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Conserved domains on  [gi|1207182391|ref|XP_021333804|]
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LOW QUALITY PROTEIN: uncharacterized protein LOC101885129 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 470-566 1.94e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 1.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKNNTESQTQSCVY--SLHKNNISRSDTG 544
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGRFSGRGDPSNGdgSLTIQNLTLSDSG 86

                          90       100
                  ....*....|....*....|..
gi 1207182391 545 IYYCAVAACGEILFGRGTQLSI 566
Cdd:pfam07686  87 TYTCAVIPSGEGVFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 47-146 1.55e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 58.50  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  47 IVQAGDTVNFTCSLSNEIRSSVV-WIKQSVGKKPLPVVSSFQIVDHRFENdfnKQNRFFVTKDDV-SFNLSITNTEVSDS 124
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYIyWYRQKPGQGPEFLIYLSSSKGKTKGG---VPGRFSGSRDGTsSFSLTISNLQPEDS 85

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 125 ATYYCITY----AYHFTFGNSTDLIV 146
Cdd:cd00099    86 GTYYCAVSesggTDKLTFGSGTRLTV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 345-453 3.13e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTCTFS---WHTQLTkaWIKHTNNGKSQQIVSIYGSQKPSWNPKFEntnRFNADK-GDNFFNL 420
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSssfSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVPG---RFSGSRdGTSSFSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207182391 421 TILKTNLSDSATYYCVVSSYQATGM---GSGTRLLV 453
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSESGGTDKltfGSGTRLTV 111
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 160-253 2.59e-07

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd04984:

Pssm-ID: 472250  Cd Length: 105  Bit Score: 49.38  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 160 SASESPSED--LQCSIISQSCAEEHrVYWFRQRSGESPPGVIYTQDSRSA----QCENSSDPNsTAHKCIYSLPKTDEdp 233
Cdd:cd04984     7 SLSVSPGETvtITCTGSSGNISGNY-VNWYQQKPGSAPRYLIYEDKHRPSgipdRFSGSKSGN-TASLTISGAQTEDE-- 82

                          90       100
                  ....*....|....*....|
gi 1207182391 234 AIYYCAVAACGQILFGDGRK 253
Cdd:cd04984    83 ADYYCQVWDSNSYVFGGGTK 102
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 470-566 1.94e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 1.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKNNTESQTQSCVY--SLHKNNISRSDTG 544
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGRFSGRGDPSNGdgSLTIQNLTLSDSG 86

                          90       100
                  ....*....|....*....|..
gi 1207182391 545 IYYCAVAACGEILFGRGTQLSI 566
Cdd:pfam07686  87 TYTCAVIPSGEGVFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 47-146 1.55e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 58.50  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  47 IVQAGDTVNFTCSLSNEIRSSVV-WIKQSVGKKPLPVVSSFQIVDHRFENdfnKQNRFFVTKDDV-SFNLSITNTEVSDS 124
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYIyWYRQKPGQGPEFLIYLSSSKGKTKGG---VPGRFSGSRDGTsSFSLTISNLQPEDS 85

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 125 ATYYCITY----AYHFTFGNSTDLIV 146
Cdd:cd00099    86 GTYYCAVSesggTDKLTFGSGTRLTV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 345-453 3.13e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTCTFS---WHTQLTkaWIKHTNNGKSQQIVSIYGSQKPSWNPKFEntnRFNADK-GDNFFNL 420
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSssfSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVPG---RFSGSRdGTSSFSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207182391 421 TILKTNLSDSATYYCVVSSYQATGM---GSGTRLLV 453
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSESGGTDKltfGSGTRLTV 111
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 48-146 4.57e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.36  E-value: 4.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391   48 VQAGDTVNFTCSLSNEIRSSVVWIKQsvGKKPLPvvssfqivdhrfendfnKQNRFFVTKDDVSFNLSITNTEVSDSATY 127
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--GGKLLA-----------------ESGRFSVSRSGSTSTLTISNVTPEDSGTY 66

