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Conserved domains on  [gi|1207119432|ref|XP_021322388|]
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protein MMS22-like isoform X1 [Danio rerio]

Protein Classification

MMS22L_N and MMS22L_C domain-containing protein( domain architecture ID 10633001)

MMS22L_N and MMS22L_C domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MMS22L_N pfam14910
S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl ...
29-739 0e+00

S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.


:

Pssm-ID: 464366  Cd Length: 708  Bit Score: 1266.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432   29 PPCFTCAYeAGREDTGRLSSNGYISRGALKRLLLKLDPAPADFEGDTVDIFDFPWVTETALVESTKLLFGLFRQKVLKLE 108
Cdd:pfam14910    1 PPCFSCAF-DNREGGRAFSSESYLASGSLKRLLLRLDPLPTDFEEDTVEIFGFQWVTETALVESTKLLFGLFRQQVYKLE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  109 TLVQSSSHDFGQASSLHYEAEELRQQCVLFLSYIKVFIYRFLEPSQSLDEGPVHPFKDAEAQLPSVLVEELFSITLLIGR 188
Cdd:pfam14910   80 TLVQSSSHDFGQASNLHYEAEEIRQQCVTFLHYVKVFIFRYLEPSQTEDDGPVHPYEELEAQLPSALVEELHGLTLYIGH 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  189 IGNLPANVQSAFTIQHQGKLFPPSWQLLHLHLDIHWSVLEILHLLEQRMMGQVVYAHQFVNLTGETLTNISLFEDQVNNL 268
Cdd:pfam14910  160 LSELPSNVQGAFTIQNQGKLFPPSWHLLHLHLDIHWSVLEILHILGEKMQGQVVYAHQFINLTGENLTNVSLFEEHCENL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  269 FCDLIGLAMNKYNKVRPTETLNTHHYHCLCTKELWILLIHLLEHRSKSIHTQSFWSYINALLQTVLKGTTSGDRDPGFP- 347
Cdd:pfam14910  240 LCDLIGLAMNKYTKVRPTEALTSHHYPCLCTKELWVLLIHLLDHRSKGSHTESFWSYLNKLLKTLFKGSSSTERFSGFPs 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  348 VHCKDPEGFTWWLLTHLAQIGMHNRNGTAQQEKQLEDNWSFVIGLLKSICDPKKAAQEEQIRVVVHCCLSLSLMWGPNVS 427
Cdd:pfam14910  320 VHCKDPLGFSWWIITHLASLYQFDRNGTLQEEKQMESNWSFVEELLKKSCDPQDGILEEQLRMHLHCCLTLCDLWEPNIS 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  428 AVTTFWEYYSKNLNSSFTVPWLGVSGLGSICKTPLCLLQQAKSCCSpapvgSSSHTQLYRTANSFHIFLRILALHLSQ-- 505
Cdd:pfam14910  400 AVTILWEYYSKNLNSSFTIPWLGLKGLASISKTPLSMLEQVKSCCS-----DKQHPDLYKSANSYHIFLRILALVMKKam 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  506 EHAGGAPWRQIKGRLYSKFHQRRMTELSDTGLLHFLLLFLVLAQCAELEDVASRACDLLAMLPTNSTPLALRALQWRGQL 585
Cdd:pfam14910  475 ETNGGHPWKQIKGRIYSKFHQKRMQELTEVGLQNFFLLFLVLAAVAELEDVASRVCDLLDFLSPSSVSPSQRALIWRGQL 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  586 ALVLLYLEKGLDVGALAEQLAVYFSQAAREFYLKTTEPSRKLALWAPLSSYLEGVSEVFETSPNLTLSEERLLNEGFGLL 665
Cdd:pfam14910  555 AFLLLYVEKNLDIGVLAEKLSSAFREKAKEFLVKTTDPSQKQALWTLLSTYIDGVQEVFETSSNLHLSEEKLLNEGFSML 634
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207119432  666 LPACRQSELSSALGFLQTVLAQLRRVHQRCGQ--PSHSVDSPSWAplPSVAKERHQAVAAALWSHFFPFLCSMRLS 739
Cdd:pfam14910  635 LPACRESELNTVLNFLQAVLARLRSVHQRSCQelPNENVDLPAQA--PSVAKERHLAVASALWRHFFPFLKSQRLS 708
MMS22L_C pfam14911
S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl ...
851-1226 2.04e-154

S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more C-terminal region of the proteins.


