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Conserved domains on  [gi|1207171070|ref|XP_021330594|]
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voltage-dependent L-type calcium channel subunit alpha-1C isoform X16 [Danio rerio]

Protein Classification

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type calcium channel subunit alpha-1; voltage-dependent L-type calcium channel subunit alpha-1( domain architecture ID 11999372)

Ca_chan_IQ domain-containing protein; Ca_chan_IQ domain-containing protein; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death; voltage-dependent L-type (Long-lasting) calcium channel subunit alpha-1 is part of a multisubunit voltage-dependent calcium channel that mediates the entry of calcium ions into excitable cells and is also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1252-1510 5.47e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 226.76  E-value: 5.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1252 STYFEYLMFTLILLNTICLAMQHHGQSQS-FNKAMNILNMLFTGLFTVEMILKLIAFKP-RHYFVDAWNTFDALIVVGSV 1329
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1330 VDIAITEVNGLqntednarISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG 1409
Cdd:pfam00520   81 ISLVLSSVGSL--------SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1410 KIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACspnrpcekgseinhsSEDCGSHFAIFYFVSFYMLCAFL 1489
Cdd:pfam00520  153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDT---------------IDGKGEFWAYIYFVSFIILGGFL 217

                          250       260
                   ....*....|....*....|.
gi 1207171070 1490 IINLFVAVIMDNFDYLTRDWS 1510
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 156-452 9.39e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.99  E-value: 9.39e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  156 WKPFEIIILMTIFANCVALAVYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHpnaYLRNGWNLLDFII 235
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  236 VVVGLFSAILEqatkgdggtsmgGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 315
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  316 AIIGLELFMGKMHRtcffykdghkghiaeekpapcapssahgrhcsppnitqcmmgWEGPNDGITNFDNFAFAMLTVFQC 395
Cdd:pfam00520  144 AIIGYQLFGGKLKT------------------------------------------WENPDNGRTNFDNFPNAFLWLFQT 181

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070  396 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 452
Cdd:pfam00520  182 MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 559-798 8.56e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.16  E-value: 8.56e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  559 SNVFYWLVIFLVFLNTLTIASEHHQQPEW-LTNVQDIANKVLLALFTGEMLLKMYSLGL-QAYFVSLFNRFDSFVVCGGI 636
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  637 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 716
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  717 ET---RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 793
Cdd:pfam00520  159 ENpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233


                   ....*
gi 1207171070  794 ESLTS 798
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 933-1210 4.48e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 166.67  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  933 HNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHkgsFCRNYFNILDLVVVS 1012
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1013 VSLISSGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFfy 1091
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1092 ctdtskqtqaecrgayilykdgnvgkpeKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYn 1171
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1207171070 1172 yrvvisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1210
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1582-1656 2.20e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.72  E-value: 2.20e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070 1582 NATLFALVRTALRIKTE--GNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1656
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C super family cl25181
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
 1676-2110 4.35e-32

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


The actual alignment was detected with superfamily member pfam16885:

Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 130.13  E-value: 4.35e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1676 AGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDifrrsgglfgnhvnyyhqsdghvsfPQSFTTQRPLHIS 1755
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-------------------------KAPIGSQPPSRSR 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1756 KSGSpgeaeSPSHQKLVDStftpssysssgsnaninnanntaighryPKPTVSTVDGqtGPPLTTIPLPRPTWCFPNKRS 1835
Cdd:pfam16885   56 ISVS-----LPVGDRLPDS----------------------------LSLGPSDDDG--GAPNSRQPSVPQTGSHTHRRS 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1836 CFYDTFMRSDSSDSRLPIIRREEAStdetydetflDERDQAMLSMDMLefQDEESKQLAPMVEAEVGEERRPWQSP-RRR 1914
Cdd:pfam16885  101 SGVLMFTIPEEGSSQPKGTKGQDKQ----------DEEEEVPDQLSYL--DEQAGTPSRPVLLPPHRPQHYPLREPvDRR 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1915 AFLCPTALGRRSSFHLECLRKHNRPDvsqktALPLHLVHHQAlavaGLSPLLRRSHSPTlftrlcsTPPASpsgrsgGGP 1994
Cdd:pfam16885  169 RLLPPTPAGRKPSFNIQCLRRQGSCE-----DLPIPGTYHRG----RNSGPSRAQGSWA-------TPPQR------GRL 226