                           90
                   ....*....|....*....
gi 1207182391  128 YCITYAYHFTFGNSTDLIV 146
Cdd:smart00410  67 TCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 354-454 6.75e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.70  E-value: 6.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 354 VEAGKDVKFTCTFS---WHTQLTKAWIKHTNNGKSQQIVSIYGSQKPswNPKFENTNRFNADKGDNFFNLTILKTNLSDS 430
Cdd:pfam07686   8 VALGGSVTLPCTYSssmSEASTSVYWYRQPPGKGPTFLIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 1207182391 431 ATYYCVVSSYQATGMGSGTRLLVR 454
Cdd:pfam07686  86 GTYTCAVIPSGEGVFGKGTRLTVL 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 48-146 1.43e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  48 VQAGDTVNFTCSLSNEIRS---SVVWIKQSVGKKPLPVVSSFQIVDHRFEndfnKQNRFFVTKDDVSFNLS--ITNTEVS 122
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMSEastSVYWYRQPPGKGPTFLIAYYSNGSEEGV----KKGRFSGRGDPSNGDGSltIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 1207182391 123 DSATYYC-ITYAYHFTFGNSTDLIV 146
Cdd:pfam07686  84 DSGTYTCaVIPSGEGVFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 470-566 1.93e-08

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 52.72  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTeSCAGDhSVYWFKQSSGDS-EGVLYTKGERNGRCKNNTESQTQSCV----YSLHKNNISRSDTG 544
Cdd:cd00099     9 SVQEGESVTLSCEVSS-SFSST-YIYWYRQKPGQGpEFLIYLSSSKGKTKGGVPGRFSGSRDgtssFSLTISNLQPEDSG 86

                          90       100
                  ....*....|....*....|....*
gi 1207182391 545 IYYCAVAACG---EILFGRGTQLSI 566
Cdd:cd00099    87 TYYCAVSESGgtdKLTFGSGTRLTV 111
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 160-253 2.59e-07

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 49.38  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 160 SASESPSED--LQCSIISQSCAEEHrVYWFRQRSGESPPGVIYTQDSRSA----QCENSSDPNsTAHKCIYSLPKTDEdp 233
Cdd:cd04984     7 SLSVSPGETvtITCTGSSGNISGNY-VNWYQQKPGSAPRYLIYEDKHRPSgipdRFSGSKSGN-TASLTISGAQTEDE-- 82

                          90       100
                  ....*....|....*....|
gi 1207182391 234 AIYYCAVAACGQILFGDGRK 253
Cdd:cd04984    83 ADYYCQVWDSNSYVFGGGTK 102
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 470-550 1.39e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  470 TVYPGDSVNLQCSIfteSCAGDHSVYWFKQssgDSEGVLYtkgerngrcKNNTESQTQSCVYSLHKNNISRSDTGIYYCA 549
Cdd:smart00410   5 TVKEGESVTLSCEA---SGSPPPEVTWYKQ---GGKLLAE---------SGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69


                   .
gi 1207182391  550 V 550
Cdd:smart00410  70 A 70
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 354-453 3.74e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 3.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  354 VEAGKDVKFTCTFSWHTQLTKAWIKhtnngksqqivsiygsQKPSWnpkFENTNRFNADKGDNFFNLTILKTNLSDSATY 433
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYK----------------QGGKL---LAESGRFSVSRSGSTSTLTISNVTPEDSGTY 66

                           90       100
                   ....*....|....*....|
gi 1207182391  434 YCVVSSYQATGMGsGTRLLV 453
Cdd:smart00410  67 TCAATNSSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 470-566 1.94e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.32  E-value: 1.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTESCAGDHSVYWFKQSSGDSEGVL---YTKGERNGRCKNNTESQTQSCVY--SLHKNNISRSDTG 544
Cdd:pfam07686   7 TVALGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLiayYSNGSEEGVKKGRFSGRGDPSNGdgSLTIQNLTLSDSG 86

