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Conserved domains on  [gi|1207175604|ref|XP_021331885|]
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snRNA-activating protein complex subunit 4 isoform X2 [Danio rerio]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 10412639)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677|GO:0006355|GO:0003700
PubMed:  8882580|15040448|16877755
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 430-470 2.81e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


:

Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 2.81e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207175604  430 PWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRY 470
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERW 41
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 376-439 8.08e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 58.86  E-value: 8.08e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207175604  376 WTEEEDDLLRELVEKM-----RIGNFIPYiqmshfmvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLL 439
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYgndwkQIAKELGR---------RTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
PLN03091 super family cl33633
hypothetical protein; Provisional
 426-539 9.17e-11

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 66.15  E-value: 9.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  426 LKKGPWSKEEDQLLRNAVAKYGTREWgrirTEVPG-----RTDSACRDRYLDCLRETVKKGTWSYAEMELLKEKVAKYGv 500
Cdd:PLN03091    12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKqaglqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  501 GKWAKIASEIPNRVDAQ-------CLHKwKLMTRSKKP-LKRPLSSI 539
Cdd:PLN03091    87 NRWSQIAAQLPGRTDNEiknlwnsCLKK-KLRQRGIDPnTHKPLSEV 132
SANT super family cl21498
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 316-369 1.25e-04

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


The actual alignment was detected with superfamily member cd11659:

Pssm-ID: 473887 [Multi-domain]  Cd Length: 53  Bit Score: 41.14  E-value: 1.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207175604  316 PSINKSVWKQDEIYKLQAVAEEFKmCHWDKIAEALGtnRTAFMCFQTYQRYISK 369
Cdd:cd11659      1 PSIKKTEWTREEDEKLLHLAKLLP-TQWRTIAPIVG--RTAQQCLERYNKLLDE 51
 
Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 430-470 2.81e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 2.81e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207175604  430 PWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRY 470
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERW 41
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
428-470 4.69e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 4.69e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207175604   428 KGPWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRY 470
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERW 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 428-474 2.07e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.91  E-value: 2.07e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  428 KGPWSKEEDQLLRNAVAKYGTReWGRIRTEVPGRTDSACRDRYLDCL 474
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGNR-WKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 376-439 8.08e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 58.86  E-value: 8.08e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207175604  376 WTEEEDDLLRELVEKM-----RIGNFIPYiqmshfmvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLL 439
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYgndwkQIAKELGR---------RTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
PLN03091 PLN03091
hypothetical protein; Provisional
 426-539 9.17e-11

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 66.15  E-value: 9.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  426 LKKGPWSKEEDQLLRNAVAKYGTREWgrirTEVPG-----RTDSACRDRYLDCLRETVKKGTWSYAEMELLKEKVAKYGv 500
Cdd:PLN03091    12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKqaglqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  501 GKWAKIASEIPNRVDAQ-------CLHKwKLMTRSKKP-LKRPLSSI 539
Cdd:PLN03091    87 NRWSQIAAQLPGRTDNEiknlwnsCLKK-KLRQRGIDPnTHKPLSEV 132
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
480-523 7.44e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 55.69  E-value: 7.44e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207175604   480 KGTWSYAEMELLKEKVAKYGVGKWAKIASEIPNRVDAQCLHKWK 523
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWR 44
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 482-525 1.79e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 1.79e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1207175604  482 TWSYAEMELLKEKVAKYGVGKWAKIASEIPNRVDAQCLHKWKLM 525
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNL 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 376-592 1.99e-09

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 62.11  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  376 WTEEEDDLLRELVEKmrignfIPYIQMSHF---MVGRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTReWG 452
Cdd:COG5147     23 WKRTEDEDLKALVKK------LGPNNWSKVaslLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ-WS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  453 RIRTEVPGRTDSACRDRYLDCLRETVKK-GTWSYAEMELLKEKVAKYGvgkWAKIASEIPNRVDAQCLHKW----KLMTR 527
Cdd:COG5147     96 TIADYKDRRTAQQCVERYVNTLEDLSSThDSKLQRRNEFDKIDPFNEN---SARRPDIYEDELLEREVNREasyrLRVPR 172

