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Conserved domains on  [gi|1191076451|ref|XP_020917158|]
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uncharacterized protein LOC110254492 [Exaiptasia diaphana]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-200 3.11e-36

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 3.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGN------LEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKILKcslMDIDLNAGDDKGNTALIHAALEGHDTITSMLIASLKrfslDIDKKNHRGLTAMLAALRGGREDCAR 161
Cdd:COG0666   164 GNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA----DVNAKDNDGKTALDLAAENGNLEIVK 236

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1191076451 162 VLYLQGdASLTIRDPDNFMNASEWATHNQLFDFIELIEK 200
Cdd:COG0666   237 LLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-200 3.11e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 3.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGN------LEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKILKcslMDIDLNAGDDKGNTALIHAALEGHDTITSMLIASLKrfslDIDKKNHRGLTAMLAALRGGREDCAR 161
Cdd:COG0666   164 GNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA----DVNAKDNDGKTALDLAAENGNLEIVK 236

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1191076451 162 VLYLQGdASLTIRDPDNFMNASEWATHNQLFDFIELIEK 200
Cdd:COG0666   237 LLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2-104 1.99e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNdkmyhtRYKIVRLLLKHgAKVNLTDKsGKTALMLAVIR 81
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG------HLEIVKLLLEH-ADVNLKDN-GRTALHYAARS 71

                          90       100
                  ....*....|....*....|...
gi 1191076451  82 GQKDVAEKILKCslmDIDLNAGD 104
Cdd:pfam12796  72 GHLEIVKLLLEK---GADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-181 3.41e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 3.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSvNVNVTDHHGQTPLmkAILLNdKMYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQK-DVAEKILK 92
Cdd:PHA03095   30 VRRLLAAGA-DVNFRGEYGKTPL--HLYLH-YSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  93 CSlmdIDLNAGDDKGNTALiHAALEGHDTITSMlIASLKRFSLDIDKKNHRGLTAMLAALRGGREDcARVLYLQGDASLT 172
Cdd:PHA03095  106 AG---ADVNAKDKVGRTPL-HVYLSGFNINPKV-IRLLLRKGADVNALDLYGMTPLAVLLKSRNAN-VELLRLLIDAGAD 179


                  ....*....
gi 1191076451 173 IRDPDNFMN 181
Cdd:PHA03095  180 VYAVDDRFR 188
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 23-193 2.50e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.55  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  23 VNVNVTD--HHGQTPLMKAILLNDKMYhtrykiVRLLLKHGAKVNLTDKS--------------GKTALMLAVIRGQKDV 86
Cdd:cd22193    65 INAEYTDeyYEGQTALHIAIERRQGDI------VALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  87 AEKILKCSLMDIDLNAGDDKGNTALiHAAL-------EGHDTITSM----LIASLK---RFSLDiDKKNHRGLTA-MLAA 151
Cdd:cd22193   139 VQYLLENEHQPADIEAQDSRGNTVL-HALVtvadntkENTKFVTRMydmiLIRGAKlcpTVELE-EIRNNDGLTPlQLAA 216

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191076451 152 LRGGREDCARVLylqgdaSLTIRDPD------NFmnaSEWA---THNQLFD 193
Cdd:cd22193   217 KMGKIEILKYIL------QREIKEPElrhlsrKF---TDWAygpVSSSLYD 258
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-66 8.56e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 8.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191076451   31 HGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNL 66
Cdd:smart00248   1 DGRTPLHLAA------ENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-200 3.11e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 136.24  E-value: 3.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGN------LEIVKLLLEAGADVNAQDNDGNTPLHLAAAN 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKILKcslMDIDLNAGDDKGNTALIHAALEGHDTITSMLIASLKrfslDIDKKNHRGLTAMLAALRGGREDCAR 161
Cdd:COG0666   164 GNLEIVKLLLE---AGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGA----DVNAKDNDGKTALDLAAENGNLEIVK 236

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1191076451 162 VLYLQGdASLTIRDPDNFMNASEWATHNQLFDFIELIEK 200
Cdd:COG0666   237 LLLEAG-ADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-214 1.65e-32

