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Conserved domains on  [gi|1207139617|ref|XP_021323657|]
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bromodomain-containing protein 2 isoform X1 [Danio rerio]

Protein Classification

bromodomain-containing protein( domain architecture ID 10144640)

bromodomain-containing protein binds acetylated lysines

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 72-178 1.40e-77

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99929  Cd Length: 107  Bit Score: 237.32  E-value: 1.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  72 RMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCY 151
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1207139617 152 IYNKPTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 383-477 5.81e-59

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99930  Cd Length: 102  Bit Score: 189.03  E-value: 5.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90
                  ....*....|....*
gi 1207139617 463 NPPDHDVVAMARRLQ 477
Cdd:cd05498    81 NPPDHPVHAMARKLQ 95
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 72-178 1.40e-77

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 237.32  E-value: 1.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  72 RMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCY 151
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1207139617 152 IYNKPTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 383-477 5.81e-59

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 189.03  E-value: 5.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90
                  ....*....|....*
gi 1207139617 463 NPPDHDVVAMARRLQ 477
Cdd:cd05498    81 NPPDHPVHAMARKLQ 95
BROMO smart00297
bromo domain;
75-178 5.05e-36

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 128.94  E-value: 5.05e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617   75 NQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYN 154
Cdd:smart00297   6 KKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYN 83

                           90       100
                   ....*....|....*....|....
gi 1207139617  155 KPTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:smart00297  84 GPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
383-477 4.94e-33

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 120.85  E-value: 4.94e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  383 QLRYCSTILKELLSKKHT-AYAWPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYK 461
Cdd:smart00297   4 LQKKLQELLKAVLDKLDShPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNART 81

                           90
                   ....*....|....*.
gi 1207139617  462 YNPPDHDVVAMARRLQ 477
Cdd:smart00297  82 YNGPDSEVYKDAKKLE 97
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 82-165 1.78e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.22  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  82 KALVKTLWRHHFAWPFHEPVDAAklNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIV 161
Cdd:pfam00439   2 LEILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIY 79


                  ....
gi 1207139617 162 LMAQ 165
Cdd:pfam00439  80 KAAE 83
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 387-475 2.11e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.84  E-value: 2.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 387 CSTILKELlsKKHTAYAWpFYKPVDVSSLGlhDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPD 466
Cdd:pfam00439   1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                  ....*....
gi 1207139617 467 HDVVAMARR 475
Cdd:pfam00439  76 SVIYKAAEK 84
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 95-180 5.46e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 91.41  E-value: 5.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  95 WPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174
Cdd:COG5076   167 SIFLGLPS--KREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKL 244


                  ....*.
gi 1207139617 175 VAQMPE 180
Cdd:COG5076   245 IEEIPE 250
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 391-477 2.71e-16

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 80.23  E-value: 2.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 391 LKELLSKKHTAYAWPFykPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVV 470
Cdd:COG5076   154 KKQLFLRDGRFLSSIF--LGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVY 231


                  ....*..
gi 1207139617 471 AMARRLQ 477
Cdd:COG5076   232 VDAKELE 238
 
Name Accession Description Interval E-value
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 72-178 1.40e-77

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 237.32  E-value: 1.40e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  72 RMTNQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCY 151
Cdd:cd05497     1 RHTNQLQYLLKVVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCY 80

                          90       100
                  ....*....|....*....|....*..
gi 1207139617 152 IYNKPTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:cd05497    81 IYNKPGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 383-477 5.81e-59

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 189.03  E-value: 5.81e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90
                  ....*....|....*
gi 1207139617 463 NPPDHDVVAMARRLQ 477
Cdd:cd05498    81 NPPDHPVHAMARKLQ 95
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 384-477 1.37e-36

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 130.48  E-value: 1.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 384 LRYCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05499     2 LKFCEEVLKELMKPKHSAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                          90
                  ....*....|....
gi 1207139617 464 PPDHDVVAMARRLQ 477
Cdd:cd05499    82 PEGTDVYMMGHQLE 95
BROMO smart00297
bromo domain;
75-178 5.05e-36

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 128.94  E-value: 5.05e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617   75 NQLQFLQKALVKTLWRHHFAWPFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYN 154
Cdd:smart00297   6 KKLQELLKAVLDKLDSHPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYN 83

                           90       100
                   ....*....|....*....|....
gi 1207139617  155 KPTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:smart00297  84 GPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 384-476 3.64e-35