:

Pssm-ID: 464367  Cd Length: 375  Bit Score: 467.53  E-value: 2.04e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  851 EQLAELTRQVFRLPEVEFVLQRAGLQSAAVK-DPkaaMAVFLKAVGRSYCELQLLSERSSAVSRALEYVGDILKYIKPYL 929
Cdd:pfam14911    1 EQLVELTRLVFQLPEVKELLSKASLELLEGSrDP---LILFFKAVGRKYNELQTLAERSQMVTKLLAYFGDFLKWVKPYL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  930 QNKS-REGLHLAYWTIGCLVKHWSHLL-ATSKAQQLLFRIVDVLLLPHALLQQDTAAHTQMLSALKDSLPMFLQGLSvav 1007
Cdd:pfam14911   78 TKKSpSEGLQRIYSILGCLVKHCSPLLyATSKPQCLLFRIIDCLLLPHSVLQQDKELPPALLQALKKSLPLYLQGLG--- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1008 SVSHSQGAYLKQQQHSVISQYLSRFLPATPSTGAVVNHPVLLAACEStpsPQGE-RLRKSILHVLRENFLQFKGLAPPPR 1086
Cdd:pfam14911  155 RLSQRQDAYLGQQLRNIIQQYLPRFLPASPSAGALGVHPVLLALQAD---CDSEaPLRKLILQVLRSNFLQFKGRAPPPR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1087 LAAVLCFLLELLKRNSD---RDPALLTIPLPSVLRCLMLVNEPQ-VKRLSSEVTQLIVERCTAAVGEQPCEHTTAILRAF 1162
Cdd:pfam14911  232 LASVLAFIQELLKRLNNsqeGDAELLLLTLPPLLECLMLVNEPQpVKKLSTELLQLMVELSQAGSSEEPREQLTSVLRSF 311
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207119432 1163 VDENEGVYDQQVYNVLEVVAVLHPFTVAALIPFLTLSLRKTECKRGLGKNTSLRNGYRRLLALL 1226
Cdd:pfam14911  312 VEKHLAIYTQQVFSFLEKVAVLDPDLVISLIPTITQSLRDVERKRGLGEDVALRKALSRLLSHL 375
 
Name Accession Description Interval E-value
MMS22L_N pfam14910
S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl ...
29-739 0e+00

S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.


