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Conserved domains on  [gi|1046854521|ref|XP_017453872|]
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zinc finger protein 157 isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
1-32 1.17e-09

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.14  E-value: 1.17e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1046854521    1 MLENYSSLVSLGHCVTKPELILRLEHGFRPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-390 2.12e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 234 KPYVCKECGKAFFYKSNLTRHHRT--HTGE--KPYECEE--CRKGFSSKSELTSHHRTHTGEKPYQCEEC-------GKA 300
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 301 FYCKSTLRVHQKIHTGEKPYEC--KECQKSFYYKSTLTEHQRTHTGEKPYECKD--CGKAFFYKSQLTRHHRIHTGEKPY 376
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....
gi 1046854521 377 ECEECRKAFSSKSE 390
Cdd:COG5048   448 LCSILKSFRRDLDL 461
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
402-524 9.70e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 9.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 402 KPYECEECGKCFCRKSHLTLHHRIHTGEKPYECKDCRKAFFCKSGLARHLGTHTHGTNTKNREKH--------------- 466
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 467 ----------FPATQSSVNIRNDTQVRNPVAIKN--EEKHSTINQSSVHMMDFLELRSPIDVHNAGKLAF 524
Cdd:COG5048   112 ssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-191 4.84e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 166 ELTVHHRIHTGEKPHECDECGKAFYR 191
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 1.17e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.14  E-value: 1.17e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1046854521    1 MLENYSSLVSLGHCVTKPELILRLEHGFRPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-390 2.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 234 KPYVCKECGKAFFYKSNLTRHHRT--HTGE--KPYECEE--CRKGFSSKSELTSHHRTHTGEKPYQCEEC-------GKA 300
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 301 FYCKSTLRVHQKIHTGEKPYEC--KECQKSFYYKSTLTEHQRTHTGEKPYECKD--CGKAFFYKSQLTRHHRIHTGEKPY 376
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....
gi 1046854521 377 ECEECRKAFSSKSE 390
Cdd:COG5048   448 LCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
402-524 9.70e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 9.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 402 KPYECEECGKCFCRKSHLTLHHRIHTGEKPYECKDCRKAFFCKSGLARHLGTHTHGTNTKNREKH--------------- 466
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 467 ----------FPATQSSVNIRNDTQVRNPVAIKN--EEKHSTINQSSVHMMDFLELRSPIDVHNAGKLAF 524
Cdd:COG5048   112 ssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-275 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 250 NLTRHHRTHTGEKPYECEECRKGFSS 275
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 404-426 4.68e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|...
gi 1046854521 404 YECEECGKCFCRKSHLTLHHRIH 426
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-191 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 166 ELTVHHRIHTGEKPHECDECGKAFYR 191
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-311 5.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 122 KPYEWKECQKAFCYKSALTQHQRprtrlkiyqctecrkafpskseltvhHRIHTGE--KPHECDE--CGKAFYRKSTLTV 197
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLR--------------------------SVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 198 HQKTHRGEKPYECK--ECCKAF-----YYKSTLTEHQRIHTGEKPYVC--KECGKAFFYKSNLTRHHRTHTGEKPYECE- 267
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046854521 268 -ECRKGFSSKSELTSHHRTHTGEKPYQCEECGKAFYCKSTLRVHQ 311
Cdd:COG5048   422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
1-32 1.17e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.14  E-value: 1.17e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1046854521    1 MLENYSSLVSLGHCVTKPELILRLEHGFRPWS 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-390 2.12e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.55  E-value: 2.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 234 KPYVCKECGKAFFYKSNLTRHHRT--HTGE--KPYECEE--CRKGFSSKSELTSHHRTHTGEKPYQCEEC-------GKA 300
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 301 FYCKSTLRVHQKIHTGEKPYEC--KECQKSFYYKSTLTEHQRTHTGEKPYECKD--CGKAFFYKSQLTRHHRIHTGEKPY 376
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....
gi 1046854521 377 ECEECRKAFSSKSE 390
Cdd:COG5048   448 LCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
150-496 2.85e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 150 KIYQCTECRKAFPSKSELTVHHRIHTGEKPHEC--DECGKAFYRKSTLTVHQKTHRGEKPYEC-KECCKAFYYKSTLTEH 226
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 227 QRIHTGEKPYVCKECGKAFFYKSNLTRHHRTHTGEKPYECEEC----------------------RKGFSSKSELTSHHR 284
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 285 THTGEKPYQCEECGKAFYCKSTLRVHQKIHTGEKPYECKECQKSFYYKSTLTEHQRTHTGEKPYECKDCGKAFFYKSQLT 364
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 365 RHHRIHTGE-------KPYECEECRKAFSSKSELTAHHRT--HTGE--KPYECEE--CGKCFCRKSHLTLHHRIHTGEKP 431
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1046854521 432 YECKdcrkaffcksgLARHLGTHTHGTNTKNREKHFPATQSSVNIRNDTQVRNPVAIKNEEKHST 496
Cdd:COG5048   352 AKEK-----------LLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKRDSNLS 405
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
402-524 9.70e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 9.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 402 KPYECEECGKCFCRKSHLTLHHRIHTGEKPYECKDCRKAFFCKSGLARHLGTHTHGTNTKNREKH--------------- 466
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskassssls 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 467 ----------FPATQSSVNIRNDTQVRNPVAIKN--EEKHSTINQSSVHMMDFLELRSPIDVHNAGKLAF 524
Cdd:COG5048   112 ssssnsndnnLLSSHSLPPSSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPS 181
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-275 1.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 250 NLTRHHRTHTGEKPYECEECRKGFSS 275
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1046854521 363 LTRHHRIHTGEKPYECEECRKAFSS 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
278-303 2.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 278 ELTSHHRTHTGEKPYQCEECGKAFYC 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-357 2.48e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.48e-03
                          10        20
                  ....*....|....*....|...
gi 1046854521 335 LTEHQRTHTGEKPYECKDCGKAF 357
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
307-331 2.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.56e-03
                          10        20
                  ....*....|....*....|....*
gi 1046854521 307 LRVHQKIHTGEKPYECKECQKSFYY 331
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-245 3.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.11e-03
                          10        20
                  ....*....|....*....|...
gi 1046854521 223 LTEHQRIHTGEKPYVCKECGKAF 245
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 404-426 4.68e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.68e-03
                          10        20
                  ....*....|....*....|...
gi 1046854521 404 YECEECGKCFCRKSHLTLHHRIH 426
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-191 4.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 1046854521 166 ELTVHHRIHTGEKPHECDECGKAFYR 191
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-311 5.40e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 5.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 122 KPYEWKECQKAFCYKSALTQHQRprtrlkiyqctecrkafpskseltvhHRIHTGE--KPHECDE--CGKAFYRKSTLTV 197
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLR--------------------------SVNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046854521 198 HQKTHRGEKPYECK--ECCKAF-----YYKSTLTEHQRIHTGEKPYVC--KECGKAFFYKSNLTRHHRTHTGEKPYECE- 267
Cdd:COG5048   342 HILLHTSISPAKEKllNSSSKFspllnNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1046854521 268 -ECRKGFSSKSELTSHHRTHTGEKPYQCEECGKAFYCKSTLRVHQ 311
Cdd:COG5048   422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 6.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|...
gi 1046854521 236 YVCKECGKAFFYKSNLTRHHRTH 258
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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