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207175604  528 SKKPLKRPLSSIttsYPRNKRQKLLKTVKEemfFNSSSDDESQINYMNSDESDDLAEDENLEIPQ 592
Cdd:COG5147    173 VSKADVKPREKG---EENNPDIEDLQEMKE---LKSASITRHLILPSKSEINKAFKKGETLALEQ 231
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 480-522 2.50e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 54.05  E-value: 2.50e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207175604  480 KGTWSYAEMELLKEKVAKYGvGKWAKIASEIPNRVDAQCLHKW 522
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRW 42
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 372-478 1.53e-06

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 51.23  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  372 RRTHWTEEEDDLLRELVEKMRIGNFIPYIQMSHFMvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTReW 451
Cdd:PLN03212    24 KRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR-W 100

                           90       100
                   ....*....|....*....|....*..
gi 1207175604  452 GRIRTEVPGRTDSACRDRYLDCLRETV 478
Cdd:PLN03212   101 SLIAGRIPGRTDNEIKNYWNTHLRKKL 127
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
373-424 5.39e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 5.39e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1207175604   373 RTHWTEEEDDLLRELVEKMRIGNFipyIQMSHFMVGRDGSQLAYRWTSVLDP 424
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNW---EKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 376-422 2.79e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.56  E-value: 2.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1207175604  376 WTEEEDDLLRELVEKMRIGNF--IpyiqmSHFMVGRDGSQLAYRWTSVL 422
Cdd:cd00167      2 WTEEEDELLLEAVKKYGKNNWekI-----AKELPGRTPKQCRERWRNLL 45
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 316-369 1.25e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.14  E-value: 1.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207175604  316 PSINKSVWKQDEIYKLQAVAEEFKmCHWDKIAEALGtnRTAFMCFQTYQRYISK 369
Cdd:cd11659      1 PSIKKTEWTREEDEKLLHLAKLLP-TQWRTIAPIVG--RTAQQCLERYNKLLDE 51
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 323-384 1.21e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.45  E-value: 1.21e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207175604  323 WKQDEIYKLQAVAEEFKMcHWDKIAEALGtNRTAFMCFQTYQRYISKTFRRTHWTEEEDDLL 384
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGN-DWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
320-369 9.80e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 35.66  E-value: 9.80e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1207175604   320 KSVWKQDEIYKLQAVAEEFKMCHWDKIAEALGtNRTAFMCFQTYQRYISK 369
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
 
Name Accession Description Interval E-value
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 430-470 2.81e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 65.29  E-value: 2.81e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207175604  430 PWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRY 470
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERW 41
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
428-470 4.69e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 64.94  E-value: 4.69e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207175604   428 KGPWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRY 470
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERW 43
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 428-474 2.07e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 62.91  E-value: 2.07e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  428 KGPWSKEEDQLLRNAVAKYGTReWGRIRTEVPGRTDSACRDRYLDCL 474
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLGNR-WKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 376-439 8.08e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 58.86  E-value: 8.08e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207175604  376 WTEEEDDLLRELVEKM-----RIGNFIPYiqmshfmvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLL 439
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYgndwkQIAKELGR---------RTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
PLN03091 PLN03091
hypothetical protein; Provisional
 426-539 9.17e-11

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 66.15  E-value: 9.17e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  426 LKKGPWSKEEDQLLRNAVAKYGTREWgrirTEVPG-----RTDSACRDRYLDCLRETVKKGTWSYAEMELLKEKVAKYGv 500
Cdd:PLN03091    12 LRKGLWSPEEDEKLLRHITKYGHGCW----SSVPKqaglqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLG- 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  501 GKWAKIASEIPNRVDAQ-------CLHKwKLMTRSKKP-LKRPLSSI 539
Cdd:PLN03091    87 NRWSQIAAQLPGRTDNEiknlwnsCLKK-KLRQRGIDPnTHKPLSEV 132
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
480-523 7.44e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 55.69  E-value: 7.44e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207175604   480 KGTWSYAEMELLKEKVAKYGVGKWAKIASEIPNRVDAQCLHKWK 523
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWR 44
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 426-582 9.93e-10