Pssm-ID: 464366  Cd Length: 708  Bit Score: 1266.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432   29 PPCFTCAYeAGREDTGRLSSNGYISRGALKRLLLKLDPAPADFEGDTVDIFDFPWVTETALVESTKLLFGLFRQKVLKLE 108
Cdd:pfam14910    1 PPCFSCAF-DNREGGRAFSSESYLASGSLKRLLLRLDPLPTDFEEDTVEIFGFQWVTETALVESTKLLFGLFRQQVYKLE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  109 TLVQSSSHDFGQASSLHYEAEELRQQCVLFLSYIKVFIYRFLEPSQSLDEGPVHPFKDAEAQLPSVLVEELFSITLLIGR 188
Cdd:pfam14910   80 TLVQSSSHDFGQASNLHYEAEEIRQQCVTFLHYVKVFIFRYLEPSQTEDDGPVHPYEELEAQLPSALVEELHGLTLYIGH 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  189 IGNLPANVQSAFTIQHQGKLFPPSWQLLHLHLDIHWSVLEILHLLEQRMMGQVVYAHQFVNLTGETLTNISLFEDQVNNL 268
Cdd:pfam14910  160 LSELPSNVQGAFTIQNQGKLFPPSWHLLHLHLDIHWSVLEILHILGEKMQGQVVYAHQFINLTGENLTNVSLFEEHCENL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  269 FCDLIGLAMNKYNKVRPTETLNTHHYHCLCTKELWILLIHLLEHRSKSIHTQSFWSYINALLQTVLKGTTSGDRDPGFP- 347
Cdd:pfam14910  240 LCDLIGLAMNKYTKVRPTEALTSHHYPCLCTKELWVLLIHLLDHRSKGSHTESFWSYLNKLLKTLFKGSSSTERFSGFPs 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  348 VHCKDPEGFTWWLLTHLAQIGMHNRNGTAQQEKQLEDNWSFVIGLLKSICDPKKAAQEEQIRVVVHCCLSLSLMWGPNVS 427
Cdd:pfam14910  320 VHCKDPLGFSWWIITHLASLYQFDRNGTLQEEKQMESNWSFVEELLKKSCDPQDGILEEQLRMHLHCCLTLCDLWEPNIS 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  428 AVTTFWEYYSKNLNSSFTVPWLGVSGLGSICKTPLCLLQQAKSCCSpapvgSSSHTQLYRTANSFHIFLRILALHLSQ-- 505
Cdd:pfam14910  400 AVTILWEYYSKNLNSSFTIPWLGLKGLASISKTPLSMLEQVKSCCS-----DKQHPDLYKSANSYHIFLRILALVMKKam 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  506 EHAGGAPWRQIKGRLYSKFHQRRMTELSDTGLLHFLLLFLVLAQCAELEDVASRACDLLAMLPTNSTPLALRALQWRGQL 585
Cdd:pfam14910  475 ETNGGHPWKQIKGRIYSKFHQKRMQELTEVGLQNFFLLFLVLAAVAELEDVASRVCDLLDFLSPSSVSPSQRALIWRGQL 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  586 ALVLLYLEKGLDVGALAEQLAVYFSQAAREFYLKTTEPSRKLALWAPLSSYLEGVSEVFETSPNLTLSEERLLNEGFGLL 665
Cdd:pfam14910  555 AFLLLYVEKNLDIGVLAEKLSSAFREKAKEFLVKTTDPSQKQALWTLLSTYIDGVQEVFETSSNLHLSEEKLLNEGFSML 634
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207119432  666 LPACRQSELSSALGFLQTVLAQLRRVHQRCGQ--PSHSVDSPSWAplPSVAKERHQAVAAALWSHFFPFLCSMRLS 739
Cdd:pfam14910  635 LPACRESELNTVLNFLQAVLARLRSVHQRSCQelPNENVDLPAQA--PSVAKERHLAVASALWRHFFPFLKSQRLS 708
MMS22L_C pfam14911
S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl ...
851-1226 2.04e-154

S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more C-terminal region of the proteins.


Pssm-ID: 464367  Cd Length: 375  Bit Score: 467.53  E-value: 2.04e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  851 EQLAELTRQVFRLPEVEFVLQRAGLQSAAVK-DPkaaMAVFLKAVGRSYCELQLLSERSSAVSRALEYVGDILKYIKPYL 929
Cdd:pfam14911    1 EQLVELTRLVFQLPEVKELLSKASLELLEGSrDP---LILFFKAVGRKYNELQTLAERSQMVTKLLAYFGDFLKWVKPYL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  930 QNKS-REGLHLAYWTIGCLVKHWSHLL-ATSKAQQLLFRIVDVLLLPHALLQQDTAAHTQMLSALKDSLPMFLQGLSvav 1007
Cdd:pfam14911   78 TKKSpSEGLQRIYSILGCLVKHCSPLLyATSKPQCLLFRIIDCLLLPHSVLQQDKELPPALLQALKKSLPLYLQGLG--- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1008 SVSHSQGAYLKQQQHSVISQYLSRFLPATPSTGAVVNHPVLLAACEStpsPQGE-RLRKSILHVLRENFLQFKGLAPPPR 1086
Cdd:pfam14911  155 RLSQRQDAYLGQQLRNIIQQYLPRFLPASPSAGALGVHPVLLALQAD---CDSEaPLRKLILQVLRSNFLQFKGRAPPPR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1087 LAAVLCFLLELLKRNSD---RDPALLTIPLPSVLRCLMLVNEPQ-VKRLSSEVTQLIVERCTAAVGEQPCEHTTAILRAF 1162
Cdd:pfam14911  232 LASVLAFIQELLKRLNNsqeGDAELLLLTLPPLLECLMLVNEPQpVKKLSTELLQLMVELSQAGSSEEPREQLTSVLRSF 311
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207119432 1163 VDENEGVYDQQVYNVLEVVAVLHPFTVAALIPFLTLSLRKTECKRGLGKNTSLRNGYRRLLALL 1226
Cdd:pfam14911  312 VEKHLAIYTQQVFSFLEKVAVLDPDLVISLIPTITQSLRDVERKRGLGEDVALRKALSRLLSHL 375
 