                          90       100
                  ....*....|....*....|..
gi 1207182391 545 IYYCAVAACGEILFGRGTQLSI 566
Cdd:pfam07686  87 TYTCAVIPSGEGVFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 47-146 1.55e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 58.50  E-value: 1.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  47 IVQAGDTVNFTCSLSNEIRSSVV-WIKQSVGKKPLPVVSSFQIVDHRFENdfnKQNRFFVTKDDV-SFNLSITNTEVSDS 124
Cdd:cd00099     9 SVQEGESVTLSCEVSSSFSSTYIyWYRQKPGQGPEFLIYLSSSKGKTKGG---VPGRFSGSRDGTsSFSLTISNLQPEDS 85

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 125 ATYYCITY----AYHFTFGNSTDLIV 146
Cdd:cd00099    86 GTYYCAVSesggTDKLTFGSGTRLTV 111
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 345-453 3.13e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.73  E-value: 3.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTCTFS---WHTQLTkaWIKHTNNGKSQQIVSIYGSQKPSWNPKFEntnRFNADK-GDNFFNL 420
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSssfSSTYIY--WYRQKPGQGPEFLIYLSSSKGKTKGGVPG---RFSGSRdGTSSFSL 75

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1207182391 421 TILKTNLSDSATYYCVVSSYQATGM---GSGTRLLV 453
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSESGGTDKltfGSGTRLTV 111
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 48-146 4.57e-10

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 56.36  E-value: 4.57e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391   48 VQAGDTVNFTCSLSNEIRSSVVWIKQsvGKKPLPvvssfqivdhrfendfnKQNRFFVTKDDVSFNLSITNTEVSDSATY 127
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYKQ--GGKLLA-----------------ESGRFSVSRSGSTSTLTISNVTPEDSGTY 66

                           90
                   ....*....|....*....
gi 1207182391  128 YCITYAYHFTFGNSTDLIV 146
Cdd:smart00410  67 TCAATNSSGSASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 354-454 6.75e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 56.70  E-value: 6.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 354 VEAGKDVKFTCTFS---WHTQLTKAWIKHTNNGKSQQIVSIYGSQKPswNPKFENTNRFNADKGDNFFNLTILKTNLSDS 430
Cdd:pfam07686   8 VALGGSVTLPCTYSssmSEASTSVYWYRQPPGKGPTFLIAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLTIQNLTLSDS 85

                          90       100
                  ....*....|....*....|....
gi 1207182391 431 ATYYCVVSSYQATGMGSGTRLLVR 454
Cdd:pfam07686  86 GTYTCAVIPSGEGVFGKGTRLTVL 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 47-147 8.47e-10

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 56.51  E-value: 8.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  47 IVQAGDTVNFTCSLSNEIRSSVVWIKQSVGKKPlpvvssfQIVDHRFENDFNKQN-RFFVT--KDDVSFNLSITNTEVSD 123
Cdd:cd04983     9 SVQEGENVTLNCNYSTSTFYYLFWYRQYPGQGP-------QFLIYISSDSGNKKKgRFSATldKSRKSSSLHISAAQLSD 81

                          90       100
                  ....*....|....*....|....*...
gi 1207182391 124 SATYYCIT----YAYHFTFGNSTDLIVK 147
Cdd:cd04983    82 SAVYFCALsesgGTGKLTFGKGTRLTVE 109
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 345-454 1.08e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 53.43  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTCTFS--------WHTQLTkawikhtnnGKSQQIVsIYGSqkpSWNPKFENtNRFNA--DKG 414
Cdd:cd04983     1 VTQSPQSLSVQEGENVTLNCNYStstfyylfWYRQYP---------GQGPQFL-IYIS---SDSGNKKK-GRFSAtlDKS 66

