NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1046854250|ref|XP_017453807|]
View 

zinc finger protein 316 isoform X1 [Rattus norvegicus]

Protein Classification

zinc finger and BTB domain-containing protein( domain architecture ID 12204417)

C2H2/H2C2 zinc finger and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein similar to Mus musculus hypermethylated in cancer 1 (HIC-1), a tumor suppressor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
151-211 4.25e-35

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 127.32  E-value: 4.25e-35
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046854250   151 VTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSLGYPIPKPDLIFHLEQGEEPWV 211
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
760-947 1.54e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  760 PFPCPECGARFARGSHLAAHVRG--HTGE--KPFVCGV--CGAGFSRRAHLTAHGRAHTGERPYAC--AECGRRFGQSAA 831
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  832 LTRHQWAHAEEKPHRcpdcgkgfghssdfkrhrrthtgEKPFRCAD--CGRGFAQRSNLAKHRRGHTGERP--FPCPECG 907
Cdd:COG5048    369 NEPPQSLQQYKDLKN-----------------------DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1046854250  908 KRFSQRSVLVTHQRTHTGERPYLCSNCgRRFSQSSHLLTH 947
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 3.84e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.84e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  379 HLAIHQRTHTGEKPFPCPDCGKRFVY 404
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-495 1.32e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  335 PETTCDVCGKVFPHRSRLAKHQRYHAAVKPFG------CEECGKGFVYRSHLAIHQRT--HTGE--KPFPCP--DCGKRF 402
Cdd:COG5048    254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGfslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLF 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  403 VYKSHLVTHRRIHTGERPYRCVF-------------------------------------CGAGFGRRSYLVTHQRTHTG 445
Cdd:COG5048    334 SRNDALKRHILLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLS 413

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046854250  446 ERP--YPCLHCGRSFSQSSALARHQAVHTADRPHCCPDCGqAFRLRADFQRH 495
Cdd:COG5048    414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
719-744 2.35e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  719 ALAKHQRYHAGERPHRCADCGKSFVY 744
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 707-727 6.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.99e-03
                           10        20
                   ....*....|....*....|.
gi 1046854250  707 CSDCGKTFGRRAALAKHQRYH 727
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
151-211 4.25e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 127.32  E-value: 4.25e-35
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046854250   151 VTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSLGYPIPKPDLIFHLEQGEEPWV 211
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 150-191 6.93e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 6.93e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1046854250  150 LVTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSLG 191
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 151-190 1.20e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 85.68  E-value: 1.20e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046854250  151 VTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSL 190
Cdd:cd07765      1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
760-947 1.54e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  760 PFPCPECGARFARGSHLAAHVRG--HTGE--KPFVCGV--CGAGFSRRAHLTAHGRAHTGERPYAC--AECGRRFGQSAA 831
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  832 LTRHQWAHAEEKPHRcpdcgkgfghssdfkrhrrthtgEKPFRCAD--CGRGFAQRSNLAKHRRGHTGERP--FPCPECG 907
Cdd:COG5048    369 NEPPQSLQQYKDLKN-----------------------DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1046854250  908 KRFSQRSVLVTHQRTHTGERPYLCSNCgRRFSQSSHLLTH 947
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 3.84e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.84e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  379 HLAIHQRTHTGEKPFPCPDCGKRFVY 404
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
887-912 7.33e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 7.33e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  887 NLAKHRRGHTGERPFPCPECGKRFSQ 912
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-495 1.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  335 PETTCDVCGKVFPHRSRLAKHQRYHAAVKPFG------CEECGKGFVYRSHLAIHQRT--HTGE--KPFPCP--DCGKRF 402
Cdd:COG5048    254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGfslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLF 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  403 VYKSHLVTHRRIHTGERPYRCVF-------------------------------------CGAGFGRRSYLVTHQRTHTG 445
Cdd:COG5048    334 SRNDALKRHILLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLS 413