Name Accession Description Interval E-value
MMS22L_N pfam14910
S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl ...
29-739 0e+00

S-phase genomic integrity recombination mediator, N-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more N-terminal region of the proteins.


Pssm-ID: 464366  Cd Length: 708  Bit Score: 1266.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432   29 PPCFTCAYeAGREDTGRLSSNGYISRGALKRLLLKLDPAPADFEGDTVDIFDFPWVTETALVESTKLLFGLFRQKVLKLE 108
Cdd:pfam14910    1 PPCFSCAF-DNREGGRAFSSESYLASGSLKRLLLRLDPLPTDFEEDTVEIFGFQWVTETALVESTKLLFGLFRQQVYKLE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  109 TLVQSSSHDFGQASSLHYEAEELRQQCVLFLSYIKVFIYRFLEPSQSLDEGPVHPFKDAEAQLPSVLVEELFSITLLIGR 188
Cdd:pfam14910   80 TLVQSSSHDFGQASNLHYEAEEIRQQCVTFLHYVKVFIFRYLEPSQTEDDGPVHPYEELEAQLPSALVEELHGLTLYIGH 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  189 IGNLPANVQSAFTIQHQGKLFPPSWQLLHLHLDIHWSVLEILHLLEQRMMGQVVYAHQFVNLTGETLTNISLFEDQVNNL 268
Cdd:pfam14910  160 LSELPSNVQGAFTIQNQGKLFPPSWHLLHLHLDIHWSVLEILHILGEKMQGQVVYAHQFINLTGENLTNVSLFEEHCENL 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  269 FCDLIGLAMNKYNKVRPTETLNTHHYHCLCTKELWILLIHLLEHRSKSIHTQSFWSYINALLQTVLKGTTSGDRDPGFP- 347
Cdd:pfam14910  240 LCDLIGLAMNKYTKVRPTEALTSHHYPCLCTKELWVLLIHLLDHRSKGSHTESFWSYLNKLLKTLFKGSSSTERFSGFPs 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  348 VHCKDPEGFTWWLLTHLAQIGMHNRNGTAQQEKQLEDNWSFVIGLLKSICDPKKAAQEEQIRVVVHCCLSLSLMWGPNVS 427
Cdd:pfam14910  320 VHCKDPLGFSWWIITHLASLYQFDRNGTLQEEKQMESNWSFVEELLKKSCDPQDGILEEQLRMHLHCCLTLCDLWEPNIS 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  428 AVTTFWEYYSKNLNSSFTVPWLGVSGLGSICKTPLCLLQQAKSCCSpapvgSSSHTQLYRTANSFHIFLRILALHLSQ-- 505
Cdd:pfam14910  400 AVTILWEYYSKNLNSSFTIPWLGLKGLASISKTPLSMLEQVKSCCS-----DKQHPDLYKSANSYHIFLRILALVMKKam 474
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  506 EHAGGAPWRQIKGRLYSKFHQRRMTELSDTGLLHFLLLFLVLAQCAELEDVASRACDLLAMLPTNSTPLALRALQWRGQL 585
Cdd:pfam14910  475 ETNGGHPWKQIKGRIYSKFHQKRMQELTEVGLQNFFLLFLVLAAVAELEDVASRVCDLLDFLSPSSVSPSQRALIWRGQL 554
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  586 ALVLLYLEKGLDVGALAEQLAVYFSQAAREFYLKTTEPSRKLALWAPLSSYLEGVSEVFETSPNLTLSEERLLNEGFGLL 665
Cdd:pfam14910  555 AFLLLYVEKNLDIGVLAEKLSSAFREKAKEFLVKTTDPSQKQALWTLLSTYIDGVQEVFETSSNLHLSEEKLLNEGFSML 634
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207119432  666 LPACRQSELSSALGFLQTVLAQLRRVHQRCGQ--PSHSVDSPSWAplPSVAKERHQAVAAALWSHFFPFLCSMRLS 739
Cdd:pfam14910  635 LPACRESELNTVLNFLQAVLARLRSVHQRSCQelPNENVDLPAQA--PSVAKERHLAVASALWRHFFPFLKSQRLS 708
MMS22L_C pfam14911
S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl ...
851-1226 2.04e-154

