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Conserved domains on  [gi|1207188997|ref|XP_021327702|]
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BTB/POZ domain-containing protein 10 [Danio rerio]

Protein Classification

BTB/POZ domain-containing protein( domain architecture ID 13034961)

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain-containing protein 10 plays a major role as an activator of AKT family members

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_BTBD10_GMRP1 cd18385
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-225 1.59e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


:

Pssm-ID: 349693  Cd Length: 110  Bit Score: 228.41  E-value: 1.59e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 116 TSEKVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGIS 195
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207188997 196 IPELREACDYLCISFDYSTIKCRDLSALMH 225
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110
 
Name Accession Description Interval E-value
BTB_POZ_BTBD10_GMRP1 cd18385
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-225 1.59e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349693  Cd Length: 110  Bit Score: 228.41  E-value: 1.59e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 116 TSEKVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGIS 195
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207188997 196 IPELREACDYLCISFDYSTIKCRDLSALMH 225
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110
BTB_3 pfam16017
BTB/POZ domain;
119-224 4.11e-68

BTB/POZ domain;


Pssm-ID: 464976  Cd Length: 106  Bit Score: 211.81  E-value: 4.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 119 KVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGISIPE 198
Cdd:pfam16017   1 RLTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSSMERNFTRPNEKGEYEIAEGISSTVFRAILDYYKTGVIRCPPSVSIPE 80

                          90       100
                  ....*....|....*....|....*.
gi 1207188997 199 LREACDYLCISFDYSTIKCRDLSALM 224
Cdd:pfam16017  81 LREACDYLLIPFDATTIKCQNLRALL 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 120-208 1.54e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 43.45  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997  120 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHnftrpnEKGEYEVaEGISSTVFRAILDYYKSGIIRCPDGiSIPEL 199
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES------DKSEIYL-DDVSPEDFRALLNFLYTGKLDLPEE-NVEEL 73


                   ....*....
gi 1207188997  200 REACDYLCI 208
Cdd:smart00225  74 LELADYLQI 82
 
Name Accession Description Interval E-value
BTB_POZ_BTBD10_GMRP1 cd18385
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-225 1.59e-74

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 10 (BTBD10); BTBD10, also called glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. BTBD10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349693  Cd Length: 110  Bit Score: 228.41  E-value: 1.59e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 116 TSEKVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGIS 195
Cdd:cd18385     1 TSERVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKTGIIRCPDGIS 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207188997 196 IPELREACDYLCISFDYSTIKCRDLSALMH 225
Cdd:cd18385    81 IPELREACDYLCISFDYSTIKCRDLSALMH 110
BTB_3 pfam16017
BTB/POZ domain;
119-224 4.11e-68

BTB/POZ domain;


Pssm-ID: 464976  Cd Length: 106  Bit Score: 211.81  E-value: 4.11e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 119 KVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGISIPE 198
Cdd:pfam16017   1 RLTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSSMERNFTRPNEKGEYEIAEGISSTVFRAILDYYKTGVIRCPPSVSIPE 80

                          90       100
                  ....*....|....*....|....*.
gi 1207188997 199 LREACDYLCISFDYSTIKCRDLSALM 224
Cdd:pfam16017  81 LREACDYLLIPFDATTIKCQNLRALL 106
BTB_POZ_KCTD20 cd18386
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 116-219 2.09e-66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20); KCTD20, also called potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349694  Cd Length: 104  Bit Score: 207.12  E-value: 2.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 116 TSEKVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGIS 195
Cdd:cd18386     1 APEKVTLIVDGTRFVVNPQIFTAHPDTMLGRMFGPGREYNFTRPNEKGEYEIAEGISCTVFRTVLDYYKTGIINCPDGIS 80

                          90       100
                  ....*....|....*....|....
gi 1207188997 196 IPELREACDYLCISFDYSTIKCRD 219
Cdd:cd18386    81 IPDLRDTCDYLCINFDFNTIKCQD 104
BTB_POZ_KCTD20-like cd18318
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 118-208 6.52e-66

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 20 (KCTD20) and BTB/POZ domain-containing protein 10 (BTBD10); KCTD20, also termed potassium channel tetramerization domain containing 20, is a positive regulator of Akt signaling. It may play an important role in regulating the death and growth of some non-nervous and nervous cells. BTBD10, also termed glucose metabolism-related protein 1 (GMRP1), plays a major role as an activator of AKT family members. It binds to Akt and protein phosphatase 2A (PP2A) and inhibits the PP2A-mediated dephosphorylation of Akt, thereby keeping Akt activated. It also plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells.


