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Conserved domains on  [gi|1201901542|ref|XP_021260512|]
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thrombopoietin receptor isoform X9 [Numida meleagris]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.55e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


:

Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542  33 SQDAALLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HRFYYWYSRDAPTMCAVSTQRCGTSGMRHVCVFPSLDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1201901542 110 TQLHVLVLDTTTNQTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
fn3 pfam00041
Fibronectin type III domain;
375-457 6.01e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 375 APQHVQATAAQGR-LSLQWLPPLEALAEQLEYQVRYATDNSPD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPGGpq 451
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 1201901542 452 YQGSWS 457
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 6.85e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 6.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 140 PPVNISARWAGAmGQLRVSWQPPLADYPNFFLYEVCYHPVTPTvTPHGMTPGDSSahptsrahsptargaaaslgtgqgl 219
Cdd:cd00063     3 PPTNLRVTDVTS-TSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGS------------------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1201901542 220 vqaDTWVVLRELQPGVRYHIQVRSKPDGTsmdgvWGPWSQVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.55e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542  33 SQDAALLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HRFYYWYSRDAPTMCAVSTQRCGTSGMRHVCVFPSLDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1201901542 110 TQLHVLVLDTTTNQTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
fn3 pfam00041
Fibronectin type III domain;
375-457 6.01e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 375 APQHVQATAAQGR-LSLQWLPPLEALAEQLEYQVRYATDNSPD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPGGpq 451
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 1201901542 452 YQGSWS 457
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-465 8.59e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 8.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 374 EAPQHVQATAAQGR-LSLQWLPPLEALAEQLEYQVRYATDNSPDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpggp 450
Cdd:cd00063     2 SPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 1201901542 451 QYQGSWSAWSQPVVA 465
Cdd:cd00063    77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 6.85e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 6.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 140 PPVNISARWAGAmGQLRVSWQPPLADYPNFFLYEVCYHPVTPTvTPHGMTPGDSSahptsrahsptargaaaslgtgqgl 219
Cdd:cd00063     3 PPTNLRVTDVTS-TSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGS------------------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1201901542 220 vqaDTWVVLRELQPGVRYHIQVRSKPDGTsmdgvWGPWSQVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 375-445 5.94e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 5.94e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201901542  375 APQHVQATAAQGR-LSLQWLPPLEA--LAEQLEYQVRYaTDNSPDWKVLQVPRAARKEVL-DLRPGARYRAQVRA 445
Cdd:smart00060   3 PPSNLRVTDVTSTsVTLSWEPPPDDgiTGYIVGYRVEY-REEGSEWKEVNVTPSSTSYTLtGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
140-258 3.11e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 140 PPVNISARWAGAmGQLRVSWQPPLADYPNFFLYEVCYHPVtptvtphgmtpGDSSAHPTSRAHSPTARgaaaslgtgqgl 219
Cdd:pfam00041   2 APSNLTVTDVTS-TSLTVSWTPPPDGNGPITGYEVEYRPK-----------NSGEPWNEITVPGTTTS------------ 57

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1201901542 220 vqadtwVVLRELQPGVRYHIQVRSKPDGTsmdgvWGPWS 258
Cdd:pfam00041  58 ------VTLTGLKPGTEYEVRVQAVNGGG-----EGPPS 85
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 33-133 2.55e-43

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 150.65  E-value: 2.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542  33 SQDAALLAEVPEDILCFSRSFEDLTCFWDEEEASGI---HRFYYWYSRDAPTMCAVSTQRCGTSGMRHVCVFPSLDVRLF 109
Cdd:pfam09067   1 SQAALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLpttYSFSYAYENETVKECPLYSTSGANSTRLFICFFPKNDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 1201901542 110 TQLHVLVLDTTTNQTRHRRELSVD 133
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
fn3 pfam00041
Fibronectin type III domain;
375-457 6.01e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.88  E-value: 6.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 375 APQHVQATAAQGR-LSLQWLPPLEALAEQLEYQVRYATDNSPD-WKVLQVPRAARK-EVLDLRPGARYRAQVRAQPGGpq 451
Cdd:pfam00041   2 APSNLTVTDVTSTsLTVSWTPPPDGNGPITGYEVEYRPKNSGEpWNEITVPGTTTSvTLTGLKPGTEYEVRVQAVNGG-- 79


                  ....*.
gi 1201901542 452 YQGSWS 457
Cdd:pfam00041  80 GEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 374-465 8.59e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 55.97  E-value: 8.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 374 EAPQHVQATAAQGR-LSLQWLPPLEALAEQLEYQVRYATDNSPDWKVLQVPRAARKEVL--DLRPGARYRAQVRAqpggp 450
Cdd:cd00063     2 SPPTNLRVTDVTSTsVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTltGLKPGTEYEFRVRA----- 76

                          90
                  ....*....|....*
gi 1201901542 451 QYQGSWSAWSQPVVA 465
Cdd:cd00063    77 VNGGGESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 140-265 6.85e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 47.49  E-value: 6.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 140 PPVNISARWAGAmGQLRVSWQPPLADYPNFFLYEVCYHPVTPTvTPHGMTPGDSSahptsrahsptargaaaslgtgqgl 219
Cdd:cd00063     3 PPTNLRVTDVTS-TSVTLSWTPPEDDGGPITGYVVEYREKGSG-DWKEVEVTPGS------------------------- 55

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1201901542 220 vqaDTWVVLRELQPGVRYHIQVRSKPDGTsmdgvWGPWSQVVVAET 265
Cdd:cd00063    56 ---ETSYTLTGLKPGTEYEFRVRAVNGGG-----ESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 375-445 5.94e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.83  E-value: 5.94e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201901542  375 APQHVQATAAQGR-LSLQWLPPLEA--LAEQLEYQVRYaTDNSPDWKVLQVPRAARKEVL-DLRPGARYRAQVRA 445
Cdd:smart00060   3 PPSNLRVTDVTSTsVTLSWEPPPDDgiTGYIVGYRVEY-REEGSEWKEVNVTPSSTSYTLtGLKPGTEYEFRVRA 76
fn3 pfam00041
Fibronectin type III domain;
140-258 3.11e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 39.71  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 140 PPVNISARWAGAmGQLRVSWQPPLADYPNFFLYEVCYHPVtptvtphgmtpGDSSAHPTSRAHSPTARgaaaslgtgqgl 219
Cdd:pfam00041   2 APSNLTVTDVTS-TSLTVSWTPPPDGNGPITGYEVEYRPK-----------NSGEPWNEITVPGTTTS------------ 57

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1201901542 220 vqadtwVVLRELQPGVRYHIQVRSKPDGTsmdgvWGPWS 258
Cdd:pfam00041  58 ------VTLTGLKPGTEYEVRVQAVNGGG-----EGPPS 85
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 141-257 9.52e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 35.85  E-value: 9.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201901542 141 PVNISARWAGAMGQLRVSWQPPLADYPNFFLYevcyhpvtptvtphgmtpGDSSAHPTSRAHsptarGAAASLGTGQGLV 220
Cdd:pfam16656   1 PEQVHLSLTGDSTSMTVSWVTPSAVTSPVVQY------------------GTSSSALTSTAT-----ATSSTYTTGDGGT 57

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1201901542 221 QADTWVVLRELQPGVRYHIQVRSKpdgtsmDGVWGPW 257
Cdd:pfam16656  58 GYIHRATLTGLEPGTTYYYRVGDD------NGGWSEV 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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