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 126.29  E-value: 3.64e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 384 LRYCSTILKELLSKKHtayAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05506     2 MKQCGTLLRKLMKHKW---GWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYN 78

                          90
                  ....*....|...
gi 1207139617 464 PPDHDVVAMARRL 476
Cdd:cd05506    79 PPGNDVHTMAKEL 91
BROMO smart00297
bromo domain;
383-477 4.94e-33

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 120.85  E-value: 4.94e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  383 QLRYCSTILKELLSKKHT-AYAWPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYK 461
Cdd:smart00297   4 LQKKLQELLKAVLDKLDShPLSWPFLKPVSRKEA--PDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNART 81

                           90
                   ....*....|....*.
gi 1207139617  462 YNPPDHDVVAMARRLQ 477
Cdd:smart00297  82 YNGPDSEVYKDAKKLE 97
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 76-174 5.56e-33

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 120.46  E-value: 5.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  76 QLQFLQKALVKTLWRHH--FAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIY 153
Cdd:cd05498     1 QLKFCSGILKELFSKKHkaYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|.
gi 1207139617 154 NKPTDDIVLMAQSLEKAFLQK 174
Cdd:cd05498    81 NPPDHPVHAMARKLQDVFEDR 101
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 76-178 1.01e-31

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 117.27  E-value: 1.01e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  76 QLQFLQKALVKTLWRHHFAWPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNK 155
Cdd:cd05509     1 PLYTQLKKVLDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNG 78

                          90       100
                  ....*....|....*....|...
gi 1207139617 156 PTDDIVLMAQSLEKAFLQKVAQM 178
Cdd:cd05509    79 PDTEYYKCANKLEKFFWKKLKEL 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 82-175 1.61e-31

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 116.70  E-value: 1.61e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  82 KALVKTLWRHH--FAWPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDD 159
Cdd:cd04369     6 RSLLDALKKLKrdLSEPFLEPVD--PKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPGSP 83

                          90
                  ....*....|....*.
gi 1207139617 160 IVLMAQSLEKAFLQKV 175
Cdd:cd04369    84 IYKDAKKLEKLFEKLL 99
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 83-171 4.16e-30

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 112.81  E-value: 4.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  83 ALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVL 162
Cdd:cd05506     7 TLLRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHT 86


                  ....*....
gi 1207139617 163 MAQSLEKAF 171
Cdd:cd05506    87 MAKELLKIF 95
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 385-477 5.42e-30

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 112.47  E-value: 5.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 385 RYCSTILKELLSKKHTaYAWPFYKPVDVSslGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNP 464
Cdd:cd04369     3 KKLRSLLDALKKLKRD-LSEPFLEPVDPK--EAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNG 79

                          90
                  ....*....|...
gi 1207139617 465 PDHDVVAMARRLQ 477
Cdd:cd04369    80 PGSPIYKDAKKLE 92
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 76-171 1.19e-28

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 108.94  E-value: 1.19e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  76 QLQFLQKALvKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNK 155
Cdd:cd05500     5 QHKFLLSSI-RSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNG 83

                          90
                  ....*....|....*.
gi 1207139617 156 PTDDIVLMAQSLEKAF 171
Cdd:cd05500    84 PEHPVSQMGKRLQAAF 99
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 383-477 5.06e-28

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 107.12  E-value: 5.06e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYC-STILKELLSKKHtayAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYK 461
Cdd:cd05497     5 QLQYLlKVVLKALWKHKF---AWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYI 81

                          90
                  ....*....|....*.
gi 1207139617 462 YNPPDHDVVAMARRLQ 477
Cdd:cd05497    82 YNKPGDDVVLMAQTLE 97
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 379-477 1.51e-27

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 105.71  E-value: 1.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 379 KLSQQLRycsTILKELlsKKHtAYAWPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSN 458
Cdd:cd05509     1 PLYTQLK---KVLDSL--KNH-KSAWPFLEPVDKEEA--PDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDN 72

                          90
                  ....*....|....*....
gi 1207139617 459 CYKYNPPDHDVVAMARRLQ 477
Cdd:cd05509    73 CRLYNGPDTEYYKCANKLE 91
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 91-171 1.57e-26

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 103.13  E-value: 1.57e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  91 HHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKA 170
Cdd:cd05499    18 SAYNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNPEGTDVYMMGHQLEEV 97


                  .
gi 1207139617 171 F 171
Cdd:cd05499    98 F 98
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 383-477 2.13e-23

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 94.30  E-value: 2.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYCSTILKELlskKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462
Cdd:cd05500     5 QHKFLLSSIRSL---KRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTF 81

                          90
                  ....*....|....*
gi 1207139617 463 NPPDHDVVAMARRLQ 477
Cdd:cd05500    82 NGPEHPVSQMGKRLQ 96
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 376-477 5.38e-23

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 93.61  E-value: 5.38e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 376 RRGKLSQQLRYCSTILKELLS--KKHTAyAWPFYKPVdvSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVR 453
Cdd:cd05504     2 RRSEGRHHGPLNLSALEQLLVeiVKHKD-SWPFLRPV--SKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQ 78

                          90       100
                  ....*....|....*....|....
gi 1207139617 454 LMFSNCYKYNPPDHDVVAMARRLQ 477
Cdd:cd05504    79 LVFSNCFLYNPEHTSVYKAGTRLQ 102
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 82-165 1.78e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 91.22  E-value: 1.78e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  82 KALVKTLWRHHFAWPFHEPVDAAklNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIV 161
Cdd:pfam00439   2 LEILDKLMEHPIAAPFLEPVDPD--EYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVIY 79


                  ....
gi 1207139617 162 LMAQ 165
Cdd:pfam00439  80 KAAE 83
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 387-475 2.11e-22

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 90.84  E-value: 2.11e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 387 CSTILKELlsKKHTAYAWpFYKPVDVSSLGlhDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPD 466
Cdd:pfam00439   1 CLEILDKL--MEHPIAAP-FLEPVDPDEYP--DYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPG 75


                  ....*....
gi 1207139617 467 HDVVAMARR 475
Cdd:pfam00439  76 SVIYKAAEK 84
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 387-477 3.69e-21

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 88.27  E-value: 3.69e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 387 CSTILKELlsKKHTAYAWPFYKPVdvSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNP-P 465
Cdd:cd05510    12 LDKVLNEL--KTYTEHSTPFLTKV--SKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdP 87

                          90
                  ....*....|..
gi 1207139617 466 DHDVVAMARRLQ 477
Cdd:cd05510    88 SHPLRRHANFMK 99
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 83-174 1.08e-20

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 87.07  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  83 ALVKTLWRHHFAWPFHEPVdaAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVL 162
Cdd:cd05504    19 QLLVEIVKHKDSWPFLRPV--SKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTSVYK 96

                          90
                  ....*....|..
gi 1207139617 163 MAQSLEKAFLQK 174
Cdd:cd05504    97 AGTRLQRFFIKR 108
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 384-477 1.98e-20

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 86.19  E-value: 1.98e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 384 LRYCSTILKELLSKKHTAyawPFYKPVDVSSlglHDYYDIIMYPMDLSTIKRKMD---HREYRDALQFAADVRLMFSNCY 460
Cdd:cd05502     6 QRKCERLLLELYCHELSL---PFHEPVSPSV---PNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFKNCY 79

                          90
                  ....*....|....*..
gi 1207139617 461 KYNPPDHDVVAMARRLQ 477
Cdd:cd05502    80 KFNEEDSEVAQAGKELE 96
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 95-180 5.46e-20

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 91.41  E-value: 5.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  95 WPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174
Cdd:COG5076   167 SIFLGLPS--KREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVDAKELEKYFLKL 244


                  ....*.
gi 1207139617 175 VAQMPE 180
Cdd:COG5076   245 IEEIPE 250
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 398-476 1.43e-19

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 83.65  E-value: 1.43e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 398 KHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVVAMARRL 476
Cdd:cd05495    17 KQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKL 95
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 77-175 1.08e-18

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 81.34  E-value: 1.08e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  77 LQFLQKALVKTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKP 156
Cdd:cd05495     5 RQALMPTLEKLYKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRK 84

                          90
                  ....*....|....*....
gi 1207139617 157 TDDIVLMAQSLEKAFLQKV 175
Cdd:cd05495    85 TSRVYKYCTKLAEVFEQEI 103
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 94-180 1.41e-18

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 81.16  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  94 AWPFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQS-LEKAFl 172
Cdd:cd05511    18 SWPFHTPVNKKKV--PDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEmLELAE- 94


                  ....*...
gi 1207139617 173 QKVAQMPE 180
Cdd:cd05511    95 ELLAEREE 102
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 88-174 6.45e-18