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1995 CYQPVpSLRLEGSGSyeklnssmpsvncSSWYsdsnGNHSGRAQRPVSLTVPPvTRRDSISLAHGSAGSLVEAVLISEGL 2074
Cdd:pfam16885  227 LYAPL-LLVEEGAAG-------------EGYL----GKSPGPLRTFTCLRVPG-THSDPSHGKRGSADSLVEAVLISEGL 287

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1207171070 2075 GRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNIL 2110
Cdd:pfam16885  288 GLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLL 323
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1519-1572 9.48e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207171070 1519 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1572
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1252-1510 5.47e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 226.76  E-value: 5.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1252 STYFEYLMFTLILLNTICLAMQHHGQSQS-FNKAMNILNMLFTGLFTVEMILKLIAFKP-RHYFVDAWNTFDALIVVGSV 1329
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1330 VDIAITEVNGLqntednarISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG 1409
Cdd:pfam00520   81 ISLVLSSVGSL--------SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1410 KIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACspnrpcekgseinhsSEDCGSHFAIFYFVSFYMLCAFL 1489
Cdd:pfam00520  153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDT---------------IDGKGEFWAYIYFVSFIILGGFL 217

                          250       260
                   ....*....|....*....|.
gi 1207171070 1490 IINLFVAVIMDNFDYLTRDWS 1510
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 156-452 9.39e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.99  E-value: 9.39e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  156 WKPFEIIILMTIFANCVALAVYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHpnaYLRNGWNLLDFII 235
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  236 VVVGLFSAILEqatkgdggtsmgGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 315
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  316 AIIGLELFMGKMHRtcffykdghkghiaeekpapcapssahgrhcsppnitqcmmgWEGPNDGITNFDNFAFAMLTVFQC 395
Cdd:pfam00520  144 AIIGYQLFGGKLKT------------------------------------------WENPDNGRTNFDNFPNAFLWLFQT 181

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070  396 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 452
Cdd:pfam00520  182 MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 559-798 8.56e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.16  E-value: 8.56e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  559 SNVFYWLVIFLVFLNTLTIASEHHQQPEW-LTNVQDIANKVLLALFTGEMLLKMYSLGL-QAYFVSLFNRFDSFVVCGGI 636
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  637 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 716
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  717 ET---RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 793
Cdd:pfam00520  159 ENpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233


                   ....*
gi 1207171070  794 ESLTS 798
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 933-1210 4.48e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 166.67  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  933 HNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHkgsFCRNYFNILDLVVVS 1012
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1013 VSLISSGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFfy 1091
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1092 ctdtskqtqaecrgayilykdgnvgkpeKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYn 1171
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1207171070 1172 yrvvisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1210
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1582-1656 2.20e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.72  E-value: 2.20e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070 1582 NATLFALVRTALRIKTE--GNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1656
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
 1676-2110 4.35e-32

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 130.13  E-value: 4.35e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1676 AGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDifrrsgglfgnhvnyyhqsdghvsfPQSFTTQRPLHIS 1755
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-------------------------KAPIGSQPPSRSR 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1756 KSGSpgeaeSPSHQKLVDStftpssysssgsnaninnanntaighryPKPTVSTVDGqtGPPLTTIPLPRPTWCFPNKRS 1835
Cdd:pfam16885   56 ISVS-----LPVGDRLPDS----------------------------LSLGPSDDDG--GAPNSRQPSVPQTGSHTHRRS 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1836 CFYDTFMRSDSSDSRLPIIRREEAStdetydetflDERDQAMLSMDMLefQDEESKQLAPMVEAEVGEERRPWQSP-RRR 1914
Cdd:pfam16885  101 SGVLMFTIPEEGSSQPKGTKGQDKQ----------DEEEEVPDQLSYL--DEQAGTPSRPVLLPPHRPQHYPLREPvDRR 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1915 AFLCPTALGRRSSFHLECLRKHNRPDvsqktALPLHLVHHQAlavaGLSPLLRRSHSPTlftrlcsTPPASpsgrsgGGP 1994
Cdd:pfam16885  169 RLLPPTPAGRKPSFNIQCLRRQGSCE-----DLPIPGTYHRG----RNSGPSRAQGSWA-------TPPQR------GRL 226

