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Conserved domains on  [gi|1207135128|ref|XP_021323360|]
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F-actin-uncapping protein RLTPR isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CARMIL_C super family cl24538
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 688-1005 2.75e-19

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


The actual alignment was detected with superfamily member pfam16000:

Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 89.45  E-value: 2.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  688 CPRVVQRSSVNEQLADRVAKKTRQAAHFIQNTM-HEAENSIRNKLSELKLSVSVSLVESIINEVHQDLFVAQEKLDKHMR 766
Cdd:pfam16000    5 CPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLlEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLARHLS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  767 EfsqsssikanvPQLRVMEHEFPTDDYVPviwRNSFHSRSIRPAPSIKSLLDVEgeqqaraaTHPQQEPEERGGGGGGGV 846
Cdd:pfam16000   85 Q-----------RGRTLLEPESLPDGDRP---ESSPLGPGKRHEGEIERLEELE--------TPMATLKSKRKSIHSRKL 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  847 PQVSRVGTEERRRAQSLPLATGLSVTTAGQLKPGSPSywrreadaaaapaaaaaalSNREPRRSEPAPPQPPMDLPIEGH 926
Cdd:pfam16000  143 RPVSVAFSVSELDLDKAPEEVPIHVEDASSGPPLPSS-------------------SPSEPELSASESLDSLSELPTEGQ 203

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207135128  927 TLRHYTRSRPRPNRRNRQPPSKPQEQAAEiENEANENMGRVDEGVEEFFTKKIIPDDplhFPSCLSSPRVQKAPEGGAP 1005
Cdd:pfam16000  204 KLQHLTKGRPKRNKTRAPTRPPGKVGPAQ-DGEQNGLSGRVDEGLEDFFSKKVIKLS---TPTSPTSEPSSSSLFPDSP 278
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 155-518 5.21e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 5.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  155 SLEASGLKMDFAIRMATALRESTasaVHIINLSVNAIEDKGVIALSQSLGKlSCCLSQLHLSKVSMSSKGLGCLVQVLHQ 234
Cdd:COG5238    159 LGLAARLGLLAAISMAKALQNNS---VETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEILAEALKG 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  235 STflcnTLTHLDLSGNtgCLATEEAMSLYRFLSAPNSVSHLDLSCTDCPLDTLfVSLS--LGCCTTLNYLNLSRNPfslr 312
Cdd:COG5238    235 NK----SLTTLDLSNN--QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGA-IALAkaLQGNTTLTSLDLSVNR---- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  313 kvrevtrsvrdffskstvlkyVGFSGTklppealRLLLQGLATNTHLSELelDISSCELRSAGAQVIQEHIFEAKAISSL 392
Cdd:COG5238    304 ---------------------IGDEGA-------IALAEGLQGNKTLHTL--NLAYNGIGAQGAIALAKALQENTTLHSL 353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  393 DLSDNgfesnmvtlilsigrshsikhlsigrnfamksrALTDvlhrlvqliqeeecpleslsvcdsklkTGTTILINSLG 472
Cdd:COG5238    354 DLSDN---------------------------------QIGD---------------------------EGAIALAKYLE 373

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1207135128  473 CNASLSKIDISGNCIGDTGAKMLAKALMMNtKLKTLVWDRNNVTAG 518
Cdd:COG5238    374 GNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAE 418
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 688-1005 2.75e-19

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 89.45  E-value: 2.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  688 CPRVVQRSSVNEQLADRVAKKTRQAAHFIQNTM-HEAENSIRNKLSELKLSVSVSLVESIINEVHQDLFVAQEKLDKHMR 766
Cdd:pfam16000    5 CPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLlEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLARHLS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  767 EfsqsssikanvPQLRVMEHEFPTDDYVPviwRNSFHSRSIRPAPSIKSLLDVEgeqqaraaTHPQQEPEERGGGGGGGV 846
Cdd:pfam16000   85 Q-----------RGRTLLEPESLPDGDRP---ESSPLGPGKRHEGEIERLEELE--------TPMATLKSKRKSIHSRKL 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  847 PQVSRVGTEERRRAQSLPLATGLSVTTAGQLKPGSPSywrreadaaaapaaaaaalSNREPRRSEPAPPQPPMDLPIEGH 926
Cdd:pfam16000  143 RPVSVAFSVSELDLDKAPEEVPIHVEDASSGPPLPSS-------------------SPSEPELSASESLDSLSELPTEGQ 203