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 78.57  E-value: 6.45e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  88 LWRHHFAWPFHEPVDAaKLnLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSL 167
Cdd:cd05503    12 MEAHEDAWPFLEPVNT-KL-VPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAGHNM 89


                  ....*..
gi 1207139617 168 EKAFLQK 174
Cdd:cd05503    90 RKFFEKR 96
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 109-174 7.34e-18

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 78.92  E-value: 7.34e-18
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207139617 109 PDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174
Cdd:cd05519    37 PDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKKK 102
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 105-177 1.69e-17

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 77.73  E-value: 1.69e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207139617 105 KLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKVAQ 177
Cdd:cd05515    33 KSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVLLETKRE 105
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 96-177 4.27e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 76.95  E-value: 4.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  96 PFHEPVdaaKLNLPDYYNIIKQPMDMGTIKKRLE---NNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFL 172
Cdd:cd05502    24 PFHEPV---SPSVPNYYKIIKTPMDLSLIRKKLQpksPQHYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFE 100


                  ....*
gi 1207139617 173 QKVAQ 177
Cdd:cd05502   101 EQLKE 105
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 86-169 5.75e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 76.71  E-value: 5.75e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  86 KTLWRHHFawPFHEPVdaAKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNK-PTDDIVLMA 164
Cdd:cd05510    20 KTYTEHST--PFLTKV--SKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNSdPSHPLRRHA 95


                  ....*
gi 1207139617 165 QSLEK 169
Cdd:cd05510    96 NFMKK 100
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 388-476 5.90e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 76.53  E-value: 5.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 388 STILKELLSKKHTA-YAWPFYKPVDvsSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPD 466
Cdd:cd05511     2 SFILDEIVNELKNLpDSWPFHTPVN--KKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPD 79

                          90
                  ....*....|
gi 1207139617 467 HDVVAMARRL 476
Cdd:cd05511    80 SVYTKKAKEM 89
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 384-469 8.53e-17

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 75.49  E-value: 8.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 384 LRYCSTILKELlsKKHtAYAWPFYKPVDVSSLGlhDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05503     2 LALCETILDEM--EAH-EDAWPFLEPVNTKLVP--GYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFN 76


                  ....*.
gi 1207139617 464 PPDHDV 469
Cdd:cd05503    77 EDDSEV 82
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 391-477 2.71e-16

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 80.23  E-value: 2.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 391 LKELLSKKHTAYAWPFykPVDVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVV 470
Cdd:COG5076   154 KKQLFLRDGRFLSSIF--LGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVY 231


                  ....*..
gi 1207139617 471 AMARRLQ 477
Cdd:COG5076   232 VDAKELE 238
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 389-476 9.29e-16

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 73.53  E-value: 9.29e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 389 TILKELLSKKHTAYAWPFYKPVDVSSLgLHDYYDIIMYPMDLSTIKRKMDHREYR--DALQFaaDVRLMFSNCYKYNPPD 466
Cdd:cd05529    31 SGLDKLLLSLQLEIAEYFEYPVDLRAW-YPDYWNRVPVPMDLETIRSRLENRYYRslEALRH--DVRLILSNAETFNEPN 107

                          90
                  ....*....|
gi 1207139617 467 HDVVAMARRL 476
Cdd:cd05529   108 SEIAKKAKRL 117
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 72-173 1.89e-15

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 72.75  E-value: 1.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  72 RMTNQLQFLQKALVKTLwrhhfAWPFHEPVDAaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCY 151
Cdd:cd05529    28 RLISGLDKLLLSLQLEI-----AEYFEYPVDL-RAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAE 101

                          90       100
                  ....*....|....*....|..
gi 1207139617 152 IYNKPTDDIVLMAQSLEKAFLQ 173
Cdd:cd05529   102 TFNEPNSEIAKKAKRLSDWLLR 123
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 390-479 2.25e-15

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 71.63  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 390 ILKELLSKKHtayAWPFYKPVdvSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDV 469
Cdd:cd05507    11 VYRTLASHRY---ASVFLKPV--TEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDV 85

                          90
                  ....*....|
gi 1207139617 470 VAMARRLQFC 479
Cdd:cd05507    86 YLMAVEMQRE 95
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 97-154 2.45e-14

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 68.58  E-value: 2.45e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207139617  97 FHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYN 154
Cdd:cd05512    22 FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYN 77
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 86-179 3.47e-14