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1995 CYQPVpSLRLEGSGSyeklnssmpsvncSSWYsdsnGNHSGRAQRPVSLTVPPvTRRDSISLAHGSAGSLVEAVLISEGL 2074
Cdd:pfam16885  227 LYAPL-LLVEEGAAG-------------EGYL----GKSPGPLRTFTCLRVPG-THSDPSHGKRGSADSLVEAVLISEGL 287

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1207171070 2075 GRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNIL 2110
Cdd:pfam16885  288 GLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLL 323
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1519-1572 9.48e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207171070 1519 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1572
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1634-1662 6.02e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 64.55  E-value: 6.02e-13
                            10        20
                    ....*....|....*....|....*....
gi 1207171070  1634 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1662
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQEL 29
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1252-1510 5.47e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 226.76  E-value: 5.47e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1252 STYFEYLMFTLILLNTICLAMQHHGQSQS-FNKAMNILNMLFTGLFTVEMILKLIAFKP-RHYFVDAWNTFDALIVVGSV 1329
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1330 VDIAITEVNGLqntednarISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFG 1409
Cdd:pfam00520   81 ISLVLSSVGSL--------SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1410 KIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACspnrpcekgseinhsSEDCGSHFAIFYFVSFYMLCAFL 1489
Cdd:pfam00520  153 GKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDT---------------IDGKGEFWAYIYFVSFIILGGFL 217

                          250       260
                   ....*....|....*....|.
gi 1207171070 1490 IINLFVAVIMDNFDYLTRDWS 1510
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 156-452 9.39e-67

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 225.99  E-value: 9.39e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  156 WKPFEIIILMTIFANCVALAVYIPFPEDDSnaTNSNLERVEYLFLIIFTVEAFLKVIAYGLLCHpnaYLRNGWNLLDFII 235
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEP--LTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  236 VVVGLFSAILEqatkgdggtsmgGKAAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIY 315
Cdd:pfam00520   76 VLPSLISLVLS------------SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIF 143

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  316 AIIGLELFMGKMHRtcffykdghkghiaeekpapcapssahgrhcsppnitqcmmgWEGPNDGITNFDNFAFAMLTVFQC 395
Cdd:pfam00520  144 AIIGYQLFGGKLKT------------------------------------------WENPDNGRTNFDNFPNAFLWLFQT 181

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070  396 ITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAK 452
Cdd:pfam00520  182 MTTEGWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 559-798 8.56e-51

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 180.16  E-value: 8.56e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  559 SNVFYWLVIFLVFLNTLTIASEHHQQPEW-LTNVQDIANKVLLALFTGEMLLKMYSLGL-QAYFVSLFNRFDSFVVCGGI 636
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  637 LEtiLVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD 716
Cdd:pfam00520   81 IS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  717 ET---RRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGgpsfpGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 793
Cdd:pfam00520  159 ENpdnGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQEL 233


                   ....*
gi 1207171070  794 ESLTS 798
Cdd:pfam00520  234 TERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 933-1210 4.48e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 166.67  E-value: 4.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070  933 HNIFTNLILFFILLSSISLAAEDPVKNDSFRNQILGYADYVFTGIFTIEIILKMTAYGAFLHkgsFCRNYFNILDLVVVS 1012
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1013 VSLISSGIQS-SAINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFfy 1091
Cdd:pfam00520   78 PSLISLVLSSvGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1092 ctdtskqtqaecrgayilykdgnvgkpeKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYn 1171
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEFWAYIY- 206

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1207171070 1172 yrvvisifFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQE 1210
Cdd:pfam00520  207 --------FVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1582-1656 2.20e-36

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 132.72  E-value: 2.20e-36
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207171070 1582 NATLFALVRTALRIKTE--GNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKK 1656
Cdd:pfam08763    1 TATLFALIRTSLKIKLApaGEMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
CAC1F_C pfam16885
Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of ...
 1676-2110 4.35e-32

Voltage-gated calcium channel subunit alpha, C-term; CAC1F_C is the C-terminal region of voltage-gated calcium channel subunit alpha in higher eukaryotes. The exact function of this domain is not known.This region lies immediately downstream from the CDB motif, pfam08673.