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207135128  927 TLRHYTRSRPRPNRRNRQPPSKPQEQAAEiENEANENMGRVDEGVEEFFTKKIIPDDplhFPSCLSSPRVQKAPEGGAP 1005
Cdd:pfam16000  204 KLQHLTKGRPKRNKTRAPTRPPGKVGPAQ-DGEQNGLSGRVDEGLEDFFSKKVIKLS---TPTSPTSEPSSSSLFPDSP 278
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 155-518 5.21e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 5.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  155 SLEASGLKMDFAIRMATALRESTasaVHIINLSVNAIEDKGVIALSQSLGKlSCCLSQLHLSKVSMSSKGLGCLVQVLHQ 234
Cdd:COG5238    159 LGLAARLGLLAAISMAKALQNNS---VETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEILAEALKG 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  235 STflcnTLTHLDLSGNtgCLATEEAMSLYRFLSAPNSVSHLDLSCTDCPLDTLfVSLS--LGCCTTLNYLNLSRNPfslr 312
Cdd:COG5238    235 NK----SLTTLDLSNN--QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGA-IALAkaLQGNTTLTSLDLSVNR---- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  313 kvrevtrsvrdffskstvlkyVGFSGTklppealRLLLQGLATNTHLSELelDISSCELRSAGAQVIQEHIFEAKAISSL 392
Cdd:COG5238    304 ---------------------IGDEGA-------IALAEGLQGNKTLHTL--NLAYNGIGAQGAIALAKALQENTTLHSL 353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  393 DLSDNgfesnmvtlilsigrshsikhlsigrnfamksrALTDvlhrlvqliqeeecpleslsvcdsklkTGTTILINSLG 472
Cdd:COG5238    354 DLSDN---------------------------------QIGD---------------------------EGAIALAKYLE 373

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1207135128  473 CNASLSKIDISGNCIGDTGAKMLAKALMMNtKLKTLVWDRNNVTAG 518
Cdd:COG5238    374 GNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAE 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 309-553 1.72e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 66.61  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  309 FSLRKVREVTRSVRDFFSKSTVLKYVGFSGTKLPPEALRLLLQGLATNTHLSELELdiSSCELRSAGAQVIQE-HIFEAK 387
Cdd:cd00116      3 LSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCL--SLNETGRIPRGLQSLlQGLTKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  388 A-ISSLDLSDNGFESNMVTLILSIGRSHSIKHLSIGRN------FAMKSRALTDVLHRLVQLIQEEeCPLESLSVCD--- 457
Cdd:cd00116     81 CgLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNglgdrgLRLLAKGLKDLPPALEKLVLGR-NRLEGASCEAlak 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  458 -----SKLKT-----------GTTILINSLGCNASLSKIDISGNCIGDTGAKMLAKALMMNTKLKTLVWDRNNVTAGGFM 521
Cdd:cd00116    160 alranRDLKElnlanngigdaGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAA 239

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1207135128  522 DVANALE------KNLTLQNISIPMSDVLQAHRSAPEK 553
Cdd:cd00116    240 ALASALLspnislLTLSLSCNDITDDGAKDLAEVLAEK 277
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
474-499 3.32e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.85  E-value: 3.32e-03
                            10        20
                    ....*....|....*....|....*.
gi 1207135128   474 NASLSKIDISGNCIGDTGAKMLAKAL 499
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Name Accession Description Interval E-value
CARMIL_C pfam16000
CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich ...
 688-1005 2.75e-19

CARMIL C-terminus; This domain is found near to the C-terminus of leucine-rich repeat-containing proteins in the CARMIL family. In leucine-rich repeat-containing protein 16A (LRRC16A) it includes the region responsible for interaction with F-actin-capping protein subunit alpha-2 (CAPZA2).