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 125.84  E-value: 1.65e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   1 MLLDAIARGRLYQVKFLLESGSVNVNVTDHHGQTPLMKAILLNDKmyhtryKIVRLLLKHGAKVNLTDKSGKTALMLAVI 80
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDL------EIVKLLLEAGADVNARDKDGETPLHLAAY 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  81 RGQKDVAEKILKCslmDIDLNAGDDKGNTALIHAALEGHDTITSMLIASlkrfSLDIDKKNHRGLTAMLAALRGGREDCA 160
Cdd:COG0666   130 NGNLEIVKLLLEA---GADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA----GADVNARDNDGETPLHLAAENGHLEIV 202

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191076451 161 RVLyLQGDASLTIRDpDNFMNASEWATHNQLFDFIELIEKTKQETAPLNTQNST 214
Cdd:COG0666   203 KLL-LEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLT 254
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-221 3.43e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 90.78  E-value: 3.43e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   1 MLLDAIARGRLYQVKFLLESGSVNVNVTDHHGQTPLMKAILLNDKmyhtryKIVRLLLKHGAKVNLTDKSGKTALMLAVI 80
Cdd:COG0666    23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDL------LVALLLLAAGADINAKDDGGNTLLHAAAR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  81 RGQKDVAEKILKcslMDIDLNAGDDKGNTALIHAALEGHDTITSMLIASlkrfSLDIDKKNHRGLTAMLAALRGGREDCA 160
Cdd:COG0666    97 NGDLEIVKLLLE---AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA----GADVNAQDNDGNTPLHLAAANGNLEIV 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191076451 161 RVLyLQGDASLTIRDPDNfMNASEWATHNQLFDFIE-LIEKtkqeTAPLNTQNSTCNSADMI 221
Cdd:COG0666   170 KLL-LEAGADVNARDNDG-ETPLHLAAENGHLEIVKlLLEA----GADVNAKDNDGKTALDL 225
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2-104 1.99e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 1.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNdkmyhtRYKIVRLLLKHgAKVNLTDKsGKTALMLAVIR 81
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG------HLEIVKLLLEH-ADVNLKDN-GRTALHYAARS 71

                          90       100
                  ....*....|....*....|...
gi 1191076451  82 GQKDVAEKILKCslmDIDLNAGD 104
Cdd:pfam12796  72 GHLEIVKLLLEK---GADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
36-141 2.96e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 2.96e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  36 LMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAeKILkCSLMDIDLnagDDKGNTALIHAA 115
Cdd:pfam12796   1 LHLAAKNGN------LELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLL-LEHADVNL---KDNGRTALHYAA 69

                          90       100
                  ....*....|....*....|....*.
gi 1191076451 116 LEGHDTITSMLIASlkrfSLDIDKKN 141
Cdd:pfam12796  70 RSGHLEIVKLLLEK----GADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
75-175 2.38e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.83  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  75 LMLAVIRGQKDVAEKILKCslmDIDLNAGDDKGNTALIHAALEGHDTITSMLIASLkrfslDIDKKNHrGLTAMLAALRG 154
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLEN---GADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-----DVNLKDN-GRTALHYAARS 71

                          90       100
                  ....*....|....*....|.
gi 1191076451 155 GREDCARVLyLQGDASLTIRD 175
Cdd:pfam12796  72 GHLEIVKLL-LEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-181 3.41e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 65.43  E-value: 3.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSvNVNVTDHHGQTPLmkAILLNdKMYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQK-DVAEKILK 92
Cdd:PHA03095   30 VRRLLAAGA-DVNFRGEYGKTPL--HLYLH-YSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIK 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  93 CSlmdIDLNAGDDKGNTALiHAALEGHDTITSMlIASLKRFSLDIDKKNHRGLTAMLAALRGGREDcARVLYLQGDASLT 172
Cdd:PHA03095  106 AG---ADVNAKDKVGRTPL-HVYLSGFNINPKV-IRLLLRKGADVNALDLYGMTPLAVLLKSRNAN-VELLRLLIDAGAD 179


                  ....*....
gi 1191076451 173 IRDPDNFMN 181
Cdd:PHA03095  180 VYAVDDRFR 188
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 7-102 2.28e-10

