKVTA 399
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1174-1255 2.32e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 2.32e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1174 SPPTNLHLEANPDTGVlTVSWERSTTPDITGYRITTTPTNGQQGTSLEEV-VHADQSSCTFENLNPGLEYNVSVYTVKDD 1252
Cdd:smart00060    2 SPPSNLRVTDVTSTSV-TLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1039727579  1253 KES 1255
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 516-557 3.09e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 3.09e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039727579  516 DQCIVDD--ITYNVNDTFHKRHEeGHMLNCTCFGqGRGRWKCDP 557
Cdd:cd00061      1 EKCFDPQtgVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1723-1794 5.64e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 5.64e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579  1723 PAPTNLKFSQVTPTSFTAQWIAPSV-QLTGYRV--RVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYA 1794
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
fn1 pfam00039
Fibronectin type I domain;
2175-2210 6.16e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.39  E-value: 6.16e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579 2175 CYDD--GKTYHVGEQWQKEYL-GAICSCTCFGGQRG-WRC 2210
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 140-182 8.48e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 50.41  E-value: 8.48e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039727579  140 NRCHEG--GQSYKIGDKWRRPHEtgGYMLECLCLGNgKGEWTCKP 182
Cdd:cd00061      1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDP 42
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 907-985 1.53e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 1.53e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579   907 PPPTDLQFVELTDVKVTIMWTPP-DSVVSGYRVEVLPVSLPGEHGQR--LPVNRNTFAEITGLSPGVTYLFKVFAVHQGR 983
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1039727579   984 ES 985
Cdd:smart00060   82 EG 83
fn1 pfam00039
Fibronectin type I domain;
53-88 2.03e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 49.23  E-value: 2.03e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1039727579   53 CFDN--GKHYQINQQWERTYL-GNALVCTCYGGSRG-FNC 88
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1815-1889 2.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 2.44e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  1815 SPPRRARVTDATETTITISWRTKTET-----ITGFQVDAIPANGQTpVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDN 1889
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEW-KEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 726-808 6.38e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.42  E-value: 6.38e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  726 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLIL 802
Cdd:cd00063      8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                   ....*.
gi 1039727579  803 STSQTT 808
Cdd:cd00063     88 SVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1091-1158 7.20e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.20e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039727579 1091 PPYN---TEVTETTIVITWTPAPR-----IGFKLGVRPSQGGEAPREVT--SDSGSIVVSGLTPGVEYTYTIQVLRDG 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
2000-2055 7.94e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.95  E-value: 7.94e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 2000 TISWT-PFQESSE---YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEAL 2055
Cdd:pfam00041   17 TVSWTpPPDGNGPitgYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1270-1346 1.71e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.99  E-value: 1.71e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039727579  1270 TDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1346
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1785-1973 6.00e-06

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 51.87  E-value: 6.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1785 ATKYEVSVYALKDT--LTSRPAQGVITTLEnVSPPRRARVTDATETTITISWRTKTETITgFQVDAIPANGQ-TPVQRSI 1861
Cdd:COG4733    508 AVQHAPEKYAAIDAgaFDDVPPQWPPVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNwVSVPRTS 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1862 SPdvrSYTITGLQPGtDYKIHLYTLNDNARSSPVIIDASTAI----DAPSNLRFLTTTPNSLLV--SW-QAPRARITGYI 1934
Cdd:COG4733    586 GT---SFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTE 661

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039727579 1935 IKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYV 1973
Cdd:COG4733    662 IRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRA 700
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 726-790 7.63e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 7.63e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039727579   726 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 790
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-688 9.19e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 9.19e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039727579   616 ITETPSQPNSHPIQWNAPEPSHITKYILRWRP--KTSTGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYG 688
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVeyREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-1224 1.52e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 50.33  E-value: 1.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  723 TSESVTEITASSFVVSWVSASDTVSGFRVEyelSEEGDE----PQYLDLPSTATSVNI-PDLLPGRKYIV--------NV 789
Cdd:COG4733    427 TLDRPVTMEAGDRYLRVRLPDGTSVARTVQ---SVAGRTltvsTAYSETPEAGAVWAFgPDELETQLFRVvsieenedGT 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  790 YQIS----EEGKQSLILSTSQTTAPDAPPDPTV----------DQVDDTSIVVRWSRPQAPITgYRIVYSPsveGSSTEL 855
Cdd:COG4733    504 YTITavqhAPEKYAAIDAGAFDDVPPQWPPVNVttseslsvvaQGTAVTTLTVSWDAPAGAVA-YEVEWRR---DDGNWV 579

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  856 NLPET-ANSVTLSDLQPGvQYNITIYAVEENQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDvKVTIMWT-PPDSVV 933
Cdd:COG4733    580 SVPRTsGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLG-GITLSWSfPVDADT 657

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  934 SGYRVEVLPVSLPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAV-HQGRESnPLTAQQTTKLDAPTNLQFVN----ET 1008
Cdd:COG4733    658 LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVdRSGNVS-AWWVSGQASADAAGILDAITgqilET 736

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1009 DRTVLVTWTPPRARIAGYRLTAGLTRGGQpkqynVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGVFTTLQPLR 1088
Cdd:COG4733    737 ELGQELDAIIQNATVAEVVAATVTDVTAQ-----IDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDA 811

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1089 SIppYNTEVTETTIVITWTPAPRIgfklgvrpsqggeapREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNR 1168
Cdd:COG4733    812 SG--GVTAGTSGTTGAGDTAASTT---------------RVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAV 874