Pssm-ID: 464966 [Multi-domain]  Cd Length: 299  Bit Score: 89.45  E-value: 2.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  688 CPRVVQRSSVNEQLADRVAKKTRQAAHFIQNTM-HEAENSIRNKLSELKLSVSVSLVESIINEVHQDLFVAQEKLDKHMR 766
Cdd:pfam16000    5 CPHVMQKAGVRQDLEKALSEKMTLPEEFVKSTLlEQAGVDIFNKLSEVKLSVASFLSDRIVDEVLEALSRSHHKLARHLS 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  767 EfsqsssikanvPQLRVMEHEFPTDDYVPviwRNSFHSRSIRPAPSIKSLLDVEgeqqaraaTHPQQEPEERGGGGGGGV 846
Cdd:pfam16000   85 Q-----------RGRTLLEPESLPDGDRP---ESSPLGPGKRHEGEIERLEELE--------TPMATLKSKRKSIHSRKL 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  847 PQVSRVGTEERRRAQSLPLATGLSVTTAGQLKPGSPSywrreadaaaapaaaaaalSNREPRRSEPAPPQPPMDLPIEGH 926
Cdd:pfam16000  143 RPVSVAFSVSELDLDKAPEEVPIHVEDASSGPPLPSS-------------------SPSEPELSASESLDSLSELPTEGQ 203

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207135128  927 TLRHYTRSRPRPNRRNRQPPSKPQEQAAEiENEANENMGRVDEGVEEFFTKKIIPDDplhFPSCLSSPRVQKAPEGGAP 1005
Cdd:pfam16000  204 KLQHLTKGRPKRNKTRAPTRPPGKVGPAQ-DGEQNGLSGRVDEGLEDFFSKKVIKLS---TPTSPTSEPSSSSLFPDSP 278
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 155-518 5.21e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 5.21e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  155 SLEASGLKMDFAIRMATALRESTasaVHIINLSVNAIEDKGVIALSQSLGKlSCCLSQLHLSKVSMSSKGLGCLVQVLHQ 234
Cdd:COG5238    159 LGLAARLGLLAAISMAKALQNNS---VETVYLGCNQIGDEGIEELAEALTQ-NTTVTTLWLKRNPIGDEGAEILAEALKG 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  235 STflcnTLTHLDLSGNtgCLATEEAMSLYRFLSAPNSVSHLDLSCTDCPLDTLfVSLS--LGCCTTLNYLNLSRNPfslr 312
Cdd:COG5238    235 NK----SLTTLDLSNN--QIGDEGVIALAEALKNNTTVETLYLSGNQIGAEGA-IALAkaLQGNTTLTSLDLSVNR---- 303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  313 kvrevtrsvrdffskstvlkyVGFSGTklppealRLLLQGLATNTHLSELelDISSCELRSAGAQVIQEHIFEAKAISSL 392
Cdd:COG5238    304 ---------------------IGDEGA-------IALAEGLQGNKTLHTL--NLAYNGIGAQGAIALAKALQENTTLHSL 353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  393 DLSDNgfesnmvtlilsigrshsikhlsigrnfamksrALTDvlhrlvqliqeeecpleslsvcdsklkTGTTILINSLG 472
Cdd:COG5238    354 DLSDN---------------------------------QIGD---------------------------EGAIALAKYLE 373

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1207135128  473 CNASLSKIDISGNCIGDTGAKMLAKALMMNtKLKTLVWDRNNVTAG 518
Cdd:COG5238    374 GNTTLRELNLGKNNIGKQGAEALIDALQTN-RLHTLILDGNLIGAE 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 309-553 1.72e-11

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 66.61  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  309 FSLRKVREVTRSVRDFFSKSTVLKYVGFSGTKLPPEALRLLLQGLATNTHLSELELdiSSCELRSAGAQVIQE-HIFEAK 387
Cdd:cd00116      3 LSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCL--SLNETGRIPRGLQSLlQGLTKG 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  388 A-ISSLDLSDNGFESNMVTLILSIGRSHSIKHLSIGRN------FAMKSRALTDVLHRLVQLIQEEeCPLESLSVCD--- 457
Cdd:cd00116     81 CgLQELDLSDNALGPDGCGVLESLLRSSSLQELKLNNNglgdrgLRLLAKGLKDLPPALEKLVLGR-NRLEGASCEAlak 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  458 -----SKLKT-----------GTTILINSLGCNASLSKIDISGNCIGDTGAKMLAKALMMNTKLKTLVWDRNNVTAGGFM 521
Cdd:cd00116    160 alranRDLKElnlanngigdaGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAA 239

