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Conserved domains on  [gi|1207111502|ref|XP_021335690|]
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supervillin isoform X5 [Danio rerio]

Protein Classification

supervillin family protein( domain architecture ID 10181714)

supervillin family protein, a villin/gelsolin superfamily member, directly binds and cross-links F-actin; also regulates myosin II contractility subjacent to plasma membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1447-1558 6.39e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200449  Cd Length: 101  Bit Score: 155.12  E-value: 6.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1447 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1526
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111502 1527 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1558
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1143-1239 5.07e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1143 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1222
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111502 1223 GANTHThaakdFWKILG 1239
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1580-1683 3.89e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 3.89e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1580 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1659
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111502 1660 VSIQECDEGAEPQGFWEALGKRDR 1683
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1264-1364 2.72e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


:

Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1264 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1342
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111502 1343 DPGECNALIPRKGQG-RPDWAVF 1364
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
ADF_gelsolin super family cl15697
Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization ...
 1700-1821 3.45e-13

Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization factor/cofilin-like domains are present in a family of essential eukaryotic actin regulatory proteins; these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments.


The actual alignment was detected with superfamily member cd11291:

Pssm-ID: 472830 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1700 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1779
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111502 1780 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1821
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
VHP pfam02209
Villin headpiece domain;
1877-1919 3.36e-12

Villin headpiece domain;


:

Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.40  E-value: 3.36e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111502 1877 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1919
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
 
Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1447-1558 6.39e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200449  Cd Length: 101  Bit Score: 155.12  E-value: 6.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1447 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1526
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111502 1527 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1558
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1143-1239 5.07e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1143 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1222
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111502 1223 GANTHThaakdFWKILG 1239
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1580-1683 3.89e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 3.89e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1580 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1659
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111502 1660 VSIQECDEGAEPQGFWEALGKRDR 1683
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1146-1240 2.44e-21

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 90.04  E-value: 2.44e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1146 LIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQTIEEGAN 1225
Cdd:smart00262    2 LVRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELA--VELDDTLGPGPVQVRVVDEGKE 79

                            90
                    ....*....|....*
gi 1207111502  1226 THThaakdFWKILGG 1240
Cdd:smart00262   80 PPE-----FWSLFGG 89
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1264-1364 2.72e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1264 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1342
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111502 1343 DPGECNALIPRKGQG-RPDWAVF 1364
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
gelsolin_S6_like cd11291
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; ...
 1700-1821 3.45e-13

Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200447 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1700 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1779
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111502 1780 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1821
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1456-1561 1.13e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 65.39  E-value: 1.13e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1456 VWHILEFDYSRLP--KQSIGQFHEGDTYVVKWKYMIsravgkrlhseriigpgkekccyFFWQGRNSTVNEKGTSALMTV 1533
Cdd:smart00262    2 LVRVKGKRNVRVPevPFSQGSLNSGDCYILDTGSEI-----------------------YVWVGKKSSQDEKKKAAELAV 58

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207111502  1534 ELDEERG---AQVQ-VQQGKEPPCFLQCFNGG 1561
Cdd:smart00262   59 ELDDTLGpgpVQVRvVDEGKEPPEFWSLFGGW 90
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1583-1679 3.33e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 64.24  E-value: 3.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1583 YCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNipKASLYLWHGCKAQVHTRDVGRTTANKIKEQCPleaglhsSSKVSI 1662
Cdd:smart00262    1 FLVRVKGKRNVRVPEVPFSQGSLNSGDCYILDT--GSEIYVWVGKKSSQDEKKKAAELAVELDDTLG-------PGPVQV 71

                            90
                    ....*....|....*..
gi 1207111502  1663 QECDEGAEPQGFWEALG 1679
Cdd:smart00262   72 RVVDEGKEPPEFWSLFG 88
VHP pfam02209
Villin headpiece domain;
1877-1919 3.36e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.40  E-value: 3.36e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111502 1877 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1919
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
VHP smart00153
Villin headpiece domain;
1877-1919 1.74e-10