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1207182391 415 DNFFNLTILKTNLSDSATYYCVVSSYQATG---MGSGTRLLVR 454
Cdd:cd04983    67 RKSSSLHISAAQLSDSAVYFCALSESGGTGkltFGKGTRLTVE 109
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 48-146 1.43e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.85  E-value: 1.43e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  48 VQAGDTVNFTCSLSNEIRS---SVVWIKQSVGKKPLPVVSSFQIVDHRFEndfnKQNRFFVTKDDVSFNLS--ITNTEVS 122
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMSEastSVYWYRQPPGKGPTFLIAYYSNGSEEGV----KKGRFSGRGDPSNGDGSltIQNLTLS 83

                          90       100
                  ....*....|....*....|....*
gi 1207182391 123 DSATYYC-ITYAYHFTFGNSTDLIV 146
Cdd:pfam07686  84 DSGTYTCaVIPSGEGVFGKGTRLTV 108
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 470-566 1.93e-08

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 52.72  E-value: 1.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTeSCAGDhSVYWFKQSSGDS-EGVLYTKGERNGRCKNNTESQTQSCV----YSLHKNNISRSDTG 544
Cdd:cd00099     9 SVQEGESVTLSCEVSS-SFSST-YIYWYRQKPGQGpEFLIYLSSSKGKTKGGVPGRFSGSRDgtssFSLTISNLQPEDSG 86

                          90       100
                  ....*....|....*....|....*
gi 1207182391 545 IYYCAVAACG---EILFGRGTQLSI 566
Cdd:cd00099    87 TYYCAVSESGgtdKLTFGSGTRLTV 111
IGv smart00406
Immunoglobulin V-Type;
53-129 2.33e-07

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 48.53  E-value: 2.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391   53 TVNFTCSLSN--EIRSSVVWIKQSVGKkPLPVVSSFQIVDHRFENDFNKqNRFFVTKDDV--SFNLSITNTEVSDSATYY 128
Cdd:smart00406   1 SVTLSCKFSGstFSSYYVSWVRQPPGK-GLEWLGYIGSNGSSYYQESYK-GRFTISKDTSknDVSLTISNLRVEDTGTYY 78


                   .
gi 1207182391  129 C 129
Cdd:smart00406  79 C 79
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 160-253 2.59e-07

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 49.38  E-value: 2.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 160 SASESPSED--LQCSIISQSCAEEHrVYWFRQRSGESPPGVIYTQDSRSA----QCENSSDPNsTAHKCIYSLPKTDEdp 233
Cdd:cd04984     7 SLSVSPGETvtITCTGSSGNISGNY-VNWYQQKPGSAPRYLIYEDKHRPSgipdRFSGSKSGN-TASLTISGAQTEDE-- 82

                          90       100
                  ....*....|....*....|
gi 1207182391 234 AIYYCAVAACGQILFGDGRK 253
Cdd:cd04984    83 ADYYCQVWDSNSYVFGGGTK 102
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 48-146 3.89e-07

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 48.61  E-value: 3.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  48 VQAGDTVNFTCSLSNEIRSS--VVWIKQSVGKKPLPVVSsfqivdhrfendFNKQ------NRFFVTKDDVSFNLSITNT 119
Cdd:cd04984    10 VSPGETVTITCTGSSGNISGnyVNWYQQKPGSAPRYLIY------------EDKHrpsgipDRFSGSKSGNTASLTISGA 77

                          90       100
                  ....*....|....*....|....*...
gi 1207182391 120 EVSDSATYYC-ITYAYHFTFGNSTDLIV 146
Cdd:cd04984    78 QTEDEADYYCqVWDSNSYVFGGGTKLTV 105
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 493-566 3.94e-07

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 48.98  E-value: 3.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 493 SVYWFKQ--------------SSGDSEGVLYtkGERNGRCKNNTESQTQSCVYSLHKNNISRSDTGIYYCAVAACGEILF 558
Cdd:cd07700    30 RIYWLRQrqapskdshfeflaSWDPSKGIVY--GEGVDQEKLIILSDSDSSRYILSLMSVKPEDSGTYFCMTVGSPELIF 107


