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Conserved domains on  [gi|1207180971|ref|XP_021333407|]
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novel immune-type receptor 1d [Danio rerio]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10309807)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to matrix remodeling-associated protein 8 which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 151-243 2.97e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.39  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 151 GDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKN--STESQTQSCVYSLHKNNISRSDTGIYYC 225
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGrfSGRGDPSNGDGSLTIQNLTLSDSGTYTC 90

                          90
                  ....*....|....*...
gi 1207180971 226 AVATCGEIMLGRGTQLNI 243
Cdd:pfam07686  91 AVIPSGEGVFGKGTRLTV 108
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 35-130 7.92e-10

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04983:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 109  Bit Score: 55.35  E-value: 7.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  35 DVNFTCTFPWLVQSTKAWFKQaNNGKSLQIVSLYESQKPSwnhnfEKTNRFNV--NKGDFYFNLTIVKTKPSDSATYYCV 112
Cdd:cd04983    15 NVTLNCNYSTSTFYYLFWYRQ-YPGQGPQFLIYISSDSGN-----KKKGRFSAtlDKSRKSSSLHISAAQLSDSAVYFCA 88

                          90       100
                  ....*....|....*....|.
gi 1207180971 113 VSSYQATG---MGSGTRLLVR 130
Cdd:cd04983    89 LSESGGTGkltFGKGTRLTVE 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 151-243 2.97e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.39  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 151 GDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKN--STESQTQSCVYSLHKNNISRSDTGIYYC 225
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGrfSGRGDPSNGDGSLTIQNLTLSDSGTYTC 90

                          90
                  ....*....|....*...
gi 1207180971 226 AVATCGEIMLGRGTQLNI 243
Cdd:pfam07686  91 AVIPSGEGVFGKGTRLTV 108
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 35-130 7.92e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 55.35  E-value: 7.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  35 DVNFTCTFPWLVQSTKAWFKQaNNGKSLQIVSLYESQKPSwnhnfEKTNRFNV--NKGDFYFNLTIVKTKPSDSATYYCV 112
Cdd:cd04983    15 NVTLNCNYSTSTFYYLFWYRQ-YPGQGPQFLIYISSDSGN-----KKKGRFSAtlDKSRKSSSLHISAAQLSDSAVYFCA 88

                          90       100
                  ....*....|....*....|.
gi 1207180971 113 VSSYQATG---MGSGTRLLVR 130
Cdd:cd04983    89 LSESGGTGkltFGKGTRLTVE 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 35-130 1.07e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.46  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  35 DVNFTCTFP--WLVQST-KAWFKQaNNGKSLQIVSLYESQKpswNHNFEKTNRF----NVNKGDFYfnLTIVKTKPSDSA 107
Cdd:pfam07686  13 SVTLPCTYSssMSEASTsVYWYRQ-PPGKGPTFLIAYYSNG---SEEGVKKGRFsgrgDPSNGDGS--LTIQNLTLSDSG 86

                          90       100
                  ....*....|....*....|...
gi 1207180971 108 TYYCVVSSYQATGMGSGTRLLVR 130
Cdd:pfam07686  87 TYTCAVIPSGEGVFGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 148-243 4.04e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 4.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  148 VDPGDSVNLQCSIfteSCAGDHSVYWFKQssgDSEGVLYtkgerNGRCKNSTESQTqscvYSLHKNNISRSDTGIYYCAv 227
Cdd:smart00410   6 VKEGESVTLSCEA---SGSPPPEVTWYKQ---GGKLLAE-----SGRFSVSRSGST----STLTISNVTPEDSGTYTCA- 69

                           90
                   ....*....|....*.
gi 1207180971  228 ATCGEIMLGRGTQLNI 243
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 170-243 1.14e-06

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 46.67  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 170 SVYWFKQ--------------SSGDSEGVLYtkGERNGRCKNSTESQTQSCVYSLHKNNISRSDTGIYYCAVATCGEIML 235
Cdd:cd07700    30 RIYWLRQrqapskdshfeflaSWDPSKGIVY--GEGVDQEKLIILSDSDSSRYILSLMSVKPEDSGTYFCMTVGSPELIF 107