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 60.86  E-value: 9.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  426 LKKGPWSKEEDQLLRNAVAKYGTREWgRIRTEVPG--RTDSACRDRYLDCLRETVKKGTWSYAEMELLKeKVAKYGVGKW 503
Cdd:PLN03212    23 MKRGPWTVEEDEILVSFIKKEGEGRW-RSLPKRAGllRCGKSCRLRWMNYLRPSVKRGGITSDEEDLIL-RLHRLLGNRW 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  504 AKIASEIPNRVDAQCLHKW------KLMTRSKKP-LKRPLSSITTSYPRNKRQKLLKTVKEEMffNSSSDDESQINYMNS 576
Cdd:PLN03212   101 SLIAGRIPGRTDNEIKNYWnthlrkKLLRQGIDPqTHKPLDANNIHKPEEEVSGGQKYPIEPI--SSSHTDDTTVNGGDG 178


                   ....*.
gi 1207175604  577 DESDDL 582
Cdd:PLN03212   179 DSKNSI 184
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 482-525 1.79e-09

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 54.50  E-value: 1.79e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1207175604  482 TWSYAEMELLKEKVAKYGVGKWAKIASEIPNRVDAQCLHKWKLM 525
Cdd:cd00167      1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNL 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 376-592 1.99e-09

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 62.11  E-value: 1.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  376 WTEEEDDLLRELVEKmrignfIPYIQMSHF---MVGRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTReWG 452
Cdd:COG5147     23 WKRTEDEDLKALVKK------LGPNNWSKVaslLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ-WS 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  453 RIRTEVPGRTDSACRDRYLDCLRETVKK-GTWSYAEMELLKEKVAKYGvgkWAKIASEIPNRVDAQCLHKW----KLMTR 527
Cdd:COG5147     96 TIADYKDRRTAQQCVERYVNTLEDLSSThDSKLQRRNEFDKIDPFNEN---SARRPDIYEDELLEREVNREasyrLRVPR 172

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207175604  528 SKKPLKRPLSSIttsYPRNKRQKLLKTVKEemfFNSSSDDESQINYMNSDESDDLAEDENLEIPQ 592
Cdd:COG5147    173 VSKADVKPREKG---EENNPDIEDLQEMKE---LKSASITRHLILPSKSEINKAFKKGETLALEQ 231
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 431-491 2.29e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 54.62  E-value: 2.29e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207175604  431 WSKEEDQLLRNAVAKYGtREWGRIRTEVPGRTDSACRDRYLDCLRETVKKGTWSYAEMELL 491
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 480-522 2.50e-09

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 54.05  E-value: 2.50e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207175604  480 KGTWSYAEMELLKEKVAKYGvGKWAKIASEIPNRVDAQCLHKW 522
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRW 42
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 426-583 3.74e-08

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 57.88  E-value: 3.74e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  426 LKKGPWSKEEDQLLRNAVAKYGTREWGRIRTEVPGRTDSACRDRYLDCLRETVKKGTWSYAEMELLKEKVAKYGVgKWAK 505
Cdd:COG5147     18 RKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGT-QWST 96

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207175604  506 IASEIPNRVDAQCLHKWklmTRSKKPLkrplssitTSYPRNKRQKLLKTVKEEMF-FNSSSDDESQINYMNSDESDDLA 583
Cdd:COG5147     97 IADYKDRRTAQQCVERY---VNTLEDL--------SSTHDSKLQRRNEFDKIDPFnENSARRPDIYEDELLEREVNREA 164
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 483-527 4.14e-07

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 47.95  E-value: 4.14e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1207175604  483 WSYAEMELLKEKVAKYGVGKWAKI---ASEIPNRVDAQCLHKWKLMTR 527
Cdd:cd11660      3 WTDEEDEALVEGVEKYGVGNWAKIlkdYFFVNNRTSVDLKDKWRNLKK 50
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 372-478 1.53e-06