                  ....*...
gi 1207182391 559 GRGTQLSI 566
Cdd:cd07700   108 GTGTKLSV 115
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 46-146 7.90e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 48.05  E-value: 7.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  46 KIVQAGDTVNFTCSLSNEiRSSVVWIKQSVGKkPLPVVSSFQIVDHRFENDFnKQNRFFVTK-DDVSFNLSITNTEVSDS 124
Cdd:cd05899     8 LIKRRGQSVTLRCSQKSG-HDNMYWYRQDPGK-GLQLLFYSYGGGLNEEGDL-PGDRFSASRpSLTRSSLTIKSAEPEDS 84

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 125 ATYYCIT----YAYHFTFGNSTDLIV 146
Cdd:cd05899    85 AVYLCASslggGADEAYFGPGTRLTV 110
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 49-146 9.20e-07

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 48.13  E-value: 9.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  49 QAGDTVNFTCSLSNE-IRSSVV-WIKQSVGKKP---LPVVSSFQivdHRFENDFNKqNRFFVTKDDVSFN--LSITNTEV 121
Cdd:cd04982    11 EESKSVTISCKVSGIdFSTTYIhWYRQKPGQALerlLYVSSTSA---VRKDSGKTK-NKFEARKDVGKSTstLTITNLEK 86

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207182391 122 SDSATYYCITY-----AYHFTFGNSTDLIV 146
Cdd:cd04982    87 EDSATYYCAYWesgsgYYIKVFGSGTKLIV 116
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 470-550 1.39e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.39e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  470 TVYPGDSVNLQCSIfteSCAGDHSVYWFKQssgDSEGVLYtkgerngrcKNNTESQTQSCVYSLHKNNISRSDTGIYYCA 549
Cdd:smart00410   5 TVKEGESVTLSCEA---SGSPPPEVTWYKQ---GGKLLAE---------SGRFSVSRSGSTSTLTISNVTPEDSGTYTCA 69


                   .
gi 1207182391  550 V 550
Cdd:smart00410  70 A 70
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 474-566 2.29e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 46.49  E-value: 2.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 474 GDSVNLQCSiFTEScaGDHSVYWFKQSSGDS-----EGVLYTKGERNGRCKNN-TESQTQScvySLHKNNISRSDTGIYY 547
Cdd:cd04983    13 GENVTLNCN-YSTS--TFYYLFWYRQYPGQGpqfliYISSDSGNKKKGRFSATlDKSRKSS---SLHISAAQLSDSAVYF 86

                          90       100
                  ....*....|....*....|..
gi 1207182391 548 CAV---AACGEILFGRGTQLSI 566
Cdd:cd04983    87 CALsesGGTGKLTFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 354-453 3.74e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 3.74e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  354 VEAGKDVKFTCTFSWHTQLTKAWIKhtnngksqqivsiygsQKPSWnpkFENTNRFNADKGDNFFNLTILKTNLSDSATY 433
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVTWYK----------------QGGKL---LAESGRFSVSRSGSTSTLTISNVTPEDSGTY 66

                           90       100
                   ....*....|....*....|
gi 1207182391  434 YCVVSSYQATGMGsGTRLLV 453
Cdd:smart00410  67 TCAATNSSGSASS-GTTLTV 85
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 470-566 2.43e-05

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 43.60  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTESCAGDHsVYWFKQSSGDS-EGVLYTKGER--------NGRCKNNTESQTQScvyslhknNISR 540
Cdd:cd04984     9 SVSPGETVTITCTGSSGNISGNY-VNWYQQKPGSApRYLIYEDKHRpsgipdrfSGSKSGNTASLTIS--------GAQT 79

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 541 SDTGIYYCAVAACGEILFGRGTQLSI 566
Cdd:cd04984    80 EDEADYYCQVWDSNSYVFGGGTKLTV 105
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 345-453 3.32e-05

