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Conserved domains on  [gi|1046845824|ref|XP_017445590|]
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myeloid cell surface antigen CD33 isoform X1 [Rattus norvegicus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 21-139 6.11e-44

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05712:

Pssm-ID: 472250  Cd Length: 119  Bit Score: 146.00  E-value: 6.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824  21 FQLVAPKSVTVEEALCVHVPCSVSYPSIRPTFGPVTGYWLLKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDC 100
Cdd:cd05712     1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046845824 101 SLLIRDAQKNDTGVYFFRVVREPFVRYSYRANQLLLHVT 139
Cdd:cd05712    81 SLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 145-230 8.03e-32

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd20987:

Pssm-ID: 472250  Cd Length: 94  Bit Score: 113.82  E-value: 8.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSNLSCSVPWACEQGtPPTFSWMSDALTSL---------SSRTTNSSVLTLTPRPQDHGTKLTCLVT 215
Cdd:cd20987     1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                          90
                  ....*....|....*
gi 1046845824 216 FSGAGVTVERTIRLN 230
Cdd:cd20987    80 FPGATVTTERTIQLN 94
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 21-139 6.11e-44

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 146.00  E-value: 6.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824  21 FQLVAPKSVTVEEALCVHVPCSVSYPSIRPTFGPVTGYWLLKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDC 100
Cdd:cd05712     1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046845824 101 SLLIRDAQKNDTGVYFFRVVREPFVRYSYRANQLLLHVT 139
Cdd:cd05712    81 SLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 145-230 8.03e-32

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 113.82  E-value: 8.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSNLSCSVPWACEQGtPPTFSWMSDALTSL---------SSRTTNSSVLTLTPRPQDHGTKLTCLVT 215
Cdd:cd20987     1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                          90
                  ....*....|....*
gi 1046845824 216 FSGAGVTVERTIRLN 230
Cdd:cd20987    80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-139 5.42e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.62  E-value: 5.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824  26 PKSVTVEEALCVHVPCSVSyPSIRPTFGPVtgYWLlKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDCSLLIR 105
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYS-SSMSEASTSV--YWY-RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1046845824 106 DAQKNDTGVYFFRVVREPFVRYSyraNQLLLHVT 139
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFG---KGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
37-116 1.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824   37 VHVPCSVSYPsirpTFGPVTGYWL----LKGTS-LHEDSPVATNDPRQLVQkatqGRFQLLGDPQKHDCSLLIRDAQKND 111
Cdd:smart00406   2 VTLSCKFSGS----TFSSYYVSWVrqppGKGLEwLGYIGSNGSSYYQESYK----GRFTISKDTSKNDVSLTISNLRVED 73


                   ....*
gi 1046845824  112 TGVYF 116
Cdd:smart00406  74 TGTYY 78
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 145-214 2.28e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 36.63  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSN--LSCSVpwaCEQGTPPTFSWMSD------ALTSLSSRT-----TNSSVLTLTPRPQDHGTKLT 211
Cdd:pfam08205   1 PTIEPPASLLEGEGPEvvATCSS---AGGKPAPRITWYLDgkpleaAETSSEQDPesglvTVTSELKLVPSRSDHGQSLT 77


                  ...
gi 1046845824 212 CLV 214
Cdd:pfam08205  78 CQV 80
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 21-139 6.11e-44

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 146.00  E-value: 6.11e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824  21 FQLVAPKSVTVEEALCVHVPCSVSYPSIRPTFGPVTGYWLLKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDC 100
Cdd:cd05712     1 WGLQMPKSVTVQEGLCVLIPCSFSYPADYWVSNPVHGYWYRGGPYPKYRPPVATNNRTREVHESTQGRFRLLGDPGKKNC 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1046845824 101 SLLIRDAQKNDTGVYFFRVVREPFVRYSYRANQLLLHVT 139
Cdd:cd05712    81 SLSISDARPEDSGKYFFRVERGDSNKYSYLSNQLSLTVT 119
IgC2_CD33_d2_like cd20987
Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member ...
 145-230 8.03e-32

