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Conserved domains on  [gi|1046861246|ref|XP_017455174|]
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DDB1- and CUL4-associated factor 11 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 1.33e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICsiygegDTHTALDL 259
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLW------DLATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RP-DERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRR 338
Cdd:COG2319   156 RTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 339 TmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAATqqN 404
Cdd:COG2319   235 T-----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgkLLASG--S 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 405 WDYRWqqvpkKAWkklKLPGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKA 484
Cdd:COG2319   308 DDGTV-----RLW---DLATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*..
gi 1046861246 485 CVRDVSWHPFEEKIVSSSWDGSLRLWQ 511
Cdd:COG2319   374 AVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 1.33e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICsiygegDTHTALDL 259
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLW------DLATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RP-DERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRR 338
Cdd:COG2319   156 RTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 339 TmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAATqqN 404
Cdd:COG2319   235 T-----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgkLLASG--S 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 405 WDYRWqqvpkKAWkklKLPGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKA 484
Cdd:COG2319   308 DDGTV-----RLW---DLATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*..
gi 1046861246 485 CVRDVSWHPFEEKIVSSSWDGSLRLWQ 511
Cdd:COG2319   374 AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-511 1.93e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICSIYGEGDTHTALDL 259
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDAICKVWDRRT 339
Cdd:cd00200    90 TGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 340 MreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwqqvpkkawkk 419
Cdd:cd00200   167 G-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 420 lklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIV 499
Cdd:cd00200   208 ----TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         330
                  ....*....|..
gi 1046861246 500 SSSWDGSLRLWQ 511
Cdd:cd00200   278 SGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 6.96e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 6.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 141 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 217
Cdd:PLN00181  458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICSIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181  523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181  601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                         250
                  ....*....|....*.
gi 1046861246 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181  674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 3.55e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1046861246  472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 4.44e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.44e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046861246 473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
180-511 1.33e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.13  E-value: 1.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICsiygegDTHTALDL 259
Cdd:COG2319    86 FSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG----AVRSVAFSPDGKTLASGSADGTVRLW------DLATGKLL 155

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RP-DERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRR 338
Cdd:COG2319   156 RTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLA 234

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 339 TmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAATqqN 404
Cdd:COG2319   235 T-----GKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlatgelLRTLTGHSGGVNSvafspdgkLLASG--S 307

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 405 WDYRWqqvpkKAWkklKLPGDSSLMTYRGHGVLHTLIrcRFSPahsTGQQfIYSGCSTGKVVVYDLLSGHIVKKLTNHKA 484
Cdd:COG2319   308 DDGTV-----RLW---DLATGKLLRTLTGHTGAVRSV--AFSP---DGKT-LASGSDDGTVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*..
gi 1046861246 485 CVRDVSWHPFEEKIVSSSWDGSLRLWQ 511
Cdd:COG2319   374 AVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-511 1.93e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 1.93e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWsvldVAFTPDGNhFLYSSWSDyiHICSIYGEGDTHTALDL 259
Cdd:cd00200    17 FSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRD----VAASADGT-YLASGSSD--KTIRLWDLETGECVRTL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RPDErrFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFaDISSQILFSGGDDAICKVWDRRT 339
Cdd:cd00200    90 TGHT--SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAF-SPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 340 MreddpKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRrfssregmeasrlaatqqnwdyrwqqvpkkawkk 419
Cdd:cd00200   167 G-----KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 420 lklpGDSSLMTYRGHgvLHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIV 499
Cdd:cd00200   208 ----TGKCLGTLRGH--ENGVNSVAFSP----DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLA 277

                         330
                  ....*....|..
gi 1046861246 500 SSSWDGSLRLWQ 511
Cdd:cd00200   278 SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
219-510 1.98e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 1.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 219 WSVLDVAFTPDGNHFLYSSWSDYIHIcsiygeGDTHTALDLRPDER-RFAVFSIAVSSDGREVLGGANDGCLYVFDREQN 297
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRL------WDLATGLLLRTLTGhTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 298 RRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQ 377
Cdd:COG2319   153 KLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 378 TIKLWD------IRRFSSREGMEAS--------RLAATQQN-----WDyrwqqvpkkawkklkLPGDSSLMTYRGHGvlH 438
Cdd:COG2319   227 TVRLWDlatgklLRTLTGHSGSVRSvafspdgrLLASGSADgtvrlWD---------------LATGELLRTLTGHS--G 289