Pssm-ID: 465298 [Multi-domain]  Cd Length: 355  Bit Score: 130.13  E-value: 4.35e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1676 AGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDifrrsgglfgnhvnyyhqsdghvsfPQSFTTQRPLHIS 1755
Cdd:pfam16885    1 AGLRSLQDLGPEIRQALTCDTEEEEEEEEGQEGEEEEDSKDP-------------------------KAPIGSQPPSRSR 55

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1756 KSGSpgeaeSPSHQKLVDStftpssysssgsnaninnanntaighryPKPTVSTVDGqtGPPLTTIPLPRPTWCFPNKRS 1835
Cdd:pfam16885   56 ISVS-----LPVGDRLPDS----------------------------LSLGPSDDDG--GAPNSRQPSVPQTGSHTHRRS 100

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1836 CFYDTFMRSDSSDSRLPIIRREEAStdetydetflDERDQAMLSMDMLefQDEESKQLAPMVEAEVGEERRPWQSP-RRR 1914
Cdd:pfam16885  101 SGVLMFTIPEEGSSQPKGTKGQDKQ----------DEEEEVPDQLSYL--DEQAGTPSRPVLLPPHRPQHYPLREPvDRR 168

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1915 AFLCPTALGRRSSFHLECLRKHNRPDvsqktALPLHLVHHQAlavaGLSPLLRRSHSPTlftrlcsTPPASpsgrsgGGP 1994
Cdd:pfam16885  169 RLLPPTPAGRKPSFNIQCLRRQGSCE-----DLPIPGTYHRG----RNSGPSRAQGSWA-------TPPQR------GRL 226

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1995 CYQPVpSLRLEGSGSyeklnssmpsvncSSWYsdsnGNHSGRAQRPVSLTVPPvTRRDSISLAHGSAGSLVEAVLISEGL 2074
Cdd:pfam16885  227 LYAPL-LLVEEGAAG-------------EGYL----GKSPGPLRTFTCLRVPG-THSDPSHGKRGSADSLVEAVLISEGL 287

                          410       420       430
                   ....*....|....*....|....*....|....*.
gi 1207171070 2075 GRYAHDPSFIQVAKQEIAEACDMTMEEMENAADNIL 2110
Cdd:pfam16885  288 GLFAQDPKFVALAKQEIADACHLTLDEMDSAASDLL 323
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1519-1572 9.48e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 115.83  E-value: 9.48e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207171070 1519 EFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMP 1572
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1634-1662 6.02e-13

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 64.55  E-value: 6.02e-13
                            10        20
                    ....*....|....*....|....*....
gi 1207171070  1634 DEVTVGKFYATFLIQEYFRKFKKRKEQGL 1662
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQEL 29
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1291-1503 6.14e-09

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 58.44  E-value: 6.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1291 LFTGLFTVEMILKlIAFKPRHYFVDAWNTFDALIVVGSVVDIAI-----TEVNGL-QNTEDNARISITFFRLFRV----- 1359
Cdd:pfam08016   19 VFFLYFVVEEILK-IRKHRPSYLRSVWNLLDLAIVILSVVLIVLniyrdFLADRLiKSVEASPVTFIDFDRVAQLdnlyr 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207171070 1360 -----------MRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGkialrdnsqiNRNNNFQTF 1428
Cdd:pfam08016   98 iilaflvfltwLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG----------TQAPNFSNF 167

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207171070 1429 PQAVLLLFRcatgeawqeIMLacspnrpcekGSEINHSSEDCGSHFAIFYFVSFYMLCAFLIINLFVAVIMDNFD 1503
Cdd:pfam08016  168 VKSILTLFR---------TIL----------GDFGYNEIFSGNRVLGPLLFLTFVFLVIFILLNLFLAIINDSYV 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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