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PREDICTED: suppressor of fused homolog isoform X4 [Bos indicus]
suppressor of fused domain protein( domain architecture ID 10523847)
suppressor of fused domain protein similar to Mus musculus suppressor of fused homolog, a negative regulator in the hedgehog/smoothened signaling pathway
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
SUFU_C super family | cl13854 | Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ... |
254-433 | 2.88e-65 | ||||
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs. The actual alignment was detected with superfamily member pfam12470: Pssm-ID: 463598 Cd Length: 200 Bit Score: 209.19 E-value: 2.88e-65
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SUFU | pfam05076 | Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ... |
64-240 | 1.61e-55 | ||||
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems. : Pssm-ID: 461543 Cd Length: 171 Bit Score: 182.90 E-value: 1.61e-55
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Name | Accession | Description | Interval | E-value | ||||
SUFU_C | pfam12470 | Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ... |
254-433 | 2.88e-65 | ||||
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs. Pssm-ID: 463598 Cd Length: 200 Bit Score: 209.19 E-value: 2.88e-65
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SUFU | pfam05076 | Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ... |
64-240 | 1.61e-55 | ||||
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems. Pssm-ID: 461543 Cd Length: 171 Bit Score: 182.90 E-value: 1.61e-55
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Name | Accession | Description | Interval | E-value | ||||
SUFU_C | pfam12470 | Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in ... |
254-433 | 2.88e-65 | ||||
Suppressor of Fused Gli/Ci N terminal binding domain; This domain family is found in eukaryotes, and is typically between 192 and 219 amino acids in length. The family is found in association with pfam05076. There is a conserved HGRHFT sequence motif. This family is the C terminal domain of the Suppressor of Fused protein (Su(fu)). Su(fu) is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade. It functions by binding these proteins and preventing their translocation to the nucleus. The C terminal domain is only found in eukaryotic Su(fu) proteins; it is not present in bacterial homologs. The C terminal domain binds to the N terminal of Gli/Ci while the N terminal of Su(fu) binds to the C terminal of Gli/Ci. This dual binding mechanism is likely an evolutionary advancement in this signalling cascade which is not present in bacterial homologs. Pssm-ID: 463598 Cd Length: 200 Bit Score: 209.19 E-value: 2.88e-65
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SUFU | pfam05076 | Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila ... |
64-240 | 1.61e-55 | ||||
Suppressor of fused protein (SUFU); SUFU, encoding the human orthologue of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signaling. SUFU exerts its repressor role by physically interacting with GLI proteins in both the cytoplasm and the nucleus. SUFU has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signaling pathway. Genomic contextual analysis of bacterial SUFU versions revealed that they are immunity proteins against diverse nuclease toxins in polymorphic toxin systems. Pssm-ID: 461543 Cd Length: 171 Bit Score: 182.90 E-value: 1.61e-55
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Blast search parameters | ||||
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