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046861246 439 TLIRCRFSPahsTGQQFIySGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:COG2319   290 GVNSVAFSP---DGKLLA-SGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 268-513 2.30e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 2.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 268 VFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQiLFSGGDDAICKVWDRRTmreddPKP 347
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-----GEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 348 VGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRFssregmeasrlaatqqnwdyrwqqvpkkawkklklpgdSS 427
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--------------------------------------KC 127

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 428 LMTYRGH--GVLHtlirCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDG 505
Cdd:cd00200   128 LTTLRGHtdWVNS----VAFSP----DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDG 199


                  ....*...
gi 1046861246 506 SLRLWQYR 513
Cdd:cd00200   200 TIKLWDLS 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 220-513 4.56e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 4.56e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 220 SVLDVAFTPDGNHFLYSSWSDYIHICSIYGEGDTHTaldlrPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRR 299
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRT-----LKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 300 TLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTI 379
Cdd:cd00200    86 VRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVET-----GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 380 KLWDIRrfssregmeasrlaatqqnwdyrwqqvpkkawkklklpGDSSLMTYRGH--GVLHtlirCRFSPahsTGQQFIy 457
Cdd:cd00200   160 KLWDLR--------------------------------------TGKCVATLTGHtgEVNS----VAFSP---DGEKLL- 193

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046861246 458 SGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLWQYR 513
Cdd:cd00200   194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
180-385 1.15e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.01  E-value: 1.15e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKardvGWSVLDVAFTPDGNHFLYSSWSDYIHICsiygegDTHTALDL 259
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH----SGSVRSVAFSPDGRLLASGSADGTVRLW------DLATGELL 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RP-DERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRR 338
Cdd:COG2319   282 RTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLA 360

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1046861246 339 TmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIR 385
Cdd:COG2319   361 T-----GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 5.06e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 5.06e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKV 334
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRL 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD------IRRFSSREGMEAS--------RLAA 400
Cdd:COG2319   147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDlatgklLRTLTGHTGAVRSvafspdgkLLAS 221

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 401 TQQN-----WDyrwqqvpkkawkklkLPGDSSLMTYRGHGVLHTLIrcRFSPahstGQQFIYSGCSTGKVVVYDLLSGHI 475
Cdd:COG2319   222 GSADgtvrlWD---------------LATGKLLRTLTGHSGSVRSV--AFSP----DGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1046861246 476 VKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 176-383 3.98e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 105.11  E-value: 3.98e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 176 FCGIYSKDGQIFMSACQDQTIRLYDCRYGRFHK-FKSIKArdvgwSVLDVAFTPDgNHFLYSSWSD-YIHICSIYGEGDT 253
Cdd:cd00200    97 SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTtLRGHTD-----WVNSVAFSPD-GTFVASSSQDgTIKLWDLRTGKCV 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 254 HTALDLRPDerrfaVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICK 333
Cdd:cd00200   171 ATLTGHTGE-----VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIR 244

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1046861246 334 VWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:cd00200   245 VWDLRT-----GECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 302-516 7.21e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 7.21e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 302 QIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRTMReddpkPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKL 381
Cdd:cd00200     4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGE-----LLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 382 WDIRrfssregmeasrlaatqqnwdyrwqqvpkkawkklklpGDSSLMTYRGH--GVLHtlirCRFSPAHstgqQFIYSG 459
Cdd:cd00200    78 WDLE--------------------------------------TGECVRTLTGHtsYVSS----VAFSPDG----RILSSS 111

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046861246 460 CSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLWQYRQAE 516
Cdd:cd00200   112 SRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
255-510 2.20e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 87.27  E-value: 2.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 255 TALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAIcKV 334
Cdd:COG2319    26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 335 WDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDIRRfssregmeasrlaatqqnwdyrwqqvpk 414
Cdd:COG2319   105 WDLAT-----GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT---------------------------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 415 kaWKKLKlpgdsslmTYRGHGvlHTLIRCRFSPahsTGQqFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPF 494
Cdd:COG2319   152 --GKLLR--------TLTGHS--GAVTSVAFSP---DGK-LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 215