Second immunoglobulin domain of Cluster of Differentiation (CD) 33 and related Siglecs; member of the C2-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig) domain of Cluster of Differentiation (CD) 33 (also known as sialic-acid binding immunoglobulin type-lectin 3 (Siglec-3)) and related Siglecs. CD33, a Siglec family member, is a well-known immunotherapeutic target in acute myeloid leukemia (AML). It is an inhibitory sialoadhesin expressed in human leukocytes of the myeloid lineage and some lymphoid subsets, including natural killer (NK) cells. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. CD33 (Siglec-3) is the smallest Siglec member. It preferentially binds to alpha2-6- and alpha2-3-sialylated glycans and strongly binds to sialylated ligands on leukemic cell lines. Ig Superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group includes CD33-related Siglecs which belong to the C2-set of IgSF domains. Unlike the C1-set, the C2-set structures do not have a D strand.


Pssm-ID: 409579  Cd Length: 94  Bit Score: 113.82  E-value: 8.03e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSNLSCSVPWACEQGtPPTFSWMSDALTSL---------SSRTTNSSVLTLTPRPQDHGTKLTCLVT 215
Cdd:cd20987     1 PNIHVPEELEAGQEVTLTCSVPDNCPAL-SPEFSWLGAALTPLppvlgrleeEGTTTHSSVLTFTPRPEDHGTNLTCQVK 79

                          90
                  ....*....|....*
gi 1046845824 216 FSGAGVTVERTIRLN 230
Cdd:cd20987    80 FPGATVTTERTIQLN 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 26-139 5.42e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 58.62  E-value: 5.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824  26 PKSVTVEEALCVHVPCSVSyPSIRPTFGPVtgYWLlKGTSLHEDSPVATNDPRQLVQKATQGRFQLLGDPQKHDCSLLIR 105
Cdd:pfam07686   3 PREVTVALGGSVTLPCTYS-SSMSEASTSV--YWY-RQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQ 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1046845824 106 DAQKNDTGVYFFRVVREPFVRYSyraNQLLLHVT 139
Cdd:pfam07686  79 NLTLSDSGTYTCAVIPSGEGVFG---KGTRLTVL 109
IgC1_CD22_d2 cd20938
Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 ...
 145-231 5.01e-06

Second immunoglobulin domain of Cluster of Differentiation (CD) 22; member of the Constant 1 (C1)-set of IgSF domains; The members here are composed of the second immunoglobulin domain of clusters of differentiation (CD) 22 (also known as Siglec-2). CD22, a sialic-acid binding immunoglobulin type-lectin (Siglec) family member, is an inhibitory co-receptor of the B-cell receptor (BCR). The inhibitory function of CD22 and its restricted expression on B cells makes CD22 an attractive target against dysregulated B cells that cause autoimmune diseases and B-cell-derived cancers. CD22 plays a vital role in establishing a baseline level of B-cell inhibition, and thus is an important determinant of homeostasis in humoral immunity. Siglecs are primarily expressed on immune cells and recognize sialic acid-containing glycan ligands. Siglecs are organized as an extracellular module composed of Ig-like domains (an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains), followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG (Siglec-4, myelin-associated glycoprotein), the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. This group belongs to the C1-set of IgSF domains.


Pssm-ID: 409532  Cd Length: 98  Bit Score: 44.17  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSNLSCSVPWACeQGTPPTFSWM-------SDALTSLSSRTTN---SSVLTLTPRPQDHGTKLTCLV 214
Cdd:cd20938     3 PHIQLPPEIQESQEVTLTCLLNFSC-YGYPIQLQWLlegspmrQAAVTSTSLTIKSvftRSELKFQPKWSHHGKIVTCQL 81