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 51.23  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  372 RRTHWTEEEDDLLRELVEKMRIGNFIPYIQMSHFMvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTReW 451
Cdd:PLN03212    24 KRGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNR-W 100

                           90       100
                   ....*....|....*....|....*..
gi 1207175604  452 GRIRTEVPGRTDSACRDRYLDCLRETV 478
Cdd:PLN03212   101 SLIAGRIPGRTDNEIKNYWNTHLRKKL 127
PLN03091 PLN03091
hypothetical protein; Provisional
 372-480 4.90e-06

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 51.13  E-value: 4.90e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207175604  372 RRTHWTEEEDDLLRELVEKMRIGNFIPYIQMSHFMvgRDGSQLAYRWTSVLDPSLKKGPWSKEEDQLLRNAVAKYGTReW 451
Cdd:PLN03091    13 RKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAGLQ--RCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNR-W 89

                           90       100
                   ....*....|....*....|....*....
gi 1207175604  452 GRIRTEVPGRTDSACRDRYLDCLRETVKK 480
Cdd:PLN03091    90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQ 118
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
373-424 5.39e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 44.91  E-value: 5.39e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1207175604   373 RTHWTEEEDDLLRELVEKMRIGNFipyIQMSHFMVGRDGSQLAYRWTSVLDP 424
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNW---EKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 376-422 2.79e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 42.56  E-value: 2.79e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1207175604  376 WTEEEDDLLRELVEKMRIGNF--IpyiqmSHFMVGRDGSQLAYRWTSVL 422
Cdd:cd00167      2 WTEEEDELLLEAVKKYGKNNWekI-----AKELPGRTPKQCRERWRNLL 45
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 424-470 3.26e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 42.68  E-value: 3.26e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  424 PSLKKGPWSKEEDQLLRNAVAKYGTReWGRIrTEVPGRTDSACRDRY 470
Cdd:cd11659      1 PSIKKTEWTREEDEKLLHLAKLLPTQ-WRTI-APIVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 430-470 3.27e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 42.55  E-value: 3.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1207175604  430 PWSKEEDQLLRNAVAKYGTREWGRIR---TEVPGRTDSACRDRY 470
Cdd:cd11660      2 KWTDEEDEALVEGVEKYGVGNWAKILkdyFFVNNRTSVDLKDKW 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 483-529 1.02e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 41.53  E-value: 1.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207175604  483 WSYAEMELLKEKVAKYGvGKWAKIASEIPNRVDAQCLHKWKLMTRSK 529
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPK 46
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 316-369 1.25e-04

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.14  E-value: 1.25e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207175604  316 PSINKSVWKQDEIYKLQAVAEEFKmCHWDKIAEALGtnRTAFMCFQTYQRYISK 369
Cdd:cd11659      1 PSIKKTEWTREEDEKLLHLAKLLP-TQWRTIAPIVG--RTAQQCLERYNKLLDE 51
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 323-384 1.21e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 38.45  E-value: 1.21e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207175604  323 WKQDEIYKLQAVAEEFKMcHWDKIAEALGtNRTAFMCFQTYQRYISKTFRRTHWTEEEDDLL 384
Cdd:pfam13921    1 WTEEEDEKLLKLVEKYGN-DWKQIAKELG-RRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 373-422 1.74e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 37.48  E-value: 1.74e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1207175604  373 RTHWTEEEDDLLRELVEKM-----RIGNFIPyiqmshfmvGRDGSQLAYRWTSVL 422
Cdd:pfam00249    1 RGPWTPEEDELLLEAVEKLgnrwkKIAKLLP---------GRTDNQCKNRWQNYL 46
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
320-369 9.80e-03

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 35.66  E-value: 9.80e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 1207175604   320 KSVWKQDEIYKLQAVAEEFKMCHWDKIAEALGtNRTAFMCFQTYQRYISK 369
Cdd:smart00717    1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELP-GRTAEQCRERWRNLLKP 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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