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 68.54  E-value: 3.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  86 KTLWRHHFAWPFHEPV--DAAklnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLM 163
Cdd:cd05507    13 RTLASHRYASVFLKPVteDIA----PGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLM 88

                          90
                  ....*....|....*.
gi 1207139617 164 AQSLEKAFLQKVAQMP 179
Cdd:cd05507    89 AVEMQREVMSQIQQLL 104
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 405-464 5.19e-14

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 68.25  E-value: 5.19e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 405 PFYKPVDVssLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNP 464
Cdd:cd05496    25 PFRQPVDL--LKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTP 82
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 393-466 1.61e-13

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 66.27  E-value: 1.61e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207139617 393 ELLSKKHTAYAwpFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPD 466
Cdd:cd05512    11 DQLQEKDTAEI--FSEPVDLSEV--PDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKD 80
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 383-479 1.82e-13

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 66.02  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYCSTILKELLSKKHTayaWPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKY 462
Cdd:cd05505     1 ELQKCEEILSKILKYRFS---WPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKY 75

                          90
                  ....*....|....*..
gi 1207139617 463 NPPDHDVVAMARRLQFC 479
Cdd:cd05505    76 YENGSYVLSCMRKTEQC 92
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 96-178 2.36e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 66.23  E-value: 2.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  96 PFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNkPTDD-----IVLMAQSLEKA 170
Cdd:cd05528    23 AFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYN-PDRDpadklIRSRACELRDE 99


                  ....*...
gi 1207139617 171 FLQKVAQM 178
Cdd:cd05528   100 VHAMIEAE 107
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 109-175 3.98e-13

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 65.16  E-value: 3.98e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207139617 109 PDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKV 175
Cdd:cd05518    37 PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKEKR 103
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 80-171 4.00e-13

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 65.25  E-value: 4.00e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  80 LQKA--LVKTLWRHHFAWPFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPT 157
Cdd:cd05505     2 LQKCeeILSKILKYRFSWPFREPVTADEA--EDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENG 79

                          90
                  ....*....|....
gi 1207139617 158 DDIVLMAQSLEKAF 171
Cdd:cd05505    80 SYVLSCMRKTEQCC 93
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 80-156 8.61e-13

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 64.35  E-value: 8.61e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  80 LQKA---LVKTLWRHH----FAWPFHEPVdaaklnLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYI 152
Cdd:cd05513     2 LQKAleqLIRQLQRKDphgfFAFPVTDFI------APGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMK 75


                  ....
gi 1207139617 153 YNKP 156
Cdd:cd05513    76 YNKP 79
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 419-477 1.29e-12

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 63.86  E-value: 1.29e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQ 477
Cdd:cd05515    38 DYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQ 96
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 383-477 1.32e-12

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 64.30  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 383 QLRYC-STILKELLSKKHTAyawPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYK 461
Cdd:cd05528     3 ELRLFlRDVLKRLASDKRFN---AFTKPVDEEEV--PDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALE 77

                          90       100
                  ....*....|....*....|
gi 1207139617 462 YNPPDHD----VVAMARRLQ 477
Cdd:cd05528    78 YNPDRDPadklIRSRACELR 97
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 108-171 2.65e-12

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 63.22  E-value: 2.65e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207139617 108 LPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAF 171
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVF 100
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 82-154 1.12e-11

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 61.70  E-value: 1.12e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207139617  82 KALVKTLWRHHFAWPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYN 154
Cdd:cd05496    11 KELVNLMWDCEDSEPFRQPVD--LLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 109-171 7.01e-11

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 58.79  E-value: 7.01e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207139617 109 PDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAF 171
Cdd:cd05522    38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEA 100
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 419-477 3.51e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 56.96  E-value: 3.51e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQ 477
Cdd:cd05520    38 DYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQ 96
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 109-175 5.49e-10

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 56.58  E-value: 5.49e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207139617 109 PDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKV 175
Cdd:cd05520    37 PDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKDAEKLQKLMQAKK 103
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 391-476 7.95e-10

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 55.88  E-value: 7.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 391 LKELLSKK--HTAYAWPfykpvdVSSLGLHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHD 468
Cdd:cd05513     9 LIRQLQRKdpHGFFAFP------VTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTI 82


                  ....*...
gi 1207139617 469 VVAMARRL 476
Cdd:cd05513    83 YYKAAKKL 90
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 419-466 2.80e-09