S-phase genomic integrity recombination mediator, C-terminal; MMS22L (Methyl methanesulfonate-sensitivity protein 22-like) is found in yeast, plants and vertebrates, and is integrally concerned with DNA forking and repair mechanisms during replication. MMS22L complexes with TONSL and this complex accumulates at regions of ssDNA associated with distressed replication forks or at processed DNA breaks. Its depletion results in high levels of endogenous DNA double-strand breaks caused by an inability to complete DNA synthesis after replication fork collapse. Thus the complex mediates recovery from replication stress and homologous recombination in vertebrates, yeasts and plants. This family is the more C-terminal region of the proteins.


Pssm-ID: 464367  Cd Length: 375  Bit Score: 467.53  E-value: 2.04e-154
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  851 EQLAELTRQVFRLPEVEFVLQRAGLQSAAVK-DPkaaMAVFLKAVGRSYCELQLLSERSSAVSRALEYVGDILKYIKPYL 929
Cdd:pfam14911    1 EQLVELTRLVFQLPEVKELLSKASLELLEGSrDP---LILFFKAVGRKYNELQTLAERSQMVTKLLAYFGDFLKWVKPYL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432  930 QNKS-REGLHLAYWTIGCLVKHWSHLL-ATSKAQQLLFRIVDVLLLPHALLQQDTAAHTQMLSALKDSLPMFLQGLSvav 1007
Cdd:pfam14911   78 TKKSpSEGLQRIYSILGCLVKHCSPLLyATSKPQCLLFRIIDCLLLPHSVLQQDKELPPALLQALKKSLPLYLQGLG--- 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1008 SVSHSQGAYLKQQQHSVISQYLSRFLPATPSTGAVVNHPVLLAACEStpsPQGE-RLRKSILHVLRENFLQFKGLAPPPR 1086
Cdd:pfam14911  155 RLSQRQDAYLGQQLRNIIQQYLPRFLPASPSAGALGVHPVLLALQAD---CDSEaPLRKLILQVLRSNFLQFKGRAPPPR 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207119432 1087 LAAVLCFLLELLKRNSD---RDPALLTIPLPSVLRCLMLVNEPQ-VKRLSSEVTQLIVERCTAAVGEQPCEHTTAILRAF 1162
Cdd:pfam14911  232 LASVLAFIQELLKRLNNsqeGDAELLLLTLPPLLECLMLVNEPQpVKKLSTELLQLMVELSQAGSSEEPREQLTSVLRSF 311
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207119432 1163 VDENEGVYDQQVYNVLEVVAVLHPFTVAALIPFLTLSLRKTECKRGLGKNTSLRNGYRRLLALL 1226
Cdd:pfam14911  312 VEKHLAIYTQQVFSFLEKVAVLDPDLVISLIPTITQSLRDVERKRGLGEDVALRKALSRLLSHL 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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