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1207135128  522 DVANALE------KNLTLQNISIPMSDVLQAHRSAPEK 553
Cdd:cd00116    240 ALASALLspnislLTLSLSCNDITDDGAKDLAEVLAEK 277
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 325-536 1.73e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.43  E-value: 1.73e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  325 FSKSTVLKYVGFSGTKLPPEALRLLLQGLATNTHLSELELdiSSCELRSAGAQVIQEHIFEAKAISSLDLSDNGF-ESNM 403
Cdd:COG5238    176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWL--KRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIgDEGV 253

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  404 VTLILSIGRSHSIKHLSIGRNF--AMKSRALTDVLHRLVQLiqeeecplESLSVCDSKLK-TGTTILINSLGCNASLSKI 480
Cdd:COG5238    254 IALAEALKNNTTVETLYLSGNQigAEGAIALAKALQGNTTL--------TSLDLSVNRIGdEGAIALAEGLQGNKTLHTL 325

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207135128  481 DISGNCIGDTGAKMLAKALMMNTKLKTLVWDRNNVTAGGFMDVANALEKNLTLQNI 536
Cdd:COG5238    326 NLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 329-533 2.08e-10

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 64.04  E-value: 2.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  329 TVLKYVGFSGTKLPPEALRLLLQGLATNTHLSELeLDISSCELRSAGAQVIQEHIFEAKAISSLDLSDNGF-ESNMVTLI 407
Cdd:COG5238    151 LGGNAVHLLGLAARLGLLAAISMAKALQNNSVET-VYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIgDEGAEILA 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  408 LSIGRSHSIKHLSIGRNfamksrALTDvlhrlvqliqeeecpleslsvcdsklkTGTTILINSLGCNASLSKIDISGNCI 487
Cdd:COG5238    230 EALKGNKSLTTLDLSNN------QIGD---------------------------EGVIALAEALKNNTTVETLYLSGNQI 276

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1207135128  488 GDTGAKMLAKALMMNTKLKTLVWDRNNVTAGGFMDVANALEKNLTL 533
Cdd:COG5238    277 GAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTL 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
242-538 3.27e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 3.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  242 LTHLDLSGNTGclateeamslyrfLSAPNSVSHLDLSctDCPLDTLFVSLslGCCTTLNYLNLSRNPFSlrkvrevtrSV 321
Cdd:COG4886     98 LTELDLSGNEE-------------LSNLTNLESLDLS--GNQLTDLPEEL--ANLTNLKELDLSNNQLT---------DL 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  322 RDFFSKSTVLKYVGFSGTK---LPPEALRLllqglatnTHLSELelDISSCELRSagaqvIQEHIFEAKAISSLDLSDNG 398
Cdd:COG4886    152 PEPLGNLTNLKSLDLSNNQltdLPEELGNL--------TNLKEL--DLSNNQITD-----LPEPLGNLTNLEELDLSGNQ 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  399 FESnmvtLILSIGRSHSIKHLSIGRNfamksrALTDvLHRLVQLIQeeecpLESLSVCDSKLKTgttilINSLGCNASLS 478
Cdd:COG4886    217 LTD----LPEPLANLTNLETLDLSNN------QLTD-LPELGNLTN-----LEELDLSNNQLTD-----LPPLANLTNLK 275

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207135128  479 KIDISGNCIGDTGAKMLA--KALMMNTKLKTLVWDRNNVTAGGFMDVANALEKNLTLQNISI 538
Cdd:COG4886    276 TLDLSNNQLTDLKLKELEllLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-570 2.04e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  245 LDLSGNTGCLATEEAMSLYRFLSAPNSVSHLDLSCTDcpldtlfvslSLGCCTTLNYLNLSRNPFSlrkvrevtrSVRDF 324
Cdd:COG4886     71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE----------ELSNLTNLESLDLSGNQLT---------DLPEE 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  325 FSKSTVLKYVGFSGTKLppealRLLLQGLATNTHLSELelDISSCELRSagaqvIQEHIFEAKAISSLDLSDNGFESnmv 404
Cdd:COG4886    132 LANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSL--DLSNNQLTD-----LPEELGNLTNLKELDLSNNQITD--- 196