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 57.33  E-value: 1.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207111502  1877 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1919
Cdd:smart00153    1 YLSDEDFE-------EVFGMTREEFYKLPLWKQNQLKKKKGLF 36
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1731-1820 1.12e-07

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 51.14  E-value: 1.12e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1731 PFLQEDLYTAtqpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDRKCAMETVLQYSKEKNEKKTPkSYLIHAGLEP 1810
Cdd:smart00262   17 PFSQGSLNSG---DCYILDTGSEIYVWVG-----KKSS-------QDEKKKAAELAVELDDTLGPGPVQ-VRVVDEGKEP 80

                            90
                    ....*....|
gi 1207111502  1811 LTFTNMFPSW 1820
Cdd:smart00262   81 PEFWSLFGGW 90
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1288-1383 1.87e-06

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 47.67  E-value: 1.87e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1288 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpldpgecnaLIPRKGQGRpdwavfgRL 1367
Cdd:smart00262   21 GSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELAVELDDT-------------------LGPGPVQVR-------VV 74

                            90
                    ....*....|....*.
gi 1207111502  1368 TQHNETTLFKEKFLDW 1383
Cdd:smart00262   75 DEGKEPPEFWSLFGGW 90
Gelsolin pfam00626
Gelsolin repeat;
1164-1201 1.88e-06

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 47.30  E-value: 1.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207111502 1164 ASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELA 1201
Cdd:pfam00626   12 QESLNSGDCYLLDNGFTIFLWVGKGSSLLEKLFAALLA 49
Gelsolin pfam00626
Gelsolin repeat;
1513-1555 3.56e-03

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 38.06  E-value: 3.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111502 1513 FFWQGRNSTVNEKGTSALMTVELD-EERGA---QVQVQQGKEPPCFL 1555
Cdd:pfam00626   30 FLWVGKGSSLLEKLFAALLAAQLDdDERFPlpeVIRVPQGKEPARFL 76
 
Name Accession Description Interval E-value
gelsolin_S4_like cd11293
Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; ...
 1447-1558 6.39e-44

Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200449  Cd Length: 101  Bit Score: 155.12  E-value: 6.39e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1447 FEISTLSVDVWHILEFDYSRLPKQSIGQFHEGDTYVVKWKYMISravgkrlhseriigpGKEKCCYFFWQGRNSTVNEKG 1526
Cdd:cd11293      2 YDDGSGKVEVWRIENDEKVPVPKEEYGQFYGGDCYIVLYTYQGG---------------GKEEHILYFWQGRHSSQDERA 66

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1207111502 1527 TSALMTVELDEE---RGAQVQVQQGKEPPCFLQCF 1558
Cdd:cd11293     67 AAALLTVELDEElkgRAVQVRVVQGKEPPHFLALF 101
gelsolin_S2_like cd11289
Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; ...
 1143-1239 5.07e-33

Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200445  Cd Length: 92  Bit Score: 123.50  E-value: 5.07e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1143 KLMLIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFVQTKHDLGCRASYVQTIEE 1222
Cdd:cd11289      1 KPRLLHVKGRRNVRAREVELSWSSLNSGDVFILDLGSTIYQWNGSKSNRFEKAKAMQLAQGIRDERRLGRAKVIVLDEGD 80

                           90
                   ....*....|....*..
gi 1207111502 1223 GANTHThaakdFWKILG 1239
Cdd:cd11289     81 TNESPE-----FWKVLG 92
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1580-1683 3.89e-24

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 98.07  E-value: 3.89e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1580 WRLYCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNiPKaSLYLWHGCKAQVHTRDVGRTTANKIKEqcpleaglhsssK 1659
Cdd:cd11288      3 TRLFQVRGNGSGNTRAVEVDADASSLNSNDVFVLKT-PS-SVYLWVGKGSSEDERELAKDVASFLKP------------K 68

                           90       100
                   ....*....|....*....|....
gi 1207111502 1660 VSIQECDEGAEPQGFWEALGKRDR 1683
Cdd:cd11288     69 ASLQEVAEGSEPDEFWEALGGKSE 92
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1146-1240 2.44e-21