Pssm-ID: 349627  Cd Length: 92  Bit Score: 205.63  E-value: 6.52e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 118 EKVTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHNFTRPNEKGEYEVAEGISSTVFRAILDYYKSGIIRCPDGISIP 197
Cdd:cd18318     1 EKVTLVVDGTRFVVDPSLFTAHPDTMLGRMFGSGLENNFTRPNERGEYEVADGISATVFRAILDYYKTGIIRCPPSVSVA 80

                          90
                  ....*....|.
gi 1207188997 198 ELREACDYLCI 208
Cdd:cd18318    81 ELREACDYLLI 91
BTB_POZ_Kv_KCTD cd18187
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 120-206 2.28e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins; This family includes two protein groups: voltage-gated potassium (Kv) channels and potassium channel tetramerization domain-containing (KCTD) proteins. Kv channels are membrane proteins with fundamental physiological roles. They are responsible for a variety of electrical phenomena, such as the repolarization of the action potential, spike frequency adaptation, synaptic repolarization, and smooth muscle contraction. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels, and others. All family members contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.


Pssm-ID: 349498  Cd Length: 83  Bit Score: 104.09  E-value: 2.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 120 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREhnFTRPNEKGEYEVAEgiSSTVFRAILDYYKSGIIRCPDGISIPEL 199
Cdd:cd18187     1 VVLNVSGTRFVTNRQTLTRHPDTLLGRMFKPGRE--FTFPNETGEYFIDR--DPTVFRTILNYYRTGKLNCPDGISIPDL 76


                  ....*..
gi 1207188997 200 REACDYL 206
Cdd:cd18187    77 REECDFY 83
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 120-208 1.54e-05

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 43.45  E-value: 1.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997  120 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFGSGREHnftrpnEKGEYEVaEGISSTVFRAILDYYKSGIIRCPDGiSIPEL 199
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKES------DKSEIYL-DDVSPEDFRALLNFLYTGKLDLPEE-NVEEL 73


                   ....*....
gi 1207188997  200 REACDYLCI 208
Cdd:smart00225  74 LELADYLQI 82
BTB_POZ_Kv cd18317
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 120-205 2.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.


Pssm-ID: 349626  Cd Length: 82  Bit Score: 42.21  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 120 VTLIVDNTRFVVDPSIFTAQPNTMLGRMfgSGREHNFTRPNEKGEYEVaegiSSTVFRAILDYYKSGIIRCPDGISIPEL 199
Cdd:cd18317     1 VVLNVGGTRFELSRSTLLRFPDTRLGKL--AKESHAYDESTNEYFFDR----NPEVFEAILDYYRTGELHLPSNVCPASF 74


                  ....*.
gi 1207188997 200 REACDY 205
Cdd:cd18317    75 KEELEF 80
BTB_2 pfam02214
BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific ...
 120-205 4.62e-05

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.


Pssm-ID: 426665 [Multi-domain]  Cd Length: 93  Bit Score: 41.81  E-value: 4.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 120 VTLIVDNTRFVVDPSIFTAQPNTMLGRMFgsGREHNFTRPnEKGEYEVAEgiSSTVFRAILDYYKSGI-IRCPDGISIPE 198
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLL--ELECDDYDD-DTNEYFFDR--SPKHFETILNFYRTGGkLHRPEEVCLDE 75


                  ....*..
gi 1207188997 199 LREACDY 205
Cdd:pfam02214  76 FLEEAEF 82
BTB_POZ_KCTD-like cd18316
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 127-205 1.98e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349625  Cd Length: 83  Bit Score: 37.15  E-value: 1.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207188997 127 TRFVVDPSIFTAQPNTMLGRMFGSGREHnftRPNEKGEYEvaegI--SSTVFRAILDYYKSGIIRCP-DGISIPEL-REA 202
Cdd:cd18316     8 TLFTTSRSTLLKDPDSLLAALFSGRWPL---PRDEDGSIF----IdrDPELFRHILNFLRTGKLPLPsDFVELEELlAEA 80


                  ...
gi 1207188997 203 CDY 205
Cdd:cd18316    81 EFY 83
BTB_POZ_KCTD8-like cd18367
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 134-202 7.45e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD8, KCTD12, KCTD16 and similar proteins; This subfamily of KCTD proteins includes KCTD8, KCTD12 (also called predominantly fetal expressed T1 domain/Pfetin), and KCTD16. They act as auxiliary subunits of GABAB receptors associated with mood disorders. KCTD8 interacts as a tetramer with GABRB1 and GABRB2. KCTD12 regulates agonist potency and kinetics of GABAB receptor signaling. It promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. KCTD16 interacts with amyloid beta precursor protein (APP), a type I transmembrane protein involved in a variety of cellular processes such as cell adhesion, and axon guidance. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.


Pssm-ID: 349676  Cd Length: 100  Bit Score: 35.73  E-value: 7.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207188997 134 SIFTAQPNTMLGRMFGSGREHNFTRPNeKGEYEV-AEGIsstVFRAILDYYKSGIIRCPDGisIPE----LREA 202
Cdd:cd18367    19 STLIKDPDSLLGRMFSGKNRQELARDS-KGRYFLdRDGV---LFRYILDYLRNQKLVLPEN--FPErerlKREA 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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