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046854250  446 ERP--YPCLHCGRSFSQSSALARHQAVHTADRPHCCPDCGqAFRLRADFQRH 495
Cdd:COG5048    414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.01e-04
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  435 YLVTHQRTHTGERPYPCLHCGRSFSQ 460
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
719-744 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  719 ALAKHQRYHAGERPHRCADCGKSFVY 744
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
transpos_ISL3 NF033550
ISL3 family transposase;
838-896 1.39e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 42.19  E-value: 1.39e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046854250  838 AHAEEKPHRCPDCGKgfgHSSDFKRHRRTH-----TGEKP---------FRCADCGRGFAQRSNLAKHRRGHT 896
Cdd:NF033550     4 AELTRGDATCPECGK---PSRRVHDTGKRRirhlpIFGRPvylelrvrrFKCPECGKTFTEELPWARKRSRIT 73
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 899-952 1.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1046854250  899 RPFpCPECGKRFSQRSVLVTHQRTHTgerpYLCSNCGRRFSQSSHLLTHMKT-HR 952
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQvHK 50
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 707-727 6.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.99e-03
                           10        20
                   ....*....|....*....|.
gi 1046854250  707 CSDCGKTFGRRAALAKHQRYH 727
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
151-211 4.25e-35

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 127.32  E-value: 4.25e-35
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046854250   151 VTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSLGYPIPKPDLIFHLEQGEEPWV 211
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 150-191 6.93e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.07  E-value: 6.93e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1046854250  150 LVTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSLG 191
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 151-190 1.20e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 85.68  E-value: 1.20e-20
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046854250  151 VTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENYGILVSL 190
Cdd:cd07765      1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
760-947 1.54e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.80  E-value: 1.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  760 PFPCPECGARFARGSHLAAHVRG--HTGE--KPFVCGV--CGAGFSRRAHLTAHGRAHTGERPYAC--AECGRRFGQSAA 831
Cdd:COG5048    289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  832 LTRHQWAHAEEKPHRcpdcgkgfghssdfkrhrrthtgEKPFRCAD--CGRGFAQRSNLAKHRRGHTGERP--FPCPECG 907
Cdd:COG5048    369 NEPPQSLQQYKDLKN-----------------------DKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1046854250  908 KRFSQRSVLVTHQRTHTGERPYLCSNCgRRFSQSSHLLTH 947
Cdd:COG5048    426 KSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-772 2.59e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.67  E-value: 2.59e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  747 HLARHRRTHTGERPFPCPECGARFAR 772
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
379-404 3.84e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 44.28  E-value: 3.84e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  379 HLAIHQRTHTGEKPFPCPDCGKRFVY 404
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
887-912 7.33e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 7.33e-06
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  887 NLAKHRRGHTGERPFPCPECGKRFSQ 912
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
335-495 1.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  335 PETTCDVCGKVFPHRSRLAKHQRYHAAVKPFG------CEECGKGFVYRSHLAIHQRT--HTGE--KPFPCP--DCGKRF 402
Cdd:COG5048    254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGfslpikSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLF 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854250  403 VYKSHLVTHRRIHTGERPYRCVF-------------------------------------CGAGFGRRSYLVTHQRTHTG 445
Cdd:COG5048    334 SRNDALKRHILLHTSISPAKEKLlnssskfspllnneppqslqqykdlkndkksetlsnsCIRNFKRDSNLSLHIITHLS 413