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 90.04  E-value: 2.44e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1146 LIQVKGRRHVQTRLVEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQTIEEGAN 1225
Cdd:smart00262    2 LVRVKGKRNVRVPEVPFSQGSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELA--VELDDTLGPGPVQVRVVDEGKE 79

                            90
                    ....*....|....*
gi 1207111502  1226 THThaakdFWKILGG 1240
Cdd:smart00262   80 PPE-----FWSLFGG 89
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1145-1243 8.37e-18

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 79.97  E-value: 8.37e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1145 MLIQVKGRRHVQTRLVE--PRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELATFvqtkhdLGCRASYvQTIEE 1222
Cdd:cd11288      4 RLFQVRGNGSGNTRAVEvdADASSLNSNDVFVLKTPSSVYLWVGKGSSEDERELAKDVASF------LKPKASL-QEVAE 76

                           90       100
                   ....*....|....*....|.
gi 1207111502 1223 GANThthaaKDFWKILGGQTS 1243
Cdd:cd11288     77 GSEP-----DEFWEALGGKSE 92
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1264-1364 2.72e-16

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 75.48  E-value: 2.72e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1264 NCIYRLMEDKlvphDDYWGRVPRCS-MLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpl 1342
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASsSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLAKELDEE------------ 65

                           90       100
                   ....*....|....*....|...
gi 1207111502 1343 DPGECNALIPRKGQG-RPDWAVF 1364
Cdd:cd11280     66 RKGKPEIVRIRQGQEpREFWSLF 88
gelsolin_S1_like cd11290
Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; ...
 1454-1567 8.87e-14

Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin_like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200446  Cd Length: 113  Bit Score: 69.17  E-value: 8.87e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1454 VDVWHILEFDYSRLPKQSIGQFHEGDTYVVkwkymisravgkrLHSERIiGPGKEKCCYFFWQGRNSTVNEKGTSALMTV 1533
Cdd:cd11290     10 LQIWRIENFELVPVPESFYGKFYEGDSYIV-------------LKTTLD-PSGSLSYDIHYWLGKEASQDEAGAAAIKAV 75

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1207111502 1534 ELDEERGAQ-VQVQ--QGKEPPCFLQCFNGGMIVHAG 1567
Cdd:cd11290     76 ELDDYLGGRpVQHRevQGHESEEFLSYFKKGIIYIEG 112
gelsolin_S6_like cd11291
Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; ...
 1700-1821 3.45e-13

Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200447 [Multi-domain]  Cd Length: 99  Bit Score: 67.32  E-value: 3.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1700 PRLFQLSSASGeFAAVEFVYPsrepnlvnsmpFLQEDLytATQpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDR 1779
Cdd:cd11291      2 PRLFRCSNESG-FFKVEEISD-----------FSQDDL--DTD-DIMLLDTGDEVFVWVG-----SESS-------DEEK 54

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207111502 1780 KCAMETVLQYSK----EKNEKKTPKsYLIHAGLEPLTFTNMFPSWE 1821
Cdd:cd11291     55 KEALTSAKKYIEtdplGRSKPRTPI-YLVKQGNEPPTFTGYFHAWD 99
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1456-1561 1.13e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 65.39  E-value: 1.13e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1456 VWHILEFDYSRLP--KQSIGQFHEGDTYVVKWKYMIsravgkrlhseriigpgkekccyFFWQGRNSTVNEKGTSALMTV 1533
Cdd:smart00262    2 LVRVKGKRNVRVPevPFSQGSLNSGDCYILDTGSEI-----------------------YVWVGKKSSQDEKKKAAELAV 58

                            90       100       110
                    ....*....|....*....|....*....|..
gi 1207111502  1534 ELDEERG---AQVQ-VQQGKEPPCFLQCFNGG 1561
Cdd:smart00262   59 ELDDTLGpgpVQVRvVDEGKEPPEFWSLFGGW 90
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1583-1679 3.33e-12