                          90
                  ....*....|....*..
gi 1046845824 215 TFSGAGVTVERTIRLNV 231
Cdd:cd20938    82 QDADGKVLSEDTVQLNV 98
IGv smart00406
Immunoglobulin V-Type;
37-116 1.15e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 36.98  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824   37 VHVPCSVSYPsirpTFGPVTGYWL----LKGTS-LHEDSPVATNDPRQLVQkatqGRFQLLGDPQKHDCSLLIRDAQKND 111
Cdd:smart00406   2 VTLSCKFSGS----TFSSYYVSWVrqppGKGLEwLGYIGSNGSSYYQESYK----GRFTISKDTSKNDVSLTISNLRVED 73


                   ....*
gi 1046845824  112 TGVYF 116
Cdd:smart00406  74 TGTYY 78
C2-set_2 pfam08205
CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.
 145-214 2.28e-03

CD80-like C2-set immunoglobulin domain; These domains belong to the immunoglobulin superfamily.


Pssm-ID: 400489  Cd Length: 89  Bit Score: 36.63  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 145 PDIIIPETLRAGHPSN--LSCSVpwaCEQGTPPTFSWMSD------ALTSLSSRT-----TNSSVLTLTPRPQDHGTKLT 211
Cdd:pfam08205   1 PTIEPPASLLEGEGPEvvATCSS---AGGKPAPRITWYLDgkpleaAETSSEQDPesglvTVTSELKLVPSRSDHGQSLT 77


                  ...
gi 1046845824 212 CLV 214
Cdd:pfam08205  78 CQV 80
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 150-227 4.99e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.63  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046845824 150 PETLRAGHPSNLSCSVPwacEQGTPPTFSWMSDALTSLSS--------RTTNSSVLTLTPRPQDHGTkLTCLVTFSGAGV 221
Cdd:pfam00047   5 TVTVLEGDSATLTCSAS---TGSPGPDVTWSKEGGTLIESlkvkhdngRTTQSSLLISNVTKEDAGT-YTCVVNNPGGSA 80


                  ....*.
gi 1046845824 222 TVERTI 227
Cdd:pfam00047  81 TLSTSL 86
IgC1_2_Nectin-2_Necl-5_like cd07703
Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; ...
 165-215 6.27e-03

Second immunoglobulin (Ig) domain of Nectin-2 and Nectin-like protein 5, and similar domains; member of the C1-set of the Ig superfamily (IgSF) domains; The members here are composed of the second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or Cluster of Differentiation 112 (CD112)), nectin-like protein 5 (CD155), and similar proteins. Nectins and Nectin-like molecules are a family of Ca(2+)-independent immunoglobulin-like transmembrane glycoproteins belonging to the class of adhesion receptors, consisting of nine members (nectins 1 through 4 and nectin-like proteins 1 through 5). Nectins are synaptic cell adhesion molecules (CAMs) which facilitate adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. Nectin-2 and nectin-3 localize at Sertoli-spermatid junctions where they form heterophilic trans-interactions between the cells that are essential for the formation and maintenance of the junctions and for spermatid development. CD155 is the fifth member in the nectin-like molecule family, and functions as the receptor of poliovirus; therefore, CD155 is also referred to as Necl-5, or PVR. In contrast to all other family members, CD155 lacks self-adhesion capacity, yet it shares with nectins the feature to interact with other nectins. For instance, CD155 heterophilically trans-interacts with nectin-3, thereby contributing significantly to the establishment of adherens junctions between epithelial cells. This group belongs to the Constant 1 (C1)-set of IgSF domains, which has one beta-sheet that is formed by strands A-B-E-D and the other strands by G-F-C-C'.


Pssm-ID: 409500  Cd Length: 97  Bit Score: 35.46  E-value: 6.27e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046845824 165 VPWA-CE--QGTPP-TFSWMSDA---------LTSLSSRTTNSSVLTLTPRPQDHGTKLTCLVT 215
Cdd:cd07703    17 VPVArCVsaNGRPPaRISWSSTLngnanttqvPGPDSGTVTVTSEYSLVPTPEANGKEVTCKVE 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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