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 54.65  E-value: 2.80e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPD 466
Cdd:cd05524    40 EYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPD 87
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 419-477 2.86e-09

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 54.55  E-value: 2.86e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDHDVVAMARRLQ 477
Cdd:cd05522    39 EYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLE 97
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 105-176 8.03e-09

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 53.10  E-value: 8.03e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207139617 105 KLNLPDYYNIIKQPMDMGTIKKRLENnyYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKVA 176
Cdd:cd05521    34 RKDYPDYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYINDVII 103
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 105-174 1.21e-08

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 52.44  E-value: 1.21e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 105 KLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQK 174
Cdd:cd05517    33 KVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIFTAK 102
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 419-463 1.75e-08

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 52.06  E-value: 1.75e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05518    38 DYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYN 82
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 419-463 3.00e-08

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 51.57  E-value: 3.00e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05519    38 DYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYN 82
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 105-173 1.36e-07

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 49.70  E-value: 1.36e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 105 KLNLPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQ 173
Cdd:cd05525    35 KKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYYGRKSPIGRDVCRLRKAYYQ 103
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 109-183 3.73e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 48.48  E-value: 3.73e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207139617 109 PDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKPTDDIVLMAQSLEKAFLQKVAQMPEVEE 183
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEHKDACKLWELFLSARNEVLSGGE 113
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 110-171 3.74e-07

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 48.19  E-value: 3.74e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207139617 110 DYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYNKpTDDIVLMAQSLEKAF 171
Cdd:cd05501    32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYK-DDDFGQVGITLEKKF 92
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 77-129 1.34e-06

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 47.05  E-value: 1.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207139617  77 LQFLQKALV--KTLWRHHFAWPFHEPVDAAKLNLPDYYNIIKQPMDMGTIKKRLE 129
Cdd:cd05494     2 YEALERVLRelKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVNNIV 56
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 94-171 1.85e-06

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 49.80  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617  94 AWPFHEPVDaaKLNLPDYYNIIKQPMDMGTIKKRLENNYYRsaseCMQDF----NTMFTNCYIYNKPTDDIVLMAQSLEK 169
Cdd:COG5076   281 AWPFLRPVS--DEEVPDYYKDIRDPMDLSTKELKLRNNYYR----PEETFvrdaKLFFDNCVMYNGEVTDYYKNANVLED 354


                  ..
gi 1207139617 170 AF 171
Cdd:COG5076   355 FV 356
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 388-476 2.25e-06

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 45.84  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207139617 388 STILKELLSKKHTAYAWPFYKPVDVSSLglHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDH 467
Cdd:cd05508     5 SKLLKFALERMKQPGAEPFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDH 82


                  ....*....
gi 1207139617 468 DVVAMARRL 476
Cdd:cd05508    83 KLTQAAKAI 91
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 419-473 3.44e-06

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 45.78  E-value: 3.44e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHreYRDALQFAADVRLMFSNCYKYNPPDHDVVAMA 473
Cdd:cd05521    39 DYYKIIKNPLSLNTVKKRLPH--YTNAQEFVNDLAQIPWNARLYNTKGSVIYKYA 91
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 417-463 6.98e-06

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 44.73  E-value: 6.98e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1207139617 417 LHDYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05516    37 LPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFN 83
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 96-154 3.75e-05

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 42.37  E-value: 3.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617  96 PFHEPVDAAKLnlPDYYNIIKQPMDMGTIKKRLENNYYRSASECMQDFNTMFTNCYIYN 154
Cdd:cd05508    22 PFLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYN 78
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 386-433 8.07e-05

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 42.05  E-value: 8.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1207139617 386 YCSTILKELLSKKHTAYAWPFYKPVDVSSLGLHDYYDIIMYPMDLSTI 433
Cdd:cd05494     4 ALERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTK 51
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 419-477 1.09e-04

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 41.26  E-value: 1.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPPDhDVVAMARRLQ 477
Cdd:cd05501    32 DYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDD-DFGQVGITLE 89
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 419-463 1.30e-04

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 41.22  E-value: 1.30e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYN 463
Cdd:cd05525    40 DYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 419-465 2.64e-03

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 37.42  E-value: 2.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1207139617 419 DYYDIIMYPMDLSTIKRKMDHREYRDALQFAADVRLMFSNCYKYNPP 465
Cdd:cd05517    38 DYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEP 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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