                  ....*...
gi 1207180971 236 GRGTQLNI 243
Cdd:cd07700   108 GTGTKLSV 115
IGv smart00406
Immunoglobulin V-Type;
35-113 5.53e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 40.83  E-value: 5.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971   35 DVNFTCTFpWLVQSTK---AWFKQANnGKSLQIVSLYESQKPSWNHNFEKtNRFNVNK----GDFYfnLTIVKTKPSDSA 107
Cdd:smart00406   1 SVTLSCKF-SGSTFSSyyvSWVRQPP-GKGLEWLGYIGSNGSSYYQESYK-GRFTISKdtskNDVS--LTISNLRVEDTG 75


                   ....*.
gi 1207180971  108 TYYCVV 113
Cdd:smart00406  76 TYYCAV 81
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 151-243 2.97e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 59.39  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 151 GDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKN--STESQTQSCVYSLHKNNISRSDTGIYYC 225
Cdd:pfam07686  11 GGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGrfSGRGDPSNGDGSLTIQNLTLSDSGTYTC 90

                          90
                  ....*....|....*...
gi 1207180971 226 AVATCGEIMLGRGTQLNI 243
Cdd:pfam07686  91 AVIPSGEGVFGKGTRLTV 108
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 35-130 7.92e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 55.35  E-value: 7.92e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  35 DVNFTCTFPWLVQSTKAWFKQaNNGKSLQIVSLYESQKPSwnhnfEKTNRFNV--NKGDFYFNLTIVKTKPSDSATYYCV 112
Cdd:cd04983    15 NVTLNCNYSTSTFYYLFWYRQ-YPGQGPQFLIYISSDSGN-----KKKGRFSAtlDKSRKSSSLHISAAQLSDSAVYFCA 88

                          90       100
                  ....*....|....*....|.
gi 1207180971 113 VSSYQATG---MGSGTRLLVR 130
Cdd:cd04983    89 LSESGGTGkltFGKGTRLTVE 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 35-130 1.07e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.46  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  35 DVNFTCTFP--WLVQST-KAWFKQaNNGKSLQIVSLYESQKpswNHNFEKTNRF----NVNKGDFYfnLTIVKTKPSDSA 107
Cdd:pfam07686  13 SVTLPCTYSssMSEASTsVYWYRQ-PPGKGPTFLIAYYSNG---SEEGVKKGRFsgrgDPSNGDGS--LTIQNLTLSDSG 86

                          90       100
                  ....*....|....*....|...
gi 1207180971 108 TYYCVVSSYQATGMGSGTRLLVR 130
Cdd:pfam07686  87 TYTCAVIPSGEGVFGKGTRLTVL 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 52-129 1.77e-08

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 51.57  E-value: 1.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  52 WFKQaNNGKSLQIVSLYESQKPSWNHNFEKtnRFNVNK-GDFYFNLTIVKTKPSDSATYYCVVSSYQATGM---GSGTRL 127
Cdd:cd00099    33 WYRQ-KPGQGPEFLIYLSSSKGKTKGGVPG--RFSGSRdGTSSFSLTISNLQPEDSGTYYCAVSESGGTDKltfGSGTRL 109


                  ..
gi 1207180971 128 LV 129
Cdd:cd00099   110 TV 111
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 52-129 2.17e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 48.43  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  52 WFKQaNNGKSLQIVSLYESQKPSWNHNFeKTNRFNVNK-GDFYFNLTIVKTKPSDSATYYCVVSSYQATG---MGSGTRL 127
Cdd:cd05899    31 WYRQ-DPGKGLQLLFYSYGGGLNEEGDL-PGDRFSASRpSLTRSSLTIKSAEPEDSAVYLCASSLGGGADeayFGPGTRL 108


                  ..
gi 1207180971 128 LV 129
Cdd:cd05899   109 TV 110
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 148-243 4.04e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.11  E-value: 4.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  148 VDPGDSVNLQCSIfteSCAGDHSVYWFKQssgDSEGVLYtkgerNGRCKNSTESQTqscvYSLHKNNISRSDTGIYYCAv 227
Cdd:smart00410   6 VKEGESVTLSCEA---SGSPPPEVTWYKQ---GGKLLAE-----SGRFSVSRSGST----STLTISNVTPEDSGTYTCA- 69