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 62.99  E-value: 2.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   7 ARGRLYQVKFLLESGSvNVNVTDHHGQTPLMKAILLNdkmyhtRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDV 86
Cdd:PTZ00322   91 ASGDAVGARILLTGGA-DPNCRDYDGRTPLHIACANG------HVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                          90
                  ....*....|....*.
gi 1191076451  87 AEKILKCSLMDIDLNA 102
Cdd:PTZ00322  164 VQLLSRHSQCHFELGA 179
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-233 4.99e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 60.74  E-value: 4.99e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  32 GQTPLMKAILLNDKMYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKcslMDIDLNAGDDKGNTAL 111
Cdd:COG0666    15 LLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLA---AGADINAKDDGGNTLL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451 112 IHAALEGHDTITSMLIASlkrfSLDIDKKNHRGLTAMLAALRGGREDCARVLyLQGDASLTIRDPDNfMNASEWATHNQL 191
Cdd:COG0666    92 HAAARNGDLEIVKLLLEA----GADVNARDKDGETPLHLAAYNGNLEIVKLL-LEAGADVNAQDNDG-NTPLHLAAANGN 165

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1191076451 192 FDFIE-LIEKtkqeTAPLNTQNstcnsadmirtetPRLETPLM 233
Cdd:COG0666   166 LEIVKlLLEA----GADVNARD-------------NDGETPLH 191
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
2-108 1.23e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 59.58  E-value: 1.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNDKmyhtryKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:COG0666   190 LHLAAENGHLEIVKLLLEAG-ADVNAKDNDGKTALDLAAENGNL------EIVKLLLEAGADLNAKDKDGLTALLLAAAA 262

                          90       100
                  ....*....|....*....|....*..
gi 1191076451  82 GQKDVAEKILKCSLMDIDLNAGDDKGN 108
Cdd:COG0666   263 GAALIVKLLLLALLLLAAALLDLLTLL 289
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-184 3.30e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 59.50  E-value: 3.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAIllnDKMYHtryKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAK-LDPDIGDSKGRTPLHIAA---SKGYE---DCVLVLLKHACNVHIRDANGNTALWNAISA 601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKILKCSLMDIDLNAGDdkgntALIHAALEGHDTitsMLIASLKRfSLDIDKKNHRGLTAMLAALRGGREDCAR 161
Cdd:PLN03192  602 KHHKIFRILYHFASISDPHAAGD-----LLCTAAKRNDLT---AMKELLKQ-GLNVDSEDHQGATALQVAMAEDHVDMVR 672

                         170       180
                  ....*....|....*....|...
gi 1191076451 162 VLYLQGdASLTIRDPDNFMNASE 184
Cdd:PLN03192  673 LLIMNG-ADVDKANTDDDFSPTE 694
Ank_5 pfam13857
Ankyrin repeats (many copies);
17-78 7.85e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.58  E-value: 7.85e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191076451  17 LLESGSVNVNVTDHHGQTPLMKAILLNdkmyhtRYKIVRLLLKHGAKVNLTDKSGKTALMLA 78
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYG------ALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-184 2.86e-08

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.19  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHHGQTPLmkAILLndKMYHTRYKIVRLLLKHGAKVNLTDKSGKTAL--MLAVIRGQKDVAEKIL 91
Cdd:PHA03095  135 IRLLLRKG-ADVNALDLYGMTPL--AVLL--KSRNANVELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELI 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  92 KcslMDIDLNAGDDKGNTALIHAALegHDTITSMLIASLKRFSLDIDKKNHRGLTA-MLAALRGGREDCARVLYLqgDAS 170
Cdd:PHA03095  210 R---AGCDPAATDMLGNTPLHSMAT--GSSCKRSLVLPLLIAGISINARNRYGQTPlHYAAVFNNPRACRRLIAL--GAD 282

                         170
                  ....*....|....
gi 1191076451 171 LTIRDPDNFMNASE 184
Cdd:PHA03095  283 INAVSSDGNTPLSL 296
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-93 4.34e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 4.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHHGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKC 93
Cdd:PHA03100  175 VNYLLSYG-VPINIKDVYGFTPLHYAV------YNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNN 247
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-115 4.58e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 4.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHHGQTPLmkAILLNDKMYHtrYKIVRLLLKHGAKVNLTDKSGKTALMLAV--IRGQKDVAEKIL 91
Cdd:PHA03100   89 VKLLLEYG-ANVNAPDNNGITPL--LYAISKKSNS--YSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLI 163

