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Conserved domains on  [gi|1207175029|ref|XP_021331688|]
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leucine-rich repeat and WD repeat-containing protein 1 isoform X2 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-101 7.57e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 97
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                  ....
gi 1207175029  98 LEDN 101
Cdd:COG4886   257 LSNN 260
WD40 super family cl43672
WD40 repeat [General function prediction only];
394-582 4.66e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 394 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 463
Cdd:COG2319    98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 464 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 543
Cdd:COG2319   173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1207175029 544 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 582
Cdd:COG2319   239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-101 7.57e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 97
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                  ....
gi 1207175029  98 LEDN 101
Cdd:COG4886   257 LSNN 260
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-130 2.41e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  43 LSKLCRLEKLDLSGN------------ML-------QKIPKGLRL-----------PCLKILNCSNNDMEDVLSLEALTN 92
Cdd:cd21340    64 LENLVNLKKLYLGGNrisvveglenltNLeelhienQRLPPGEKLtfdprslaalsNSLRVLNISGNNIDSLEPLAPLRN 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207175029  93 LEELRLEDNL---------------YLT--------VNDEHK----VIFLLPNLRMFNGKDISST 130
Cdd:cd21340   144 LEQLDASNNQisdleelldllsswpSLReldltgnpVCKKPKyrdkIILASKSLEVLDGKEITDT 208
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 69-105 3.13e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 3.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1207175029  69 PCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLT 105
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT 37
WD40 COG2319
WD40 repeat [General function prediction only];
394-582 4.66e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 394 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 463
Cdd:COG2319    98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 464 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 543
Cdd:COG2319   173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1207175029 544 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 582
Cdd:COG2319   239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-101 7.57e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.57e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLksEDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDVLSLEALTNLEELR 97
Cdd:COG4886   180 NLTNLKELDLSNNQI--TDLPEPL-GNLTNLEELDLSGNQLTDLPEPLaNLTNLETLDLSNNQLTDLPELGNLTNLEELD 256


                  ....
gi 1207175029  98 LEDN 101
Cdd:COG4886   257 LSNN 260
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-101 2.04e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 2.04e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLKseDLPVPLlSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDVLSLEALTNLEELRL 98
Cdd:COG4886   203 NLTNLEELDLSGNQLT--DLPEPL-ANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDL 279


                  ...
gi 1207175029  99 EDN 101
Cdd:COG4886   280 SNN 282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-130 2.41e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  43 LSKLCRLEKLDLSGN------------ML-------QKIPKGLRL-----------PCLKILNCSNNDMEDVLSLEALTN 92
Cdd:cd21340    64 LENLVNLKKLYLGGNrisvveglenltNLeelhienQRLPPGEKLtfdprslaalsNSLRVLNISGNNIDSLEPLAPLRN 143

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207175029  93 LEELRLEDNL---------------YLT--------VNDEHK----VIFLLPNLRMFNGKDISST 130
Cdd:cd21340   144 LEQLDASNNQisdleelldllsswpSLReldltgnpVCKKPKyrdkIILASKSLEVLDGKEITDT 208
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
3-123 7.31e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 7.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029   3 KITEKILLEKSSTKTNKLDQIKTLNLSRMslksedlpvPLLSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDM 81
Cdd:COG4886    78 SLLLLSLLLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELaNLTNLKELDLSNNQL 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1207175029  82 EDV-LSLEALTNLEELRLEDNLYLTVNDEhkvIFLLPNLRMFN 123
Cdd:COG4886   149 TDLpEPLGNLTNLKSLDLSNNQLTDLPEE---LGNLTNLKELD 188
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-101 7.51e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 7.51e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLKseDLPVPLlSKLCRLEKLDLSGNMLQKIPKGL-RLPCLKILNCSNNDMEDV-LSLEALTNLEEL 96
Cdd:COG4886   157 NLTNLKSLDLSNNQLT--DLPEEL-GNLTNLKELDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLpEPLANLTNLETL 233