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  405 tLILSIGRSHSIKHLSIGRNfamksrALTDVLHRLVQLIQeeecpLESLSVCDSKLKTgttilINSLGCNASLSKIDISG 484
Cdd:COG4886    197 -LPEPLGNLTNLEELDLSGN------QLTDLPEPLANLTN-----LETLDLSNNQLTD-----LPELGNLTNLEELDLSN 259

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  485 NCIGDtgakmlAKALMMNTKLKTLVWDRNNVTaggfmdvANALEKNLTLQNISIPMSDVLQAHRSAPEKTEEALQKIQDF 564
Cdd:COG4886    260 NQLTD------LPPLANLTNLKTLDLSNNQLT-------DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326


                   ....*.
gi 1207135128  565 LRRNNQ 570
Cdd:COG4886    327 LLLLKG 332
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 185-528 5.34e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 49.66  E-value: 5.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  185 NLSVNAIEDKG-VIALSQSLgkLSCCLSQLHLSkvsMSSKGLGCLVQVLHQstflCNTLTHLDLSGNtgCLATEEAMSLY 263
Cdd:cd00116     34 TLGEEAAKALAsALRPQPSL--KELCLSLNETG---RIPRGLQSLLQGLTK----GCGLQELDLSDN--ALGPDGCGVLE 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  264 RFLSAPnSVSHLDLscTDCPLDTL---FVSLSLG-CCTTLNYLNLSRNpfslRKVREVTRSVRDFFSKSTVLKYVGFSGT 339
Cdd:cd00116    103 SLLRSS-SLQELKL--NNNGLGDRglrLLAKGLKdLPPALEKLVLGRN----RLEGASCEALAKALRANRDLKELNLANN 175

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  340 KLPPEALRLLLQGLATNTHLSELelDISSCELRSAGAQVIQEHIFEAKAISSLDLSDNGfesnmvtlilsigrshsikhl 419
Cdd:cd00116    176 GIGDAGIRALAEGLKANCNLEVL--DLNNNGLTDEGASALAETLASLKSLEVLNLGDNN--------------------- 232

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  420 sigrnfamksraLTDVlhrlvqliqeeecpleslsvCDSKLKTGttilinSLGCNASLSKIDISGNCIGDTGAKMLAKAL 499
Cdd:cd00116    233 ------------LTDA--------------------GAAALASA------LLSPNISLLTLSLSCNDITDDGAKDLAEVL 274

                          330       340
                   ....*....|....*....|....*....
gi 1207135128  500 MMNTKLKTLVWDRNNVTAGGFMDVANALE 528
Cdd:cd00116    275 AEKESLLELDLRGNKFGEEGAQLLAESLL 303
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
297-516 1.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  297 TTLNYLNLSRNPFSLRKVREVTRSVRDFFSKSTVLKYVGFSGTKLPPEALRLLLQGLATNTHLSELE-LDISSCELRSag 375
Cdd:COG4886     50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLEsLDLSGNQLTD-- 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  376 aqvIQEHIFEAKAISSLDLSDNGFESnmvtLILSIGRSHSIKHLSIGRNfamksrALTDVLHRLVQLIQeeecpLESLSV 455
Cdd:COG4886    128 ---LPEELANLTNLKELDLSNNQLTD----LPEPLGNLTNLKSLDLSNN------QLTDLPEELGNLTN-----LKELDL 189

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207135128  456 CDSKLKTgttiLINSLGCNASLSKIDISGNCIGDtgakmLAKALMMNTKLKTLVWDRNNVT 516
Cdd:COG4886    190 SNNQITD----LPEPLGNLTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLT 241
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 418-543 4.01e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.09  E-value: 4.01e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  418 HLSIGRNFAMKSRALTDVLHRLVQLiqeeecPLESLSVCDSKLKTGTTILINSLGCNASLSKIDISGNCIGDTGAKMLAK 497
Cdd:COG5238    129 DSLILYLALPRRINLIQVLKDPLGG------NAVHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELAE 202