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1191076451  92 --------KCSL-----MDIDLNAGDDKGNTALIHAA 115
Cdd:PHA03100  164 dkgvdinaKNRVnyllsYGVPINIKDVYGFTPLHYAV 200
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-167 6.73e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 6.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGSVNVNVTDHHGQTPLMKAILLNdkmyhtRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:PHA02875   72 LHDAVEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILK------KLDIMKLLIARGADPDIPNTDKFSPLHLAVMM 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKILKCSLMdidLNAGDDKGNTALIHAALEGHDTITSMLIASlkrfSLDIDKKNHRG-LTAMLAALRGGREDCA 160
Cdd:PHA02875  146 GDIKGIELLIDHKAC---LDIEDCCGCTPLIIAMAKGDIAICKMLLDS----GANIDYFGKNGcVAALCYAIENNKIDIV 218


                  ....*..
gi 1191076451 161 RVLYLQG 167
Cdd:PHA02875  219 RLFIKRG 225
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-158 2.01e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.05  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHHGQTPLMkaILLNDKMYHTRYK-IVRLLLKHGAKVNLTDKSGKTALMLAVIR--GQKDVAEKI 90
Cdd:PHA03100   51 VKILLDNG-ADINSSTKNNSTPLH--YLSNIKYNLTDVKeIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  91 LkcsLMDIDLNAGDDKGNTaLIHAALEGHDTITSML---------------IASLKRFSLDIDKKNHRGLTAMLAALRGG 155
Cdd:PHA03100  128 L---DNGANVNIKNSDGEN-LLHLYLESNKIDLKILkllidkgvdinaknrVNYLLSYGVPINIKDVYGFTPLHYAVYNN 203


                  ...
gi 1191076451 156 RED 158
Cdd:PHA03100  204 NPE 206
Ank_4 pfam13637
Ankyrin repeats (many copies);
34-91 3.78e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 3.78e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1191076451  34 TPLMKAIllndkmYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKIL 91
Cdd:pfam13637   3 TALHAAA------ASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
2-58 1.60e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 1.60e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAIllndkmYHTRYKIVRLLL 58
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAA------SNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
107-163 2.37e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 2.37e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191076451 107 GNTALIHAALEGHDTITSMLIAslkrFSLDIDKKNHRGLTAMLAALRGGREDCARVL 163
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLE----KGADINAVDGNGETALHFAASNGNVEVLKLL 53
Ank_5 pfam13857
Ankyrin repeats (many copies);
57-114 3.25e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 3.25e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191076451  57 LLKHG-AKVNLTDKSGKTALMLAVIRGQKDVAEKILKcslMDIDLNAGDDKGNTALIHA 114
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLA---YGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-69 3.42e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 3.42e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1191076451  31 HGQTPLMKAILLNDkmyhtRYKIVRLLLKHGAKVNLTDK 69
Cdd:pfam00023   1 DGNTPLHLAAGRRG-----NLEIVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 14-127 4.17e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHhgqtplmkaillndkmyhtrykiVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKC 93
Cdd:PHA03100  159 LKLLIDKG-VDINAKNR-----------------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDL 214

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1191076451  94 SlmdIDLNAGDDKGNTALIHAALEGHDTITSMLI 127
Cdd:PHA03100  215 G---ANPNLVNKYGDTPLHIAILNNNKEIFKLLL 245
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 14-114 6.47e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 6.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSVnVNVTDHHGQTPLMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKC 93
Cdd:PHA02874  173 IKLLLEKGAY-ANVKDNNGESPLHNAAEYGD------YACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAIELLINNA 245

                          90       100
                  ....*....|....*....|.
gi 1191076451  94 SLMDIDLNagddkGNTALIHA 114
Cdd:PHA02874  246 SINDQDID-----GSTPLHHA 261
PHA02798 PHA02798
ankyrin-like protein; Provisional
 14-111 2.28e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 43.67  E-value: 2.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSvNVNVTDHHGQTPLMkAILLNDKMYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKC 93
Cdd:PHA02798   54 VKLFINLGA-NVNGLDNEYSTPLC-TILSNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLFM 131

