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Conserved domains on  [gi|1046843935|ref|XP_017445083|]
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gem-associated protein 7 isoform X1 [Rattus norvegicus]

Protein Classification

gem-associated protein 7( domain architecture ID 10184828)

gem-associated protein 7 plays a role in the splicing of cellular pre-mRNAs as a component of the SMN complex that functions in the assembly of small nuclear ribonucleoproteins (snRNPs)-the major components of the spliceosome; may be a partial protein

Gene Symbol:  GEMIN7
Gene Ontology:  GO:0000398|GO:0000387|GO:0000245
PubMed:  33827399|17381311

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
 68-144 2.71e-44

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


:

Pssm-ID: 212488  Cd Length: 77  Bit Score: 139.70  E-value: 2.71e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046843935  68 QEQRARAALRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSFK 144
Cdd:cd11677     1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
 
Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
 68-144 2.71e-44

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


Pssm-ID: 212488  Cd Length: 77  Bit Score: 139.70  E-value: 2.71e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046843935  68 QEQRARAALRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSFK 144
Cdd:cd11677     1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
Gemin7 pfam11095
Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron ...
 68-143 2.41e-42

Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE.


Pssm-ID: 463219  Cd Length: 76  Bit Score: 135.01  E-value: 2.41e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046843935  68 QEQRARAALRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSF 143
Cdd:pfam11095   1 EEQEARAFLRERFLRSLLALVGKPATFTLYENTTVTATFKGSDIDEENFLVSNLQTPLGTIKEALLRCSDIISISF 76
 
Name Accession Description Interval E-value
Gemin7 cd11677
Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and ...
 68-144 2.71e-44

Gemin 7; Gemins 7, together with the survival motor neuron (SMN) protein, other Gemins, and Unr-interacting protein (UNRIP) form the SMN complex, which plays an important role in the Sm core assembly reaction, by binding directly to the Sm proteins, as well as UsnRNAs. Gemin 7 forms a heterodimer with Gemin 6, which serve as a surrogate for the SmB-SmD3 dimer during the formation of the heptameric Sm ring.


Pssm-ID: 212488  Cd Length: 77  Bit Score: 139.70  E-value: 2.71e-44
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1046843935  68 QEQRARAALRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSFK 144
Cdd:cd11677     1 LEQEARAFLRERFLRSLLALAGKPVEFTMHENTTVTATFKACDIDVENFQVSNLKTPLGIQPEALLRTSDIISITFD 77
Gemin7 pfam11095
Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron ...
 68-143 2.41e-42

Gem-associated protein 7 (Gemin7); Gemin7 is a novel component of the survival of motor neuron complex which functions in the assembly of spliceosomal small nuclear ribonucleoproteins. Gemin7 interacts with several Sm proteins of spliceosomal small nuclear ribonucleoproteins, especially SmE.


Pssm-ID: 463219  Cd Length: 76  Bit Score: 135.01  E-value: 2.41e-42
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046843935  68 QEQRARAALRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSF 143
Cdd:pfam11095   1 EEQEARAFLRERFLRSLLALVGKPATFTLYENTTVTATFKGSDIDEENFLVSNLQTPLGTIKEALLRCSDIISISF 76
Sm_like cd00600
Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to ...
 84-142 1.60e-03

Sm and related proteins; The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet. Sm-like proteins exist in archaea as well as prokaryotes that form heptameric and hexameric ring structures similar to those found in eukaryotes.


Pssm-ID: 212462 [Multi-domain]  Cd Length: 63  Bit Score: 34.92  E-value: 1.60e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046843935  84 LLAMVGHPVSFTLHEGVHVTAQFGATDlDVANFYVSQLQTP-----IGVQAEALLRCSDIISYS 142
Cdd:cd00600     1 LKDFIGKTVSVELKDGRVLTGTLVAFD-KYMNLVLDDVVETgrdgkVRVLGLVLIRGSNIVSIR 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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