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207135128  498 ALMMNTKLKTLVWDRNNVTAGGFMDVANALEKNLTLQNISIPMSDV 543
Cdd:COG5238    203 ALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQI 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
183-411 5.55e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.85  E-value: 5.55e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  183 IINLSVNAIEDkgviaLSQSLGKLScclsqlHLSKVSMSSKGLGCLVQVLHQstflCNTLTHLDLSGNtgclateeamsl 262
Cdd:COG4886    117 SLDLSGNQLTD-----LPEELANLT------NLKELDLSNNQLTDLPEPLGN----LTNLKSLDLSNN------------ 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  263 yRFLSAPNSVSHLD----LSCTDCPLDTLfvSLSLGCCTTLNYLNLSRNPFSlrkvrevtrSVRDFFSKSTVLKYVGFSG 338
Cdd:COG4886    170 -QLTDLPEELGNLTnlkeLDLSNNQITDL--PEPLGNLTNLEELDLSGNQLT---------DLPEPLANLTNLETLDLSN 237

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207135128  339 TKLPPealrllLQGLATNTHLSelELDISSCELRSAGaqviqeHIFEAKAISSLDLSDNGFESNMVTLILSIG 411
Cdd:COG4886    238 NQLTD------LPELGNLTNLE--ELDLSNNQLTDLP------PLANLTNLKTLDLSNNQLTDLKLKELELLL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
268-516 8.56e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 8.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  268 APNSVSHLDLSCTDCPLDTLFVSLSLGCCTTLNYLNLSRNPFSLRKVREVTRSVRDFFSKSTVLKYVGFSGTKLPPEALR 347
Cdd:COG4886      1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  348 LLLQGLATNTHLSEL----ELDISSCElrsagaqviqeHIFEAKAISSLDLSDNGFESnmvtLILSIGRSHSIKHLSIGR 423
Cdd:COG4886     81 LLSLLLLGLTDLGDLtnltELDLSGNE-----------ELSNLTNLESLDLSGNQLTD----LPEELANLTNLKELDLSN 145

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  424 NfamksrALTDVLHRLVQLIQeeecpLESLSVCDSKLKTgttiLINSLGCNASLSKIDISGNCIGDtgakmLAKALMMNT 503
Cdd:COG4886    146 N------QLTDLPEPLGNLTN-----LKSLDLSNNQLTD----LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLT 205

                          250
                   ....*....|...
gi 1207135128  504 KLKTLVWDRNNVT 516
Cdd:COG4886    206 NLEELDLSGNQLT 218
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 146-250 1.33e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  146 ARSSALEEVSLEASGLKMDFAIRMATALreSTASAVHIINLSVNAIEDKGVIALSQSLGKLSCCLSQLHLSKVSMSSKGL 225
Cdd:cd00116    190 KANCNLEVLDLNNNGLTDEGASALAETL--ASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGA 267

                           90       100
                   ....*....|....*....|....*
gi 1207135128  226 GCLVQVLHQSTflcnTLTHLDLSGN 250
Cdd:cd00116    268 KDLAEVLAEKE----SLLELDLRGN 288
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 147-371 2.59e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 2.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  147 RSSALEEVSLEASGLKMDFAIRMATALRESTAsaVHIINLSVNAIEDKGVIALSQSLgKLSCCLSQLHLSKvsmsskglg 226
Cdd:cd00116    135 LPPALEKLVLGRNRLEGASCEALAKALRANRD--LKELNLANNGIGDAGIRALAEGL-KANCNLEVLDLNN--------- 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207135128  227 clvqvlhqstflcNTLTHldlsgnTGCLATEEAmslyrfLSAPNSVSHLDLSctDCPLDTL----FVSLSLGCCTTLNYL 302
Cdd:cd00116    203 -------------NGLTD------EGASALAET------LASLKSLEVLNLG--DNNLTDAgaaaLASALLSPNISLLTL 255

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207135128  303 NLSRNPFSLRKVREVTRSVRDFFSkstvLKYVGFSGTKLPPEALRLLLQGLATNTHlSELELDISSCEL 371
Cdd:cd00116    256 SLSCNDITDDGAKDLAEVLAEKES----LLELDLRGNKFGEEGAQLLAESLLEPGN-ELESLWVKDDSF 319
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
474-499 3.32e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 35.85  E-value: 3.32e-03
                            10        20
                    ....*....|....*....|....*.
gi 1207135128   474 NASLSKIDISGNCIGDTGAKMLAKAL 499
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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