                          90
                  ....*....|....*...
gi 1191076451  94 SLMDIDLNAGDDKGNTAL 111
Cdd:PHA02798  132 IENGADTTLLDKDGFTML 149
PHA03095 PHA03095
ankyrin-like protein; Provisional
 14-129 2.97e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.47  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGsVNVNVTDHHGQTPLMKAillndKMYHT-RYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILK 92
Cdd:PHA03095  205 VRELIRAG-CDPAATDMLGNTPLHSM-----ATGSScKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIA 278

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1191076451  93 cslMDIDLNAGDDKGNTALIHAALEGHDTITSMLIAS 129
Cdd:PHA03095  279 ---LGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 14-156 2.98e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 43.33  E-value: 2.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSVNVNVTDHHGQTPLMKAILLNDkmyhtrYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEKILKC 93
Cdd:PHA02878  150 TKLLLSYGADINMKDRHKGNTALHYATENKD------QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLEN 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191076451  94 SlmdIDLNAGDDKGNTALihaalegHDTITSMLIASLKRFSL----DIDKKNH-RGLTAMLAALRGGR 156
Cdd:PHA02878  224 G---ASTDARDKCGNTPL-------HISVGYCKDYDILKLLLehgvDVNAKSYiLGLTALHSSIKSER 281
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 5-113 3.30e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 3.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   5 AIARGRLYQVKFLLESGSvNVNVTDHHGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRGQ- 83
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGA-DVNIEDDNGCYPIHIAI------KHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDy 203

                          90       100       110
                  ....*....|....*....|....*....|
gi 1191076451  84 KDVAEKILKCSLMDIDLNAGDDKGNTALIH 113
Cdd:PHA02874  204 ACIKLLIDHGNHIMNKCKNGFTPLHNAIIH 233
Ank_2 pfam12796
Ankyrin repeats (3 copies);
111-198 3.67e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 39.71  E-value: 3.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451 111 LIHAALEGHDTITSMLIASLKrfslDIDKKNHRGLTAMLAALRGGREDCARVLYLQGDasltIRDPDNFMNASEWATHNQ 190
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGA----DANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD----VNLKDNGRTALHYAARSG 72


                  ....*...
gi 1191076451 191 LFDFIELI 198
Cdd:pfam12796  73 HLEIVKLL 80
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 22-158 6.12e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.34  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  22 SVNVNVTDHHGQTPLMKAILLNDKMYHT---------RYKIVRLLLKHGAKVNLTDKSGKTALML-----AVIRGQKDVA 87
Cdd:PHA03100   10 SRIIKVKNIKYIIMEDDLNDYSYKKPVLplylakearNIDVVKILLDNGADINSSTKNNSTPLHYlsnikYNLTDVKEIV 89

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191076451  88 EKILKcslMDIDLNAGDDKGNTALIHAALE--GHDTITSMLIASLKrfslDIDKKNHRGLTAMLAALRGGRED 158
Cdd:PHA03100   90 KLLLE---YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGA----NVNIKNSDGENLLHLYLESNKID 155
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 31-65 8.09e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 8.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1191076451  31 HGQTPLMKAILLNdkmyhtRYKIVRLLLKHGAKVN 65
Cdd:pfam13606   1 DGNTPLHLAARNG------RLEIVKLLLENGADIN 29
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 14-153 1.51e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 41.27  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSvNVNvtdHHG--QTPLMkAILLNDKMYHTRYK-IVRLLLKHGAKVNLTDKSGKTALMLAVIRGQKDVAEkI 90
Cdd:PHA02989   53 VKLLIDNGA-DVN---YKGyiETPLC-AVLRNREITSNKIKkIVKLLLKFGADINLKTFNGVSPIVCFIYNSNINNCD-M 126

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191076451  91 LKCSLMD-IDLNAGDDKGNTALIHAALEGHdTITSMLIASLKRFSLDI-DKKNHRGLTAMLAALR 153
Cdd:PHA02989  127 LRFLLSKgINVNDVKNSRGYNLLHMYLESF-SVKKDVIKILLSFGVNLfEKTSLYGLTPMNIYLR 190
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 15-164 2.08e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  15 KFLLESGSvNVNVTDHHGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNLTDKSGKTALMLAVIRgQKDVaeKILKCS 94
Cdd:PHA02878  185 ELLLSYGA-NVNIPDKTNNSPLHHAV------KHYNKPIVHILLENGASTDARDKCGNTPLHISVGY-CKDY--DILKLL 254