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 64.24  E-value: 3.33e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1583 YCVRGEKPIEGHLLEAVCHCSSLRSRTSMILLNipKASLYLWHGCKAQVHTRDVGRTTANKIKEQCPleaglhsSSKVSI 1662
Cdd:smart00262    1 FLVRVKGKRNVRVPEVPFSQGSLNSGDCYILDT--GSEIYVWVGKKSSQDEKKKAAELAVELDDTLG-------PGPVQV 71

                            90
                    ....*....|....*..
gi 1207111502  1663 QECDEGAEPQGFWEALG 1679
Cdd:smart00262   72 RVVDEGKEPPEFWSLFG 88
VHP pfam02209
Villin headpiece domain;
1877-1919 3.36e-12

Villin headpiece domain;


Pssm-ID: 460493  Cd Length: 36  Bit Score: 62.40  E-value: 3.36e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207111502 1877 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1919
Cdd:pfam02209    1 YLSDEDFE-------EVFGMSREEFYKLPKWKQNNLKKKAGLF 36
VHP smart00153
Villin headpiece domain;
1877-1919 1.74e-10

Villin headpiece domain;


Pssm-ID: 128458  Cd Length: 36  Bit Score: 57.33  E-value: 1.74e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207111502  1877 YLSDEDFEgvgasgkKALEMTRSEYEALPGWKQVNVKKAKGLF 1919
Cdd:smart00153    1 YLSDEDFE-------EVFGMTREEFYKLPLWKQNQLKKKKGLF 36
gelsolin_S3_like cd11292
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ...
 1288-1380 3.52e-09

Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200448  Cd Length: 98  Bit Score: 55.72  E-value: 3.52e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1288 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAkhlwngtfdytncdinpldpgecNALIPRKgqGRPDWAVFGRL 1367
Cdd:cd11292     29 EMLDSEDCYILDCGSEIFVWVGKGASLDERKAALKNA-----------------------EEFLRKK--KRPPYTQVTRV 83

                           90
                   ....*....|...
gi 1207111502 1368 TQHNETTLFKEKF 1380
Cdd:cd11292     84 TEGGESALFKSKF 96
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1700-1817 4.81e-09

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 55.07  E-value: 4.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502 1700 PRLFQLSSASgefaAVEFVYPSREPNLVNSMPFLQEDLYTatqpalflvdnhhEVYLWQGWwpqdsestGSARIRWDSDR 1779
Cdd:cd11280      2 PRLYRVRGSK----AIEIEEVPLASSSLDSDDVFVLDTGS-------------EIYIWQGR--------ASSQAELAAAA 56

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1207111502 1780 KCAMETvlqyskEKNEKKTPKSYLIHAGLEPLTFTNMF 1817
Cdd:cd11280     57 LLAKEL------DEERKGKPEIVRIRQGQEPREFWSLF 88
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1731-1820 1.12e-07

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 51.14  E-value: 1.12e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1731 PFLQEDLYTAtqpALFLVDNHHEVYLWQGwwpqdSESTgsarirwDSDRKCAMETVLQYSKEKNEKKTPkSYLIHAGLEP 1810
Cdd:smart00262   17 PFSQGSLNSG---DCYILDTGSEIYVWVG-----KKSS-------QDEKKKAAELAVELDDTLGPGPVQ-VRVVDEGKEP 80

                            90
                    ....*....|
gi 1207111502  1811 LTFTNMFPSW 1820
Cdd:smart00262   81 PEFWSLFGGW 90
gelsolin_S3_like cd11292
Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; ...
 1165-1236 4.78e-07

Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200448  Cd Length: 98  Bit Score: 49.56  E-value: 4.78e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207111502 1165 SSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAT-FVQTKHdlgcRASY--VQTIEEGAntHTHAAKDFWK 1236
Cdd:cd11292     29 EMLDSEDCYILDCGSEIFVWVGKGASLDERKAALKNAEeFLRKKK----RPPYtqVTRVTEGG--ESALFKSKFA 97
GEL smart00262
Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and ...
 1288-1383 1.87e-06

Gelsolin homology domain; Gelsolin/severin/villin homology domain. Calcium-binding and actin-binding. Both intra- and extracellular domains.