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 43.42  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTC-------TFSWHTQLTK---AWIKHTNNGKSQQIVSIYGSqkpswnpkfentnRFNADKG 414
Cdd:cd05899     1 VTQSPRYLIKRRGQSVTLRCsqksghdNMYWYRQDPGkglQLLFYSYGGGLNEEGDLPGD-------------RFSASRP 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1207182391 415 DN-FFNLTILKTNLSDSATYYCVVSSYQATG---MGSGTRLLV 453
Cdd:cd05899    68 SLtRSSLTIKSAEPEDSAVYLCASSLGGGADeayFGPGTRLTV 110
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 354-453 4.53e-05

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 42.83  E-value: 4.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 354 VEAGKDVKFTCTFS--WHTQLTKAWIKHtNNGKSQQIVSIYGSQKPSWNPkfentNRFNADKGDNFFNLTILKTNLSDSA 431
Cdd:cd04984    10 VSPGETVTITCTGSsgNISGNYVNWYQQ-KPGSAPRYLIYEDKHRPSGIP-----DRFSGSKSGNTASLTISGAQTEDEA 83

                          90       100
                  ....*....|....*....|..
gi 1207182391 432 TYYCVVSSYQATGMGSGTRLLV 453
Cdd:cd04984    84 DYYCQVWDSNSYVFGGGTKLTV 105
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 48-144 7.17e-05

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 42.38  E-value: 7.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  48 VQAGDTVNFTCSLSNEIRSS-VVWIKQSVGKKPLPVVSSfqiVDHRFENDfnkQNRFFVTKDDVSFNLSITNTEVSDSAT 126
Cdd:cd04980    12 VSPGERVTISCKASQSISSNyLAWYQQKPGQAPKLLIYY---ASTLHSGV---PSRFSGSGSGTDFTLTISSVEPEDAAV 85

                          90
                  ....*....|....*....
gi 1207182391 127 YYCITY-AYHFTFGNSTDL 144
Cdd:cd04980    86 YYCQQGyTFPYTFGGGTKL 104
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 464-566 7.89e-05

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 42.54  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 464 HQSLIDTVypGDSVNLQCSIFTEScAGDHSVYWFKQSSGDSEGVLYTKGERNGrckNNTESQTQSCVYSLHKNNI----- 538
Cdd:cd20988     5 HQTVTVSV--GKPVTLKCSMKGEA-ISNYYINWYRKTQGNTMTFIYREGGIYG---PGFKDNFRGDIDSSNNLAVlkile 78

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207182391 539 -SRSDTGIYYCAVAACGEI------LFGRGTQLSI 566
Cdd:cd20988    79 aSERDEGSYYCASDTPGGGreydplIFGKGTYLTV 113
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 345-453 1.35e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 41.74  E-value: 1.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 345 VVQEDNVKIVEAGKDVKFTCTF--SWhTQLTKAWIKHTNNGKSQQIVSIYGSQKPSWNPKFEntnrFNADKGDNFFNLTI 422
Cdd:cd07706     2 VTQAQPDVSVQVGEEVTLNCRYetSW-TNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYS----VNFQKAQKSISLTI 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1207182391 423 LKTNLSDSATYYCVVSSYQATG---MGSGTRLLV 453
Cdd:cd07706    77 SALQLEDSAKYFCALSLPYDTDkliFGKGTRLTV 110
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 473-566 1.10e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 39.19  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 473 PGDSVNLQCSIFTescagDH-SVYWFKQSSGDS--------EGVLYTKG-----ERNGRCKNNTESqtqscvySLHKNNI 538
Cdd:cd05899    12 RGQSVTLRCSQKS-----GHdNMYWYRQDPGKGlqllfysyGGGLNEEGdlpgdRFSASRPSLTRS-------SLTIKSA 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1207182391 539 SRSDTGIYYCAVAACG---EILFGRGTQLSI 566
Cdd:cd05899    80 EPEDSAVYLCASSLGGgadEAYFGPGTRLTV 110
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 388-441 1.47e-03