                  ....*
gi 1207175029  97 RLEDN 101
Cdd:COG4886   234 DLSNN 238
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-119 2.51e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  19 KLDQIKTLNLSRMSLKSedlpVPLLSKLCRLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMEDvLSLEALTNLEELRL 98
Cdd:COG4886   226 NLTNLETLDLSNNQLTD----LPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD-LKLKELELLLGLNS 300

                          90       100
                  ....*....|....*....|.
gi 1207175029  99 EDNLYLTVNDEHKVIFLLPNL 119
Cdd:COG4886   301 LLLLLLLLNLLELLILLLLLT 321
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 69-105 3.13e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 3.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1207175029  69 PCLKILNCSNNDMEDVLSLEALTNLEELRLEDNLYLT 105
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNKIT 37
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 48-92 6.73e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 6.73e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1207175029  48 RLEKLDLSGNMLQKIPKGLRLPCLKILNCSNNDMedVLSLEALTN 92
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
WD40 COG2319
WD40 repeat [General function prediction only];
394-582 4.66e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 4.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 394 DDFSTQLWACA-------FEPQQDD--SIDISGGSQTIATCGG-ETLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsR 463
Cdd:COG2319    98 ADGTVRLWDLAtglllrtLTGHTGAvrSVAFSPDGKTLASGSAdGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-----P 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 464 TGgsarpcNILAAGGKRGCVKLIHPRVNLAFGEFRVSRRAISIMRFNPRKpTFLFTGTYDKKIFLWDIGGLDQdynfkis 543
Cdd:COG2319   173 DG------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKL------- 238

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1207175029 544 kLLTLET-SSTPLHLALlpsSPD-THLLSGCDEG-LYCFDVQ 582
Cdd:COG2319   239 -LRTLTGhSGSVRSVAF---SPDgRLLASGSADGtVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
412-533 1.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 412 SIDISGGSQTIATCGGE-TLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsRTGgsarpcNILAAGGKRGCVKLIHPRV 490
Cdd:COG2319   293 SVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFS-----PDG------KTLASGSDDGTVRLWDLAT 361

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1207175029 491 NLAFGEFRVSRRAISIMRFNPRKPTfLFTGTYDKKIFLWDIGG 533
Cdd:COG2319   362 GELLRTLTGHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
412-575 1.38e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 412 SIDISGGSQTIATCGGE-TLCVINCESGLVLKKYKVPGEDFFSLAWStvlmsRTGgsarpcNILAAGGKRGCVKLIHPRV 490
Cdd:COG2319   251 SVAFSPDGRLLASGSADgTVRLWDLATGELLRTLTGHSGGVNSVAFS-----PDG------KLLASGSDDGTVRLWDLAT 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029 491 NLAFGEFRVSRRAISIMRFNPrKPTFLFTGTYDKKIFLWDIGGLDQdynfkiskLLTLETSSTPLH-LALlpsSPD-THL 568
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGEL--------LRTLTGHTGAVTsVAF---SPDgRTL 387


                  ....*..
gi 1207175029 569 LSGCDEG 575
Cdd:COG2319   388 ASGSADG 394
LRR_9 pfam14580
Leucine-rich repeat;
20-127 3.49e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.98  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175029  20 LDQIKTLNLSRMSLKSEDlPVPLLSklcRLEKLDLSGNMLQKIPKGLR--LPCLKILNCSNNDME---DVLSLEALTNLE 94
Cdd:pfam14580  41 LDQFDTIDFSDNEIRKLD-GFPLLR---RLKTLLLNNNRICRIGEGLGeaLPNLTELILTNNNLQelgDLDPLASLKKLT 116

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207175029  95 ELRLEDNlyLTVNDEH---KVIFLLPNLRMFNGKDI 127
Cdd:pfam14580 117 FLSLLRN--PVTNKPHyrlYVIYKVPQLRLLDFRKV 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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