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191076451  95 L-MDIDLNAGDDKGNTALIHAALEGHDTITSMLiaslkRFSLDIDKKNHRGLTAMLAAL--RGGREDCARVLY 164
Cdd:PHA02878  255 LeHGVDVNAKSYILGLTALHSSIKSERKLKLLL-----EYGADINSLNSYKLTPLSSAVkqYLCINIGRILIS 322
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
 23-193 2.50e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 40.55  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  23 VNVNVTD--HHGQTPLMKAILLNDKMYhtrykiVRLLLKHGAKVNLTDKS--------------GKTALMLAVIRGQKDV 86
Cdd:cd22193    65 INAEYTDeyYEGQTALHIAIERRQGDI------VALLVENGADVHAHAKGrffqpkyqgegfyfGELPLSLAACTNQPDI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  87 AEKILKCSLMDIDLNAGDDKGNTALiHAAL-------EGHDTITSM----LIASLK---RFSLDiDKKNHRGLTA-MLAA 151
Cdd:cd22193   139 VQYLLENEHQPADIEAQDSRGNTVL-HALVtvadntkENTKFVTRMydmiLIRGAKlcpTVELE-EIRNNDGLTPlQLAA 216

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191076451 152 LRGGREDCARVLylqgdaSLTIRDPD------NFmnaSEWA---THNQLFD 193
Cdd:cd22193   217 KMGKIEILKYIL------QREIKEPElrhlsrKF---TDWAygpVSSSLYD 258
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 2-128 2.88e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451   2 LLDAIARGRLYQVKFLLESGsVNVNVTDHHGQTPLMKAILLNDKMyhtrykIVRLLLKHGAKVNLTDKSGKTALMLAVIR 81
Cdd:PHA02875    6 LCDAILFGELDIARRLLDIG-INPNFEIYDGISPIKLAMKFRDSE------AIKLLMKHGAIPDVKYPDIESELHDAVEE 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1191076451  82 GQKDVAEKilkcsLMDIDLNAGD---DKGNTALIHAALEGHDTITSMLIA 128
Cdd:PHA02875   79 GDVKAVEE-----LLDLGKFADDvfyKDGMTPLHLATILKKLDIMKLLIA 123
Ank_4 pfam13637
Ankyrin repeats (many copies);
73-127 4.37e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.33  E-value: 4.37e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1191076451  73 TALMLAVIRGQKDVAEKILKCSlmdIDLNAGDDKGNTALIHAALEGHDTITSMLI 127
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKG---ADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 14-146 7.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 37.88  E-value: 7.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  14 VKFLLESGSvNVN-VTDHHGQTPLMKAILLNDKMyhtRYKIVRLLLKHGAKVNLTDKSGKTAL--MLAVIRGQKDVAEKI 90
Cdd:PHA02859   69 LKFLIENGA-DVNfKTRDNNLSALHHYLSFNKNV---EPEILKILIDSGSSITEEDEDGKNLLhmYMCNFNVRINVIKLL 144

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1191076451  91 LK--CSLMDIDlnagDDKGNTALIHAALEGHDTITSMLIAslkrFSLDIDKKNHRGLT 146
Cdd:PHA02859  145 IDsgVSFLNKD----FDNNNILYSYILFHSDKKIFDFLTS----LGIDINETNKSGYN 194
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 29-157 8.47e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 38.97  E-value: 8.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191076451  29 DHHGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNLTDKS--------------GKTALMLAVIRGQKDVAEKIL-KC 93
Cdd:cd22194   138 AYEGQTALNIAI------ERRQGDIVKLLIAKGADVNAHAKGvffnpkykhegfyfGETPLALAACTNQPEIVQLLMeKE 211

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191076451  94 SlmdIDLNAGDDKGNTALiHAALEGHDTITSMlIASLKRFSLDIDKK----------NHRGLTAM-LAALRGGRE 157
Cdd:cd22194   212 S---TDITSQDSRGNTVL-HALVTVAEDSKTQ-NDFVKRMYDMILLKsenknletirNNEGLTPLqLAAKMGKAE 281
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 31-66 8.56e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.10  E-value: 8.56e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1191076451   31 HGQTPLMKAIllndkmYHTRYKIVRLLLKHGAKVNL 66
Cdd:smart00248   1 DGRTPLHLAA------ENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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