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039727579 1169 VVTplspPTNLHLEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVV 1224
Cdd:COG4733    875 ATT----VSGTTAADVSAVADSTAASLTAIVIAATTIIDAIGDGTTREPAGDIGAS 926
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1095-1160 2.49e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.53  E-value: 2.49e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039727579  1095 TEVTETTIVITWTP-------APRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:smart00060   10 TDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGE 82
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 308-347 2.75e-05

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 43.11  E-value: 2.75e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 1039727579   308 CVTD-SGVVYSVGMQWLKSQGNKQML-CTCLGNG---VSCQETAV 347
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPYEGGHVLqCTCLGGGrgeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 307-345 3.86e-05

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 42.70  E-value: 3.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039727579  307 HCVTDS-GVVYSVGMQWLKSQGNKQMLCTCLGN--GVSCQET 345
Cdd:cd00061      2 KCFDPQtGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 611-678 8.82e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 43.25  E-value: 8.82e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579  611 PVQVIITETpsQPNSHPIQWNAPEP--SHITKYILRWRPKTSTGRWKEATIPGHLNSYTIKGLTPGVIYE 678
Cdd:cd00063      4 PTNLRVTDV--TSTSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1095-1160 2.74e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 2.74e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039727579 1095 TEVTETTIVITWTP-----APRIGFKLGVRPSQGGEaPREVTSDSG---SIVVSGLTPGVEYTYTIQVLRDGQE 1160
Cdd:cd00063     10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVEVTPGsetSYTLTGLKPGTEYEFRVRAVNGGGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1821-2048 3.35e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.62  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1821 RVTDATETTITISWRTKTETITGFQVDAIP--------ANGQTPVQRSI----SPDVRS--YTITGLQPGTD--YKIHL- 1883
Cdd:COG4733    430 RPVTMEAGDRYLRVRLPDGTSVARTVQSVAgrtltvstAYSETPEAGAVwafgPDELETqlFRVVSIEENEDgtYTITAv 509

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1884 ------YTLNDNArsspvIIDASTAIDAPSNLRFLT--------TTPNSLLVSWQAPRARITgYIIKYEKPGSpprEVVP 1949
Cdd:COG4733    510 qhapekYAAIDAG-----AFDDVPPQWPPVNVTTSEslsvvaqgTAVTTLTVSWDAPAGAVA-YEVEWRRDDG---NWVS 580

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1950 RPRPGVTEATITGLEPGTeYTIYVIAL-KNNQKSEPLIGRKK--TGQEA-------------LSQTTISWTPFQES--SE 2011
Cdd:COG4733    581 VPRTSGTSFEVPGIYAGD-YEVRVRAInALGVSSAWAASSETtvTGKTApppaptgltatggLGGITLSWSFPVDAdtLR 659

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1039727579 2012 YIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTY 2048
Cdd:COG4733    660 TEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTY 696
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1549-1908 3.68e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.62  E-value: 3.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1549 STPTSLLISWEPPAVSVRYYrITYgETGGNSPVQEFTVpgSKSTATINNIKPGaDYTITLYAVTGRGDSPASSKPVSINY 1628
Cdd:COG4733    549 TAVTTLTVSWDAPAGAVAYE-VEW-RRDDGNWVSVPRT--SGTSFEVPGIYAG-DYEVRVRAINALGVSSAWAASSETTV 623

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1629 KTEIDKPSQMQ--VTDVQDNSISVRW-LPSTSPVTGYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQ 1705
Cdd:COG4733    624 TGKTAPPPAPTglTATGGLGGITLSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAV 703

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1706 NRNGESQPLVQTAVTTIPAPTNLKF--SQVTPTSFTAQWIAPSVQLTgyrVRVNPKEKTGPMKEINLSPDSSSVIVSGLM 1783
Cdd:COG4733    704 DRSGNVSAWWVSGQASADAAGILDAitGQILETELGQELDAIIQNAT---VAEVVAATVTDVTAQIDTAVLFAGVATAAA 780

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1784 VATkYEVSVYALKDTLTSRPAQGVITTLENVSPPRRARVTDATET-TITISWRTKTETITGFQVDAIPANGQTPVQRSIS 1862
Cdd:COG4733    781 IGA-EARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTTGaGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGD 859

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1039727579 1863 PDVrsYTITGLQPGTDYKIHLYTLNDNARSSPVIIDASTAIDAPSN 1908
Cdd:COG4733    860 IVA--TGDIASAAAGAVATTVSGTTAADVSAVADSTAASLTAIVIA 903
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1097-1285 8.28e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 41.47  E-value: 8.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1097 VTETTIVITWTPAP-RIGFKLGVRPSqGGEAPREVTSDSGSIVVSGLTPGvEYTYTIQ-VLRDGQERDAPIVNRV----- 1169
Cdd:COG4733    549 TAVTTLTVSWDAPAgAVAYEVEWRRD-DGNWVSVPRTSGTSFEVPGIYAG-DYEVRVRaINALGVSSAWAASSETtvtgk 626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039727579 1170 VTPLSPPTNLhlEANPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVVHAdQSSCTFENLNPGLEYNVSVYTV 1249
Cdd:COG4733    627 TAPPPAPTGL--TATGGLGGITLSWSFPVDADTLRTEIRYSTTGDWASATVAQALYP-GNTYTLAGLKAGQTYYYRARAV 703

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039727579 1250 -KDDKESA-PISDTVVPEVPQLTDLSFVDITDSSIGLR 1285
Cdd:COG4733    704 dRSGNVSAwWVSGQASADAAGILDAITGQILETELGQE 741
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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