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 38.62  E-value: 1.47e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1207182391 388 IVSIYGSQKPSWNPKfENTNRFNADKGDNFFNLTILKTNLSDSATYYCVVSSYQ 441
Cdd:cd05720    46 LLYLSSSNKTKWAEG-LDSKRFSGSRSGSSYVLTLKDFRKEDEGYYFCSVISNS 98
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 470-550 1.51e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.94  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 470 TVYPGDSVNLQCSIFTESCAGDhsVYWFKQSSGDSEGVLYTKGERNgrcknntesQTQScvySLHKNNISRSDTGIYYCA 549
Cdd:pfam00047   7 TVLEGDSATLTCSASTGSPGPD--VTWSKEGGTLIESLKVKHDNGR---------TTQS---SLLISNVTKEDAGTYTCV 72


                  .
gi 1207182391 550 V 550
Cdd:pfam00047  73 V 73
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 473-564 1.53e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.88  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 473 PGDSVNLQCSIFTESCAGDhSVYWFKQSSGDS-EGVLY---------TKGERNGRCKNNTESQTQSCvySLHKNNISRSD 542
Cdd:cd04982    12 ESKSVTISCKVSGIDFSTT-YIHWYRQKPGQAlERLLYvsstsavrkDSGKTKNKFEARKDVGKSTS--TLTITNLEKED 88

                          90       100
                  ....*....|....*....|....*.
gi 1207182391 543 TGIYYCAVAACGEI----LFGRGTQL 564
Cdd:cd04982    89 SATYYCAYWESGSGyyikVFGSGTKL 114
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 355-453 2.86e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.11  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 355 EAGKDVKFTCTFSWHTQLTKA--WIKHTNNGKSQQIVSiYGSQKPSWNPKFENTNRFNADKGDNFFNLTILKTNL--SDS 430
Cdd:cd04982    11 EESKSVTISCKVSGIDFSTTYihWYRQKPGQALERLLY-VSSTSAVRKDSGKTKNKFEARKDVGKSTSTLTITNLekEDS 89

                          90       100
                  ....*....|....*....|....*..
gi 1207182391 431 ATYYCVV----SSYQATGMGSGTRLLV 453
Cdd:cd04982    90 ATYYCAYwesgSGYYIKVFGSGTKLIV 116
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 48-129 3.63e-03

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 37.67  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  48 VQAGDTVNFTCSLSNEIRSS--VVWIKQSVGKKP--LPVVSSFQiVDHRFENDFnkQNRFFVTKDDVS--FNLSITNTEV 121
Cdd:cd04981    10 VKPGQSLKLSCKASGFTFTSygMGWVRQAPGKGLewIGLIYPGG-GDTYYADSF--KGRFTITRDTSKstAYLQLNSLTS 86


                  ....*...
gi 1207182391 122 SDSATYYC 129
Cdd:cd04981    87 EDTAVYYC 94
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 163-253 3.78e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 37.73  E-value: 3.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391 163 ESPSEDLQCsIISQSCAEEHRVYWFRQRSGESPPGVIYTqDSRSAQcENSSDPNS---TAHK------CIYSLPK-TDED 232
Cdd:cd04982    12 ESKSVTISC-KVSGIDFSTTYIHWYRQKPGQALERLLYV-SSTSAV-RKDSGKTKnkfEARKdvgkstSTLTITNlEKED 88

                          90       100
                  ....*....|....*....|....*
gi 1207182391 233 PAIYYCAVAACGQI----LFGDGRK 253
Cdd:cd04982    89 SATYYCAYWESGSGyyikVFGSGTK 113
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 47-130 5.88e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.00  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182391  47 IVQAGDTVNFTCSLSNEIRSSVVWIKQSVGKKPLPVVSSFQivdhrfendfnkqnrffvtkDDVSFNLSITNTEVSDSAT 126
Cdd:pfam13927  12 TVREGETVTLTCEATGSPPPTITWYKNGEPISSGSTRSRSL--------------------SGSNSTLTISNVTRSDAGT 71


                  ....
gi 1207182391 127 YYCI 130
Cdd:pfam13927  72 YTCV 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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