                         250
                  ....*....|....*.
gi 1046861246 495 EEKIVSSSWDGSLRLW 510
Cdd:COG2319   216 GKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
180-339 5.73e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 5.73e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 180 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARdvgwSVLDVAFTPDGNHFLYSSWSDYIHICSIyGEGDTHTALDL 259
Cdd:COG2319   254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG----GVNSVAFSPDGKLLASGSDDGTVRLWDL-ATGKLLRTLTG 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 260 RPDerrfAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADiSSQILFSGGDDAICKVWDRRT 339
Cdd:COG2319   329 HTG----AVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-510 1.22e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 1.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 347 PVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWDirrfssregmeasrlaatqqnwdyrwqqvpkkawkklkLPGDS 426
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD--------------------------------------LETGE 42

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 427 SLMTYRGHgvLHTLIRCRFSPAHstgqQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGS 506
Cdd:cd00200    43 LLRTLKGH--TGPVRDVAASADG----TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116


                  ....
gi 1046861246 507 LRLW 510
Cdd:cd00200   117 IKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
272-510 3.38e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 3.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 272 AVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddpKPVGAL 351
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG------ALLATL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 352 AGHQDGITFIDSKGDARYLISNSKDQTIKLWDirrfssregmeasrlaatqqnwdyrwqqvpkkawkklkLPGDSSLMTY 431
Cdd:COG2319    75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWD--------------------------------------LATGLLLRTL 116

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046861246 432 RGHGvlHTLIRCRFSPahstGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:COG2319   117 TGHT--GAVRSVAFSP----DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 141-384 6.96e-11

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 65.11  E-value: 6.96e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 141 GLCHRGSFSlgeQSRVMSHFLPNDLsftdTYSQKAFCGI-YSKDGQIFMSACQDQTIRLYDCrygrfhkfKSI--KARDV 217
Cdd:PLN00181  458 GLCKYLSFS---KLRVKADLKQGDL----LNSSNLVCAIgFDRDGEFFATAGVNKKIKIFEC--------ESIikDGRDI 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 218 GWSVLDVAFTPDGNHFLYSSW-------SDYIHICSIYGEGDTHTALDLRPDERRfaVFSIAVSSDGREVLG-GANDGCL 289
Cdd:PLN00181  523 HYPVVELASRSKLSGICWNSYiksqvasSNFEGVVQVWDVARSQLVTEMKEHEKR--VWSIDYSSADPTLLAsGSDDGSV 600

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 290 YVFDREQNRRTLQIEShEDDVNAVAFADISSQILFSGGDDAICKVWDRRtmredDPK-PVGALAGHQDGITFIDSKgDAR 368
Cdd:PLN00181  601 KLWSINQGVSIGTIKT-KANICCVQFPSESGRSLAFGSADHKVYYYDLR-----NPKlPLCTMIGHSKTVSYVRFV-DSS 673

                         250
                  ....*....|....*.
gi 1046861246 369 YLISNSKDQTIKLWDI 384
Cdd:PLN00181  674 TLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 472-510 3.55e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 3.55e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1046861246  472 SGHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
473-510 4.44e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 4.44e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046861246 473 GHIVKKLTNHKACVRDVSWHPFEEKIVSSSWDGSLRLW 510
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
346-383 5.17e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 5.17e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046861246 346 KPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 258-384 1.34e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 1.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 258 DLRPDERRFAVFSIAVSSD----GREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQILFSGGDDAICK 333
Cdd:PTZ00420   21 DLRICSRVIDSCGIACSSGfvavPWEVEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIR 100

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046861246 334 VWDRRTMRED-----DPKPVgaLAGHQDGITFIDSKGDARYLISNSK-DQTIKLWDI 384
Cdd:PTZ00420  101 VWEIPHNDESvkeikDPQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDSFVNIWDI 155
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 344-383 1.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046861246  344 DPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD 383
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-336 8.57e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.57e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1046861246  303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:smart00320   8 LKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
303-336 1.46e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.46e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1046861246 303 IESHEDDVNAVAFADiSSQILFSGGDDAICKVWD 336
Cdd:pfam00400   7 LEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 301-403 6.38e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 6.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046861246 301 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTmreddPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIK 380
Cdd:PTZ00421  119 VHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-----GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLN 193

                          90       100
                  ....*....|....*....|...
gi 1046861246 381 LWDIRRFSSREGMEASRLAATQQ 403
Cdd:PTZ00421  194 IIDPRDGTIVSSVEAHASAKSQR 216
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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