                           90
                   ....*....|....*.
gi 1207180971  228 ATCGEIMLGRGTQLNI 243
Cdd:smart00410  70 ATNSSGSASSGTTLTV 85
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 170-243 1.14e-06

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 46.67  E-value: 1.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 170 SVYWFKQ--------------SSGDSEGVLYtkGERNGRCKNSTESQTQSCVYSLHKNNISRSDTGIYYCAVATCGEIML 235
Cdd:cd07700    30 RIYWLRQrqapskdshfeflaSWDPSKGIVY--GEGVDQEKLIILSDSDSSRYILSLMSVKPEDSGTYFCMTVGSPELIF 107


                  ....*...
gi 1207180971 236 GRGTQLNI 243
Cdd:cd07700   108 GTGTKLSV 115
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 150-243 1.47e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 46.17  E-value: 1.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 150 PGDSVNLQCSIFTeSCAGDhSVYWFKQSSGDS-EGVLYTKGERNGRCKNSTESQTQSCV----YSLHKNNISRSDTGIYY 224
Cdd:cd00099    12 EGESVTLSCEVSS-SFSST-YIYWYRQKPGQGpEFLIYLSSSKGKTKGGVPGRFSGSRDgtssFSLTISNLQPEDSGTYY 89

                          90       100
                  ....*....|....*....|..
gi 1207180971 225 CAVATCG---EIMLGRGTQLNI 243
Cdd:cd00099    90 CAVSESGgtdKLTFGSGTRLTV 111
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 151-244 1.29e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 43.41  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 151 GDSVNLQCSiFTEScaGDHSVYWFKQSSGDS-----EGVLYTKGERNGR-CKNSTESQTQScvySLHKNNISRSDTGIYY 224
Cdd:cd04983    13 GENVTLNCN-YSTS--TFYYLFWYRQYPGQGpqfliYISSDSGNKKKGRfSATLDKSRKSS---SLHISAAQLSDSAVYF 86

                          90       100
                  ....*....|....*....|...
gi 1207180971 225 CAVAT---CGEIMLGRGTQLNIK 244
Cdd:cd04983    87 CALSEsggTGKLTFGKGTRLTVE 109
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 140-243 5.07e-05

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 41.68  E-value: 5.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 140 LHQSLIDAVDPGDSVNLQCSIFTESCAGDHsVYWFKQSSGDSEGVL--YTKGERNG---RCKNSTESQTQSCVYSlhknN 214
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGNY-VNWYQQKPGSAPRYLiyEDKHRPSGipdRFSGSKSGNTASLTIS----G 76

                          90       100
                  ....*....|....*....|....*....
gi 1207180971 215 ISRSDTGIYYCAVATCGEIMLGRGTQLNI 243
Cdd:cd04984    77 AQTEDEADYYCQVWDSNSYVFGGGTKLTV 105
IGv smart00406
Immunoglobulin V-Type;
35-113 5.53e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 40.83  E-value: 5.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971   35 DVNFTCTFpWLVQSTK---AWFKQANnGKSLQIVSLYESQKPSWNHNFEKtNRFNVNK----GDFYfnLTIVKTKPSDSA 107
Cdd:smart00406   1 SVTLSCKF-SGSTFSSyyvSWVRQPP-GKGLEWLGYIGSNGSSYYQESYK-GRFTISKdtskNDVS--LTISNLRVEDTG 75


                   ....*.
gi 1207180971  108 TYYCVV 113
Cdd:smart00406  76 TYYCAV 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 74-129 6.44e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 40.95  E-value: 6.44e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971   74 SWNHNFEK----TNRFNVNKGDFYFNLTIVKTKPSDSATYYCVVSSYQATGMGsGTRLLV 129
Cdd:smart00410  27 TWYKQGGKllaeSGRFSVSRSGSTSTLTISNVTPEDSGTYTCAATNSSGSASS-GTTLTV 85
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 141-244 6.96e-05

