DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein ...
52-861
0e+00
DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), which is arranged in four supersecondary alpha-helical structures, N1 to N4, that resemble HEAT repeats. Therefore, this domain is also known as N-HEAT. This domain likely mediates DNA binding and, together with the Circular Cradle, forms a ring through which Ku70/80 may present DNA for repair. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It is recruited by Ku70/80 heterodimer to DNA ends.
:
Pssm-ID: 466649 Cd Length: 810 Bit Score: 1422.18 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic ...
951-1755
0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ) which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. It folds into three well-defined large structural units, consisting of a N-terminal region, the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This entry represents CC1 and CC2, which contain the Highly conserved region I (HCR-I).
:
Pssm-ID: 466651 Cd Length: 810 Bit Score: 1381.32 E-value: 0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, ...
2209-2891
0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, also known as M-HEAT repeats) from DNA-dependent protein kinase catalytic subunit (DNA-PKcs), containing most of the supersecondary structure CC4 and the complete CC5. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It interacts with the C-terminal peptide of Ku80 which presents the DNA ends for repair. The structures in this entry contain Ku-binding site B and one of the caspase-3 cleavage sites.
:
Pssm-ID: 466153 Cd Length: 641 Bit Score: 1102.75 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic ...
1813-2198
0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ), which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand breaks (DSBs) repair. DNA-PKcs phosphorylates a number of protein substrates, including the heat shock protein 90 (HSP90), the transcription factors p53, specificity protein 1 (Sp1), among others. It folds into three well-defined large structural units, consisting of a N-terminal region (arranged in four supersecondary alpha-helical structures, N1-N4), the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1-CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This domain represents a region of the Circular Cradle segment (CC) from DNA-PKcs that covers the complete CC3 and part of CC4. This domain contains the Ku-binding site A and a the highly conserved region (HCR) II.
:
Pssm-ID: 462387 Cd Length: 387 Bit Score: 618.99 E-value: 0e+00
DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein ...
52-861
0e+00
DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), which is arranged in four supersecondary alpha-helical structures, N1 to N4, that resemble HEAT repeats. Therefore, this domain is also known as N-HEAT. This domain likely mediates DNA binding and, together with the Circular Cradle, forms a ring through which Ku70/80 may present DNA for repair. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It is recruited by Ku70/80 heterodimer to DNA ends.
Pssm-ID: 466649 Cd Length: 810 Bit Score: 1422.18 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic ...
951-1755
0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ) which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. It folds into three well-defined large structural units, consisting of a N-terminal region, the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This entry represents CC1 and CC2, which contain the Highly conserved region I (HCR-I).
Pssm-ID: 466651 Cd Length: 810 Bit Score: 1381.32 E-value: 0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, ...
2209-2891
0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, also known as M-HEAT repeats) from DNA-dependent protein kinase catalytic subunit (DNA-PKcs), containing most of the supersecondary structure CC4 and the complete CC5. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It interacts with the C-terminal peptide of Ku80 which presents the DNA ends for repair. The structures in this entry contain Ku-binding site B and one of the caspase-3 cleavage sites.
Pssm-ID: 466153 Cd Length: 641 Bit Score: 1102.75 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic ...
1813-2198
0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ), which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand breaks (DSBs) repair. DNA-PKcs phosphorylates a number of protein substrates, including the heat shock protein 90 (HSP90), the transcription factors p53, specificity protein 1 (Sp1), among others. It folds into three well-defined large structural units, consisting of a N-terminal region (arranged in four supersecondary alpha-helical structures, N1-N4), the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1-CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This domain represents a region of the Circular Cradle segment (CC) from DNA-PKcs that covers the complete CC3 and part of CC4. This domain contains the Ku-binding site A and a the highly conserved region (HCR) II.
Pssm-ID: 462387 Cd Length: 387 Bit Score: 618.99 E-value: 0e+00
DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein ...
52-861
0e+00
DNA-PKcs, N-terminal; This entry represents the N-terminal domain of DNA-dependent protein kinase catalytic subunit (DNA-PKcs), which is arranged in four supersecondary alpha-helical structures, N1 to N4, that resemble HEAT repeats. Therefore, this domain is also known as N-HEAT. This domain likely mediates DNA binding and, together with the Circular Cradle, forms a ring through which Ku70/80 may present DNA for repair. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It is recruited by Ku70/80 heterodimer to DNA ends.
Pssm-ID: 466649 Cd Length: 810 Bit Score: 1422.18 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic ...
951-1755
0e+00
DNA-dependent protein kinase catalytic subunit, CC1/2; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ) which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand break (DSB) repair. It folds into three well-defined large structural units, consisting of a N-terminal region, the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1 to CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The N-terminal and CCs regions resemble HEAT repeats, and thus, they are also referred to as N-HEAT and M-HEAT ('middle'), respectively. The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This entry represents CC1 and CC2, which contain the Highly conserved region I (HCR-I).
Pssm-ID: 466651 Cd Length: 810 Bit Score: 1381.32 E-value: 0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, ...
2209-2891
0e+00
DNA-PKcs, CC5; This entry represents the C-terminal region of the circular cradle segment (CC, also known as M-HEAT repeats) from DNA-dependent protein kinase catalytic subunit (DNA-PKcs), containing most of the supersecondary structure CC4 and the complete CC5. DNA-PKcs is involved in DNA nonhomologous end joining (NHEJ), required for double-strand break (DSB) repair. It interacts with the C-terminal peptide of Ku80 which presents the DNA ends for repair. The structures in this entry contain Ku-binding site B and one of the caspase-3 cleavage sites.
Pssm-ID: 466153 Cd Length: 641 Bit Score: 1102.75 E-value: 0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic ...
1813-2198
0e+00
DNA-dependent protein kinase catalytic subunit, CC3; DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is involved in DNA nonhomologous end joining (NHEJ), which is recruited by Ku70/80 heterodimer to DNA ends and required for double-strand breaks (DSBs) repair. DNA-PKcs phosphorylates a number of protein substrates, including the heat shock protein 90 (HSP90), the transcription factors p53, specificity protein 1 (Sp1), among others. It folds into three well-defined large structural units, consisting of a N-terminal region (arranged in four supersecondary alpha-helical structures, N1-N4), the Circular Cradle (consisting of five supersecondary alpha-helical structures CC1-CC5), and the C-terminal Head (comprising FAT, FRB, kinase, and FATC). The CCs form a curved elliptical ring that serves as a scaffold to maintain the integrity of the whole complex. This domain represents a region of the Circular Cradle segment (CC) from DNA-PKcs that covers the complete CC3 and part of CC4. This domain contains the Ku-binding site A and a the highly conserved region (HCR) II.
Pssm-ID: 462387 Cd Length: 387 Bit Score: 618.99 E-value: 0e+00
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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