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Conserved domains on  [gi|1046905059|ref|XP_017452138|]
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myelin-associated neurite-outgrowth inhibitor isoform X4 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCRP1 super family cl25766
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
 23-174 1.77e-57

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


The actual alignment was detected with superfamily member pfam14944:

Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 180.12  E-value: 1.77e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046905059  23 PGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQlslfspqQGTYYTQPLYAAPPHVIHHTTVVQ 102
Cdd:pfam14944  93 FRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQ-------QGAYYTQPLYAAQPHVIHHTTVVQ 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046905059 103 PNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 174
Cdd:pfam14944 166 PNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
 23-174 1.77e-57

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 180.12  E-value: 1.77e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046905059  23 PGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQlslfspqQGTYYTQPLYAAPPHVIHHTTVVQ 102
Cdd:pfam14944  93 FRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQ-------QGAYYTQPLYAAQPHVIHHTTVVQ 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046905059 103 PNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 174
Cdd:pfam14944 166 PNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
 
Name Accession Description Interval E-value
TCRP1 pfam14944
Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in ...
 23-174 1.77e-57

Tongue Cancer Chemotherapy Resistant Protein 1; This family of proteins are found in eukaryotes. Tongue Cancer Chemotherapy Resistant-associated Protein 1 (TCRP1) is resistant to the chemotherapy drug, cisplatin, which induces apoptosis in tumour cells. There is suggestion that TCRP1 can be targeted to reverse chemotherapy resistance. The precise mechanism of TCRP1 inducing resistance against chemotherapy is still not clear, but it is thought that TCRP1 alters cell signalling pathways affecting apoptosis or DNA repair capacity. Proteins in this family are typically between 194 and 235 amino acids in length.


Pssm-ID: 434335 [Multi-domain]  Cd Length: 237  Bit Score: 180.12  E-value: 1.77e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046905059  23 PGYTPGTPYKVSCSPTSGAVPPYSSSPNPYQTAVYPVRSAYPQQSPYAQlslfspqQGTYYTQPLYAAPPHVIHHTTVVQ 102
Cdd:pfam14944  93 FRYTPGTPYKVSPSPSNGAVPPYSSSPNPYPTAVYPIRSAYPQQNPYAQ-------QGAYYTQPLYAAQPHVIHHTTVVQ 165

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046905059 103 PNGMPATVYPAPIPPPRGSGVTMGMVAGTTMAMSAGTLLTAHSPTPVAPHPVTVPTYRAPGTPTYSYVPPQW 174
Cdd:pfam14944 166 PNGMPAAMYPAPIPPPRNNGVAMGMVAGTTMAMSAGTLLTTPSPTPVGPHPVTVPTYRPPGTPTYSYVPPQW 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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