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Conserved domains on  [gi|1046845797|ref|XP_017445579|]
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zinc finger protein 665 isoform X1 [Rattus norvegicus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204806)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 3.93e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.93e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046845797   27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVGYSIPSPGVIFRLEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
388-790 6.16e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 6.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 388 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 464
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 465 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 538 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 617
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 618 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 683
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 684 LKSHYQIHTGEKPCKCP--DCGKSFS------KTSQLKAHSRIHTgERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPY 753
Cdd:COG5048   339 LKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1046845797 754 KCNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 790
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
796-820 4.19e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 796 LQEHERIHTGERPYVCTHCGKAFRS 820
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-372 2.90e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1046845797 348 ALQQHEQIHTEEKPYVCTLCGKAFS 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 3.93e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.93e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046845797   27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVGYSIPSPGVIFRLEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 2.82e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 2.82e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046845797  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVG 67
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 1.73e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.73e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046845797  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLS 65
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
388-790 6.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 6.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 388 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 464
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 465 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 538 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 617
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 618 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 683
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 684 LKSHYQIHTGEKPCKCP--DCGKSFS------KTSQLKAHSRIHTgERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPY 753
Cdd:COG5048   339 LKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1046845797 754 KCNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 790
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-485 1.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 461 LKVHQRIHTGEKPYVCSQCGKAFNQ 485
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
796-820 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 796 LQEHERIHTGERPYVCTHCGKAFRS 820
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-372 2.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1046845797 348 ALQQHEQIHTEEKPYVCTLCGKAFS 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
27-84 3.93e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 104.60  E-value: 3.93e-27
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1046845797   27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVGYSIPSPGVIFRLEKGKE 84
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEE 58
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 27-67 2.82e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 2.82e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1046845797  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLSVG 67
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 27-65 1.73e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.73e-16
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1046845797  27 MSFEDVTVNFSQEEWQQLDSAQRLLYQEVMLEIYSHLLS 65
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
388-790 6.16e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 6.16e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 388 TPFICDICGKAFLRKSELTSHKQSHSGEKPYKCND--CGKSFKFPSQLKVHRQIHTGEKPYECR-ECGKSFSKTAKLKVH 464
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 465 QRIHTGEKPYVCSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKS-------FNYPSQLKVHCHSHTgekPYKCHECGK 537
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKD---PSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 538 SFNFPCELKVHYQNHTGEKPYKcrecwKLFSKMSQLKAHYRVhtgerPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT 617
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYS-----IPSSSSDQNLENSSS-----SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSAS 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 618 ECGKAFSSRSSFRKHQLIHT-------KEKPFVSQKCETGL-QESTLTPHQQ--LHIGE--KPYKCP--DCGKLFNYPSQ 683
Cdd:COG5048   259 ESPRSSLPTASSQSSSPNESdsssekgFSLPIKSKQCNISFsRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDA 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 684 LKSHYQIHTGEKPCKCP--DCGKSFS------KTSQLKAHSRIHTgERPYVCSV--CGKAFKQLSTLSRHEKIHMVEKPY 753
Cdd:COG5048   339 LKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPY 417

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1046845797 754 KCNF--CGKSFCSPSELKVHLLIHTGERPYkCNSCWKAF 790
Cdd:COG5048   418 NCKNppCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSF 455
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
332-744 5.77e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 5.77e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 332 DPYKCSSCEESFCTEAALQQHEQIHTEEKPYVCTL--CGKAFSDGSAFYEHELIHKNHTPFICDICGKafLRKSELTSHK 409
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 410 QSHSGEKPYKCNDCgkSFKFPSQLKVHRQIHTGEKPYECRECG--KSFSKTAKLKVHQRIHtGEKPYVCSQCGKAFNQKS 487
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPlpGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 488 ILdrHEKLHPGEKPYKCSDCGKSFNYPSQLKVHCHSHTGEKPYKCHECgkSFNFPCELKVHYQNHTGEKPYKCRECWKLF 567
Cdd:COG5048   187 LI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 568 S----KMSQLKAHYRVHTGER-----PYKCSHCGKAFSTKEQVQEHER--IHTGE--KPFVCTE--CGKAFSSRSSFRKH 632
Cdd:COG5048   263 SslptASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 633 QLIHTKEKPF---------VSQKCETGLQESTLTPHQQLHIgEKPYKCPDCGKLFNYPSQ--LKSHYQIHTGEKP--CKC 699
Cdd:COG5048   343 ILLHTSISPAkekllnsssKFSPLLNNEPPQSLQQYKDLKN-DKKSETLSNSCIRNFKRDsnLSLHIITHLSFRPynCKN 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1046845797 700 PDCGKSFSKTSQLKAHSRIHTGERPYVCSVCGKAFKQLSTLSRHE 744
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
584-864 6.36e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 6.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 584 RPYKCSHCGKAFSTKEQVQEHERIHTGEKPFVCT--ECGKAFSSRSSFRKHQLIHTKEKPFVSQKCetGLQESTLTPHQQ 661
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKS--LPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 662 L----HIGEKPYKCPDCGKLFNYPSQLKSHYQIHTGEKPCKCPDCGKSFSKTSQ----------------------LKAH 715
Cdd:COG5048   110 LssssSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLIS 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 716 SRIHTGERPYVCSVCGKAFKQLSTLSRHEKIHMVEKPYKCNFCG----------------------------------KS 761
Cdd:COG5048   190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspksllsqspsslsssdssssasesprsslptAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 762 FCSPSELKVHLLIHTGER-PYKCNSCWKAFCTKVQLQEHER--IHTGE--RPYVCTH--CGKAFRSRSVFSKHKLIHRKV 834
Cdd:COG5048   270 SQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1046845797 835 TPFIC--ERCGKVFLQKSELTSHLQTHIEDKP 864
Cdd:COG5048   350 SPAKEklLNSSSKFSPLLNNEPPQSLQQYKDL 381
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 664-745 1.59e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 664 IGEKPYKCP--DCGKLFNYPSQLKSH-YQIHTGEKPCKCPDCGKsfsktsqlkaHSRIHTGERPYVCSVCGKAFKQLSTL 740
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*
gi 1046845797 741 SRHEK 745
Cdd:COG5189   415 KYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-485 1.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.72e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 461 LKVHQRIHTGEKPYVCSQCGKAFNQ 485
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
740-762 3.87e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.87e-04
                          10        20
                  ....*....|....*....|...
gi 1046845797 740 LSRHEKIHMVEKPYKCNFCGKSF 762
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
796-820 4.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.19e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 796 LQEHERIHTGERPYVCTHCGKAFRS 820
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
712-736 5.62e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.62e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 712 LKAHSRIHTGERPYVCSVCGKAFKQ 736
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
602-625 5.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.74e-04
                          10        20
                  ....*....|....*....|....
gi 1046845797 602 QEHERIHTGEKPFVCTECGKAFSS 625
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
489-513 6.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.26e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 489 LDRHEKLHPGEKPYKCSDCGKSFNY 513
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-540 7.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.55e-04
                          10        20
                  ....*....|....*....|....
gi 1046845797 517 LKVHCHSHTGEKPYKCHECGKSFN 540
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
433-457 8.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.83e-04
                          10        20
                  ....*....|....*....|....*
gi 1046845797 433 LKVHRQIHTGEKPYECRECGKSFSK 457
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-597 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 1046845797 573 LKAHYRVHTGERPYKCSHCGKAFST 597
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-428 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1046845797 404 ELTSHKQSHSGEKPYKCNDCGKSFK 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 437-524 2.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 437 RQIHTGEKPYECR--ECGKSFSKTAKLKVHqRIHtgekpyvcSQCGKAFNQKSILDRHEKLHPGEKPYKCSDCGKSFNYP 514
Cdd:COG5189   341 MLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNL 411

                          90
                  ....*....|.
gi 1046845797 515 SQLKVH-CHSH 524
Cdd:COG5189   412 NGLKYHrKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-372 2.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.90e-03
                          10        20
                  ....*....|....*....|....*
gi 1046845797 348 ALQQHEQIHTEEKPYVCTLCGKAFS 372
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 418-440 3.12e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.12e-03
                          10        20
                  ....*....|....*....|...
gi 1046845797 418 YKCNDCGKSFKFPSQLKVHRQIH 440
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 694-771 4.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845797 694 EKPCKCPDCGKSFSKTSQLKAH---SRIHT-GERPYVCSV--CGKAFKQLSTLSRHEK-------------------IHM 748
Cdd:COG5189   315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSA 394

                          90       100
                  ....*....|....*....|...
gi 1046845797 749 VEKPYKCNFCGKSFCSPSELKVH 771
Cdd:COG5189   395 KDKPYRCEVCDKRYKNLNGLKYH 417
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 753-775 6.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.84e-03
                          10        20
                  ....*....|....*....|...
gi 1046845797 753 YKCNFCGKSFCSPSELKVHLLIH 775
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 614-636 9.46e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.46e-03
                          10        20
                  ....*....|....*....|...
gi 1046845797 614 FVCTECGKAFSSRSSFRKHQLIH 636
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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