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1046854250  446 ERP--YPCLHCGRSFSQSSALARHQAVHTADRPHCCPDCGqAFRLRADFQRH 495
Cdd:COG5048    414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILK-SFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
859-884 4.03e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 4.03e-05
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  859 DFKRHRRTHTGEKPFRCADCGRGFAQ 884
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
884-953 7.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 7.13e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046854250  884 QRSNLAKHRRGHTgerPFPCPECGKRFSQRSVLVTHQRT--HTGE--RPYLC--SNCGRRFSQSSHLLTHMKTHRG 953
Cdd:COG5048    276 NESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
435-460 1.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 1.01e-04
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  435 YLVTHQRTHTGERPYPCLHCGRSFSQ 460
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 845-867 1.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.48e-04
                           10        20
                   ....*....|....*....|...
gi 1046854250  845 HRCPDCGKGFGHSSDFKRHRRTH 867
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 393-415 1.82e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.59  E-value: 1.82e-04
                           10        20
                   ....*....|....*....|...
gi 1046854250  393 FPCPDCGKRFVYKSHLVTHRRIH 415
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
719-744 2.35e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 2.35e-04
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  719 ALAKHQRYHAGERPHRCADCGKSFVY 744
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 929-951 4.35e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 4.35e-04
                           10        20
                   ....*....|....*....|...
gi 1046854250  929 YLCSNCGRRFSQSSHLLTHMKTH 951
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 901-923 4.95e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.95e-04
                           10        20
                   ....*....|....*....|...
gi 1046854250  901 FPCPECGKRFSQRSVLVTHQRTH 923
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
899-949 4.99e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 4.99e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046854250  899 RPFPCPECGKRFSQRSVLVTHQRTHTGERPYLCSNCGRRFSQSS------HLLTHMK 949
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplelsrHLRTHHN 88
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
759-812 5.30e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 5.30e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046854250  759 RPFPCPECGARFARGSHLAAHVRGHTGEKPFVCGV--CGAGFSRRAHLTAHGRAHT 812
Cdd:COG5048     32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 733-755 1.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.05e-03
                           10        20
                   ....*....|....*....|...
gi 1046854250  733 HRCADCGKSFVYGSHLARHRRTH 755
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 449-471 1.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 1.11e-03
                           10        20
                   ....*....|....*....|...
gi 1046854250  449 YPCLHCGRSFSQSSALARHQAVH 471
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
transpos_ISL3 NF033550
ISL3 family transposase;
838-896 1.39e-03

ISL3 family transposase;


Pssm-ID: 468079 [Multi-domain]  Cd Length: 369  Bit Score: 42.19  E-value: 1.39e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046854250  838 AHAEEKPHRCPDCGKgfgHSSDFKRHRRTH-----TGEKP---------FRCADCGRGFAQRSNLAKHRRGHT 896
Cdd:NF033550     4 AELTRGDATCPECGK---PSRRVHDTGKRRirhlpIFGRPvylelrvrrFKCPECGKTFTEELPWARKRSRIT 73
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 873-895 1.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.56e-03
                           10        20
                   ....*....|....*....|...
gi 1046854250  873 FRCADCGRGFAQRSNLAKHRRGH 895
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 899-952 1.73e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.73e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1046854250  899 RPFpCPECGKRFSQRSVLVTHQRTHTgerpYLCSNCGRRFSQSSHLLTHMKT-HR 952
Cdd:cd20908      1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQvHK 50
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 367-387 2.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.65e-03
                           10        20
                   ....*....|....*....|.
gi 1046854250  367 CEECGKGFVYRSHLAIHQRTH 387
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
775-800 3.57e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.57e-03
                           10        20
                   ....*....|....*....|....*.
gi 1046854250  775 HLAAHVRGHTGEKPFVCGVCGAGFSR 800
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
InsA COG3677
Transposase InsA [Mobilome: prophages, transposons];
847-893 4.67e-03

Transposase InsA [Mobilome: prophages, transposons];


Pssm-ID: 442893 [Multi-domain]  Cd Length: 241  Bit Score: 39.85  E-value: 4.67e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1046854250  847 CPDCGkgfghSSDFKRHRRTHTGEKPFRCADCGRGFAQRSNLAKHRR 893
Cdd:COG3677     19 CPHCG-----STRIVKNGKTRNGRQRYRCKDCGRTFTVTTGTIFEGS 60
zf-H2C2_2 pfam13465
Zinc-finger double domain;
407-430 6.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.51e-03
                           10        20
                   ....*....|....*....|....
gi 1046854250  407 HLVTHRRIHTGERPYRCVFCGAGF 430
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 707-727 6.99e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.99e-03
                           10        20
                   ....*....|....*....|.
gi 1046854250  707 CSDCGKTFGRRAALAKHQRYH 727
Cdd:pfam00096    3 CPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 338-359 7.57e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 7.57e-03
                           10        20
                   ....*....|....*....|..
gi 1046854250  338 TCDVCGKVFPHRSRLAKHQRYH 359
Cdd:pfam00096    2 KCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH