MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
78-153
8.89e-34
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.
:
Pssm-ID: 461317 Cd Length: 75 Bit Score: 122.37 E-value: 8.89e-34
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
324-513
7.53e-23
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.
The actual alignment was detected with superfamily member pfam10469:
Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 96.57 E-value: 7.53e-23
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
78-153
8.89e-34
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.
Pssm-ID: 461317 Cd Length: 75 Bit Score: 122.37 E-value: 8.89e-34
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
324-513
7.53e-23
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.
Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 96.57 E-value: 7.53e-23
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
327-513
5.03e-03
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]
Pssm-ID: 274058 [Multi-domain] Cd Length: 179 Bit Score: 38.03 E-value: 5.03e-03
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
78-153
8.89e-34
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.
Pssm-ID: 461317 Cd Length: 75 Bit Score: 122.37 E-value: 8.89e-34
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
324-513
7.53e-23
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.
Pssm-ID: 402204 [Multi-domain] Cd Length: 207 Bit Score: 96.57 E-value: 7.53e-23
2'-5' RNA ligase superfamily; This family contains proteins related to pfam02834. These ...
365-492
7.76e-06
2'-5' RNA ligase superfamily; This family contains proteins related to pfam02834. These proteins are likely to be enzymes, but they may not share the RNA ligase activity.
Pssm-ID: 433312 [Multi-domain] Cd Length: 152 Bit Score: 45.88 E-value: 7.76e-06
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two ...
327-513
5.03e-03
2'-5' RNA ligase; This protein family consists of bacterial and archaeal proteins with two tandem copies of Pfam domain pfam02834. Members for which activity has been measured perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The physiological substrate(s) in prokaryotes may include small 2'-5'-link-containing oligonucleotides, perhaps with regulatory or biosynthetic roles. [Transcription, RNA processing]
Pssm-ID: 274058 [Multi-domain] Cd Length: 179 Bit Score: 38.03 E-value: 5.03e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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