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 41.77  E-value: 6.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 141 HQSLIDAVdpGDSVNLQCSIFTEScAGDHSVYWFKQSSGDSEGVLYTKGERNGrckNSTESQTQSCVYSLHKNNI----- 215
Cdd:cd20988     5 HQTVTVSV--GKPVTLKCSMKGEA-ISNYYINWYRKTQGNTMTFIYREGGIYG---PGFKDNFRGDIDSSNNLAVlkile 78

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207180971 216 -SRSDTGIYYCAVATCGEI------MLGRGTQLNIK 244
Cdd:cd20988    79 aSERDEGSYYCASDTPGGGreydplIFGKGTYLTVE 114
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 52-129 1.60e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 40.58  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  52 WFKQANNGkSLQIVSLYESQKPSwnhnfEKTNRFNVN--KGDFYFNLTIVKTKPSDSATYYCVVSSYQATG---MGSGTR 126
Cdd:cd07706    34 WYKQLPSG-EMTFLIRQDSSEQN-----AKSGRYSVNfqKAQKSISLTISALQLEDSAKYFCALSLPYDTDkliFGKGTR 107


                  ...
gi 1207180971 127 LLV 129
Cdd:cd07706   108 LTV 110
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 52-129 4.62e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 36.57  E-value: 4.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  52 WFKQaNNGKSLQIVSLYESQKPSWNHNFEKTNRFNVNK--GDFYFNLTIVKTKPSDSATYYCVV----SSYQATGMGSGT 125
Cdd:cd04982    34 WYRQ-KPGQALERLLYVSSTSAVRKDSGKTKNKFEARKdvGKSTSTLTITNLEKEDSATYYCAYwesgSGYYIKVFGSGT 112


                  ....
gi 1207180971 126 RLLV 129
Cdd:cd04982   113 KLIV 116
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 150-229 5.07e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 35.63  E-value: 5.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 150 PGDSVNLQCSIFTESCAGDhsVYWFKQSSGDSEGVLYTKGERNgrcknstesQTQScvySLHKNNISRSDTGIYYCAVAT 229
Cdd:pfam00047  10 EGDSATLTCSASTGSPGPD--VTWSKEGGTLIESLKVKHDNGR---------TTQS---SLLISNVTKEDAGTYTCVVNN 75
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 36-129 6.54e-03

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 35.90  E-value: 6.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971  36 VNFTCTFPWLVQSTKA--WFKQaNNGKSLQIVSLYESQKPSwnhnfEKTNRFNVNKGDFYFNLTIVKTKPSDSATYYCVV 113
Cdd:cd04984    16 VTITCTGSSGNISGNYvnWYQQ-KPGSAPRYLIYEDKHRPS-----GIPDRFSGSKSGNTASLTISGAQTEDEADYYCQV 89

                          90
                  ....*....|....*.
gi 1207180971 114 SSYQATGMGSGTRLLV 129
Cdd:cd04984    90 WDSNSYVFGGGTKLTV 105
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 147-225 8.74e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 34.85  E-value: 8.74e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207180971 147 AVDPGDSVNLQCSIFTEScagDHSVYWFKQSSGDSEGVLYTKGERNGRCknstesqtqscvySLHKNNISRSDTGIYYC 225
Cdd:pfam13927  12 TVREGETVTLTCEATGSP---PPTITWYKNGEPISSGSTRSRSLSGSNS-------------TLTISNVTRSDAGTYTC 74
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 139-226 9.76e-03

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 35.36  E-value: 9.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207180971 139 TLHQSLIDAVDPGDSVNLQC--SIFTEScagDHSVYWFKQSSG-DSE--GVLYTKGER---NGRCKNS---TESQTQSCV 207
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCkaSGFTFT---SYGMGWVRQAPGkGLEwiGLIYPGGGDtyyADSFKGRftiTRDTSKSTA 77

                          90
                  ....*....|....*....
gi 1207180971 208 YsLHKNNISRSDTGIYYCA 226
Cdd:cd04981    78 Y-LQLNSLTSEDTAVYYCA 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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