Pssm-ID: 214590 [Multi-domain]  Cd Length: 90  Bit Score: 47.67  E-value: 1.87e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207111502  1288 SMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGtfdytncdinpldpgecnaLIPRKGQGRpdwavfgRL 1367
Cdd:smart00262   21 GSLNSGDCYILDTGSEIYVWVGKKSSQDEKKKAAELAVELDDT-------------------LGPGPVQVR-------VV 74

                            90
                    ....*....|....*.
gi 1207111502  1368 TQHNETTLFKEKFLDW 1383
Cdd:smart00262   75 DEGKEPPEFWSLFGGW 90
Gelsolin pfam00626
Gelsolin repeat;
1164-1201 1.88e-06

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 47.30  E-value: 1.88e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207111502 1164 ASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELA 1201
Cdd:pfam00626   12 QESLNSGDCYLLDNGFTIFLWVGKGSSLLEKLFAALLA 49
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1160-1238 1.99e-06

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 47.75  E-value: 1.99e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207111502 1160 VEPRASSLNSGDCFLLITPHHCFIWIGEFANVIEKAKAAELAtfVQTKHDLGCRASYVQtIEEGanthtHAAKDFWKIL 1238
Cdd:cd11280     18 VPLASSSLDSDDVFVLDTGSEIYIWQGRASSQAELAAAALLA--KELDEERKGKPEIVR-IRQG-----QEPREFWSLF 88
gelsolin_S5_like cd11288
Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; ...
 1285-1331 2.76e-05

Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200444  Cd Length: 92  Bit Score: 44.53  E-value: 2.76e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111502 1285 PRCSMLNPKEVLVFDFGSEVYVWHGKEVTLAQRKVAFQLAKHLWNGT 1331
Cdd:cd11288     23 ADASSLNSNDVFVLKTPSSVYLWVGKGSSEDERELAKDVASFLKPKA 69
gelsolin_like cd11280
Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin ...
 1513-1558 6.02e-05

Tandemly repeated domains found in gelsolin, severin, villin, and related proteins; Gelsolin repeats occur in gelsolin, severin, villin, advillin, villidin, supervillin, flightless, quail, fragmin, and other proteins, usually in several copies. They co-occur with villin headpiece domains, leucine-rich repeats, and several other domains. These gelsolin-related actin binding proteins (GRABPs) play regulatory roles in the assembly and disassembly of actin filaments; they are involved in F-actin capping, uncapping, severing, or the nucleation of actin filaments. Severing of actin filaments is Ca2+ dependent. Villins are also linked to generating bundles of F-actin with uniform filament polarity, which is most likely mediated by their extra villin headpiece domain. Many family members have also adopted functions in the nucleus, including the regulation of transcription. Supervillin, gelsolin, and flightless I are involved in intracellular signaling via nuclear hormone receptors. The gelsolin-like domain is distantly related to the actin depolymerizing domains found in cofilin and similar proteins.


Pssm-ID: 200436  Cd Length: 88  Bit Score: 43.51  E-value: 6.02e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1207111502 1513 FFWQGRNSTVNEKGTSALMTVELDEERG---AQVQVQQGKEPPCFLQCF 1558
Cdd:cd11280     40 YIWQGRASSQAELAAAALLAKELDEERKgkpEIVRIRQGQEPREFWSLF 88
Gelsolin pfam00626
Gelsolin repeat;
1513-1555 3.56e-03

Gelsolin repeat;


Pssm-ID: 395501 [Multi-domain]  Cd Length: 76  Bit Score: 38.06  E-value: 3.56e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207111502 1513 FFWQGRNSTVNEKGTSALMTVELD-EERGA---QVQVQQGKEPPCFL 1555
Cdd:pfam00626   30 FLWVGKGSSLLEKLFAALLAAQLDdDERFPlpeVIRVPQGKEPARFL 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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